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nutritional Profile of Children with Major Sickle Cell Syndrome at the Centre of Medical and health Advice of Kipé, Conakry, 2018

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Case Reports in Clinical Medicine 2024年第3期13卷 73-84页

作者： Mamadou Aliou Doukoure Ibrahima Sory Diallo M’mah Aminata Bangoura Amadou Oury Toure Mamadou Moustapha Diop Fatoumata Binta Diallo Mohamed Sama Cherif Thierno Saidou Diallo Saidouba Cherif Camara Abdoulaye Toure Faculty of health Science and Technology Gamal Abdel Nasser University Conakry Guinea National AIDS Control programme Ministry of Health Gamal Abdel Nasser University Conakry Guinea

Introduction: Growth is a reflection of a child’s health and nutritional status. Children with sickle cell disease often have slower statural and weight development. The aim of this study was to evaluate the nutritional profile of children with sickle cell disease (SCD) registered in the CEMECO centre database. Methodology: This was a cross-sectional study with simple random sampling of children aged 1 to 16 years registered in the clinic database. Results: We collected information on 208 children, 121 of whom had sickle cell disease and 87 of whom were normal, with a sex ratio of 1.02. The mean age of the sickle cell patients was 8.7 ± 4.4 years, while that of the non-sickle cell patients was 9.5 ± 4 years. Haemoglobin electrophoresis revealed 103 homozygous (SS), 18 double heterozygous (SC, SBetaThal, SE) and 87 normal (AA) and/or sickle cell trait (AS) sickle cell cases. We observed a significant difference in the height/age ratio (P ¥). Conclusion: The results of our study revealed stunted growth in children with sickle cell disease.

关键词： Sickle Cell Disease nutrition Growth Puberty Guinea

Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

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World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of Population and Public health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

Recent advances in the production of single cell protein from renewable resources and applications

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Carbon Resources Conversion 2024年第2期7卷 38-49页

作者： Danai Ioanna Koukoumaki Erminta Tsouko Seraphim Papanikolaou Zacharias Ioannou Panagiota Diamantopoulou Dimitris Sarris Laboratory of Physico-Chemical and Biotechnological Valorization of Food By-Products Department of Food Science&NutritionSchool of EnvironmentUniversity of the AegeanLeoforos Dimokratias 66Myrina 81400LemnosGreece Department of Food Science and Human nutrition Agricultural University of Athens75Iera Odos11855 AthensGreece Laboratory of Edible Fungi Institute of Technology of Agricultural ProductsHellenic Agricultural Organization-Dimitra1Sof.Venizelou14123 LykovrysiGreece

Single Cell Protein(SCP)refers to dry cells of microorganisms,and it constitutes a highly promising and alternative protein source for multiple *** presents a rich nutritional profile containing valuable amino acids and fatty acids,nucleic acids,minerals,and several *** businesses worldwide have introduced SCP into their production cycles,hence expanding the scope of its application in value added market chains such as the edible food *** is produced by a plethora of microorganisms,including fungi,yeasts,bacteria,and algae while many of them are Generally Recognized as Safe(GRAS).Selected microbial strains present satisfying growth capability with high yields when cultivated in renewable ***,production rates and process sustainability could be enhanced via the valorization of industrial and agricultural wastes as the nutrient sources,combined with optimization of process parameters,i.e fermentation mode and feeding strategy,pH,temperature,C/N ratio,agitation rate and oxygen *** review addresses the latest developments made towards the SCP production,highlighting efficient microbial SCP producers,and production systems that valorize solid and liquid streams from several agricultural *** applications,challenges in sensorial-,and safety-aspects as well as consumers perception issues of SCP incorporation into food-related matrices are also discussed.

关键词： Alternative protein Sustainability Sensorial aspects Safety Food and feed Packaging applications

DHA Depletion in Rat Brain Is Associated With Impairment on Spatial Learning and Memory

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Biomedical and Environmental Sciences 2006年第6期19卷 474-480页

作者： YING XIAO LING WANG RUO-JUN XU ZHEN-YU CHEN Food and nutrition Sciences programme Department of Biochemistry The Chinese University of Hong Kong Shatin NT Hong Kong China Department of nutrition and Food Hygiene School of Public Health Peking University Health Science Center Beijing China Food and nutrition Division Department of Zoology The University of Hong Kong Hong Kong China Department of nutrition and Food Hygiene College of Public Health Zhengzhou University China

Objective To examine the effect of docosahexaenoic acid （DHA） deficiency in brain on spatial learning and memory in rats. Methods Sprague Dawley rats were fed with an n-3 fatty acid deficient diet for two generations to induce DHA depletion in brain, DHA in seven brain regions was analyzed using the gas-liquid chromatography. Morris water maze （MWM） was employed as an assessing index of spatial learning and memory in the n-3 fatty acid deficient adult rats of second generation. Results Feeding an n-3 deficient diet for two generations depleted DHA differently by 39%-63% in the seven brain regions including cerebellum, medulla, hypothalamus, striatum, hippocampus, cortex and midbrain, The MWM test showed that the n-3 deficient rats took a longer time and swam a longer distance to find the escape platform than the n-3 Adq group. Condusion The spatial learning and memory in adult rats are partially impaired by brain DHA depletion.

