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Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

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Cellular & Molecular Immunology 2020年第6期17卷 647-649页

作者： Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye Institute of Immunology PLAThird Military Medical UniversityChongqing 400038China State key laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbinHeilongjiang 150001China College of Veterinary medicine Northeast Agricultural UniversityHarbin Heilongjiang 150030China Chongqing Public Health Medical Center Chongqing 400038China comparative Immunology Research Center College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Biomedical Analysis Center Third Military Medical UniversityChongqing 400038China Cancer Center The General Hospital of Western Theater CommandChengduSichuan 610083China Institute of Human Virology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalShenzhenGuangdong 518112China NHC key laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical College100176 BeijingChina

According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020.

关键词： respiratory monoclonal mortality

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Evidence of return of chum salmon released from Tangwang River by strontium marking method

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Acta Oceanologica Sinica 2021年第8期40卷 182-186页

作者： Jilong Wang Wei Liu Peilun Li Fujiang Tang Wanqiao Lu Jian Yang Tao Jiang heilongjiang River Fisheries Research Institute Chinese Academy of Fishery SciencesHarbin 150070China Scientific Observing and Experimental Station of Fishery Resources and Environment in heilongjiang River Basin Ministry of Agriculture and Rural AffairsHarbin 150070China key laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River Freshwater Fisheries Research CenterChinese Academy of Fishery SciencesWuxi 214081China

In order to assess the effect of enhancement release of chum salmon(Oncorhynchus keta),otolith strontium(Sr)marking method was used to tag chum salmon released in Tangwang River in *** homing chum salmon were detected and the samples were collected in Tangwang River,Ussuri River and Suifen River in the autumn *** samples were analyzed by examining Sr and calcium(Ca)fingerprints in the otolith using electron probe *** results suggested that two samples collected in Tangwang River had the marking ring near the core of otolith where the Sr concentration and Sr/Ca ratio were significantly higher than comparative *** that the two fish belonged to the released population in Tangwang River in *** article indicated the success of the enhancement release of chum salmon from the Tangwang River for the first time and also confirmed the validity of Sr marking in enhancement release of fishes.

关键词： chum salmon(Oncorhynchus keta) otolith strontium(Sr)marking enhancement release

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表观遗传调控分子miR-218抗病毒感染的作用机制

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中国预防兽医学报 2021年第6期43卷 688-688页

作者： ZHANG LIN ZHANG LU PAN YU ‡ These authors contributed equally to this work. State key laboratory of Veterinary Biotechnology National Poultry Laboratory Animal Resource Center Heilongjiang Provincial Key Laboratory of Laboratory Animal and Comparative Medicine Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin China

Micro RNAs(miRNA)是一类内源性、长度约为22个碱基的非编码RNA,在基因转录后调控其编码蛋白的表达中发挥重要作用。MiRNAs最初从基因组转录为初级miRNAs,通过生物加工过程形成一系列中间体,最终加工为成熟的单链miRNAs。

关键词：抗病毒感染非编码RNA 转录后调控表观遗传调控 miRNAs 内源性

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Phylogeny and Homologous Recombination Occurring in Classical Swine Fever Viruses

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Journal of Northeast Agricultural University(English Edition) 2019年第3期26卷 57-65页

作者： Jiang Qing-yun Gao Yu Li Wei-qun Ding Fan Juergen Richt Ren Yu-dong Li Guang-xing College of Veterinary medicine Heilongjiang Key Laboratory for Animal and Comparative Medicine Northeast Agricultural University Harbin 150030 China Department of Health Chinese Armed Police Force Command Beijing 100048 China Department of Diagnostic medicine/Pathobiology College of Veterinary Medicine Kansas State University Manhattan KS 66506 5606 USA College of Electrical and Information Northeast Agricultural University Harbin 150030 China

