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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang hefei national Research Center for physical sciences at the microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Optical determination of the Boltzmann constant

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Chinese Physics B 2015年第5期24卷 87-92页

作者：程存峰孙羽胡水明 hefei national laboratory for physical sciences at microscale University of Science and Technology of China

The Boltzmann constant kB is a fundamental physical constant in thermodynamics. The present CODATA recommended value of kB is 1.3806488（13） × 10^-23 J/K （relative uncertainty 0.91 ppm）, which is mainly determined by acoustic methods. Doppler broadening thermometry （DBT） is an optical method which determines kBT by measuring the Doppler width of an atomic or molecular transition. The methodology and problems in DBT are reviewed, and DBT measurement using the sensitive cavity ring-down spectroscopy （CRDS） is proposed. Preliminary measurements indicate that CRDS- based DBT measurement can potentially reach an accuracy at the 1 ppm level.

关键词： Boltzmann constant Doppler broadening thermometry metrology

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Recombination-induced voltage-dependent photocurrent collection loss in CdTe thin film solar cell

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Chinese Physics B 2022年第10期31卷 607-616页

作者： Ling-Ling Wu Guang-Wei Wang Juan Tian Dong-Ming Wang De-Liang Wang hefei national laboratory for physical sciences at microscale University of Science and Technology of ChinaHefei 230026China

Recently, the efficiency of CdTe thin film solar cell has been improved by using new type of window layer Mg_(x)Zn_(1-x)O(MZO). However, it is hard to achieve such a high efficiency as expected. In this report a comparative study is carried out between the MZO/CdTe and CdS/CdTe solar cells to investigate the factors affecting the device performance of MZO/CdTe solar cells. The efficiency loss quantified by voltage-dependent photocurrent collection efficiency(ηC(V′)) is 3.89% for MZO/CdTe and 1.53% for CdS/CdTe solar cells. The higher efficiency loss for the MZO/CdTe solar cell is induced by more severe carrier recombination at the MZO/CdTe p-n junction interface and in CdTe bulk region than that for the CdS/CdTe solar cell. Activation energy(Ea) of the reverse saturation current of the MZO/CdTe and CdS/CdTe solar cells are found to be 1.08 e V and 1.36 e V, respectively. These values indicate that for the CdS/CdTe solar cell the carrier recombination is dominated by bulk Shockley-Read-Hall(SRH) recombination and for the MZO/CdTe solar cell the carrier recombination is dominated by the p-n junction interface recombination. It is found that the tunneling-enhanced interface recombination is also involved in carrier recombination in the MZO/CdTe solar cell. This work demonstrates the poor device performance of the MZO/CdTe solar cell is induced by more severe interface and bulk recombination than that of the CdS/CdTe solar cell.

关键词： CdTe solar cell voltage-dependent photocurrent collection efficiency interface recombination bulk recombination

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First-principles Study of Electron Transport Through Oligoacenes

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Chinese Journal of Chemical Physics 2009年第1期22卷 7-12页

作者： Zhen Pan Qun-xiang Li Qin-wei Shi Xiao-ping Wang hefei national laboratory for physical sciences at microscale University of Science and Technology of China Hefei 230026 China

The electronic transport properties of oligoacenes sandwiched between two Au（111） surfaces with serial and parrallel configurations were investigeted by using a fully self-consistent nonequilibrium Green＇s function method combined with density functional calculations. This theoretical results show that the conductivity of oligoacenes with both sandwiched configurations at low bias voltage is mainly determined by the tail of the transmission peak from the perturbed highest occupied molecular orbital. When the molecular length increases, the zero-bias voltage conductance G（0） of oligoacenes with serial configuration neither follows Magoga＇s exponential law nor displays the even-odd oscillation effect, while the G（O） of the oligoacenes sandwiched with parallel configuration monotonically increases. The reduction of energy gaps, the alignment of the Fermi level, and the spatial distribution of the perturbed molecular orbitals are used to self-consistently explore the transport mechanism through oligoacenes.

关键词： Transport property Oligoacene Zero-bias voltage conductance First-principles calculation

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Lattice Dynamics and Superconductivity of RUB2： A First-Principles Study

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Chinese Physics Letters 2008年第8期25卷 3036-3039页

作者：汪月琴袁岚峰杨金龙 hefei national laboratory for physical sciences at microscale University of Science and Technology of China Hefei 230026

We report the first-principles linear response calculations on lattice dynamics and electron-phonon coupling （EPC） of superhard material RuB2. Phonon frequencies and eigenvectors are obtained throughout the whole Brillouin zone. The calculated EPC paracneters for the optical phonon modes at F indicate that the d electrons of transition metal play the most important role in deciding the superconducting behaviour, and there are sizeable contributions from B p electrons to EPC. Our calculated EPC constant is 0.41, and the estimated superconducting transition temperature Tc is 1.6K using the Coulomb pseudopotential u^＊ = 0.12, in excellent agreement with the experimental ones.

