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Potential Benefits of Green Tea in Prostate Cancer Prevention and Treatment: A Comprehensive Review

Chinese Journal of Integrative Medicine 2024年第11期30卷 1045-1055页

作者： LIU Gui-hong YAO Ze-qin CHEN Guo-qiang LI Ya-lang LIANG Bing Department of Urology Sanya Central Hospital (The Third People's Hospital of Hainan Province) Department of Urology Yuzhou People's Hospital

Prostate cancer is a prevalent and debilitating disease that necessitates effective prevention and treatment strategies. Green tea, a well-known beverage derived from the Camellia sinensis plant, contains bioactive compounds with potential health benefits, including catechins and polyphenols. This comprehensive review aims to explore the potential benefits of green tea in prostate cancer prevention and treatment by examining existing literature. Green tea possesses antioxidant, anti-inflammatory, and anti-carcinogenic properties attributed to its catechins, particularly epigallocatechin gallate. Epidemiological studies have reported an inverse association between green tea consumption and prostate cancer risk, with potential protection against aggressive forms of the disease. Laboratory studies demonstrate that green tea components inhibit tumor growth, induce apoptosis, and modulate signaling pathways critical to prostate cancer development and progression. Clinical trials and human studies further support the potential benefits of green tea. Green tea consumption has been found to be associated with a reduction in prostate-specific antigen levels, tumor markers, and played a potential role in slowing disease progression. However, challenges remain, including optimal dosage determination, formulation standardization, and conducting large-scale, long-term clinical trials. The review suggests future research should focus on combinatorial approaches with conventional therapies and personalized medicine strategies to identify patient subgroups most likely to benefit from green tea interventions.

关键词： epigallocatechin gallate green tea prevention prostate cancer review treatment

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Analysis of the Effect of Respiratory Rehabilitation Nursing on the Quality of Life of Patients with Chronic Obstructive Pulmonary Disease

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Journal of Clinical and Nursing Research 2024年第5期8卷 342-347页

作者： Meini Li hechi third people’s hospital Hechi 547000Guangxi ProvinceChina

Objective:To understand the impact of respiratory rehabilitation nursing on the quality of life of patients with chronic obstructive pulmonary disease(COPD),and to provide a theoretical basis for better clinical implementation of this nursing ***:68 COPD patients admitted from september 2022 to July 2023 were selected to determine the type of COPD(mild,moderate,severe)based on clinical manifestations and laboratory test results,and were divided into a study group(42 cases)and a control group(26 cases),with the control group adopting the conventional treatment plan,and the patients in the study group receiving individualized respiratory rehabilitation nursing *** patients’respiratory function and quality of life after treatment are ***:The total score of the study group(65.71±12.02)was significantly higher than that of the control group(52.73±11.54),and the difference was statistically significant(Ps of pulmonary function,the results of pulmonary function tests of the two groups of patients were in the normal range after treatment,and the study group was slightly better than that of the control group,and the difference was statistically significant(Pscore of the study group in terms of exercise endurance was significantly higher than that of the control group,and the difference was statistically significant(Psion:Respiratory rehabilitation nursing can effectively improve the quality of life of COPD patients,and is worthy of popularization and application.

关键词： Respiratory rehabilitation nursing Chronic obstructive pulmonary disease Quality of life

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Correlation between psychological traits and the use of smart medical services in young and middle-aged adults: An observational study

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World Journal of Psychiatry 2024年第8期14卷 1224-1232页

作者： Hu Zhang Yan Liu Rui Gu Department of Internet hospital Management The Third People's Hospital of ChengduChengdu 610031Sichuan ProvinceChina Department of Neurology The Third People's Hospital of ChengduThe Affiliated Hospital of Southwest Jiaotong UniversityChengdu 610031Sichuan ProvinceChina

BACKGROUND Psychological problems affect economic ***,there is a huge gap between mental health service resources and mental health service *** mental health service technology and platforms cannot meet all the diverse mental health needs of *** medicine is a new medical system based online that can effectively improve the quality and efficiency of medical services and make mental health services *** To explore the level of intelligent medical use among young and middle-aged people and its correlation with psychological *** Convenience sampling was used to select 200 young and middle-aged patients with medical experience at the third people's hospital of Chengdu between January 2022 and January 2023 as the research *** general condition Questionnaire,Eysenck Personality Questionnaire,symptom Checklist-90,General Health Questionnaire,and smart Medical service Use Intention Questionnaire were used to collect ***’s correlation was used to analyze the correlation between the participants’willingness to use smart medical services and their personality characteristics,psychological symptoms,and mental *** The results revealed that the mental health of young and middle-aged people was poor,and some had psycho-logical problems such as anxiety,depression,and physical ***,acceptance,and usage of smart healthcare in this population are at a medium level,and these levels correlate with psychological *** was positively correlated with E,and negatively correlated with P,anxiety,fear,anxiety/insomnia,and social *** degree of use was negatively correlated with P,obsessive-compulsive symptoms,depression,anxiety,hostility,paranoia,and somatic *** The familiarity,acceptance,and usage of smart medical services among the middle-aged and young groups are related to various psychological characteristics.

