检索结果-南通市图书馆

Photoluminescence and photothermal conversion in boric acid derived carbon dots for targeted microbial theranostics

Chinese Chemical Letters 2024年第9期35卷 232-237页

作者： Yiqiao Chen Ao Liu Biwen Yang Zhenzhen Li Binggang Ye Zhouyi Guo Zhiming Liu Haolin Chen Department of Anesthesiology General Hospital of Southern Theater Command of People’s Liberation ArmyGuangzhou 510010China MOE Key Laboratory of Laser Life Science&guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China healthy medical engineering technology research center Guangdong Food and Drug Vocational CollegeGuangzhou 510520China

Theranostic carbon dots(CDs)have attracted widespread attention recently due to their tunable optical properties and diverse *** fluorescent imaging application,the photothermal property endows CDs with the potential for microbial ***,realization of the effective conversion between fluorescence and heat in one CD system has rarely been ***,we provide a simple strategy for targeted microbial theranostics based on 4-carboxyphenylboronic acid-derived CDs(PCBA-CDs)which possess concentration-dependent photoluminescence/photothermal *** lower concentrations,PCBA-CDs show bright and stable fluorescent signals ranging from blue to *** fluorescence intensity gradually decreases with increasing concentration,while on the contrary,the photothermal effect of PCBA-CDs ascends progressively due to the rearrangement of electronic transitions in aggregated ***-CDs also demonstrate high affinity to the polysaccharide structures on the surface of microbe which allows rapid microbial fluorescence imaging as well as specific photothermal ablation of pathogens in skin wounds using PCBA-CDs at lower and higher concentrations,*** study supplies a facile nanotheranostic strategy for just-in-time microbial management using bioactive CDs.

关键词： Theranostic carbon dots Fluorescence imaging Phenylboronic acid Photothermal therapy Nanotheranostic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1361-1373页

作者： Wen-Feng Luo Yu-Ting Jiao Xiao-Ling Lin Ying Zhao Sheng-Bo Wang Jian Shen Jie Deng Yu-Feng Ye Ze-Ping Han Fang-Mei Xie Jin-Hua He Yu Wan Central Laboratory of Panyu Central Hospital Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational medical research Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Digestive Disease center Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Shunde vocational and Technical college Foshan 528300Guangdong ProvinceChina medical Imaging Institute of Panyu Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies ***-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum ***(CRC)is among the most prevalent and life-threatening malignancies ***2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum *** To validate the effectiveness of fecal DNA mSDC2 testing in the detection of CRC among a high-risk Chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in *** A high-risk Chinese cohort consisting of 1130 individuals aged 40-79 years was selected for evaluation via fecal mSDC2 *** and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were ***-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the *** A total of 1035 high-risk individuals were included in this study according to established *** them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological *** of the mSDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other *** predictive values of the mSDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,mSDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(P<0.001).CONCLUSION Our findings confirmed that offering fecal mSDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high

关键词： Colorectal cancer Syndecan-2 DNA methylation Chinese population

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rapid label-free SERS detection of foodborne pathogenic bacteria based on hafnium ditelluride-Au nanocomposites

引用

Journal of Innovative Optical Health Sciences 2020年第5期3卷 105-115页

作者： Yang Li Yanxian Guo Binggang Ye Zhengfei Zhuang Peilin Lan Yue Zhang Huiqing Zhong Hao Liu Zhouyi Guo Zhiming Liu SATCM Third Grade Laboratory of Chinese Medicine and Photonics technology&guangdong Provincial Key Laboratory of Laser Life Science college of Biophotonics South China Normal University GuangzhouGuangdong 510631P.R.China healthy medical engineering technology research center guangdong food and drug vocational college guangzhou 510520 P.R.China

Two-dimensional(2D)nanomaterials have captured an increasing attention in biophotonics owing to their excellent optical ***,2D hafnium ditelluride(HfTe_(2)),a new member of transition metal tellurides,is exploited to support gold nanoparticles fabricating HfTe_(2)-Au *** nanohybrids can serve as novel 2D surface-enhanced Raman scattering(SERS)substrate for the label-free detection of analyte with high sensitivity and *** mechanism originated from HfTe_(2) nanosheets and the electromagnetic enhancement induced by the hot spots on the nano-hybrids may largely contribute to the superior SERS effect of HfTe_(2)-Au ***,HfTe_(2)-Au nanocomposites are utilized for the label-free SERS analysis of foodborne pathogenic bac-teria,which realize the rapid and ultrasensitive Raman test of Escherichia coli,Listeria mono-cytogenes,Staphylococcus aureus and Salmonella with the limit of detection of 10 CFU/mL and the maximum Raman enhancement factor up to 1.7×10^(8).Combined with principal component analysis,HfTe_(2)-Au-based SERS analysis also completes the bacterial classification without extra treatment.

