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research on ozone formation sensitivity based on observational methods:Development history,methodology,and application and prospects in China

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Journal of Environmental Sciences 2024年第4期138卷 543-560页

作者： Wanghui Chu Hong Li Yuanyuan Ji Xin Zhang Likun Xue Jian Gao Cong An State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Environment research Institute Shandong UniversityQingdao 266237China

Observation-based method for O_(3)formation sensitivity research is an important tool to analyze the causes of ground-level O_(3)pollution,which has broad application potentials in determining the O_(3)pollution formation mechanism and developing prevention and control *** paper outlined the development history of research on O_(3)formation sensitivity based on observational methods,described the principle and applicability of the methodology,summarized the relative application results in China and provided recommendations on the prevention and control of O_(3)pollution in China based on relevant study results,and finally pointed out the shortcomings and future development prospects in this field in *** overview study showed that the O_(3)formation sensitivity in some urban areas in China in recent years presented a gradual shifting tendency from the VOC-limited regime to the transition regime or the NO_(x)-limited regime due to the implementation of the O_(3)precursors emission reduction policies;O_(3)pollution control strategies and precursor control countermeasures should be formulated based on local conditions and the dynamic control capability of O_(3)pollution control measures should be *** are still some current deficiencies in the study field in ***,it is recommended that a stereoscopic monitoring network for atmospheric photochemical components should be further constructed and improved;the atmospheric chemical mechanisms should be vigorously developed,and standardized methods for determining the O_(3)formation sensitivity should be established in China in the near future.

关键词： Observation-based method Ozone formation sensitivity Ozone pollution prevention and control VOCs NO_(x) OBM

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Multi-Organ Pathogenesis and Therapeutic Strategies for Cystic Fibrosis

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Journal of Biosciences and Medicines 2024年第5期12卷 312-329页

作者： Oluwaseun Babatunde Ogonna William David Richard Ifeanyichukwu Ikwugbado Oluwaseyi Oyewole Fetal research and Therapy program Wake Forest Institute for Regenerative Medicine Winston-Salem NC USA Department of Chemistry University of Houston Houston TX USA Biotechnology Graduate program School of Sciences and Engineering The American University in Cairo New Cairo Egypt

Cystic Fibrosis (CF) is the most common lethal autosomal inherited disorder that affects all races and ethnicities in the United States. However, it is mostly predominant in the Caucasian populace accounting for about 80% of all CF cases. CF most severe complication can be referred to as pulmonary bronchiectasis and infections of the airways, nonetheless, the devastating effects of the disease have far-reaching consequences beyond lung damage. CF is a heterogeneous disease that is caused by mutations in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. The impairment or absence of this gene can affect multiple organs and systems and is characterized not only by chronic lung blockage, infections, and inflammation but also by exocrine gland dysfunction, intestinal obstruction, liver pathology, elevated sweat chloride concentration, and in males, infertility due to the congenital bilateral absence of the vas deferens. To this end, we briefly explore the pathological effects of CF and how CF mediates the destruction of several critical organs in the body and some of the gene therapeutical approaches such as gene editing and viral-based strategies available for the treatment of this multi-organ disease.

关键词： Cystic Fibrosis Gene Therapy Organ Damage

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DAIS: a method for identifying spatial domains based on density clustering of spatial omics data

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Journal of Genetics and Genomics 2024年第8期51卷 884-887页

作者： Qichao Yu Ru Tian Xin Jin Liang Wu College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China BGI research ShenzhenGuangdong 518083China BGI ResearchChongqing 401329China BGI research ShenzhenGuangdong 518083China BGI research Chongqing 401329China

In multicellular organisms,the spatial arrangement of cells profoundly influences the biological functions of tissues,underscoring the importance of identifying spatial domains in *** advancements in spatial omics,particularly spatial transcriptomics(ST)(Bressan et al.,2023),have enhanced our understanding of tissue spatial organization(Zhang et al.,2022;Tian et al.,2023).

关键词： arrangement identifying domains

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The processed C-terminus of AvrRps4 effector suppresses plant immunity via targeting multiple WRKYs

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Journal of Integrative Plant Biology 2024年第8期66卷 1769-1787页

作者： Quang-Minh Nguyen Arya Bagus Boedi Iswanto Hobin Kang Jiyun Moon Kieu Anh Thi Phan Geon Hui Son Mi Chung Suh Eui-Hwan Chung Walter Gassmann Sang Hee Kim Division of Applied Life Science(BK21 Four program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea Department of Life Science Sogang UniversitySeoul 04107Korea Department of Plant Biotechnology Korea UniversitySeoul 02841Korea Division of Plant Science and Technology Christopher S.Bond Life Sciences Center and Interdisciplinary Plant GroupUniversity of MissouriColumbiaMissouri 65211USA Division of Life Science and research Institute of Molecular Alchemy Gyeongsang National UniversityJinju 52828Korea