关键词： Docosahexaenoic acid Memory Morris water maze Spatial learning

Anti-methanogenic potential of seaweeds and seaweed-derived compounds in ruminant feed:current perspectives,risks and future prospects

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Journal of Animal Science and Biotechnology 2024年第2期15卷 463-489页

作者： Ailbhe McGurrin Julie Maguire Brijesh K.Tiwari Marco Garcia-Vaquero Section of Food and nutrition School of Agriculture and Food ScienceUniversity College DublinDublin 4BelfieldIreland TEAGASC Food Research CentreDublin 15AshtownIreland Bantry Marine Research Station Ltd BantryCo.CorkP75 AX07GearhiesIreland

With methane emissions from ruminant agriculture contributing 17%of total methane emissions worldwide,there is increasing urgency to develop strategies to reduce greenhouse gas emissions in this *** of the proposed strategies is ruminant feed intervention studies focused on the inclusion of anti-methanogenic compounds which are those capable of interacting with the rumen microbiome,reducing the capacity of ruminal microorganisms to produce ***,seaweeds have been investigated for their ability to reduce methane in ruminants in vitro and in vivo,with the greatest methane abatement reported when using the red seaweed Asparagopsis taxiformis(attributed to the bromoform content of this species).From the literature analysis in this study,levels of up to 99%reduction in ruminant methane emissions have been reported from inclusion of this seaweed in animal feed,although further in vivo and microbiome studies are required to confirm these results as other reports showed no effect on methane emission resulting from the inclusion of seaweed to basal *** review explores the current state of research aiming to integrate seaweeds as anti-methanogenic feed additives,as well as examining the specific bioactive compounds within seaweeds that are likely to be related to these *** effects of the inclusion of seaweeds on the ruminal microbiome are also reviewed,as well as the future challenges when considering the largescale inclusion of seaweeds into ruminant diets as anti-methanogenic agents.

关键词： Asparagopsis Bromoform Methanogenesis Phlorotannin Saponin Tannin

A Case Study on the Impact of Mother-to-Mother Support Groups on Maternal, Infant and Young Child nutrition and Care Practices in Habaswein and Wajir South Districts of North Eastern Kenya

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Food and nutrition Sciences 2013年第10期4卷 31-35页

作者： Charles Muruka Hellen Ekisa health and nutrition programme Save the Children Wajir County Kenya

Only about 25% of babies are exclusively breast fed until six months of age in developing countries though they are at a greater risk of infection and infant mortality. The Global Strategy for Maternal, Infant and Young Child Feeding (MI- YCF) Strategy developed by WHO/UNICEF in 2002 was to revitalize world attention to the impact of feeding practices on the nutritional status, growth, development, health and survival of infants and children. The data for this case study was collected through key informant interviews, observations and review of Save the Children nutrition programme reports and surveys. This information was then organized to produce a detailed description of the maternal, infant and young child nutrition programme in Habaswein and Wajir South districts or sub-counties. The maternal and infant young child nutrition (MIYCN) programme was launched in Habaswein and Wajir South districts in January 2012. The MIYCN programme followed recommendations of a Knowledge, Practice and Coverage (KPC) survey report in July 2012. To date, the programme has formed 48 Mother-to-mother Support Groups (MTMSGs), which are actively promoting the uptake of the recommended MIYCN practices in the community. MIYCN indicators have been markedly improved between July 2011 and February 2013 when surveys were conducted. The uptake of kitchen gardening has picked up significantly at Meri site and some mothers now have a changed attitude towards unskilled home deliveries and are conducting referrals for skilled births. The marked improvements in the performance of MIYCN indicators between July 2011 and February 2013 inWajir South and Habaswein districts can be partly attributed to the MIYCN programme established in January 2012. However, a randomized community trial is still required to provide conclusive results on the impact of care support groups on maternal, infant and young child feeding in this region.

关键词： Mother-to-Mother Support Groups Maternal Infant and Young Child nutrition Impact

Dietary black soldier fly oil enhances growth performance,flesh quality,and health status of largemouth bass(Micropterus salmoides)

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Animal nutrition 2024年第3期18卷 234-245页

作者： Hailin Yuan Junru Hu Xiangce Li Qiuxuan Sun Xiaohong Tan Cuihong You Yewei Dong Yanhua Huang Meng Zhou Innovative Institute of Animal healthy Breeding College of Animal Sciences and TechnologyZhongkai University of Agriculture and EngineeringGuangzhouGuangdong 510225China Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding GuangzhouGuangdong 510225China Guangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center GuangzhouGuangdong 510225China Guangdong Provincial Key Laboratory of Animal Breeding and nutrition Research GuangzhouGuangdong 510640China