关键词： Two-dimensional nanomaterials hafnium ditelluride surface-enhanced Raman scattering foodborne pathogenic bacteria

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microelectrode glucose biosensor based on nanoporous platinum/graphene oxide nanostructure for rapid glucose detection of tomato and cucumber fruits

引用

food Quality and Safety 2022年第1期6卷 45-55页

作者： Binfang Wu Haitao Xu Yufeng Shi Zhijie Yao Jiayu Yu Hua Zhou Yunpeng Li Qiulan Chen Yongbing Long college of Electronic engineering South China Agricultural UniversityGuangzhouChina Lingnan Modern Agricultural Science and technology guangdong Laboratory GuangzhouChina Department of medical Devices Guangdong Food and Drug Vocational CollegeGuangzhouChina

A microelectrode glucose biosensor based on a three-dimensional hybrid nanoporous platinum/graphene oxide nanostructure was developed for rapid glucose detection of tomato and cucumber *** nanostructure was fabricated by a two-step modification method on a microelectrode for loading a larger amount of glucose *** nanoporous structure was prepared on the surface of the platinum microelectrode by electrochemical etching,and then graphene oxide was deposited on the prepared nanoporous electrode by electrochemical *** nanoporous platinum/graphene oxide nanostructure had the advantage of improving the effective surface area of the electrode and the loading quantity of glucose *** a result,the biosensor achieved a wide range of 0.1-20.0 mmol/L in glucose detection,which had the ability to accurately detect the glucose *** was found that the three-dimensional hybrid nanostructure on the electrode surface realized the rapid direct electrochemistry of glucose ***,the biosensor achieved high glucose detection sensitivity 11.64μA·L/(***^(2)),low detection limit(13μmol/L)and rapid response time(reaching 95%steady-state response within 3 s),when calibrating in glucose standard *** agricultural application,the as-prepared biosensor was employed to detect the glucose concentration of tomato and cucumber *** results showed that the relative deviation of this method was less than 5%when compared with that of high-performance liquid chromatography,implying high accuracy of the presented biosensor in glucose detection in plants.

关键词： Direct electrochemistry three-dimensional hybrid nanoporous platinum/graphene oxide nanostructure glucose biosensor glucose detection in plants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phosphatidylethanolamine functionalized biomimetic monolith for immobilized artificial membrane chromatography

引用

Journal of Pharmaceutical Analysis 2022年第2期12卷 332-338页

作者： Peijie Zhu Weijia Chen Qiqin Wang Huihui Wu Meng Ruan Hongwu Wang Zhengjin Jiang School of food&Pharmaceutical engineering Zhaoqing UniversityZhaoqingGuangdong526061China Institute of Pharmaceutical Analysis College of PharmacyJinan UniversityGuangzhou510632China School of Pharmaceutical engineering Guangdong Food and Drug Vocational CollegeGuangzhou510632China Department of Pharmacy and guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine&New drug research Jinan UniversityGuangzhou510632China

In this research,a new phospholipid based monolith was fabricated by in situ co-polymerization of 1-dodecanoyl-2-(11-methacrylamidoundecanoyl)-sn-glycero-3-phosphoethanolamine and ethylene dimethacrylate to mimick bio-membrane *** physicochemical properties of this novel monolith that were achieved included column efficiency,stability,and ***,the biomimetic monolith showed outstanding separation capability for a series of intact proteins and small *** particular,it exhibited good potential as an alternative to the commercial immobilized artificial membrane(IAM)column(***2)for studying drug-membrane *** study not only enriched the types of IAM stationary phases,but also provided a simple model for the prediction of phosphatidylethanolamine related properties of drug candidates.