Pathogens generate and secrete effector proteins to the host plant cells during pathogenesis to promote virulence and *** the plant carries resistance(R)proteins that recognize pathogen effectors,effector-triggered immunity(ETI)is activated,resulting in a robust immune response and hypersensitive response(HR).The bipartite effector AvrRps4 from Pseudomonas syringae *** has been well studied in terms of avirulence *** planta,AvrRps4 is processed into two *** Cterminal fragment of AvrRps4(AvrRps4^(C))induces HR in turnip and is recognized by the paired resistance proteins AtRRS1/AtRPS4 in ***,we show that AvrRps4^(C)targets a group of Arabidopsis WRKY,including WRKY46,WRKY53,WRKY54,and WRKY70,to induce its virulence ***,AvrRps4^(C)suppresses the general binding and transcriptional activities of immune-positive regulator WRKY54 and WRKY54-mediated ***4^(C)interferes with WRKY54's binding activity to target gene SARD1 in vitro,suggesting WRKY54 is sequestered from the SARD1 promoter by AvrRps4^(C).Through the interaction of Avr Rps4^(C)with four WRKYs,AvrRps4 enhances the formation of homo-/heterotypic complexes of four WRKYs and sequesters them in the cytoplasm,thus inhibiting their function in plant ***,our results provide a detailed virulence mechanism of AvrRps4 through its C-terminus.

关键词： AvrRps4 bacterial effector effector-triggered immunity immune response suppression transcription factor WRKY

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The Adsorption Properties of TEMPO Oxidized Cellulose against the Mixture of Methylene Blue and Rhemazol Yellow FG

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Journal of Renewable Materials 2024年第8期12卷 1369-1382页

作者： Mahendra, I. Putu Dinita, Kartika program Studi Kimia Fakultas Sains Insitut Teknologi Sumatera Jalan Terusan Ryacudu Way Huwi Jati Agung Lampung Selatan 35365 Indonesia

TEMPO/NaOCl/NaBr treatment significantly increased the number of negative charges on the cellulose surface. Two concentrations of NaOCl, 5 and 30 mmol/g of cellulose, were used in this study. The number of carboxyl groups in the two cellulosic samples oxidized using TEMPO/NaOCl/NaBr was 0.5160 and 1.8461 mmol/g of cellulose, respectively. The oxidized cellulose samples treated with 5 and 30 mmol/g NaOCl exhibited higher crystallinity, at 81.15% and 80.14%, respectively, compared to untreated cellulose, which had a crystallinity of 75.95%. The pH effect indicated that the highest adsorption capacity for methylene blue was achieved under alkaline conditions (pH 9), while the highest adsorption capacity for rhemazol yellow FG was achieved under acidic conditions. The kinetic model of TEMPO-oxidized cellulose for methylene blue and rhemazol yellow FG conformed to the pseudo-second-order model. The initial concentration parameter revealed that the isotherm model for the adsorption of methylene blue and rhemazol yellow FG by TEMPO-oxidized cellulose conformed to the Langmuir model. The dye removal efficiencies for methylene blue and rhemazol yellow FG using TEMPO-oxidized cellulose (30 mmol/g) were approximately 80.17% and 59.52%, respectively. These results demonstrate that TEMPO/NaOCl/NaBr-oxidized samples can effectively separate cationic and anionic dye mixtures. Furthermore, the use of TEMPO-oxidized cellulose showed good regeneration capability, maintaining more than 95% of its adsorption capacity after 8 cycles. © 2024 The Authors.

关键词： Stripping (dyes)

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Ultra-high extinction ratio optical pulse generation with a thin film lithium niobate modulator for distributed acoustic sensing

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Photonics research 2024年第1期12卷 40-50页

作者： YUAN SHEN XIAOQIAN SHU LINGMEI MA SHAOLIANG YU GENGXIN CHEN LIU LIU RENYOU GE BIGENG CHEN YUNJIANG RAO research Center for Optical Fiber Sensing Zhejiang LaboratoryHangzhou 311100China research Center for Intelligent Optoelectronic Computing Zhejiang LaboratoryHangzhou 311100China International research Center for Advanced Photonics College of Optical Science and EngineeringZhejiang UniversityHangzhou 310058China Fiber Optics research Center(FORC) Key Laboratory of Optical Fiber Sensing and CommunicationsUniversity of Electronic Science and Technology of ChinaChengdu 611731China

We experimentally demonstrate ultra-high extinction ratio(ER)optical pulse modulation with an electro-optical modulator(EOM)on thin film lithium niobate(TFLN)and its application for fiber optic distributed acoustic sensing(DAS).An interface carrier effect leading to a relaxation-tail response of TFLN EOM is discovered,which can be well addressed by a small compensation component following the main driving *** ultrahigh ER>50 dB is achieved by canceling out the tailed response during pulse modulation using the EOM based on a cascaded Mach–Zehnder interferometer(MZI)*** modulated optical_(√)pulses are then utilized as a probe light for a DAS system,showing a sensitivity up to-62.9 dB·rad∕Hz~2(7 pε/Hz)for 2-km single-mode sensing *** crosstalk suppression of 24.9 dB along the fiber is also obtained when the ER is improved from 20 dB to 50 dB,clearly revealing its importance to the sensing performance.

