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Audiovestibular functioning of post-menopausal females with osteoporosis and osteopenia

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Journal of Otology 2021年第1期16卷 27-33页

作者： Manisha K.Juneja Sanjay Munjal Anuradha Sharma Ashok K.Gupta Sanjay Bhadada Speech and hearing unit ENT DepartmentGMCHSec-32ChandigarhIndia Speech&hearing unit Dept.of OtolaryngologyPGIMERChandigarhIndia Dept.of Otolaryngology PGIMERChandigarhIndia Dept.of Endocrinology PGIMERChandigarhIndia

Introduction:Osteoporosis and osteopenia are progressive disorders characterized by decreased bone mass,especially in postmenopausal women.These can be associated with body pain,fractures,hearing loss and balance disorders.The present study aims to evaluate audio-vestibular function in postmenopausal patients with osteopenia or osteoporosis.Methods:The study included 48 postmenopausal women(new subjects)diagnosed with osteoporosis(n=23)or osteopenia(n=25)in the age range of 50e66 years,as well as 28 normal women as controls.Audiological testing included pure tone audiometry(conventional and extended high-frequency audiometry),speech audiometry,impedance audiometry and otoacoustic emissions,including both transient evoked otoacoustic emissions(TEOAEs)and distortion product otoacoustic emissions(DPOAEs).All subjects also underwent vestibular evoked myogenic potentials testing(both ocular and cervical VEMPs).Results:In the present study,hearing was worse at all frequencies in the osteoporosis group in comparison with the osteopenia and control groups,with worse speech recognition and discrimination scores and OAEs.Vestibular function was affected in 95.65%of women with osteoporosis and 76%of those with osteopenia.Conclusion:Osteoporosis and osteopenia are risk factors for vestibular dysfunction and hearing deficits in postmenopausal women.Thus,hearing and vestibular function should be monitored by audiological and vestibular testing periodically in these individuals.

关键词： hearing loss Audio-vestibular testing Pure tone audiometry(PTA) OAE’S Speech audiometry VEMP Sensorineural hearing

Nanoparticle based inner ear therapy

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World Journal of Otorhinolaryngology 2013年第4期3卷 114-133页

作者： Ilmari Pyykk Jing Zou Ya Zhang Weikai Zhang Hao Feng Paavo Kinnunen Department of Otolaryngology Hearing and Balance Research Unit University Hospital of Tampere 33520 Tampere Finland Department of Otolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Orthopedics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Biomedical Engineering and Computational Science Aalto University 02150 Esbo Finland

Synthetic nanoparticles can be used to carry drugs, genes, small interfering RNA(si RNA) and growth factors into the inner ear, to repair, restore and induce cellular regeneration. Nanoparticles(NPs) have been developed which are targetable to selected tissue, traceable in vivo, and equipped with controlled drug/gene release. The NPs are coated with a ‘stealth' layer, and decorated with targeting ligands, markers, transfection agents and endosomal escape peptides. As payloads, genes such as the BDNF-gene, Math1-gene and Prestin-gene have been constructed and delivered in vitro. Short-hairpin RNA has been used in vitro to silence the negative regulator of Math1, the inhibitors of differentiation and DNA binding. In order to facilitate the passage of cargo from the middle ear to the inner ear, the oval window transports gadolinium chelate more efficiently than the round window and is the key element in introducing therapeutic agents into the vestibule and cochlea. Depending upon the type of NPs, different migration and cellular internalization pathways are employed, and optimal carriers should be designed depending on the cargo. The use of NPs as drug/gene/si RNA carriers is fascinating and can also be used as an intraoperative adjunct to cochlear implantation to attract the peripheral processes of the cochlear nerve.

关键词：英文文摘医学杂志

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如何完成耳鼻喉科的系统评价(英文)

中国循证医学杂志 2004年第6期4卷 414-416页

作者： Martin Burton Oxford hearing & balance Centre Oxford London UK

Systematic Reviews In the 21st century, with increasing public accountability and pressure on health care resources worldwide, health care professionals and decision-makers need to be able to produce and describe the evidence on which their decisions are based. This evidencebased decision making requires a systematic appraisal of the best evidence available. However, each year vast quantities of research on the prevention, treatment and rehabilitation of health disorders are published all over the world. It is therefore impossible for an individual to keep abreast of all the primary publications in his or her own field (for example,there is an estimated 431 919 articles on otolaryngological diseases entered on MEDLINE alone[1] ), and these constitute only a fraction of the two million articles published in the biomedical literature each year.