关键词： Phosphatidylethanolamine Biomimetic monolith IAM drug-membrane interaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant-Derived Enzymes Producing Chiral Aroma Compounds and Potential Application

引用

Phyton-International Journal of Experimental Botany 2023年第2期92卷 383-398页

作者： Fang Dong Qian Fan Xinguo Su Lanting Zeng guangdong food and drug vocational college Guangzhou510520China National Navel Orange engineering research center College of Life SciencesGannan Normal UniversityGanzhou341000China Tropical Agriculture and Forestry Department Guangdong AIB Polytechnic CollegeGuangzhou510650China Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement&guangdong Provincial Key Laboratory of Applied Botany South China Botanical GardenChinese Academy of SciencesGuangzhou510650China

Aroma(volatile)compounds play important ecological functions in plants,and also contribute to the quality of plant-derived ***,chiral aroma compounds affect their functions in plants and lead to different flavor quality *** of chiral aroma compounds are due to the presence of enzymes producing these compounds in plants,which are generally involved in the final biosynthetic step of the aroma ***,we review recent progress in research on the plant-derived enzymes producing chiral aroma compounds,and their changes in response to environmental *** chiral aroma enzymes that have been reported produce(R)-linalool,(S)-linalool,(R)-limonene,and(S)-limonene,etc.,and these enzymes are found in various plant *** also discuss the origins of enantioselectivity in the plant-derived enzymes producing chiral aroma compounds and summarize the potential use of plants containing enzymes producing chiral aroma compounds for producing chiral flavors/fragrances.

关键词： Aroma chiral enantioselectivity enzyme plant volatile stereochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quercetin induced HepG2 cells apoptosis through ATM/JNK/STAT3 signaling pathways

引用

BIOCELL 2023年第1期47卷 187-194页

作者： WANTONG LIU DANYANG CHEN JINGYAO SU RUILIN ZHENG RAN KONG BING ZHU HAO DONG YINGHUA LI center Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510120China college of Light Industry and food Sciences Innovation Research Institute of Modern Agricultural EngineeringZhongkai University of Agriculture and EngineeringGuangzhou510225China

Liver cancer is the seventh most common malignant tumor in the world and is the second highest cause of death due to ***,a flavonoid with low toxicity,widely exists in various fruits and *** has the potential to be a therapeutic agent against various *** study aimed to demonstrate the anti-tumor effect of quercetin on HepG2 *** suppressed the HepG2 cell proliferation in a dose-dependent manner in cell viability *** of cell apoptosis was confirmed by apoptotic cells population(sub-G1 peak)detected by flow cytometer.A decrease in mitochondrial membrane potential and caspase-3 activation were also demonstrated in this ***,quercetin induced HepG2 cell apoptosis through ROS-mediated phosphorylated ataxia-telangiectasia mutated,c-Jun Nterminal kinases,signal transducer,and activator of transcription 3(STAT-3),and Bax signaling *** results suggest that quercetin has the potential to become an effective drug against the tumor.

关键词： Quercetin Caspase-3 Reactive oxygen species Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alleviating effects and mechanisms of action of large-leaf yellow tea drinking on diabetes and diabetic nephropathy in mice

引用

food Science and Human Wellness 2023年第5期12卷 1660-1673页

作者： Guangshan Zhao Jianyuan Teng Ruixia Dong Qiuyan Ban Lian Yang Kang Du Yifei Wang Hanlin Pu Chung S.Yang Zhe Ren Innovation Team of food Nutrition and Safety Control College of Food Science&TechnologyHenan Agricultural UniversityZhengzhou 450002China Biology Postdoctoral research Station Department of Cell BiologyCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China college of Horticulture Jinling Institute of TechnologyNanjing 211169China Department of Forestry and technology Lishui Vocational and Technical CollegeLishui 323000China Department of Tea Science College of HorticultureHenan Agricultural UniversityZhengzhou 450002China guangdong Provincial engineering center of Topical Precise drug Delivery System School of PharmacyGuangdong Pharmaceutical UniversityGuangzhou 510006China Department of Chemical Biology Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscataway 08901USA International Joint research Laboratory of Tea Chemistry and Health Effects Anhui Agricultural UniversityHefei 230036China

Our previous study found that large-leaf yellow tea(LYT)had interesting hypoglycemic activity in high-fat diet-induced obese mice and highly safety in healthy mice. To study the anti-diabetic potential of LYT, the present study further investigated the preventive effects and mechanisms of action of LYT administration on diabetes and diabetic nephropathy in high-fat diet plus streptozotocin-induced diabetic mice. Results showed that LYT infusions(1/100 and 1/50, m/V)as drinking fluid for 4 weeks reduced diabetic polydipsia and polyuria, enhanced glucose tolerance and insulin sensitivity, and lowered fasting blood glucose level. The underlying mechanisms involve downregulation of gluconeogenesis(lower protein levels of TXNIP and FBP and enzyme activity of FBP), upregulation of lipid catabolism(higher protein levels of CPT-1α and PPARα), downregulation of lipogenesis(lower protein level of SREBP-1), and modification of the structure and abundance of gut microbiota to modulate metabolic homeostasis. Moreover, LYT administration prevented diabetic nephropathy, possibly due to reduced glucose-caused osmotic diuresis and lowered levels of renal PKC-β2, NLRP3 as well as membrane PKC-α, AQP2 and glycosylated AQP2 proteins. Taken together, LYT exhibits the activities in alleviating diabetic symptoms, ameliorating glucose and lipid dysmetabolism and fatty liver, and preventing diabetic nephropathy in diabetic mice. These activities may be explored for the prevention and treatment of diabetes in humans.

