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Food Science and Human Wellness 2024年

作者： Dan Hong Xiao Xiao Aijin Ma Zhou Chen SiTing Li JunXia Xia YiLing Tian Yingmin Jia hebei Yangyuan ZhiHui Beverage Co. Ltd. Institution of Chinese walnut Industry College of Food Science and technology hebei Agricultural University hebei key laboratory of walnut nutritional function and processing technology School of Food and Health Beijing technology and Business University

Aging is an inevitable biological phenomenon that involves a multitude of physiological alterations. Dietary interventions are being considered as potential strategies for delaying age-related dysfunction. Unsaponifiable matter (USM)， a composition of highly active ingredients found in walnut oil， has demonstrated antioxidant effects. This study aims to explore the neuroprotective effects of USM on D-galactose-treated C57BL/6 mice and elucidate its underlying mechanism， which was validated in PC12 cells treated with D-galactose. The results of behavioral tests demonstrated that USM significantly improved cognitive deficits associated with aging. The morphological analysis demonstrated that USM effectively alleviated hippocampal neuronal damage， synaptic impairment， and mitochondrial dysfunction induced by D-galactose. Furthermore， USM significantly increases the antioxidant enzymes activity while reducing the malondialdehyde (MDA) andreactive oxygen species (ROS) levels. The results suggest that USM can mitigate age-related symptoms caused by D-galactose by activating the Nrf2 signaling pathway， which enhances the expression of antioxidant enzymes， restore redox balance， and improves synaptic and mitochondrial functions. This has a positive on improving cognition and memory disorders in elderly mice.

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Progress in the preparation,identification and biological activity of walnut peptides

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未来食品学报(英文) 2024年第3期4卷 205-220页

作者： Chang Liu Zijie Zhang Yuting Shang Siting Li Junxi Xia Yiling Tian Yingmin Jia Aijin Ma School of Food and Health Beijing Technology and Business UniversityBeijing 100048China hebei Yangyuan ZhiHui Beverage Co. Ltd.Hengshui 053000China Institution of Chinese walnut Industry Hengshui 053000China hebei key laboratory of walnut nutritional function and processing technology Hengshui 053000China College of Food Science and technology Hebei Agricultural UniversityBaoding 071000China

walnuts are rich in protein and are a high-quality plant protein *** recent years,with the growth of consumer demand for functional food and food for special medical purpose,the use of walnut protein for the preparation of functional walnut peptide ingredients or additives and other compositions has received increasing ***,the improvement of the yield of walnut peptides and the clarification of their functional activities are the bottlenecks that limit the development of these *** this end,this article reviews the pretreatment,preparation,purification and identification processes of walnut peptides,as well as their biological activities such as antioxidant activity,antitumour activity,improvement of memory,antihypertension and regulation of metabolic disorders are elaborated to provide a reference for the industrial development of walnut peptides.

关键词： walnut Peptide Extraction Isolation Purification Identification Biological activity

Insights into the mechanism of Sub3 inhibiting Fusarium moniliforme infection in maize

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Grain & Oil Science and technology 2022年第1期5卷 22-34页

作者： Haojie Yang Wei Zhang Pingping Tian Bangbang Li Shan Wei Shuaibing Zhang Na Li Yangyong Lyu Yuansen Hu College of Biological Engineering Henan University of TechnologyZhengzhou 450001China Henan Provincial key laboratory of Biological processing and nutritional function of Wheat Zhengzhou 450001China

Fusarium moniliforme(***) and its secondary metabolite fumonisin pose a severe threat to food safety,and searching for effective antimicrobial agents is a focus of current *** this study,the secondary structure of Sub3 was analyzed by circular dichroism,meanwhile,the inhibition rate of Sub3 against spores,mycelia of *** and infected maize was *** explore the possible inhibition mechanisms,morphological and structural changes of spores treated with Sub3 at0,1/2 MIC(minimum inhibitory concentration) and MIC were observed by scanning electron microscopy and transmission electron microscopy;the cell wall integrity,membrane integrity,reactive oxygen species,mitochondrial membrane potential,ATP synthase activity,redox reactions,and the nuclear damage of *** were also *** results showed that Sub3 was mostly in the state of random in deionized water,while mainly showed the β-sheet structure in the hydrophobic environment of 50% Trifluoroethanol(TFE) solution,indicating that Sub3 might generate partial structure deformation when acting on the cell membrane;and its MIC on *** spores was 0.2 g/*** the 1/2 MIC and MIC,the inhibition rates of Sub3 against *** infected maize were 34.3% and75.6%,*** results of inhibition mechanisms revealed that the defective pathogenicity of *** caused by Sub3 was attributed to damages on both the cell wall and the cell membrane,which might upset balance of intracellular redox system and mitochondrial energy metabolism and trigger nucleus damage,ultimately leading to cell ***,Sub3 could diminished ATP synthase enzyme activity in a dose-dependent *** results provided direct evidence for inhibition of *** infection of maize by Sub3,and useful knowledge applicable for food preservation.

