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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Modulated waveforms for harmonic minimization of far-field signals in amplitude-modulated heating of the ionosphere

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Earth and Planetary Physics 2025年第02期9卷 387-399页

作者： ZhiJian Lu Yong Li Hui Li Jian Wu JingFeng Yao XingBao Lyu ChengXun Yuan ZhongXiang Zhou Ying Wang School of Physics Harbin Institute of Technology China research institute of Radio Waves Propagation heilongjiang Provincial Key Laboratory of Plasma Physics and Application Technology heilongjiang Provincial Innovation research Center for Plasma Physics and Application Technology (International Cooperation)

This paper establishes an amplitude modulation heating model, simulating the far-field radiation of ELF/VLF signals generated by modulation heating, as well as the specific location and longitudinal extent of the radiation source. We consider various modulation waveforms and find that square-wave modulation has the highest excitation efficiency for ELF/VLF signals, and that square-wave modulation with a smaller duty cycle(<50%) exhibits higher excitation efficiency for ELF/VLF signals, while the sin2t waveform modulation yields the lowest proportion of harmonic energy in the generated signals. The amplitude of the second harmonic generated by the sin2t waveform is less than one-tenth that of the fundamental frequency, and the energy of higher-frequency harmonics can be negligibly small compared with those of the fundamental wave. It is a challenging task to achieve a balance between enhancing the excitation efficiency of ELF/VLF signals and also suppressing harmonics generated by the modulated heating process. This is because the harmonics are correspondingly enhanced as the excitation efficiency of the signals is increased. However, we find that under conditions of varying effective radiant power and modulation frequency, as long as the modulation waveform is unchanged, the energy ratio between the fundamental frequency signal generated by modulated heating and each harmonic is relatively fixed, with changes only in signal intensity and the location of the radiation source zone. This implies that one can first select modulation waveforms that make the signal less prone to distortion, then increase the effective radiated power to enhance the signal strength, without concern for harmonic interference of the fundamental signal.

关键词： ELF/VLF harmonic amplitude-modulated heating modulated waveforms

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Origin and Evolution Process of Overpressure in the Shahezi Formation of Xujiaweizi Fault Depression in the Northern Songliao Basin,NE China

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Acta Geologica Sinica(English Edition) 2025年第1期99卷 212-227页

作者： ZHANG Chengju JIANG Zhenxue LU Jiamin SHI Lidong BI Zhongyu SUN Lidong YANG Liang LI Xiaomei LIU Jiajun MIAO Huan National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China Unconventional Petroleum research institute China University of Petroleum(Beijing)Beijing 102249China Exploration and Development research institute of PetroChina Daqing Oilfield Company Limited DaqingHeilongjiang 163712China

It is of great significance for deep oil and gas exploration to understand the origin and evolution behind *** occurs in the deep Shahezi Formation of Xujiaweizi fault ***,due to limited degree of exploration,there are some problems in the study area,such as unclear understanding of the origin of overpressure and the vague investigation of overpressure *** clarify the impact of overpressure on oil and gas migration and accumulation in the study area,this study focuses on the research of the origin and evolution of overpressure in the Shahezi Formation of the study area,utilizing single well logging parameters and combining methods such as microthermometry of fluid inclusions,laser Raman spectrum,and basin *** results show that the overpressure of the Shahezi Formation in Xujiaweizi fault depression is primarily generated by hydrocarbon generation pressurization,and the evolution of overpressure is closely related to hydrocarbon *** development of overpressure can be divided into two evolutionary stages:early hydrocarbon generation pressurization and late uplift release,with slight variations in different *** glutenite gas reservoirs in the Shahezi Formation are characterized by continuous *** overall charging period ranges from the late Denglouku to the early Mingshui(110-67 Ma ago).There is an obvious paleo-overpressure during the gas reservoir formation *** gas generation period of source rocks occurred approximately 125-60 Ma ago,and the main gas generation period(112-67 Ma ago)highly coincides with the period of natural gas *** anomalously high pressure during the accumulation period is considered the significant driving force for natural gas *** addition,the sustained effect of overpressure provides better conditions for the preservation of tight gas reservoirs within the *** results of the study are of guiding significance for the in-depth expl

关键词： fluid inclusion laser Raman spectrum basin simulation overpressure genesis paleo-pressure recovery Shahezi Formation Xujiaweizi fault depression

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Electronic modulation induced by coupling RuO2 with electron-donating Co3O4 for high-active and long-life rechargeable Zn-air batteries

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Journal of Energy Chemistry 2025年第2期101卷 99-109页

作者： Xuena Ma Zhangxin Xu Mingyang Liu Panzhe Qiao Qi Li Ruihong Wang Baojiang Jiang Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China School of Chemistry and Materials ScienceHeilongjiang University Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences

