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Genes & Diseases 2024年第4期11卷 57-60页

作者： Shaolong Hao Yu Ji Weixuan Pan Hao Sun Fang Nie Jonathan Ray Warren Yuchuan Ding Wei Han department of General Surgery Beijing Luhe HospitalCapital Medical UniversityTongzhouBeijing 101149China department of Central Laboratory Beijing Luhe HospitalCapital Medical UniversityTongzhouBeijing 101149China department of Neurosurgery Wayne State University School of MedicineJohn D.Dingell VA Medical CenterDetroitMI 48201USA

Pancreatic cancer is one of the most aggressive malignant tumors of the digestive *** node metastasis(LNM),as the main way of invasion and metastasis,can occur in the early stage of pancreatic cancer and be considered... 详细信息

关键词： metastasis cancer invasion

Fatigue-resistant Hydrogels

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Chemical Research in Chinese Universities 2024年第1期40卷 64-77页

作者： LI Luofei LEI Hai CAO Yi Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State MicrostructureDepartment of PhysicsNanjing UniversityNanjing 210093P.R.China department of Physics Zhejiang UniversityHangzhou 310027P.R.China

Hydrogels have been extensively studied for applications in various fields, such as tissue engineering and soft robotics, as determined by their mechanical properties. The mechanical design of hydrogels typically focuses on the modulus, toughness, and deformability. These characteristics play important roles and make great achievements for hydrogel use. In recent years, a growing body of research has concentrated on the fatigue property of hydrogels, which determines their resistance to crack propagation in the networks during cyclic mechanical loads for applications. However, knowledge of hydrogel fatigue behavior remains notably deficient. Here, we present a brief overview of the fatigue behavior of hydrogels, encompassing the general experimental methods to measure the fatigue property and fundamental theoretical calculation models. Then, we highlight multiple strategies to enhance the fatigue resistance of hydrogels. Finally, we present our perspectives on fatigue-resistant hydrogels, outstanding challenges and potential directions for future research.

关键词： Hydrogel Fatigue-resistant Fracture

Multi-source data integration and multi-scale modeling framework for progressive prediction of complex geological interfaces in tunneling

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Underground Space 2024年第2期15卷 1-25页

作者： Jingxiao Wang Peinan Li Xiaoying Zhuang Xiaojun Li Xi Jiang Jun Wu department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China College of Environmental Science and Engineering Donghua UniversityShanghai 201620China Institute of Photonics Department of Mathematics and PhysicsLeibniz University HannoverHannover 30167Germany department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 100872China College of Civil Engineering Shanghai Normal UniversityShanghai 200233China

A reliable geological model plays a fundamental role in the efficiency and safety of mountain tunnel ***,regional models based on limited survey data represent macroscopic geological environments but not detailed internal geological characteristics,especially at tunnel portals with complex geological *** paper presents a comprehensive methodological framework for refined modeling of the tunnel surrounding rock and subsequent mechanics analysis,with a particular focus on natural space distortion of hard-soft rock interfaces at tunnel *** progressive prediction of geological structures is developed considering multi-source data derived from the tunnel survey and excavation *** improve the accuracy of the models,a novel modeling method is proposed to integrate multi-source and multi-scale data based on data extraction and potential field ***,a regional-scale model and an engineering-scale model are built,providing a clear insight into geological phenomena and supporting numerical *** addition,the proposed framework is applied to a case study,the Long-tou mountain tunnel project in Guangzhou,China,where the dominant rock type is *** results show that the data integration and modeling methods effectively improve model structure *** improved model’s calculation deviation is reduced by about 10%to 20%in the mechanical *** study contributes to revealing the complex geological environment with singular interfaces and promoting the safety and performance of mountain tunneling.

关键词： Mountain tunnel Geological modeling Multi-source data Progressive prediction Tunnel portals

Towards high-performance and robust anion exchange membranes(AEMs)for water electrolysis:Super-acid-catalyzed synthesis of AEMs

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Journal of Energy Chemistry 2024年第6期93卷 478-510,I0012页

作者： Geun Woong Ryoo Sun Hwa Park Ki Chang Kwon Jong Hun Kang Ho Won Jang Min Sang Kwon department of Materials Science and Engineering Research Institute of Advanced Materials(RIAM)Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and Science(KRISS)Daejeon 34113Republic of Korea department of Chemical and Biological Engineering and Institute of Chemical ProcessSeoul National UniversitySeoul 08826Republic of Korea department of Applied Measurement Science University of Science and TechnologyDaejeon 34113Republic of Korea

