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Wdr63 Deletion Aggravates Ulcerative Colitis Likely by Affecting Th17/Treg Balance and Gut Microbiota

生物化学与生物物理进展 2025年第1期52卷 209-222页

作者： ZHU Hao ZHU Meng-Yuan CAO Yang-Yang YANG Qiu-Bo FAN Zhi-Peng Beijing Institute for Dental Research Capital Medical University School of StomatologyBeijing 100050China Beijing Laboratory of Oral health Capital Medical UniversityBeijing 100069China Research unit of Tooth Development and Regeneration Chinese Academy of Medical SciencesBeijing 100069China

Objective Ulcerative colitis is a prevalent immunoinflammatory ***17/Treg cell imbalance and gut microbiota dysregulation are key factors in ulcerative colitis *** actin cytoskeleton contributes to regulating the proliferation,differentiation,and migration of Th17 and Treg ***63,a gene containing the WD repeat domain,participates in the structure and functional modulation of actin *** research indicates that WDR63 may serve as a regulator of cell migration and metastasis via actin polymerization *** article aims to explore the effect of Wdr63 deletion on Th17/Treg cells and ulcerative *** We constructed Wdr63-/-mice,induced colitis in mice using dextran sulfate sodium salt,collected colon tissue for histopathological staining,collected mesenteric lymph nodes for flow cytometry analysis,and collected healthy mouse feces for microbial diversity *** Compared with wild-type colitis mice,Wdr63-/-colitis mice had a more pronounced shortening of colonic tissue,higher scores on disease activity index and histological damage index,Treg cells decreased and Th17 cells increased in colonic tissue and mesenteric lymph nodes,a lower level of anti-inflammatory cytokine IL-10,and a higher level of pro-inflammatory cytokine *** addition,WDR63 has shown positive effects on maintaining intestinal microbiota *** maintains the balance of Bacteroidota and Firmicutes,promoting the formation of beneficial intestinal bacteria linked to immune *** Wdr63 deletion aggravates ulcerative colitis in mice,WDR63 inhibits colonic inflammation likely by regulating Th17/Treg balance and maintains intestinal microbiota homeostasis.

关键词： Wdr63 Th17/Treg ulcerative colitis inflammation immune microbiology

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Host cytoskeleton and membrane network remodeling in the regulation of viral replication

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生物物理学报（英文） 2025年第1期11卷 34-45页

作者： Xuedi Gao Xinming Chen Letian Yu Shuangshuang Zhao Yaming Jiu unit of Cell Biology and Imaging Study of Pathogen Host Interaction The Center for Microbes Development and Health Key Laboratory of Molecular Virology and Immunology Shanghai Institute of Immunity and Infection Chinese Academy of Sciences Shanghai 200031 China University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Virology and Biosafety Chinese Academy of Sciences Wuhan 430071 China

Viral epidemics pose major threats to global health and economies. A hallmark of viral infection is the reshaping of host cell membranes and cytoskeletons to form organelle-like structures, known as viral factories, which support viral genome replication. Viral infection in many cases induces the cytoskeletal network to form cage-like structures around viral factories, including actin rings, microtubule cages, and intermediate filament cages. Viruses hijack various organelles to create these replication factories, such as viroplasms, spherules, double-membrane vesicles, tubes, and nuclear viral factories. This review specifically examines the roles of cytoskeletal elements and the endomembrane system in material transport, structural support, and biochemical regulation during viral factory formation. Furthermore, we discuss the broader implications of these interactions for viral replication and highlight potential future research directions.

关键词： Viral replication factory Cytoskeleton Actin filaments Microtubules Intermediate filaments Rearrangement of cellular membranes

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Trans-jugular intrahepatic portosystemic stent shunting benefits and limits

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World Journal of Gastrointestinal Surgery 2025年第1期17卷 307-309页

作者： Salvatore Stefano Sciarrone Lucia Fini Luca De Luca Department of Surgery Gastroenterology and Digestive Endoscopy UnitASST Santi Paolo e CarloUniversity of MilanMilan 20142LombardyItaly

Trans-jugular intrahepatic portosystemic stent shunting(TIPSS)has been in use for many years with great results and many *** procedure essentially involves the insertion of a metal covert stent to create an Hepato-Hepatic portosystemic *** time,TIPSS has become the subject of many studies aimed at examining its clinical utility and evaluating the results of using TIPSS to manage complications related to portal *** the outset,this procedure has been met with hope and enthusiasm and give the chance to consider another possibility to treat the complications of portal hypertension without the use of *** that TIPSS is an attractive alternative to shunt surgery because it does not require the use of general anesthesia or laparotomy,in fact this method is applicable to many patients with severe liver disease not suitable for *** has been studied for the management of variceal bleeding,ascites,hepatic hydrothorax,hepatorenal syndrome,and other types of ***,some drawbacks of the TIPSS,such as shunt stenosis and hepatic encephalopathy,have also been reported in the *** the basis of the available evidence and the new epidemiological findings regarding liver disease,the following question may be posed:What is the place of TIPSS in current clinical practice?