关键词： Methodology Systematic review Otolaryngology

How to break through the diagnosis and treatment bottleneck of auditory neuropathy

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Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 2024年第5期59卷 413-422页

作者： Wang Q.J. Department of Audio-Vestibular Medicine Senior Department of Otolaryngology - Head and Neck Surgery the Sixth Medical Center of Chinese PLA General Hospital Beijing 100048 China State Key Laboratory of hearing and balance Science National Clinical Research Center for Otolaryngologic Diseases Beijing 100853 China

听神经病是一种累及听觉微环路功能的听觉障碍性疾病。自20世纪90年代发现了听神经病到21世纪以来的逐步破解听神经病，该病经历了从发现到渐入精准的发展历程。虽然，目前对听神经病的认识已逐步提升，但在临床工作中如何快速准确地发... 详细信息

听神经病是一种累及听觉微环路功能的听觉障碍性疾病。自20世纪90年代发现了听神经病到21世纪以来的逐步破解听神经病，该病经历了从发现到渐入精准的发展历程。虽然，目前对听神经病的认识已逐步提升，但在临床工作中如何快速准确地发现和鉴别听神经病？如何综合评估听神经病？如何应用多层级手段定位分型听神经病？快速进展的基因药物给听神经病的治疗带来的新希望新动能如何？这些问题值得思考和交流。因此，本文从突破听神经病诊治瓶颈的角度，阐述了诊治听神经病的关键点和相关策略，展望了听神经病从不可治到可治的新突破。

关键词：听神经病基因药物障碍性疾病微环路快速进展多层级综合评估瓶颈

Awareness and perspectives of audiologists on assessment and management of misophonia in India

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Journal of Otology 2023年第2期18卷 104-110页

作者： Sajana Aryal Prashanth Prabhu All India Institute of Speech and hearing MysoreIndia

Background:The assessment and management of misophonia need a team approach,and audiologists are essential team members.However,the role of an audiologist in this condition is not well understood,and there is a lack of awareness even among professionals about their role in the assessment and management of misophonia.Purpose:The main aim of our study is to document the present level of awareness and knowledge about misophonia assessment and management among audiologists in India.Methods:A descriptive cross-sectional study was carried out among audiologists from all over India.Descriptive statistical procedures were measured based on the type of questions being addressed,and a non-parametric chi-square test was done to see the association among variables.Results:The results show a lack of knowledge about misophonia even among audiologists,as only 15.3%of the audiologist reported being confident in handling cases with misophonia.Conclusion:Although the exact assessment and management of misophonia is still the topic of debate,it is clear that audiologists are the team's key members.However,the results clearly show a lack of confidence in handling cases of misophonia among audiologists in India.This result shows the future need for research in misophonia from an audiological perspective.

关键词： Misophonia Awareness Audiologists Viewpoint Assessment and management

Integrated Chinese Segmentation, Parsing and Named Entity Recognition

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Chinese Journal of Electronics 2018年第4期27卷 756-760页

作者： LI Dongchen ZHANG Xiantao WU Xihong Key Laboratory of Machine Perception and Intelligence Speech and hearing research Center Peking University

Segmentation, named entity recognition and parsing are standalone techniques in natural language processing community, and their annotations are inconsistent. However, the joint output is needed in some practical use, and they rely on the result of each other to make more concise output. A unified model is learned to resolve these three tasks simultaneously. At the training stage, the joint annotation of the three tasks are employed to learn a unified model. At the decoding stage, the three tasks are carried out on a given text to provide a consistent output.Experiment results demonstrate the higher performance for each task and verify the benefits of the unified framework.

关键词： Parsing Joint representation Named entity recognition

A preliminary study of the mechanism of compound hearing loss caused by ototoxic drugs combined with impulse noise

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iLABMED 2024年第1期2卷 38-52页

作者： Xin Qiu Qing‐qing Jiang Wei‐wei Guo Ning Yu Shi‐ming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of hearing and balance Science BeijingChina National Clinical research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of hearing Impairment Prevention and Treatment BeijingChina Chinese PLA Medical School BeijingChina