关键词： Young and middle-aged people smart healthcare Willingness to serve Psychological characteristics Questionnaire survey Relevance

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Therapeutic strategies targeting the epidermal growth factor receptor signaling pathway in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2362-2379页

作者： Yi Zhou shuang Wu Fan-Jie Qu Department of Oncology Affiliated Dalian Third People’s Hospital of Dalian Medical UniversityDalian 116033Liaoning ProvinceChina

More than 1.9 million new colorectal cancer(CRC)cases and 935000 deaths were estimated to occur worldwide in 2020,representing about one in ten cancer cases and ***,colorectal ranks third in incidence,but second in *** than half of the patients are in advanced stages at *** options are complex because of the heterogeneity of the patient population,including different molecular *** have included conventional fluorouracil-based chemotherapy,targeted therapy,immunotherapy,*** recent years,with the development of genetic testing technology,more and more targeted drugs have been applied to the treatment of CRC,which has further prolonged the survival of metastatic CRC patients.

关键词： Metastatic colorectal cancer Epidermal growth factor receptor B-type RAF mutation Kirsten rat sarcoma viral oncogene wild type Kirsten rat sarcoma viral oncogene G12C mutation Human epidermal growth factor receptor 2 overexpression/amplification

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Endoscopic ultrasound-guided biliary drainage vs percutaneous transhepatic bile duct drainage in the management of malignant obstructive jaundice

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1592-1600页

作者： Qin-Qin Zhu Bing-Fang Chen Yue Yang Xue-Yong Zuo Wen-Hui Liu Ting-Ting Wang Yin Zhang Department of Gastroenterology The Third Affiliated Hospital of Soochow University(The First People’s Hospital of Changzhou)Changzhou 213000Jiangsu ProvinceChina Department of Hepatobiliary and Pancreatic surgery The Third Affiliated Hospital of Soochow University(The First People’s Hospital of Changzhou)Changzhou 213000Jiangsu ProvinceChina

BACKGROUND Malignant obstructive jaundice(MOJ)is a condition characterized by varying degrees of bile duct stenosis and obstruction,accompanied by the progressive development of malignant tumors,leading to high morbidity and mortality ***,the two most commonly employed methods for its management are percutaneous transhepatic bile duct drainage(PTBD)and endoscopic ultrasound-guided biliary drainage(EUs-BD).While both methods have demonstrated favorable outcomes,additional research needs to be performed to determine their relative *** compare the therapeutic effectiveness of EUs-BD and PTBD in treating *** This retrospective analysis,conducted between september 2015 and April 2023 at The third Affiliated hospital of soochow University(The First people’s hospital of Changzhou),involved 68 patients with *** patients were divided into two groups on the basis of surgical procedure received:EUs-BD subgroup(n=33)and PTBD subgroup(n=35).Variables such as general data,preoperative and postoperative indices,blood routine,liver function indices,myocardial function indices,operative success rate,clinical effectiveness,and complication rate were analyzed and compared between the *** In the EUs-BD subgroup,hospital stay duration,bile drainage volume,effective catheter time,and clinical effect-iveness rate were superior to those in the PTBD subgroup,although the differences were not statistically significant(P>0.05).The puncture time for the EUs-BD subgroup was shorter than that for the PTBD subgroup(Pstoperative blood routine,liver function index,and myocardial function index in the EUs-BD subgroup were significantly lower than those in the PTBD subgroup(Ps-BD subgroup was lower than in the PTBD subgroup(PsION EUs-BD may reduce the number of punctures,improve liver and myocardial functions,alleviate traumatic stress,and decrease complication rates in MOJ treatment

关键词： Percutaneous hepatic biliary drainage Endoscopic ultrasound-guided biliary drainage Malignant obstructive jaundice Clinical effect Liver function Postoperative complications