关键词： Sub3 Antifungal activity Inhibition mechanism F.moniliforme Maize

Effects ofβ-1,3-glucan and ascorbic acid on the nutritional-immune response and antioxidant signaling pathways of live tiger grouper during simulated transport

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Aquaculture and Fisheries 2024年第2期9卷 265-272页

作者： Bo Wu Zhenkun Xu Jie Cao Qi Wang Jun Mei Jing Xie College of Food Science and technology Shanghai Ocean UniversityShanghai201306China National Experimental Teaching Demonstration Center for Food Science and Engineering Shanghai Ocean UniversityShanghai201306China Shanghai Engineering Research Center of Aquatic Product processing and Preservation Shanghai201306China Shanghai Professional technology Service Platform on Cold Chain Equipment Performance and Energy Saving Evaluation Shanghai201306China

Transport in water is the most common method for transporting live fish in China,however,transport is a strong *** stress could lead to a reduced immune and antioxidant system function of tiger grouper,resulting in sickness and ***,tiger grouper were continuously stressed during transport,which resulted in quality *** is necessary that find a way to relieve the stress of transportation of tiger *** acid is not only a good anti-stress agent,but it is also an effective immunostimulant.β-1,3-glucan is a feed additive that can enhance the immune response of ***,this study evaluated the effects ofβ-1,3-glucan and ascorbic acid on the nutritional-immune response and antioxidant signaling pathways of live tiger grouper during simulated *** indicated that addingβ-1,3-glucan and ascorbic acid in transport-water muted the increase of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)*** addition,β-1,3-glucan and ascorbic acid activated Nrf2 and mediated TOR expression and then up-regulate related mRNA expression of antioxidant and immune *** concluded that the application ofβ-1,3-glucan and ascorbic acid inhibit the increase of metabolism enzymes and inflammatory factors and activate immune and antioxidant signaling pathways to relieve oxidant stress,immune response,and *** the loss of amino acids provided nutrients to relieve oxidative stress and immune response,which demonstrated immune-nutritional response in live tiger grouper during simulated *** results may provide a new solution for alleviating the decline of immune and antioxidant function of tiger grouper caused by transportation stress.

关键词： Tiger grouper β-1,3-Glucan Ascorbic acid Immune response Antioxidant signaling pathway

Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice

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Food Science and Human Wellness 2023年第4期12卷 1300-1308页

作者： Aimei Liao Xing Lyu Jiarui Ma Yinchen Hou Ming Hui Na Liu Yi Zhao Yixiang Cui Jihong Huang College of Biological Engineering Henan University of TechnologyLuoyang 471000China Henan Provincial key laboratory of Biological processing and nutritional function of Wheat Luoyang 471000China Zhengzhou Synear Food Co. Ltd.Zhengzhou 450000China School of Food and Pharmacy Xuchang UniversityXuchang 461000China

Wheat embryo globulin(WEG)has been proven to possess multiple biological activities,including antioxidative properties,immunomodulatory,and so *** mouse model were established by subcutaneous injection of D-galactose(D-gal),and the effects of WEG on learning,memory,and antioxidant capacity in aging mice were explored through behavioural tests and antioxidant enzyme activities *** with the Model group,WEG improved the percentage of the platform quadrant,increased the number of crossing platforms,and enhanced the identification *** also increased total antioxidant capacity(T-AOC),superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)activities in the liver and brains of aging mice,and reduced malondialdehyde(MDA)*** observations indicated that WEG protected against damage to brain in D-gal-induced aging *** results effectively revealed that WEG not only improved the abilities of learning and memory,and the cognitive impairment,but also delayed the aging process of the D-gal-induced mice.