关键词： the power-law exponents precipitation durative abrupt precipitation change

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Improved thermoelectric performance in n-type BiTe facilitated by defect engineering

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Rare Metals 2021年第10期40卷 2829-2837页

作者： Hao Zhu Ji-Yin Zhao Chong Xiao hefei national laboratory for physical sciences at the microscale University of Science and Technology of ChinaHefei 230026China

BiTe is a potentially attractive candidate for thermoelectric applications because it is the structural analogue of the state-of-the-art thermoelectric material,bismuth telluride(Bi_(2)Te_(3)). However, BiTe has attracted little attention due to its small band gap and high electron concentration. In this study, remarkable increase in thermoelectric performance in the n-type Bi_(1-x)Sb_(x)Te compounds through tuning the carrier concentration with chemical doping is shown. The Seebeck coefficient of Bi_(1-x)Sb_(x)Te increases remarkably while the electronic thermal conductivity decreases gradually as Sb content is increased, leading to enhanced thermoelectric figure of merit(ZT). Moreover, the simultaneous optimization of the electrical and thermal transport properties leads the peak temperature of the figure of merit to shift toward lower temperature with Sb content increasing in Bi_(1-x)Sb_(x)Te, thus making Bi_(1-x)Sb_(x)Te a potential alternative to bismuth telluride for near-room-temperature thermoelectric applications. In addition, the presence of multiple low-frequency optical phonons and their coupling with the long-wavelength heat carrying acoustic phonons in all the Bi_(1-x)Sb_(x)Te investigated are revealed based on the combined Debye-Einstein model. The present results provide the underlying mechanism connecting thermoelectric performance and lattice dynamics in Bi_(1-x)Sb_(x)Te compounds.

关键词： BiTe Thermoelectric material Carrier concentration Defect engineering Einstein oscillators Near-room-temperature application

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Fermi Surface Topology of Na0.5CoO2 from the Hybrid Density Functional

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Chinese Physics Letters 2005年第12期22卷 3155-3158页

作者：陈招英向红军杨金龙 hefei national laboratory for physical sciences at microscale University of Science and Technology of China Hefei 230026

The Fermi surface topology of Na0.5CoO2 is studied using the hybrid density functional theory. We first study a single （CoO2）^0.5- layer model with the percentage of the nonlocal Hartree-Fock exchange changing from 0% to 20%. The results show that only when the mixed nonlocal Hartree-Fock exchange is between 1% and 5%, the Fermi surface topology is similar to the experimental one. With 3% HF exchange in the hybrid density functional, considering the effects of Na ions in the Na0.5CoO2 system, we find that the Fermi surface is split to double holes and small gaps open near the intersections between the Brillouin zone and the Fermi surface. Our results show that both the amounts of the nonlocal Hartree-Fock exchange in the hybrid density functional and the Na ions have much influence on the Fermi surface topology.

关键词： EXCHANGE ENERGY

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Real-Time Observation of Pyoverdine Dissolving Ferric Hydroxide

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Chinese Journal of Chemical Physics 2017年第1期30卷 117-122,I0002页

作者： Jia-hong Li hefei national laboratory for physical sciences at the microscale University of Science and Technology of China Hefei 230025 China

Pyoverdine is one of the siderphores excreted by Pseudomonas aeruginosa that can help microbe to uptake iron in vitro. To determine the effect of pyoverdine chelating with iron, we purified the free pyoverdine and applied the dynamic laser light scattering （DLS） to detect the interaction between the pyoverdine and ferric hydroxide. The real-time DLS data analysis indicated that pyoverdine can directly combine with Fe（OH）3 to form complexes and these substances are gradually degraded by themselves then completely disappeared. In our experiment, we have demonstrated that pyoverdine may not only chelate ferric ion but also availably dissolve ferric hydroxide which assists bacteria to survive in iron-deficient environments.

关键词： Pyoverdine Ferric hydroxide Dissolution Dynamic laser light scattering

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Scanning Tunneling Spectroscopy of Metal Phthalocyanines on a Au(111) Surface with a Ni Tip

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Chinese Physics Letters 2011年第7期28卷 242-245页

作者： JIA Zhi-Chun HU Zhen-Peng ZHAO Ai-Di LI Zhen-Yu LI Bin hefei national laboratory for physical sciences at microscale University of Science and Technology of ChinaHefei 230026

Scanning tunneling spectroscopy of metal phthalocyanines(MPc)adsorbed on a Au(111)surface with a Ni(111)scanning tunneling microscopy tip is simulated on the basis of first-principles calculations and a modified Bardeen *** d orbital symmetry matching between the molecule and the Ni tip brings obvious negative differential resistance(NDR)phenomena,of which,bias voltage and resonant orbitals can be tuned sensitively by the central ion of the *** dependences of the NDR peak on the tip−molecule distance at two bias polarities and rectifying phenomena are also interpreted in terms of specific structures of 3d orbitals of the adsorbed MPc and Ni tip.

关键词： approximation Au(111) tunneling

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Electron Momentum Spectroscopy of Ethanethiol Complete Valence Shell

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Chinese Journal of Chemical Physics 2008年第6期21卷 515-520页

作者： Xin-xia Xue Mi Yan Fang Wu Xu Shan Ke-zun Xu Xiang-jun Chen hefei national laboratory for physical sciences at microscale and Department of Modern Physics University of Science and Technology of China Hefei 230025 China

The binding energy spectra and electron momentum distributions for the complete valence orbitals of ethanethiol were measured for the first time by binary （e, 2e） electron momentum spectroscopy employing non-coplanar symmetric kinematics at an impact energy of 1200 eV plus binding energy. The experimental results are generally consistent with the theoretical calculations using density functional theory and Hartree-Fock methods with various basis sets. A possible satellite line at 17.8 eV in binding energy spectrum was observed and studied by electron momentum spectroscopy.

关键词： Ethanethiol Electron momentum spectroscopy Valence orbital Satellite line Binding energy spectrum

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