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Characterization of the CpsQ Regulon Reveals Its Role in the Transcription of Type Ⅵ secretion system 2 Genes in Vibrio parahaemolyticus

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Biomedical and Environmental sciences 2024年第4期37卷 436-439页

作者： LUO Xi LI Xue ZHANG Miao Miao HUANG Qing Lian ZHANG Yi Quan JI shen Jie LU Ren Fei Department of Clinical Laboratory Affiliated Nantong Hospital 3 of Nantong UniversityNantong Third People’s HospitalNantong 226006JiangsuChina Department of Clinical Laboratory Qidong People’s HospitalQidong 226200JiangsuChina

Vibrio parahaemolyticus,a gram-negative halophilic bacterium that naturally inhabits coastal waters,causes gastroenteritis,skin infections,and septicemia in human beings[1].This bacterium produces multiple virulence factors,including thermostable direct hemolysin(TDH),TDH-related hemolysin(TRH),type Ⅲ secretion system 1(T3ss1),T3ss2,type Ⅵ secretion system 1(T6ss1),and T6ss2[1].Furthermore,Ⅴ.parahaemolyticus forms biofilms on the surface,which help it in adapting to unfavorable conditions[2].Mature biofilm formation requires special structures,including lateral and polar flagella,exopolysaccharide(EPs),and type Ⅳ pili[2].

关键词： coastal system T3ss

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Isolation and characterization of mpox virus from the first mpox case in shenzhen,China

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Virologica sinica 2024年第2期39卷 335-337页

作者： Lin Cheng Liuqing Yang Miao Wang Yabo Peng Haiyan Wang Xiaoxiang Yang Juanjuan Zhao Mingxia Zhang Fuxiang Wang Zheng Zhang Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalShenzhen518112China Department of Infectious Diseases Shenzhen Third People's HospitalShenzhen 518112China The second Affiliated hospital School of MedicineSouthern University of Science and TechnologyShenzhen 518112China

Dear Editor,Unlike previous outbreaks of the mpox(previously known as monkeypox),which were localized in Africa and resulted in small numbers of infections due to limited human-to-human transmission,the current outbreak beginning in May 2022,has spread rapidly primarily through human-to-human transmission in non-endemic countries(Gong et al.,2022).As of 27 sep 2023,115 countries and regions have reported cases of mpox to the World Health Organization(WHO),bringing the total number of confirmed cases to 90,618 including 125 *** the number of new cases has decreased in most WHO regions in the second half of 2022,the curves reveal a long outbreak tail in different subregions of the *** worrying,106 mpox cases were reported in the mainland of China in June 2023.

关键词： mainland bringing

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Impact of High sodium Diet on Neovascularization and Osseointegration around Titanium Implant:An in Vivo and in Vitro study

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Biomedical and Environmental sciences 2024年第7期37卷 739-753页

作者： Keyuan Xu Xiaoting Tang Yun Xiang Yiding shen Zhennan Deng Pingping Ma Xinkun shen Department of Orthopaedics The Third Affiliated Hospital of Wenzhou Medical University(Ruian People’s Hospital)Wenzhou 325016ZhejiangChina school and hospital of stomatology Wenzhou Medical UniversityWenzhou 325027ZhejiangChina

Objective A high sodium(Hs)diet is believed to affect bone metabolism *** its impact on osseointegration of titanium(Ti)implants holds significant implications for postoperative dietary management of implanted *** This investigation probed the impact of sodium ions(Na^(+))on neovascularization and osteogenesis around Ti implants in vivo,utilizing micro-computed tomography,hematoxylin and eosin staining,and immunohistochemical ***,in vitro experiments assessed the effects of varied Na^(+)concentrations and exposure durations on human umbilical vein endothelial cells(HUVECs)and MC3T3-E1 *** In vivo,increased dietary sodium(0.8%-6.0%)led to a substantial decline in CD34 positive HUVECs and new bone formation around Ti implants,alongside an increase in inflammatory *** vitro,an increase in Na^(+)concentration(140-150 mmol/L)adversely affected the proliferation,angiogenesis,and migration of HUVECs,especially with prolonged *** MC3T3-E1 cells initially exhibited less susceptibility to high Na^(+)concentrations compared to HUVECs during short-term exposure,prolonged exposure to a Hs environment progressively diminished their proliferation,differentiation,and osteogenic *** These findings suggest that Hs diet had a negative effect on the early osseointegration of Ti implants by interfering with the process of postoperative vascularized bone regeneration.