The increasing demand for hydrogen energy to address environmental issues and achieve carbon neutrality has elevated interest in green hydrogen production,which does not rely on fossil *** various hydrogen production technologies,anion exchange membrane water electrolyzer(AEMWE)has emerged as a next-generation technology known for its high hydrogen production efficiency and its ability to use non-metal ***,this technology faces significant challenges,particularly in terms of the membrane durability and low ionic *** address these challenges,research efforts have focused on developing membranes with a new backbone structure and anion exchange groups to enhance durability and ionic ***,the super-acid-catalyzed condensation(SACC)synthesis method stands out due to its user convenience,the ability to create high molecular weight(MW)polymers,and the use of oxygen-tolerant organic *** the synthesis of anion exchange membranes(AEMs)using the SACC method began in 2015,and despite growing interest in this synthesis approach,there remains a scarcity of review papers focusing on AEMs synthesized using the SACC *** review covers the basics of SACC synthesis,presents various polymers synthesized using this method,and summarizes the development of these polymers,particularly their building blocks including aryl,ketone,and anion exchange *** systematically describe the effects of changes in the molecular structure of each polymer component,conducted by various research groups,on the mechanical properties,conductivity,and operational stability of the *** review will provide insights into the development of AEMs with superior performance and operational stability suitable for water electrolysis applications.

关键词： Green hydrogen production Water electrolysis Anion exchange membrane water electrolyzer(AEMWE) Anion exchange membranes(AEMs) Super-acid-catalyzed condensation(SACC)

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Integrated Single-cell Multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 67-88页

作者： Manickam Ashokkumar Wenwen Mei Jackson J.Peterson Yuriko Harigaya David M.Murdoch David M.Margolis Caleb Kornfein Alex Oesterling Zhicheng Guo Cynthia D.Rudin Yuchao Jiang Edward P.Browne department of Medicine University of North Carolina at Chapel HillChapel HillNC 27599USA HIV Cure Center University of North Carolina at Chapel HillChapel HillNC 27599USA department of Biostatistics University of North Carolina at Chapel HillChapel HillNC 27599USA department of Microbiology and Immunology University of North Carolina at Chapel HillChapel HillNC 27599USA department of Genetics University of North Carolina at Chapel HillChapel HillNC 27599USA department of Medicine Duke UniversityDurhamNC 27708USA department of Computer Science Duke UniversityDurhamNC 27708USA department of Statistics Texas A&M UniversityCollege StationTX 77843USA department of Biology Texas A&M UniversityCollege StationTX 77843USA department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA

Despite the success of antiretroviral therapy,human immunodeficiency virus(HIV)cannot be cured because of a reservoir of latently infected cells that evades *** understand the mechanisms of HIV latency,we employed an integrated single-cell RNA sequencing(scRNA-seq)and single-cell assay for transposase-accessible chromatin with sequencing(scATAC-seq)approach to simultaneously profile the transcriptomic and epigenomic characteristics of~125,000 latently infected primary CD4^(+)T cells after reactivation using three different latency reversing *** expressed genes and differentially accessible motifs were used to examine transcriptional pathways and transcription factor(TF)activities across the cell *** identified cellular transcripts and TFs whose expression/activity was correlated with viral reactivation and demonstrated that a machine learning model trained on these data was 75%-79%accurate at predicting viral ***,we validated the role of two candidate HIV-regulating factors,FOXP1 and GATA3,in viral *** data demonstrate the power of integrated multimodal single-cell analysis to uncover novel relationships between host cell factors and HIV latency.

关键词： HIV latency reversal Primary CD4þT cell Single-cell multiomics HIV-regulating factor Machine learning

Treadmill exercise improves hippocampal neural plasticity and relieves cognitive deficits in a mouse model of epilepsy

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Neural Regeneration Research 2024年第3期19卷 657-662页

作者： Hang Yu Mingting Shao Xi Luo Chaoqin Pang Kwok-Fai So Jiandong Yu Li Zhang Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina department of Neurosurgery The First Affiliated Hospital of Bengbu Medical CollegeBengbuShandong ProvinceChina School of Psychology Shanghai University of SportShanghaiChina

Epilepsy frequently leads to cognitive dysfunction and approaches to treatment remain *** regular exercise effectively improves learning and memory functions across multiple neurological diseases,its application in patients with epilepsy remains ***,we adopted a 14-day treadmill-exercise paradigm in a pilocarpine injection-induced mouse model of *** assays confirmed the improvement of object and spatial memory after endurance training,and electrophysiological studies revealed the maintenance of hippocampal plasticity as a result of physical *** of the mechanisms underlying this effect revealed that exercise protected parvalbumin interneurons,probably via the suppression of neuroinflammation and improved integrity of blood-brain *** summary,this work identified a previously unknown mechanism through which exercise improves cognitive rehabilitation in epilepsy.