The study aimed to assess the effects of dietary black soldier fly oil(BSFO)on the growth performance,flesh quality,and health status of largemouth bass(Micropterus salmoides).Six iso-nitrogenous and isolipid diets were formulated by substituting fish oil and soybean oil(1/2,wt/wt)with BSFO in percentages of 0%,20%,40%,60%,80%,and 100%,*** diets were fed to 960 fish(initial body weight=16.5 g)in four replicates for 8 *** related to growth performance,body composition,hematology,flesh quality,expression of genes related to inflammatory cytokines and apoptosis,and the response of fish to Aeromonas veronii challenge were *** results showed that the weight gain rate was numerically improved in all BSFO substitution groups,ranging from 9.3%to 44.0%compared to the control *** highest survival rate and the lowest hepatosomatic index and condition factor were observed in the BFSO20 *** terms of flesh quality,the water-holding capacity of the dorsal muscle was elevated with higher levels of dietary ***,significant changes in texture properties(cohesiveness,gluing,and chewiness)were observed in the BSFO20 group(Phealth status were significantly influenced by dietary BSFO substitution levels in a dose-dependent manner(P<0.05).In conclusion,substituting around 20%of dietary fish oil and soybean oil with BSFO is promisin

关键词： Micropterus salmoides Black soldier fly oil(BSFO) Growth performance Flesh quality health status

Emerging Food-borne Pathogens

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Biomedical and Environmental Sciences 2001年第1期14卷 44-52页

作者： JRGEN SCHLUNDT programme of Food Safety

The epidemiology of foodborne diseases is changing. While in many developing nations the efficient treatment of diarrhoeal diseases through oral rehydration has probably led to the prevention of many food related deaths, the underlying problems have not been solved. In these countries, the disease incidence of food_and waterborne disease is still increasing, and now data from other parts of the world indicate that new foodborne pathogens have emerged as important public health problems. Over the last two decades, bacterial infections caused by Campylobacter and enterohaemorrhagic Escherichia coli have emerged, well_recognized pathogens, such as Salmonella enteritidis, have increased dramatically in disease incidence and important foodborne pathogens have become increasingly resistant to antimicrobial agents. The future strategy for prevention of foodborne disease should be founded in scientifically based evaluations of the whole food production chain ‘from farm to table’, including a description of the most important (risk) factors. Epidemiological studies of outbreaks as well as sporadic cases should be aimed at a better understanding of these factors. In terms of public health importance of the problem, the focus should be on the size of the problem, and the potential for improvement. The indications are that both in developed and developing countries there is significant potential for an improvement of the situation. With this aim in mind, international effort should focus on scientific assessments of the potential for risk reduction under different regional conditions.

关键词： FOODBORNE DISEASES EPIDEMIOLOGY SURVEILLANCE VIBRIO

Risk factors and mortality rates of carbapenem-resistant Gram-negative bacterial infections in intensive care units

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Journal of Intensive Medicine 2024年第3期4卷 347-354页

作者： Tulay Orhan Kuloglu Gamze Kalin Unuvar Fatma Cevahir Aysegul Ulu Kilic Emine Alp Infection Control Committee Faculty of MedicineErciyes UniversityKayseriTurkey Department of Infectious Diseases Faculty of MedicineErciyes UniversityKayseriTurkey programme of First and Emergency Aid Sakarya UniversitySakaryaTurkey Department of Infectious Diseases Faculty of MedicineYıldırım Beyazıt UniversityAnkaraTurkey

Background The prevalence of hospital-acquired infections caused by carbapenem-resistant gram-negative bacteria(CRGNB)is increasing *** risk factors have been associated with such *** present study aimed to identify risk factors and determine the mortality rates associated with CRGNB infections in intensive care *** This retrospective case-control study was conducted at Erciyes University Hospital(Kayseri,Turkey)between January 2017 and December *** and laboratory data were obtained from the Infection Control Committee data and record *** who had CRGNB infection 48–72 h after hospitalization were assigned to the case group,while those who were not infected with CRGNB during hospitalization formed the control *** factors,comorbidity,demographic data,and mortality rates were compared between the two *** Approximately 1449 patients(8.97%)were monitored during the active follow-up period;of those,1171 patients were included in this *** infection developed in 14 patients(70.00%)who had CRGNB colonization at admission;in 162(78.26%)were colonized during hospitalization,whereas 515(54.56%)were not *** was no significant difference in age,sex(male/female)or *** total length of hospital stay was statistically significantly longer(P=0.001)in the case group(median:24[interquartile range:3–378]days)than the control group(median:16[interquartile range:3–135]days).The rates of colonization at admission(25.5%;vs.10.6%,P=0.001)and mortality(64.4%vs.45.8%,P=0.001)were also significantly higher in the cases than in the control group,*** the univariate analysis,prolonged hospitalization,the time from intensive care unit admission to the development of infection,presence of CRGNB colonization at admission,transfer from other hospitals,previous antibiotic use,enteral nutrition,transfusion,hemodialysis,mechanical ventilation,tracheostomy,reintubation,central veno

关键词： Multidrug resistance Gram-negative bacteria Infection Intensive care units