Classical swine fever virus(CSFV) is the causative agent of classical swine fever, a highly contagious disease of pigs. But there is little information on the recombination in natural populations of CSFVs. Therefore, a phylogenetic analysis of 62 fulllength genome CSFV strains, isolated from all over the world, was performed to detect potential recombination events, with the recombinant sequences being analyzed with the SimPlot and RDP programs. The results identified a mosaic virus, Chinese CSFV HCLV(2)(AF091507.1), which is the one naturally emerged recombinant CSFV with two recombination breakpoints at 2 484 and 2 900 bp of the genome alignment. Its two putative parental-like strains were CSFV Shimen(AF092448.2) and CSFV strain C/HVRI(AY805221.1). This work demonstrated that homologous recombination did occur in natural CSFV populations. It had significant implications for understanding the molecular epidemiology of CSFV, and revealed that recombination was an important factor for high genetic diversities of CSFV.

关键词： classical swine fever virus homologous recombination phylogeny genetic diversity

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Reliability Analysis of Satellite Turntable System under Multiple Operation Modes Based on Multi-Valued Decision Diagrams

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Journal of Beijing Institute of Technology 2023年第1期32卷 52-68页

作者： Peng Zhang Zhijie Zhou Yao Ding Dao Zhao Yijun Zhang the key laboratory for Fault Diagnosis and Maintenance of Spacecraft in Orbit Xi’anShaanxi 710043China the High-Tech Institute of Xi’an Xi’anShaanxi 710025China Institute of Information and Communication National University of Defense TechnologyWuhan 430079China

As a payload support system deployed on satellites,the turntable system is often switched among different working modes during the on-orbit operation,which can experience great state *** each mode,the missions to be completed are different,consecutive and non-over-lapping,from which the turntable system can be considered to be a phased-mission system(PMS).Reliability analysis for PMS has been widely ***,the system mode cycle characteristic has not been taken into account *** this paper,reliability analysis method of the satellite turntable system is proposed considering its multiple operation modes and mode cycle ***,the multi-valued decision diagrams(MDD)manipulation rules between two adjacent mission cycles are *** this basis,MDD models for the turntable system in different states are established and the reliability is calculated using the continuous time Markov chains(CTMC)***,the comparative study is carried out to show the effectiveness of our proposed method.

关键词： phased-mission systems multi-valued decision diagrams continuous time Markov chains(CTMC) reliability analysis satellite turntable system

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The Influence of Oxygen on the Development of Nanorana parkeri Tadpoles

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Asian Herpetological Research 2018年第1期9卷 50-55页

作者： Xingzhi HAN Qiong ZHANG Liqing FAN Le YANG Zhensheng LIU College of Wildlife Resources Northeast Forestry University Harbin 150040 Heilongjiang China key laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Tibet Agriculture and Animal Husbandry College Linzhi 860000 Tibet China Tibet Plateau Institute of Biology Lhasa 850001 Tibet China

Ectothermic animals are tolerant of variable oxygen availability, whether low-oxygen levels constrain the fitness of ectotherms remains unclear. Nanorana parkeri, an anuran endemic to the southern Tibetan plateau, is an excellent model with which to answer this question. In this study, we raised tadpoles ofN. parkeri in oxygenated water （high-oxygen group） and deoxygenated unchlorinated tap water （low-oxygen group） and monitored their growth, mortality, and telomere length. The growth rate for body length and body weight was higher in the low-oxygen group than in the high-oxygen group. However, dissolved oxygen did not affect development time, mortality, and telomere length of the tadpoles. These results suggest that although the oxygen concentration influenced some phenotype traits of plateau tadpoles, but it didn＇t influence the telomere length and survival rate, potential explanations are the local adaptation and N. parkeri tadpoles＇ wide oxygen tolerance, and fluctuant toxic content that resulted in little oxidative stress on tadpoles. These results indicated that low oxygen was not a stress to N. parkeri tadpoles＇ fitness and survival. This study is helpful in understanding the adaptation mechanisms of Tibetan plateau amphibians.