关键词： modulator pulse interferometer

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Daytime-nighttime variations in the concentration of PM_(0.1) carbonaceous particles during a biomass fire episode in Chiang Mai,Thailand

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Particuology 2024年第4期87卷 316-324页

作者： Worradorn Phairuang Thaneeya Chetiyanukornkul Phuchiwan Suriyawong Sotasing Ho Phakphum Paluang Masami Furuuchi Muhammand Amin Mitsuhiko Hata Faculty of Gesciences and CivilEngineering Institute of Science and Enginering Kanazawa UniverityKanazawaIshkawa92192Japan Department of Geography Faculty of Social SciencesChiang Mai UniversityMuangChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityMuangChiang Mai50200Thailand research Unit for Eergyonomics and Eological Management Multidisciplinary research Insttute Chiang Mai UniversityChiang Mai50200Thailand Management and Development Training program Office National Institute of ScienceTechnology and Innovation120601Cambodia Faculty of Engineering Maritim University of Raja Ali HajTanjung PinangKepulauan Riau29115Indonesia

Carbonaceous aerosols affect air quality adversely,affect global warming,and human ***,our understanding of the impact of ultrafine(PM_(0.1))carbonaceous particulate matter is incomplete,particularly the effects during haze *** study monitored diurnal variations in PM_(0.1) in Chiang Mai,Thailand,from March to April *** investigated carbonaceous PM_(0.1) collected by an ambient nano-sampler and evaluated their effect by using a carbon analyzer(IMPROVE_TOR).The results showed that burning large open areas in the dry season was crucial for increasing the particle mass concentration because of the large open burnings that occurred in this *** majority of biomass fires near the sampling site occurred during the night,which would allow more particles to be released thus resulting in higher concentrations of PM_(0.1).Hence,the release of PM_(0.1) during the night would obviously result in higher concentrations than that during the *** the eight carbon profiles,organic carbon 3(OC3)was predicted to be a marker of biomass *** carbon indices displayed that PM_(0.1) was influenced by biomass burning both daytime and *** findings reported herein should be of great impor-tance in terms of establishing biomass burning control policies for mitigating heavy haze pollution in Thailand and elsewhere.

关键词： Biomass burning Carbon Forest fires Nanoparticles Ultrafine particles

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Resonance mechanism of flapping wing based on fluid structure interaction simulation

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Chinese Journal of Aeronautics 2024年第5期37卷 243-262页

作者： Yueyang GUO Wenqing YANG Yuanbo DONG Dong XUE National Key Laboratory of Science and Technology on Aerodynamic Design and research School of AeronauticsNorthwestern Polytechnical UniversityXi'an 710072China research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China Yangtze River Delta research Institute of Northwestern Polytechnical University Taicang 215400China

Certain insect species have been observed to exploit the resonance mechanism of their *** order to achieve resonance and optimize aerodynamic performance,the conventional approach is to set the flapping frequency of flexible wings based on the Traditional Structural Modal(TSM)***,there exists controversy among researchers regarding the relationship between frequency and aerodynamic *** that the structural response of wings can be influenced by the surrounding air vibrations,an analysis known as Acoustic Structure Interaction Modal(ASIM)is introduced to calculate the resonant *** this study,Fluid Structure Interaction(FSI)simulations are employed to investigate the aerodynamic performance of flapping wings at modal frequencies derived from both TSM and ASIM *** performance is evaluated for various mass ratios and frequency ratios,and the findings indicate that the deformation and changes in vortex structure exhibit similarities at mass ratios that yield the highest aerodynamic ***,the flapping frequency associated with the maximum time-averaged vertical force coefficient at each mass ratio closely aligns with the ASIM frequency,as does the frequency corresponding to maximum ***,the ASIM analysis can provide an effective means for predicting the optimal flapping frequency for flexible ***,it enables the prediction that flexible wings with varying mass ratios will exhibit similar deformation and vortex structure *** paper offers a fresh perspective on the ongoing debate concerning the resonance mechanism of Flexible Flapping Wings(FFWs)and proposes an effective methodology for predicting their aerodynamic performance.