关键词： High-sodium Implants Vascularization Osseointegration

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superhydrophobic surface-Assisted Preparation of Microspheres and supraparticles and Their Applications

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Nano-Micro Letters 2024年第4期16卷 110-138页

作者： Mengyao Pan Huijuan shao Yue Fan Jinlong Yang Jiaxin Liu Zhongqian Deng Zhenda Liu Zhidi Chen Jun Zhang Kangfeng Yi Yucai su Dehui Wang Xu Deng Fei Deng Institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China school of Materials science and Engineering Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China shenzhen Institute for Advanced study University of Electronic Science and Technology of ChinaShenzhen 518110People’s Republic of China Pharmaceutical Glass Co.Ltd Zibo 256100People’s Republic of China Department of Nephropathy School of MedicineSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduPeople’s Republic of China Department of Nephrology Sichuan Provincial People’s Hospital Jinniu HospitalChengdu Jinniu District People’s HospitalChengduPeople’s Republic of China

superhydrophobic surface(sHs) has been well developed, as sHs renders the property of minimizing the water/solid contact interface. Water droplets deposited onto sHs with contact angles exceeding 150°, allow them to retain spherical shapes, and the low adhesion of sHs facilitates easy droplet collection when tilting the substrate. These characteristics make sHs suitable for a wide range of applications. One particularly promising application is the fabrication of microsphere and supraparticle materials. sHs offers a distinct advantage as a universal platform capable of providing customized services for a variety of microspheres and supraparticles. In this review, an overview of the strategies for fabricating microspheres and supraparticles with the aid of sHs, including cross-linking process, polymer melting,and droplet template evaporation methods, is first presented. Then, the applications of microspheres and supraparticles formed onto sHs are discussed in detail, for example, fabricating photonic devices with controllable structures and tunable structural colors, acting as catalysts with emerging or synergetic properties, being integrated into the biomedical field to construct the devices with different medicinal purposes, being utilized for inducing protein crystallization and detecting trace amounts of analytes. Finally,the perspective on future developments involved with this research field is given, along with some obstacles and opportunities.

关键词： superhydrophobic surface Microspheres and supraparticles Photonic devices Catalysts Biomedical and trace detections

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UsP19 stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells

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Current Medical science 2024年第4期44卷 707-717页

作者： Xiao-hui YAN Yin-na ZHU Yan-ting ZHU Kidney Disease and Dialysis Center Shaanxi Provincial People's HospitalXi'an 710068China Department of Nephrology The Third Affiliated Hospital of Xi'an Medical UniversityXi'an 710000China Nephrology and Hemodialysis Center Shaanxi Provincial People's HospitalXi'an 710068China

Objective Obesity-induced kidney injury contributes to the development of diabetic nephropathy(DN).Here,we identified the functions of ubiquitin-specific peptidase 19(UsP19)in HK-2 cells exposed to a combination of high glucose(HG)and free fatty acid(FFA)and determined its association with TGF-beta-activated kinase 1(TAK1).Methods HK-2 cells were exposed to a combination of HG and ***19 mRNA expression was detected by quantitative RT-PCR(qRT-PCR),and protein analysis was performed by immunoblotting(IB).Cell growth was assessed by Cell Counting Kit-8(CCK-8)viability and 5-ethynyl-2′-deoxyuridine(EdU)proliferation *** cycle distribution and apoptosis were detected by flow *** UsP19/TAK1 interaction and ubiquitinated TAK1 levels were assayed by coimmunoprecipitation(Co-IP)assays and *** In HG+FFA-challenged HK-2 cells,UsP19 was highly ***19 knockdown attenuated HG+FFA-triggered growth inhibition and apoptosis promotion in HK-2 ***,UsP19 knockdown alleviated HG+FFA-mediated PTEN-induced putative kinase 1(PINK1)/Parkin pathway inactivation and increased mitochondrial reactive oxygen species(ROs)generation in HK-2 ***,UsP19 stabilized the TAK1 protein through ***,increased TAK1 expression reversed the UsP19 knockdown-mediated phenotypic changes and PINK1/Parkin pathway activation in HG+FFA-challenged HK-2 *** The findings revealed that UsP19 plays a crucial role in promoting HK-2 cell dysfunction induced by combined stimulation with HG and FFAs by stabilizing TAK1,providing a potential therapeutic strategy for combating DN.

关键词： HK-2 cells high glucose free fatty acid dysfunction UsP19 deubiquitination

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