关键词： blood-brain barrier cognition hippocampus interneurons long-term potentiation microglial cell neuroinflammation spatial memory temporal epilepsy treadmill exercise

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Effects of salt and rice flour concentration on microbial diversity and the quality of sour meat,a Chinese traditional meat

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Food Science and Human Wellness 2024年第5期13卷 2790-2798页

作者： Mengyang Liu Xinping Lin Jing Yang Xu Yan Chaofan Ji Huipeng Liang Sufang Zhang Liang Dong SKL of Marine Food Processing&safety Control National Engineering Research Center of SeafoodCollaborative Innovation Center of Provincial and Ministerial Co-construction for Seafood Deep ProcessingLiaoning Province Collaborative Innovation Center for Marine Food Deep ProcessingSchool of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China department of Agricultural Forest and Food SciencesUniversity of TorinoTurin 10095Italy Institute of Technology China Resources Beer(Holdings)Company LimitedBeijing 100005China

This study investigated the effects of salt(3%and 6%,m/m)and rice flour(10%and 20%,m/m)addition in sour meat,a traditional Chinese fermented *** was found that salt has greater effect than rice flour addition in spontaneous ***-salt groups had lower pH and higher titratable total *** the low-salt groups,the dominant genera were Lactobacillus and Lactococcus,whereas Staphylococcus,Weissella,and Tetragenococcus were dominant in the high-salt *** total free amino acids and essential amino acids,organic acids,hexanoic acid ethyl ester and octanoic acid ethyl ester were found in the low-salt *** RDA analysis revealed that Lactococcus was closely related to product quality,with the S3F10(3%salt and 10%rice f lour)group outperforming the others in the sensory ***,3%salt and 10%rice flour were considered more appropriate for the production of healthy and tasty fermented sour meats.

关键词： Low salt Fermented meat Bacterial community Amino acid content Volatile compounds Ester Sour meat

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Machine-learned wearable sensors for real-time hand-motion recognition: toward practical applications

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National Science Review 2024年第2期11卷 231-263页

作者： Kyung Rok Pyun Kangkyu Kwon Myung Jin Yoo Kyun Kyu Kim Dohyeon Gong Woon-Hong Yeo Seungyong Han Seung Hwan Ko department of Mechanical Engineering Seoul National University IEN Center for Human-Centric Interfaces and Engineering Institute for Electronics and NanotechnologyGeorgia Institute of Technology School of Electrical and Computer Engineering Georgia Institute of Technology department of Chemical Engineering Stanford University department of Mechanical Engineering Ajou University George W.Woodruff School of Mechanical Engineering Georgia Institute of Technology Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National University

Soft electromechanical sensors have led to a new paradigm of electronic devices for novel motion-based wearable applications in our daily lives. However, the vast amount of random and unidentified signals generated by complex body motions has hindered the precise recognition and practical application of this technology. Recent advancements in artificial-intelligence technology have enabled significant strides in extracting features from massive and intricate data sets, thereby presenting a breakthrough in utilizing wearable sensors for practical applications. Beyond traditional machine-learning techniques for classifying simple gestures, advanced machine-learning algorithms have been developed to handle more complex and nuanced motion-based tasks with restricted training data sets. Machine-learning techniques have improved the ability to perceive, and thus machine-learned wearable soft sensors have enabled accurate and rapid human-gesture recognition, providing real-time feedback to users. This forms a crucial component of future wearable electronics, contributing to a robust human–machine interface. In this review, we provide a comprehensive summary covering materials, structures and machine-learning algorithms for hand-gesture recognition and possible practical applications through machine-learned wearable electromechanical sensors.

关键词： wearable sensor soft electronics artificial intelligence machine learning human–machine interfaces gesture recognition

High energy storage density in NaNbO_(3) antiferroelectrics with double hysteresis loop

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Journal of Materiomics 2024年第5期10卷 1026-1035页

作者： Li Ma Zhenpei Chen Gengguang Luo Zhiyi Che Chao Xu Dongliang Shan Zhenyong Cen Qin Feng Xiyong Chen Toyohisa Fujita Ye Zhu Yunya Liu Jing-Feng Li Shujun Zhang Nengneng Luo State Key Laboratory of Featured Metal Materials and Life-cycle safety for Composite Structures School of ResourcesEnvironment and MaterialsGuangxi UniversityNanning530004China School of Chemistry and Chemical Engineering Guangxi UniversityNanning530004China department of Applied Physics Research Institute for Smart EnergyThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education School of Materials Science and EngineeringXiangtan UniversityXiangtan411105HunanChina State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Institute for Superconducting and Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongWollongongNSW2500Australia