Background:hearing loss(HL)is becoming increasingly common and is more commonly caused by noise,ototoxic substances,or a combination of ototoxic factors.However,so far,few studies have examined the mechanism by which compound factors cause HL.The only relevant study is about occupational ototoxic substances combined with environmental noise at 85-110 dB SPL.In this study,to address the shortcomings of existing research,we innovatively focused on HL induced by loud noise(impulse noise,>160 dB SPL)combined with common ototoxic drugs.The aim of this study was to establish and validate a mature animal model,and then to compare the characteristics of audiology,pathomorphology and molecular features,and to preliminarily predict pathogenesis in compound HL.Materials and Methods:We selected guinea pigs to construct in vivo HL model groups for different extents of exposure,including a blank control group,a single-drug group,a single-impulse noise group,and a compound group.The animal model of the mature compound HL group was established using gentamicin combined with impulse noise.We then performed audio-logical and pathological verification.We analyzed the auditory brainstem response(ABR),pathological morphology of the cochlea,and molecules(including important self-radicals,cytokines,and apoptosis signal trans-duction pathway proteins in the pathogenesis of drug-and noise-induced HL),compared the effect of different extents of exposure on HL,and preliminarily predict the pathogenic mechanism of compound HL.Results:Four groups of animal models were established successfully and verified by audiology and pathology.Regarding audiology,there were no sig-nificant differences in the ABR thresholds before exposure(p>0.05),but differences emerged among the groups after exposure.Notably,after 3,7,and 14 days of exposure,there were significant differences in the ABR thresholds between the compound group and both the drug and noise groups(p<0.01),and after 14 days,the HL of the compound group was much more severe(greater than the li

关键词： auditory brainstem response gentamicin hearing loss impulse noise molecular mechanisms pathomorphology

Implementation outcomes of a sensory integration therapy program with computerized dynamic posturography in patients with balance and sensory dysfunction

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Journal of Otology 2023年第1期18卷 26-32页

作者： Francisco Javier Gonzalez Eslait Paola Andrea Escudero Trivino Yaidy Viviana Giraldo Vergara Monica Andrea Morales Garcia Vanessa Fernanda Lucero Gutierrez Universidad del Valle Audiological and Otological Balance CenterImbanaco Clinic-Grupo Quiron SaludCaliColombia research Institute.Imbanaco Clinic-Grupo Quiron Salud CaliColombia

Objective:We describe the first-year implementation experience of an Instrumented Sensory Integration Therapy Program in Audiological&balance Center patients.Design:This is a retrospective descriptive study.Participants included Seventy-three adults with diagnoses of acute,episodic,or chronic vestibular syndromes.They were classified into the following two groups:group 1 included 46 individuals treated with ISIT plus VRT,and group 2 included 27 individuals treated only with ISIT.Results:The Sensory Organization Test(SOT)for both groups showed a statistical significance for all three sensory inputs;visual systems(G1:p=0.0003;G2:p=0.0337),vestibular system(G1:pbalance as demonstrated by compound balance score(G1:pbalance percentage deficit(G1:p<0.0001;G2:p=0.0078).Conclusions:The severity and complexity of functional neurological disorders in the context of vestibular syndromes seem to require between 10 and 20 therapy sessions,and combined ISIT plus VRT appears to be more effective than ISIT as a monotherapy.

关键词： Posturography Vestibular rehabilitation therapy Dizziness handicap inventory

hearing analysis in heterozygous and homozygous klotho gene deficient mice

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Journal of Otology 2018年第4期13卷 131-134页

作者： Na Yuan Shiwei Qiu Qian Wang Wei Zhuang Guoping Li Tiantian Sun Shiming Yang Yuehua Qiao Xi Shi The Institute of Audiology and balance Science Xuzhou Medical University Department of Otolaryngology-Head & Neck Surgery Institute of Otolaryngology of PLA Chinese PIA General Hospital Clinical hearing Center Affiliated Hospital of Xuzhou Medical University

Objective: To understand the crucial role of the klotho gene in hearing development in mouse models.Methods: PCR was used to identify CBA mice with different genotypes, i.e. WT, heterozygous(klotho +/-)or homozygous(klotho-/-). Mice phenotype and weight were recorded postnatal 25 days(P-25) and auditory brainstem responses(ABR) were used to determine auditory function at P-60.Results: klotho-/-mice tended to have smaller size, lighter weight and higher ABR thresholds at P-60,showing early onset age-related hearing loss(ARHL).Conclusion: Heterozygous and homozygous klotho deficient mice exhibit different degrees of hearing loss at young age, with homozygous mice(klotho-/-) showing more severe hearing loss. Our results indicate that persisted expression of klotho protein in the inner ear may potentially delay the onset of ARHL and play an important role in the protection of auditory function.

关键词： Homozygous Klotho gene Inner ear hearing loss