关键词： amphibian frog local adaptation metamorphosis oxygen concentration telomere length

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iTRAQ-Based Proteomics Investigation of Critical Response Proteins in Embryo and Coleoptile During Rice Anaerobic Germination

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Rice science 2021年第4期28卷 391-401页

作者： Zhang Guangchen Liu Zimeng Liu Yoxihong Kuya Noriyuki HuAYuchen Shi Hongru Zhao Weilin Han Yuqing Yamamoto Toshio Chen Wenfu Sun Jian Rice Research Institute Shenyang Agricultural UniversityShenyang 110161China Institute of Crop Cultivation and Tillage Heilongjiang Academy of Agricultural Sciences/Heilongjiang Provincial Key Laboratory of Crop Molecular Design and Germplasm InnovationHaerbin 150086China Institute of Crop Science National Agriculture and Food Research OrganizationIbaraki 305-8518Japan Center of Seed Industry Development of Liaoning Province Shenyang 110034China Institute of Plant Science and Resources Okayama UniversityOkayama 710-0046Japan

Direct-seeding of rice has become popular in recent years due to its low cost and convenience,however,hypoxic condition limits seedling *** this study,weedy rice WR04-6 with high germination ability under anaerobic conditions was used as a gene donor,and we successfully improved the seedling establishment rate of rice cultivar Qishanzhan(QSZ)based on selection of a new rice line R42 from the recombinant inbred line population.R42 inherited high anaerobic germination(AG)ability,and was used for isobaric tags for relative and absolute quantitation(iTRAQ)-based comparative proteomic studies with QSZ to further explore the molecular mechanism of AG.A total of 719 differentially abundant proteins(DAPs)were shared by R42 and QSZ responded to AG,and thus defined as common response DAPs.A total of 300 DAPs that responded to AG were only identified from R42,which were defined as tolerance-specific *** common response and tolerance-specific DAPs had similar biochemical reaction processes and metabolic pathways in response to anoxic stress,however,they involved different *** tolerance-specific DAPs were involved in amino acid metabolism,starch and sucrose metabolism,tricarboxylic acid cycle pathway,ethylene synthesis pathway,cell wall-associated proteins and activity of active oxygen scavenging *** in silico protein-protein interactions for the top 60 DAPs indicated that tolerance-specific DAPs had relatively independent protein interaction networks in response to an anoxic environment compared with common response *** results of physiological indicators showed thatα-amylase and superoxide dismutase activities of R42 were significantly increased under anoxic conditions compared with aerobic *** lines of evidence from western blot,physiological analysis and quantitatDirect seeding of rice has become popular in recent years due to its low cost and convenience,however,hypoxic conditions can limit seedling *** the

关键词： iTRAQ-based proteomics direct-seeding anaerobic germination weedy rice differentially abundant protein

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抑制猪流行性腹泻病毒增殖的新靶标:表皮生长因子受体类似物

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中国预防兽医学报 2018年第7期40卷 662-662页

作者： Yang Li-jun Xu Jia-yu Guo Long-jun State key laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin China. heilongjiang Provincial key laboratory of laboratory Animal and comparative medicine Harbin China. State key laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin China wangyue@***.

我国发展迅速的养猪业，深受多种疾病困扰，使得猪病形式变得越来越复杂，猪场的预防与控制较为困难。其中，猪流行性腹泻一直以来都是困扰我国养猪业健康发展的主要障碍之一。猪流行性腹泻是由猪流行性腹泻病毒（Porcine epidemic diar... 详细信息

我国发展迅速的养猪业，深受多种疾病困扰，使得猪病形式变得越来越复杂，猪场的预防与控制较为困难。其中，猪流行性腹泻一直以来都是困扰我国养猪业健康发展的主要障碍之一。猪流行性腹泻是由猪流行性腹泻病毒（Porcine epidemic diarrhea virus，PEDV）引起的以仔猪呕吐、腹泻、脱水为特征的高度接触性肠道传染病，致死率高达100％。

关键词：猪流行性腹泻病毒表皮生长因子受体病毒增殖类似物靶标 virus 肠道传染病养猪业

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comparative analysis of diverse toxins from a new pharmaceutical centipede,Scolopendra mojiangica