Electronic-state modulation strategy offers great potential in designing RuO2-based bifunctionalelectrocatalysts for rechargeable Zn-air batteries（ZABs）.Various three-dimensional（3D） transition metal oxides are attempted to couple with RuO2for constructing an appropriate Ru—O—M *** work aims to construct Co3O4-RuO2heterostructures on carbon sheets（Co3O4/RuO2/NCNS） for boosting electronic transfer and *** and theoretical calculations identify the electronic transfer from Co3O4to RuO2that modulates the electronic structure of metal surfaces/***,it leads to the increase in Co3+content,electron-rich state at RuO2surface and electronic accumulation at ***,this electronic-state modulation optimizes the d-band center in Co3O4/RuO2that lowers the reaction barriers and endows interfaces as the biggest contributor to oxygen reduction reaction（ORR） and oxygen evolution reaction（OER） performance,The Co3O4/RuO2/NCNS shows a quite low potential difference of 0.62 V and remarkable durability for ORR/***3O4/RuO2/NCNS-assembled ZABs exhibit an excellent specific capacity of 818.3 mA h g-1and a superior lifespan over 750 h.

关键词： Charge-discharge stability Co3O4-RuO2 heterostructure Electronic modulation Reaction energy barrier Zn-air battery

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Maternal stress and the early embryonic microenvironment:investigating long‑term cortisol effects on bovine oviductal epithelial cells using air–liquid interface culture

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Journal of Animal Science and Biotechnology 2025年第1期16卷 153-166页

作者： Fiona Wahl Jianchao Huo Shuaizhi Du Jennifer Schoen Shuai Chen Department of Reproduction Biology Leibniz Institute for Zoo and Wildlife Research(IZW)Alfred‑Kowalke‑Straße 1710315 BerlinGermany institute of Biotechnology Technische Universität BerlinStraße Des 17.Juni 13510623 BerlinGermany institute of Reproductive Biology Research Institute for Farm Animal Biology(FBN)Wilhelm‑Stahl‑Allee 218196 DummerstorfGermany

The oviduct epithelium is the initial maternal contact site for embryos after fertilization,offering the microenviron-ment before *** early gestation period is particularly sensitive to stress,which can cause reduced fertil-ity and reproductive disorders in ***,the local impact of elevated stress hormones on the ovi-duct epithelium has received limited attention to date,except for a few reports on polyovulatory species like mice and *** this study,we focused on the effects of chronic maternal stress on cattle,given its association with infertil-ity issues in this monoovulatory *** oviduct epithelial cells(BOEC)differentiated at the air–liquid interface(ALI)were stimulated with 250 nmol/L cortisol for 1 or 3 ***,they were assessed for morphology,bioelectrical properties,and gene expression related to oviduct function,glucocorticoid pathway,cortisol metabo-lism,inflammation,and *** revealed adverse effects of cortisol on epithelium structure,featured by deciliation,vacuole formation,and ***,cortisol exposure led to an increase in transepithelial potential difference,downregulated mRNA expression of the major glucocorticoid receptor(NR3C1),upregulated the expression of cortisol-responsive genes(FKBP5,TSC22D3),and significant downregulation of oviductal glycopro-tein 1(OVGP1)and steroid receptors PGR and *** systematic comparison to a similar experiment previously performed by us in porcine oviduct epithelial cells,indicated that bovine cultures were more susceptible to elevated cortisol levels than *** distinct responses between both species are likely linked to their divergence in the cortisol-induced expression changes of HSD11B2,an enzyme controlling the cellular capacity to metabolise *** findings provide insights into the species-specific reactions and reproductive consequences triggered by maternal stress.

关键词： Air–liquid interface Bovine Cortisol Early embryonic microenvironment Epithelial cells Maternal stress Oviduct

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Atomically Precise Cu Nanoclusters:Recent Advances,Challenges,and Perspectives in Synthesis and Catalytic Applications

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Nano-Micro Letters 2025年第4期17卷 130-165页

作者： Mengyao Chen Chengyu Guo Lubing Qin Lei Wang Liang Qiao Kebin Chi Zhenghua Tang New Energy research institute School of Environment and EnergySouth China University of TechnologyGuangzhou Higher Education Mega CentreGuangzhou 510006People’s Republic of China Petrochemical research institute PetroChina Company LimitedBeijing 102206People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry(heilongjiang University) Ministry of EducationHarbin 150001People’s Republic of China

Atomically precise metal nanoclusters are an emerging type of nanomaterial which has diverse interfacial metal-ligand coordination motifs that can significantly affect their physicochemical properties and *** that,Cu nanoclusters have been gaining continuous increasing research attentions,thanks to the low cost,diversified structures,and superior catalytic performance for various *** this review,we first summarize the recent progress regarding the synthetic methods of atomically precise Cu nanoclusters and the coordination modes between Cu and several typical ligands and then discuss the catalytic applications of these Cu nanoclusters with some explicit examples to explain the atomical-level structure-performance ***,the current challenges and future research perspectives with some critical thoughts are *** hope this review can not only provide a whole picture of the current advances regarding the synthesis and catalytic applications of atomically precise Cu nanoclusters,but also points out some future research visions in this rapidly booming field.