Antiferroelectrics(AFEs)possess great potential for high performance dielectric capacitors,due to their distinct double hysteresis loop with high maximum polarization and low remnant ***,the well-known NaNbO3 lead-free antiferroelectric(AFE)ceramic usually exhibits square-like P–E loop related to the irreversible AFE P phase to ferroelectric(FE)Q phase transition,yielding low recoverable energy storage density(Wrec).Herein,significantly improved Wrec up to 3.3 J/cm^(3) with good energy storage efficiency(η)of 42.4% was achieved in Na_(0.7)Ag_(0.3)Nb_(0.7)Ta_(0.3)O_(3)(30Agsingle bond30Ta)ceramic with well-defined double P–E loop,by tailoring the A-site electronegativity with Ag+and B-site polarizability with Ta^(5+).The Transmission Electron Microscope,Piezoresponse Force Microscope and in-situ Raman spectra results verified a good reversibility between AFE P phase and high-field-induced FE Q *** improved stability of AFE P phase,being responsible for the double P–E loop and improved Wrec,was attributed to the decreased octahedral tilting angles and cation *** mechanism was revealed by synchrotron X-ray diffraction and Scanning Transmission Electron *** work provides a good paradigm for achieving double P–E loop and high energy storage density in NaNbO_(3)-based ceramics.

关键词： Sodium niobate Antiferroelectrics Double hysteresis loop Energy storage performance Reversibility

Link between irritable bowel syndrome,depression,and colorectal cancer risk in young patients:Age-matched nationwide populationbased study

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World Journal of Gastrointestinal Pathophysiology 2024年第3期15卷 1-8页

作者： Sai Priyanka Mellacheruvu Sai Prasanna Lekkala Sukhjinder Chauhan Adil Sarvar Mohammed Sravya R Mundla Ankita Shenoy Bilal Khan Mohammed Jerrin Bawa Shantha Nallapothula Priyatham Gurram Akhil Jain Rupak Desai Mohammed Mustafa Nayeem department of Public health University of MassachusettsLowellMA 01854United States department of Internal Medicine Mamata Medical CollegeTelanganaKhammam 507002India department of Internal Medicine Mountainview HospitalLas VegasNV 89128United States department of Internal Medicine Central Michigan University College of MedicineSaginawMI 48602United States department of Public health Apollo Institute of Medical Sciences and ResearchTelanganaHyderabad 500090India department of Medicine Dr D.Y.Patil University School of MedicineMaharashtraNavi Mumbai 400706India department of Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States department of Internal Medicine Flushing Hospital Medical CenterQueensNY 11355United States department of Internal Medicine PES Institute of Medical Sciences and ResearchAndhra PradeshKuppam 517425India department of Gastroenterology Mayo ClinicScottsdaleAZ 85259United States Division of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTX 77079United States Independent Researcher AtlantaGA 30079United States department of Internal Medicine Parkview Medical CenterPuebloCO 81003United States

BACKGROUND There exists a link between irritable bowel syndrome(IBS)and ***,chronic depression is known to increase the risk of cancer in *** this population-based analysis,we investigated the prevalence and the odds of colorectal cancer(CRC)in young-depressed patients with *** To investigate the relationship between IBS and CRC in young,depressed patients using a nationally representative United States inpatient *** The 2019 National Inpatient Sample was used to identify young(18-44 years)patients admitted with comorbid depression in the presence vs absence of IBS using relevant International Classification of Diseases,Tenth Revision,Clinical Modification *** endpoint was the prevalence and odds of CRC in age matched(1:1)youngdepressed cohort hospitalized with IBS(IBS+)vs without IBS(IBS-).Multivariable regression analysis was performed adjusting for potential *** Age-matched(1:1)young-depressed IBS+(83.9%females,median age 36 years)and IBS-(65.8%females,median age 36 years)cohorts consisted of 14370 patients in each ***+cohort had higher rates of hypertension,uncomplicated diabetes,hyperlipidemia,obesity,peripheral vascular disease,chronic obstructive pulmonary disease,hypothyroidism,prior stroke,prior venous thromboembolism,anxiety,bipolar disorder,and borderline personality disorder(P<0.005)vs the ***,prior myocardial infarction,acquired immunodeficiency syndrome,dementia,smoking,alcohol abuse,and drug abuse(P<0.005)are high in *** rate of CRC was comparable in both cohorts[IBS+n=25(0.17%)vs IBS-n=35(0.24%)].Compared to the IBS-cohort,the odds ratio(OR)of developing CRC was not significantly higher[OR 0.71,95% confidence interval(CI)0.23-2.25]in IBS+***,adjusting for baseline sociodemographic and hospital characteristics and relevant comorbidities,the OR was found to be non-significant(OR 0.89,95%CI 0.21-3.83).CONCLUSION This nationwide propensity-matched ana

关键词： Colorectal cancer Depression Irritable bowel syndrome Young patients National inpatient sample Comorbidities