关键词： Hepatic compensation Decompensation Trans-jugular intrahepatic portosystemic stent-shunt Bleeding Ascites

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Susceptible Windows of Prenatal Ozone Exposure and Preterm Birth:A Hospital-Based Observational Study

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Biomedical and Environmental Sciences 2025年第2期38卷 255-260,I0001-I0004页

作者： Rongrong Qu Dongqin Zhang Hanying Li Jiayin Zhi Yanxi Chen Ling Chao Zhenzhen Liang Chenguang Zhang Weidong Wu Jie Song Henan International Collaborative Laboratory for health Effects and Intervention of Air Pollution School of Public HealthXinxiang Medical UniversityXinxiang 453003HenanChina School of Medical Technology Xinxiang Medical UniversityXinxiang 453003HenanChina

Preterm birth(PTB)is defined as delivery before 37 weeks of *** is associated with increased cardiovascular risk,neurodevelopmental disorders,and other diseases in infancy,childhood,and adulthood[1].Globally,approximately 15 million PTB cases are reported annually,posing a huge burden on individual families and the community economy[2].In the context of climate warming,O_(3) pollution has continuously increased in many countries in recent years,including China;therefore,scientific communities and government agencies must strive to mitigate ozone pollution.

关键词： Windows individual annually

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Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela S.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

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The Birth on a Scarred Uterus at the Reference health Center (csref) of Kolondiéba: Socio-Epidemiological and Maternel-Fetal Prognosis Aspect

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Surgical Science 2025年第1期16卷 26-33页

作者： Siaka Konaté Kélétigui Samuel Dembélé Moussa Samaké Yacouba Dembélé Magacha Goita Mamoutou Diarra Souleymane Benké Dembélé Bakary Tientigui Dembélé Adégné Pierre Togo Kolondiba Reference health Center Sikasso Mali Tominian Reference health Center Sgou Mali Commune IV Reference health Center Bamako Mali Kadiolo Reference health Center Sikasso Mali Faculty of Medicine and Odontostomatology of Bamako CHU Gabriel Tour Bamako Mali

Introduction: Childbirth on a scarred uterus is a major issue for health centers, especially peripheral, due to the major obstetric risks it presents. The objectives were to evaluate the frequency, route of delivery and maternal-fetal prognosis of this type of delivery at csref of Kolondiéba. Materials and Methods: This was a retrospective cross-sectional study for one year (1 January 2023-31 December 2023). All patients admitted to the maternity ward of the center with at least one uterine scar and treated in the center were included. We extracted data from partograms, OR records, birth records and obstetric records. Input was done on Excel 2010 and analysis on SPSS.23. Results: The frequency of scarring uterus was 16.8% (217/1285 births). The average age was 27. Pauciparous were most represented (59%). Patients were received from community health centers (44.7%). Prenatal consultation sessions (1 - 3 sessions) were performed at (64.9%). Uterine scars were obstetric in (99%). The cesarean section was performed immediately in (59.4%), it was prophylactic in 17%. The uterine test was attempted in (25.34%) with (69%) success. We recorded 3.6% uterine ruptures, 8.7% postoperative complications, 5.5% stillbirths and one maternal death (0.46%). Conclusion: Births on a scarred uterus are frequent and associated with a high rate of complications.

关键词： Uterus Scar Delivery Kolondiéba Reference health Center

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Genetic variants and mRNA expression levels of KLF4 and KLF5 with hypertension:A combination of case-control study and cohort study

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Journal of Biomedical Research 2025年第1期39卷 103-113页

作者： Xu Han Wen Li Changying Chen Jiahui Liu Junxiang Sun Feifan Wang Chao Wang Jialing Mu Xincheng Gu Fangyuan Liu Hankun Xie Song Yang Chong Shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Cardiology the Affiliated Yixing People's Hospital of Jiangsu UniversityPeople's Hospital of Yixing CityWuxiJiangsu 214200China Department of Environmental Genomics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China