关键词： Atomically precise Cu nanoclusters Controllable synthesis Catalytic applications Structure-performance relationship Challenges and perspectives

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Late spring-early summer drought and soil properties jointly modulate two pine species?decline and climatic sensitivity in temperate Northern China

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Forest Ecosystems 2025年第1期12卷 146-158页

作者： Yuheng Li Zhaofei Fan Lihong Xu Xiao Zhang Zhongjie Shi Xiaohui Yang Wei Xiong Ling Cong Semyun Kwon Leilei Pan f Hanzhi Li Shuo Wen Xiaoyan Shang institute of Geographic Sciences and Natural Resources research Chinese Academy of SciencesBeijing100101China research institute of Ecological Conservation and Restoration Chinese Academy of ForestryBeijing100091China research institute of Desertification Studies Chinese Academy of ForestryBeijing100091China College of Forestry Wildlife and EnvironmentAuburn UniversityAL36849United States Ecology and Nature Conservation institute Chinese Academy of ForestryBeijing100091China institute of Ecological Restoration Kongju National UniversityChungcheongnam-do32439Republic of Korea University of Chinese Academy of Sciences Beijing100049China

Increasing temperatures and severe droughts threaten forest vitality *** of forest response to climate change requires knowledge of the spatiotemporal patterns of monthly or seasonal climatic impacts on the growth of tree species,likely driven by local climatic aridity,climate trends,edaphic conditions,and the climatic adaption of tree *** ability of tree species to cope with changing climate and the effects of environmental variables on growth trends and growth-climate relationships across diverse bioclimatic regions are still poorly understood for many *** study investigated radial growth trends,interannual growth variability,and growth-climate sensitivity of two dominant tree species,Pinus tabulaeformis(PT)and Pinus sylvestris ***(PS),across a broad climatic gradient with a variety of soil properties in temperate Northern *** a network of 83 tree ring chronologies(54 for PT and 29 for PS)from 1971 to 2010,we documented that both species maintained constant growth trends at wet sites,while both displayed rapid declines at dry *** reported the species-specific drivers of spatial heterogeneity in growth trends,interannual growth variability,and growth-climate *** climatic variables and soil properties were identified as the most critical factors affecting the growth trends and growth-climate ***,climatic variables play more essential roles than soil properties in determining the spatial heterogeneity of the growth-climate *** clay content and higher soil nutrient regimes can exacerbate the moisture-related susceptibility of tree *** findings highlight that soil properties emerged as important modulating factors to predict the drought vulnerability of forests in addition to climatic *** the continued climate warmingdrying trend in the future,both pines will face a more severe growth decline and increase in drought vulnerability at dri

关键词： Tree rings Climate sensitivity Growth decline Global warming Drought Soil property

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Detection of Perfect Stealthy Attacks on Cyber-Physical Systems Subject to Measurement Quantizations: A Watermark-Based Strategy

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 114-125页

作者： Yu-Ang Wang Zidong Wang Lei Zou Bo Shen Hongli Dong the College of Information Science and Technology Donghua University the Engineering research Center of Digitalized Textile and Fashion Technology Ministry of Education IEEE the College of Electrical Engineering and Automation Shandong University of Science and Technology the Department of Computer Science Brunel University London Uxbridge the Sanya Offshore Oil and Gas research institute Northeast Petroleum University the Artificial Intelligence Energy research institute Northeast Petroleum University heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Northeast Petroleum University

In this paper, the attack detection problem is investigated for a class of closed-loop systems subjected to unknownbutbounded noises in the presence of stealthy attacks. The measurement outputs from the sensors are quantized before transmission.A specific type of perfect stealthy attack, which meets certain rather stringent conditions, is taken into account. Such attacks could be injected by adversaries into both the sensor-toestimator and controller-to-actuator channels, with the aim of disrupting the normal data flow. For the purpose of defending against these perfect stealthy attacks, a novel scheme based on watermarks is developed. This scheme includes the injection of watermarks(applied to data prior to quantization) and the recovery of data(implemented before the data reaches the estimator).The watermark-based scheme is designed to be both timevarying and hidden from adversaries through incorporating a time-varying and bounded watermark signal. Subsequently, a watermark-based attack detection strategy is proposed which thoroughly considers the characteristics of perfect stealthy attacks,thereby ensuring that an alarm is activated upon the occurrence of such attacks. An example is provided to demonstrate the efficacy of the proposed mechanism for detecting attacks.