关键词： Wheat embryo globulin Antioxidant activity D-galactose Superoxide dismutase Glutathione peroxidase

Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice

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Food Science and Human Wellness 2023年第6期12卷 2286-2296页

作者： Jing Li Xinyue Yu Xinxing Xu Peipei Tang Shuang Bi Xiaopu Ren Yong Shi Jihong Wu Fei Lao National Engineering Research Center for Fruit&Vegetable processing Key Laboratory of Fruit&Vegetable ProcessingMinistry of Agriculture and Rural AffairsBeijing Key Laboratory for Food Non-thermal ProcessingCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Beijing Daily Chemical Products Quality Supervision and Inspection Station Beijing 101111China Department of Food Science and technology The Ohio State UniversityColumbus 43210USA College of Food Science and Engineering Tarim UniversityAlar 843300China Haoxiangni Health Food Co. Ltd.Xinzheng 451100China

Unfermented jujube pulp(UFJP),fermented jujube pulp(FJP)in high and low doses were fed to constipated ICR *** function,serum gastrointestinal regulatory peptide,fecal short-chain fatty acids(SCFAs)and gut microbial composition were *** showed that high-dose FJP could protect intestinal mucosa tissue,shorten the first black feces defecating time by 17%and increase the number and wet weights of black feces by 72%and 71%,respectively,within 6 ***-dose FJP signifi cantly down-regulated the somatostatin level and up-regulated gastrin level in constipated mice,compared with low-dose FJP and *** high-dose FJP intervention regulated the microbiota profi le,which afterwards restored microbiota,like Bacteroidetes,Bifi dobacterium and Lactobacillus,to a less unhealthy *** study provides convincing in vivo evidence that high-dose FJP supplementation through daily diet could be a promising approach to effectively alleviate constipation and modulate gut health.

关键词： Jujube Lactic acid bacteria fermentation Short-chain fatty acid Probiotics Gut microbiota

Overview on the edible mushrooms in Egypt

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未来食品学报(英文) 2023年第1期3卷 8-15页

作者： Adel F.Ahmed Ghada Abd-Elmonsef Mahmoud Mohamed Hefzy Zhenhua Liu Changyang Ma Medicinal and Aromatic Plants Researches Department Horticulture Research InstituteAgricultural Research CenterGiza 12619Egypt National R&D Center for Edible Fungus processing technology Henan UniversityKaifeng 475004China Joint International Research laboratory of Food&Medicine Resource function Kaifeng 475004China Faculty of Science Assiut UniversityAssiut 71516Egypt Botany and Microbiology Department Department of Water Requirement and Field Irrigation ResearchSoilsWater and Environment Research InstituteAgricultural Research CenterGiza 12619Egypt Shenzhen Research Institute of Henan University Shenzhen 518000China functional Food Engineering technology Research Center Kaifeng 475004China

Edible Mushrooms have been valued as a valuable food source due to its nutritional and medicinal *** mushrooms contain various bioactive components such as proteins,polyunsaturated fatty acids,polysaccharides,dietary fibers,amino acids,vitamins,and *** have essential health effects,such as antioxidant,antimicrobial,immune-stimulatory,and anticancer,cholesterol-lowering *** of their nutritional and medicinal benefits,mushrooms have become increasingly popular in recent years all over the *** were considered immortality plants in Ancient Egypt and were given to mankind by the god *** were declared a delicacy reserved only for Egyptian nobility due to their distinct *** current study focuses on the common species of edible mushrooms in Egypt and their different bioactive ingredients,nutritional values and the health benefits.

关键词： Edible mushrooms Egypt Bioactive ingredients Health benefits

Design biodegradable Zn alloys: Second phases and their significant influences on alloy properties

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Bioactive Materials 2020年第2期5卷 210-218页

作者： Zhang-Zhi Shi Xi-Xian Gao Hai-Jun Zhang Xue-Feng Liu Hui-Yan Li Chao Zhou Yu-Xia Yin Lu-Ning Wang Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Laboratory of Metallic Materials and Processing for Modern TransportationKey Laboratory for Advanced Materials Processing of Ministry of EducationSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing100083China Department of Interventional and Vascular Surgery The Tenth People's Hospital of ShanghaiTongji UniversityShanghai200072China National United Engineering laboratory for Biomedical Material Modification Branden Industrial ParkDezhou CityShandong251100China

Alloying combined with plastic deformation processing is widely used to improve mechanical properties of pure ***-cast Zn and its alloys are *** plastic deformation processing,no effective method has yet been found to eliminate the brittleness and even endow room temperature *** phase,induced by alloying,not only largely determines the ability of plastic deformation,but also influences strength,corrosion rate and *** second phase is important for designing biodegradable Zn *** this review,knowledge related to second phases in biodegradable Zn alloys has been analyzed and summarized,including characteristics of binary phase diagrams,volume fraction of second phase in function of atomic percentage of an alloying element,and so *** about second phases in Zn-Li,Zn-Cu and Zn-Fe systems have been settled down,which benefits future *** effects of alloying elements and second phases on microstructure,strength,ductility,corrosion rate and cytotoxicity have been neatly ***,Mn,Li,Cu and Ag are recommended as the major alloying elements,owing to their prominent beneficial effects on at least one of the above *** future,synergistic effects of these elements should be more thoroughly *** other nutritional elements,such as Fe and Ca,refining second phase is a matter of vital concern.