关键词： Flexible Flapping Wing(FFW) Acoustic Structure Interaction Modal(ASIM) Fluid Structure Interaction(FSI) Resonance mechanism Aerodynamic performance

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Attenuation of arsenic-induced gut injury in mice by sulfated glycosaminoglycan from swim bladder via regulation of gut microbiota， metabolites， and intestinal barrier integrity

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Food Science and Human Wellness 2024年

作者： Jieying Ou Xiaofei Liu Jing Chen Houpei Huang Xuejing Jia Baojun Xu Zhiling Yu Saiyi Zhong Shenzhen research Institute， Guangdong Ocean University Food Science and Technology program， Department of Life Sciences， BNU-HKBU United International College Centre for Cancer and Inflammation research， School of Chinese Medicine， Hong Kong Baptist University College of Food Science and Technology， Guangdong Ocean University， Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety

Arsenic， a known environmental carcinogen， disrupts intestinal homeostasis， posing a significant threat to human health. Mitigating its toxic effects is crucial， and this study explores the potential of swim bladder sulfated glycosaminoglycan (SBSG) in achieving this. Our previous in vitro studies have shown SBSG to ameliorate arsenic-induced damage in intestinal epithelial cells， but its in vivo effects remain elusive. The current investigation demonstrates that SBSG exhibits a beneficial prebiotic action in vivo， regulating gut microbiota， metabolites， and intestinal barrier function to counter arsenic's adverse effects. Specifically， SBSG regulates microbiota composition， suppressing pathogenic species like Alistipes and Candidatus＿Saccharimonas while promoting beneficial ones such as Ruminococcus and Akkermansia. In the colon， SBSG fermentation enhances the production of short-chain fatty acids (SCFAs)， leading to upregulation of GPR43， GPR109A， and Olfr78 receptors. Additionally， SBSG strengthens the intestinal barrier by increasing the expression of Claudin-1， Occludin， and ZO-1， and enhances mucin gene expression (MUC-1 and MUC-2) to address chemical barrier disruptions. Immunologically， SBSG modulates the RORγt/Foxp-3 pathway and the TLR4/MyD88/NF-κB signaling cascade， regulating the immune barrier. These findings suggest that SBSG could be a promising prebiotic candidate for maintaining intestinal health and may serve as a dietary supplement or adjunct in heavy metal detoxification therapies.

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Ethanol steam reforming over Ni/ZSM-5 nanosheet for hydrogen production

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Chinese Journal of Chemical Engineering 2024年第3期67卷 247-256页

作者： Porapak Suriya Shanshan Xu Shengzhe Ding Sarayute Chansai Yilai Jiao Joseph Hurd Daniel Lee Yuxin Zhang Christopher Hardacre Prasert Reubroycharoen Xiaolei Fan Department of Chemical Engineering School of EngineeringThe University of ManchesterManchester M139PLUnited Kingdom program of Petrochemistry and Polymer Science Faculty of ScienceChulalongkorn UniversityBangkok10330Thailand Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Liaoning Academy of Materials Shenyang 110167China Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals(CBRC) andDepartment of Chemical TechnologyFaculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Nottingham Ningbo China Beacons of Excellence research and Innovation Institute University of Nottingham Ningbo ChinaNingbo315100China

Compared to reforming reactions using hydrocarbons,ethanol steam reforming(ESR)is a sustainable alternative for hydrogen(H_(2))production since ethanol can be produced sustainably using *** work explores the catalyst design strategies for preparing the Ni supported on ZSM-5 zeolite catalysts to promote ***,two-dimensional ZSM-5 nanosheet and conventional ZSM-5 crystal were used as the catalyst carriers and two synthesis strategies,i.e.,in situ encapsulation and wet impregnation method,were employed to prepare the *** on the comparative characterization of the catalysts and comparative catalytic assessments,it was found that the combination of the in situ encapsulation synthesis and the ZSM-5 nanosheet carrier was the effective strategy to develop catalysts for promoting H_(2) production via ESR due to the improved mass transfer(through the 2-D structure of ZSM-5 nanosheet)and formation of confined small Ni nanoparticles(resulted via the in situ encapsulation synthesis).In addition,the resulting ZSM-5 nanosheet supported Ni catalyst also showed high Ni dispersion and high accessibility to Ni sites by the reactants,being able to improve the activity and stability of catalysts and suppress metal sintering and coking during ESR at high reaction ***,the Ni supported on ZSM-5 nanosheet catalyst prepared by encapsulation showed the stable performance with~88% ethanol conversion and~65% H_(2) yield achieved during a 48-h longevity test at 550-C.

关键词： ZSM-5 nanosheet In situ encapsulation Ni catalyst Ethanol steam reforming Hydrogen production

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