关键词： Attack detection cyber-physical systems (CPSs) perfect stealthy attacks watermark-based strategy

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Modulation of rice grain shape and appearance by the GS10-encoded long coiled-coil protein

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The Crop Journal 2025年第1期13卷 158-169页

作者： Yanmin Luo Yuyu Chen Pao Xue Beifang Wang Yiwei Kang Yue Zhang Daibo Chen Yongbo Hong Weixun Wu Qunen Liu Xiaodeng Zhan Yongjun Lin Shihua Cheng Yingxin Zhang Liyong Cao State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400ZhejiangChina National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene research Huazhong Agricultural UniversityWuhan 430070HubeiChina Northern Rice research Center of Bao Qing Shuangyashan 155600HeilongjiangChina National Nanfan research institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572025HainanChina Zhejiang Key Laboratory of Super Rice research China National Rice Research InstituteHangzhou 311400ZhejiangChina

Rice grain size is a primary characteristic essential for artificial domestication and breeding,governed by grain length,width,and *** this study,we cloned Grain Size 10(GS10),a novel gene via mapbased ***,molecular,and genetic studies were performed to elucidate the GS10 involved grain size mechanism in *** of GS10 lead to reduced grain size due to alterations in cell ***,GS10 is responsible for the formation of notched-belly grains,especially in smaller grain varieties possessing loss-function *** of GS10 in Nipponbare results in increasing grain length,grain weight and improve the appearance quality of ***10 encodes conserved protein with uncharacterized ***,GS10 regulates the grain size by interacting OsBRICK1,a subunit of the WAVE complex that governs actin nucleation and affects the assembly of microfilaments in ***,our study demonstrates that,GS10 positively regulates the grain length and grain weight,which is beneficial for further improvements in yield characteristics.

关键词： GS10 Grain size Grain weight Appearance quality Microfilaments

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Late spring-early summer drought and soil properties jointly modulate two pine species? decline and climatic sensitivity in temperate Northern China

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Forest Ecosystems 2025年第01期 146-158页

作者： Yuheng Li Zhaofei Fan Lihong Xu Xiao Zhang Zhongjie Shi Xiaohui Yang Wei Xiong Ling Cong Semyun Kwon Leilei Pan Hanzhi Li Shuo Wen Xiaoyan Shang institute of Geographic Sciences and Natural Resources research Chinese Academy of Sciences research institute of Ecological Conservation and Restoration Chinese Academy of Forestry University of Chinese Academy of Sciences College of Forestry Wildlife and Environment Auburn University Ecology and Nature Conservation institute Chinese Academy of Forestry research institute of Desertification Studies Chinese Academy of Forestry institute of Ecological Restoration Kongju National University Chungcheongnam-do

Increasing temperatures and severe droughts threaten forest vitality globally. Prediction of forest response to climate change requires knowledge of the spatiotemporal patterns of monthly or seasonal climatic impacts on the growth of tree species, likely driven by local climatic aridity, climate trends, edaphic conditions, and the climatic adaption of tree species. The ability of tree species to cope with changing climate and the effects of environmental variables on growth trends and growth-climate relationships across diverse bioclimatic regions are still poorly understood for many species. This study investigated radial growth trends, interannual growth variability, and growth-climate sensitivity of two dominant tree species, Pinus tabulaeformis(PT) and Pinus sylvestris var. mongolica(PS), across a broad climatic gradient with a variety of soil properties in temperate Northern China. Using a network of 83 tree ring chronologies(54 for PT and 29 for PS) from 1971 to 2010, we documented that both species maintained constant growth trends at wet sites, while both displayed rapid declines at dry sites. We reported the species-specific drivers of spatial heterogeneity in growth trends, interannual growth variability, and growth-climate relationships. Calculated climatic variables and soil properties were identified as the most critical factors affecting the growth trends and growth-climate relationships. However, climatic variables play more essential roles than soil properties in determining the spatial heterogeneity of the growth-climate *** clay content and higher soil nutrient regimes can exacerbate the moisture-related susceptibility of tree growth. Our findings highlight that soil properties emerged as important modulating factors to predict the drought vulnerability of forests in addition to climatic variables. Considering the continued climate warmingdrying trend in the future, both pines will face a more severe growth decline and increase in dr

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