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Zoological Research 2020年第2期41卷 138-147页

作者： Zi-Chao Liu Jin-Yang Liang Xin-Qiang Lan Tao Li Jia-Rui Zhang Fang Zhao Geng Li Pei-Yi Chen Yun Zhang Wen-Hui Lee Feng Zhao key laboratory of Ethnic Medical Resources Research and Southeast Asian International Cooperation of Yunnan Universities Department of Biology and ChemistryPuer UniversityPuerYunnan 665000China key laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Engineering Research Center for Exploitation and Utilization of Leech Resources in Universities of Yunnan Province School of Agronomy and Life SciencesKunming UniversityKunmingYunnan 650214China key laboratory of Active Molecules and Drug Development Puer UniversityPuerYunnan 665000China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Institute of comparative Study of Traditional Materia Medica Institute of Integrative Medicine of Fudan UniversityShanghai 200032China Nanshan College Guangzhou Medical UniversityGuangzhouGuangdong 511436China

As the oldest venomous animals,centipedes use their venom as a weapon to attack prey and for *** venom,which contains many bioactive and pharmacologically active compounds,has been used for centuries in Chinese medicine,as shown by ancient *** on comparative analysis,we revealed the diversity of and differences in centipede toxin-like molecules between Scolopendra mojiangica,a substitute pharmaceutical material used in China,and *** *** than 6000 peptides isolated from the venom were identified by electrospray ionization-tandem mass spectrometry(ESI-MS/MS)and inferred from the *** a result,in the proteome of ***,246 unique proteins were identified:one in five were toxin-like proteins or putative toxins with unknown function,accounting for a lower percentage of total proteins than that in *** mining identified approximately 10 times more toxin-like proteins,which can characterize the precursor structures of mature toxinlike ***,the constitution and quantity of the toxin transcripts in these two centipedes were *** toxicity assays,the crude venom showed strong insecticidal and hemolytic *** findings highlight the extensive diversity of toxin-like proteins in *** and provide a new foundation for the medical-pharmaceutical use of centipede toxin-like proteins.

关键词： Centipede Toxins Pharmaceutical use Proteotranscriptomic analysis

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Molecular mechanism of Salvia miltiorrhiza Bunge and Carthamus tinctorius L. in the treatment of myocardial ischemia based on network pharmacology: a comparative study

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Asian Journal of Traditional medicines 2022年第2期17卷 51-64页

作者： Ronghong Liu Yanping Wang Wenjing Li Bo Hong College of Pharmacy Qiqihar Medical UniversityQiqihar 161000HeilongjiangChina

Based on network pharmacology and molecular docking technology,the similarities and differences of anti-myocardial ischemia mechanism between Salvia miltiorrhiza Bunge(SM)and Carthamus tinctorius L.(CT)were ***,based on the traditional Chinese medicine systems pharmacology(TCMSP),the related compounds of SM and CT were obtained,and the potential targets of these compounds were collected by the target fishing *** database was used to obtain targets related to myocardial *** cross targets of CT,SM,and myocardial ischemia were then selected,and the protein-protein interaction(PPI)network was constructed based on the STRING *** cross targets were imported into the Metascape database for Gene Oncology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)*** software was used to build the topological network diagram of the drug-compound-target ***,the binding ability of the active ingredient and the key target was verified by molecular docking.65 active ingredients and 38 potential targets were screened from SM,and 22 active ingredients and 58 potential targets were excavated from *** targets common to SM and CT were TNF,IL6,VEGFA,AKT1,*** common enrichment pathways involved are fluid shear stress and atherosclerosis,IL-17 signaling pathway,pathways in cancer,and *** findings suggested that the two traditional Chinese medicines exerted the effect of myocardial ischemia through the characteristics of multiple targets,multiple pathways,and multiple compounds.

关键词： myocardial ischemia Salvia miltiorrhiza Bunge Carthamus tinctorius L network pharmacology molecular docking

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