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Negative Effects of Maternal Smoking on Pregnancy and the Fetus in Relation to Elevated Levels of Erythropoetin in Umbilical Cord Plasma

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Open Journal of Preventive Medicine 2014年第5期4卷 307-316页

作者： Petra Sumichrastova Ingrid Skornova Erik Kudela Jana Sivakova Michaela Hrtankova Iveta Svecova Kamil Biringer Jan Danko department of Obstetrics and Gynecology Jessenius Faculty of MedicineComenius University in BratislavaMartinSlovakia hemathology and Transfusiology Clinics Jessenius Faculty of MedicineComenius University in BratislavaMartinSlovakia

Introduction: Based on many scientific research studies, there has been demonstrated a relation between smoking of pregnant women and its negative effects on pregnancy, intrauterine fetal growth, postnatal newborn condition, and development. The aim of our study is to highlight the adverse effects of cigarette use during pregnancy and to evaluate the effect of maternal smoking on the levels of erythropoietin (EPO) in umbilical cord plasma. Our aim was to show an effect of maternal smoking by determining carboxyhemoglobin (COHb) levels in maternal blood, too. Design: Prospective analysis. Setting: department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic. Methods: Our study included 174 newborns. Mothers were divided into group of smokers (n = 67) and non-smokers (n = 107). This prospective study was realized from February 2012 to November 2013 at the department of Gynecology and Obstetrics, Jessenius Faculty of Medicine in Martin, Slovak Republic. Patients signed a written informed consent and completed a questionnaire that involved medical history, and data of their smoking habits. EPO levels were measured in 174 samples of umbilical cord plasma. Infants were born spontaneously at term. Results: We observed significantly higher EPO levels in umbilical cord plasma in children born to smokers in contrast to non-smokers’ (children of non-smoking mothers: 19 ± 8 mIU/mL;children of smokers: 61 ± 33 mIU/mL, p < 0.01). The COHb levels were significantly higher in smokers (non-smokers: 0.8% ± 0.4%;smokers: 3.6% ± 1.1%, p < 0.001). Conclusion: Smoking during pregnancy is associated with elevated EPO concentrations in umbilical cord plasma at the time of birth. Based on the results of our study, we would like to support women planning pregnancy and pregnant women to quit smoking. Closer surveillance is recommended in smoking pregnant women, particularly because of the risk of placental insufficiency and fetal growth

关键词： Maternal Smoking Pregnancy Erythropoetin Carboxyhemoglobin Umbilical Cord

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Esophageal stenosis with sloughing esophagitis:A curious manifestation of graft-vs-host disease

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World Journal of Gastroenterology 2015年第30期21卷 9217-9222页

作者： Daniel Trabulo Sara Ferreira Pedro Lage Rafaela Lima Rego Gilda Teixeira A Dias Pereira Gastroenterology department Hospital de S?o BernardoCentro Hospitalar de Setúbal E.P.E.2910-446 SetúbalPortugal Gastroenterology department Instituto Português de Oncologia de Lisboa de Francisco Gentil Pathology department Instituto Português de Oncologia de Lisboa de Francisco Gentil hemathology department Instituto Português de Oncologia de Lisboa de Francisco Gentil

We report a case of a 56-year-old woman with a history of allogenic bone marrow transplantation for two years,complaining with dysphagia and weight loss. Upper endoscopy revealed esophageal stenosis and extensive mucosa sloughing. Biopsies confirmed the diagnosis of graft-vs-host disease(GVHD). Balloon dilation,corticosteroids and cyclosporin resulted in marked clinical improvement. Gastrointestinal tract is involved in the majority of patients with chronic GVHD. Esophageal manifestations are rare and include vesiculobullous disease,ulceration,esophageal webs,casts or strictures. Sloughing esophagitis along with severe stenosis requiring endoscopic dilation has never been reported in this context.

关键词： Dysphagia Esophageal stenosis Sloughingesophagitis Balloon dilation Graft-vs -host-disease

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Music therapy in children affected by brain tumors

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World Journal of Pediatric Surgery 2021年第3期4卷 44-45页

作者： Filippo Giordano Raffaella Messina Anna Riefolo Chiara Rutigliano Teresa Perillo Massimo Grassi Nicola Santoro Francesco Signorelli School of Medicine University of BariBariItaly department of Basic Medical Sciences Neurosciences and Sense OrgansDivision of NeurosurgeryUniversity of BariBariPugliaItaly Anesthesia and Intensive Care Unit Azienda Ospedaliero-Universitaria Consorziale Policlinico di BariBariPugliaItaly Pediatric hemathology-Oncology Policlinico di Bari Ospedale Giovanni XXIIIBariPugliaItaly

Children affected by brain tumors experi-ence significant levels of anxiety,nervousness,and fear regarding surgery,especially in the preoperative *** operating room can be an intimidating environment for them,and preoperative anxiety can adversely affect postoperative pain.1 Interest is growing in finding non-pharmacological means that may be used to reduce these symptoms.

关键词： tumors surgery dating

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