关键词： Biodegradable Zn alloys Alloy design Second phase Microstructure Comprehensive properties

Flammulina velutipes polysaccharide-iron (Ⅲ) complex used to treat iron deficiency anemia after being absorbed via GLUT2 and SGLT1 transporters

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Food Science and Human Wellness 2023年第5期12卷 1828-1840页

作者： Chenying Shi Chen Cheng Xiaotong Lin Yanfang Qian Yufeng Du Guitang Chen Department of Food Nutrition and Safety/National R&D Center for Chinese Herbal Medicine processing China Pharmaceutical UniversityNanjing 211198China College of Pharmacy China Pharmaceutical UniversityNanjing 211198China

Iron deficiency anemia(IDA)is a common nutritional problem, but traditional iron supplements cause many adverse reactions. Thus, the development of a novel iron supplement might be significant for the treatment of IDA. This study aimed to study the transport mechanism of Flammulina velutipes polysaccharide-iron complex(FVP1-Fe(Ⅲ))in Caco-2 cells and the therapeutic effect on IDA rats, as well as the influence on gut microbiota in vivo. These results showed that in vitro, the uptake of FVP1-Fe(Ⅲ)was mediated by sodium-dependent glucose transporter-1(SGLT1)and facilitated glucose transporter-2(GLUT2)and GLUT2 played a dominant function. The multidrug resistance-associated protein-2(MRP-2)was involved in the efflux of FVP1-Fe(Ⅲ)across the Caco-2 cells. In vivo, FVP1-Fe(Ⅲ)had a better restorative effect on blood parameters and iron status indicators in rats with IDA as compared with FeSO_4 and exerted this effect by downregulating the expression of hepcidin. FVP1-Fe(Ⅲ)could also regulate gut microbiota dysbiosis in iron deficiency rats by returning the relative abundance of gut microbiota to the normal level. Besides, as a dietary factor, vitamin C(vit C)could enhance the therapeutic effect of FVP1-Fe(Ⅲ). These present findings showed that FVP1-Fe(Ⅲ)could be exploited as a novel iron supplement to treat IDA.

关键词： Flammulina velutipes polysaccharide Iron deficiency anemia Iron supplement Caco-2 cell model Gut microbiota

Prediction of the diet nutrients digestibility of dairy cows using Gaussian process regression

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Information processing in Agriculture 2019年第3期6卷 396-406页

作者： Qiang Fu Weizheng Shen Xiaoli Wei Ping Zheng Hangshu Xin Chunjiang Zhao College of Electrical and Information Northeast Agricultural UniversityHarbin 150030PR China key laboratory of Pig-breeding Facilities Engineering Ministry of AgricultureHarbin 150030PR China College of Animal Science and technology Northeast Agricultural UniversityHarbin 150030PR China National Engineering Research Center for Information technology in Agriculture Beijing 100097PR China

In order to effectively evaluate the diet nutritional value of dairy cows,it is essential to accurately predict the diet nutrients digestibility(DND).Conventional predicting DND methods are usually based on the least squares linear regression analysis(LS-LRA),which often relies on a large amount of training samples to accomplish reliable ***,in real-world applications,it is often extremely difficult,costly and time-consuming to obtain a large number of measured samples,especially for the DND prediction of dairy *** paper applies a Gaussian process regression(GPR)technique to predict the DND indicators of dairy cows in small *** evaluate prediction accuracy effectively,we compared the GPR technique with the LS-LRA,radial basis function artificial neural network(RBF-ANN),support vector regression(SVR)and least squares support vector regression(LS-SVR)methods,using the required sample data obtained from actual digestion *** prediction results indicate that the GPR technique is superior to other conventional methods(especially the LS-LRA method)in predicting the main DND indicators of dairy cows such as dry matter digestibility(DMD),organic matter digestibility(OMD),neutral detergent fiber(NDFD),acid detergent fiber(ADFD),and crude protein digestibility(CPD).It is worth mentioning that the developed GPR-based prediction technique is more suitable for the prediction problems with small samples,which is often the case in the prediction of DND indicators of dairy cows,and then more coincide with actual needs.

关键词： Precision feeding Dairy cow diet evaluation Diet nutrients digestibility Small sample prediction GPR algorithm