关键词： Diabetes Glucose and lipid metabolism Gut microbiota Diabetic nephropathy Large-leaf yellow tea

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in targeted therapy for esophageal cancer

引用

Signal Transduction and Targeted Therapy 2020年第1期5卷 585-595页

作者： Yan-Ming Yang Pan Hong Wen Wen Xu Qing-Yu He Bin Li MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein research of guangdong Higher Education Institutes Institute of Life and Health EngineeringJinan UniversityGuangzhouChina MOE Key Laboratory of Tumor Molecular Biology and guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic MedicineInstitute of BiomedicineCollege of Life Science and TechnologyJinan UniversityGuangzhouChina

Esophageal cancer(EC)is one of the most lethal cancers in the world,and its morbidity and mortality rates rank among the top ten in ***,surgical resection,radiotherapy and chemotherapy are the primary clinical treatments for esophageal ***,outcomes are still unsatisfactory due to the limited efficacy and severe adverse effects of conventional *** a new type of approach,targeted therapies have been confirmed to play an important role in the treatment of esophageal cancer;these include cetuximab and bevacizumab,which target epidermal growth factor receptor(EGFR)and vascular endothelial growth factor(VEGF),*** addition,other drugs targeting surface antigens and signaling pathways or acting on immune checkpoints have been continuously *** example,trastuzumab,a monoclonal antibody targeting human epidermal growth factor receptor 2(HER-2),has been approved by the food and drug Administration(FDA)as a first-line treatment of HER-2-positive ***,the PD-L1 inhibitor pembrolizumab has been approved as a highly efficient drug for patients with PD-L1-positive or advanced esophageal squamous cell carcinoma(ESCC).These novel drugs can be used alone or in combination with other treatment strategies to further improve the treatment efficacy and prognosis of cancer ***,adverse events,optimal dosages and effective combinations still need further *** this review,we expound an outline of the latest advances in targeted therapies of esophageal cancer and the mechanisms of relevant drugs,discuss their efficacy and safety,and provide a clinical rationale for precision medicine in esophageal cancer.

关键词： esophageal drugs targeted

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2

引用

National Science Review 2021年第3期8卷 29-41页

作者： Ling Zhu Yong-Qiang Deng Rong-Rong Zhang Zhen Cui Chun-Yun Sun Chang-Fa Fan Xiaorui Xing Weijin Huang Qi Chen Na-Na Zhang Qing Ye Tian-Shu Cao Nan Wang Lei Wang Lei Cao Huiyu Wang Desheng Kong Juan Ma Chunxia Luo Yanjing Zhang Jianhui Nie Yao Sun Zhe Lv Neil Shaw Qianqian Li Xiao-Feng Li Junjie Hu Liangzhi Xie Zihe Rao Youchun Wang Xiangxi Wang Cheng-Feng Qin CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of Sciences State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical Sciences Beijing engineering research center of Protein and Antibody Sinocelltech Ltd. Division of Animal Model research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC) School of Basic medical Sciences Southwest Medical University Division of HIV/AIDS and Sex-Transmitted Virus Vaccines Institute for Biological Product Control NIFDC Beijing Key Laboratory of Monoclonal Antibody research and Development Sino Biological Inc. Cell Culture engineering center Chinese Academy of Medical Sciences &Peking Union Medical College guangzhou Regenerative Medicine and Health guangdong Laboratory

Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by *** these steps can cure *** we have identified and characterized a potent human monoclonal antibody,HB27,that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM ***,HB27 can also prevent SARS-CoV-2 membrane ***,a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse *** macaques showed no obvious adverse events when administrated with10 times the effective dose of ***-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 *** of the antibody also restrains any further conformational changes of the receptor binding domain,possibly interfering with progression from the prefusion to the postfusion *** results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19.

关键词： SARS-CoV-2 COVID-19 in vivo protection preclinical safety evaluation human neutralizing antibody immuno-therapy cryo-EM structure

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：