Hypertension(HT)is a major risk factor for cardiovascular ***üppel-like factors(KLFs)are important transcription factors in *** have reported that KLF4 and KLF5 are correlated with several cardiovascular diseases,but population-based studies on associations between HT and KLF4 or KLF5 have rarely been ***,the current study investigated the associations of genetic variants and m RNA expression levels of KLF4 and KLF5 with HT,as well as the effects of antihypertensive drugs on the expression levels of these *** associations of one single-nucleotide polymorphism(SNP)in KLF4 and three SNPs in KLF5with HT were analyzed using a combination of case-control and cohort *** study populations were selected from a community-based cohort in four regions of Jiangsu *** risks of HT were estimated through logistic and Cox regression *** addition,m RNA expression levels of KLF4 and KLF5 were detected in 246 controls and 385 HT cases selected from the aforementioned *** the HT cases,263were not taking antihypertensive drugs[AHD(-)]and 122 were taking antihypertensive drugs[AHD(+)].In the case-control study,SNP rs9573096(C>T)in KLF5 was significantly associated with an increased risk of HT in the additive model(adjusted odds ratio[OR],1.106;95%confidence interval[CI],1.009 to 1.212).In the cohort study of the normotensive population,rs9573096 in KLF5 was also significantly associated with an increased risk of HT in the additive model(adjusted hazards ratio[HR],1.199;95%CI,1.070 to 1.344).KLF4 and KLF5m RNA expression levels were significantly higher in the AHD(-)group than in the control group(P<0.05),but lower in the AHD(+)group than in the AHD(-)group(P<0.05).The current study demonstrated the associations of KLF4 and KLF5 genetic variants with hypertension,as well as the association of the indicative variations in m RNA expression levels of KLF4 and KLF5 with the risk of hypertension and antihypertensive

关键词： hypertension KLF4 KLF5 single-nucleotide polymorphism mRNA expression antihypertensive drugs

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Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 315-322页

作者： Dong-Qing Yuan Wei-Wei Zhang Liu-Wei Gu Qing-Huai Liu Department of Ophthalmology Jiangsu Province Hospitalthe First Affiliated Hospital of Nanjing Medical UniversityJiangsu Women and Children Health HospitalNanjing 210029Jiangsu ProvinceChina

AIM:To assess the visual electrophysiological outcomes in children with functional amblyopia who exhibited poor response to conventional ***:Twenty-one children with functional amblyopia,aged 5.7±2.1y(range:4-10y),underwent comprehensive ophthalmic and refractive *** domain-optical coherence tomography(SD-OCT)and multifocal electroretinography(mfERG)were conducted to analyze the macular retinal thickness and the first-order response P1 ring of the mfERG in the amblyopic eye(AE)compared to the fellow good eye(GE).RESULTS:Initially,visual acuity in the AE ranged from 20/800 to 20/40,while the GE exhibited a range of 20/25 to 20/20(P<0.01).After 6mo of treatment,17 patients demonstrated improved visual acuity in the AE to 20/50 or better,while 4 children showed no ***-OCT revealed comparable macular and optic disc structures between the AE and *** to treatment,the mfERG P1 ring amplitude was significantly reduced in the AE compared to GE(P<0.05).The AE/GE ratio of P1 ring amplitude showed significant improvement ***,a smaller AE/GE ratio before treatment was associated with poorer improvement ***:In the management of functional amblyopia,a thorough assessment of amblyopic eye examinations is *** 20%of amblyopic eyes may not achieve significant improvement in visual acuity,despite the absence of detectable organic retinal *** may reveal underlying *** mfERG into initial assessments or treatment follow-ups can aid in identifying potential hidden retinal defects and predicting the prognosis of the amblyopic eye.

关键词： functional amblyopia poor response optical coherence tomography multifocal electroretinography retinal defects

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Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals

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Animal Models and Experimental Medicine 2025年第1期8卷 67-91页

作者： Lujain Bader Eddin Mohamed Fizur Nagoor Meeran Niraj Kumar Jha Samer NGoyal Shreesh Ojha Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUAE UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Centre for Global health Research Saveetha Medical CollegeSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia Shri Vile Parle Kelvani Mandal's Institute of Pharmacy DhuleMaharashtraIndia Zayed Bin Sultan Center for health Sciences United Arab Emirates UniversityAl AinUnited Arab Emirates

Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular *** fi-brosis is characterized by the accumulation of extracellular matrix proteins,mainly collagen in the cardiac *** experimental studies have demonstrated that fibrotic injury in the heart is reversible;therefore,it is vital to understand differ-ent molecular mechanisms that are involved in the initiation,progression,and resolu-tion of cardiac fibrosis to enable the development of antifibrotic *** the many experimental models,one of the recent models that has gained renewed interest is isoproterenol(ISP)-induced cardiac *** is a synthetic catecholamine,sympa-thomimetic,and nonselectiveβ-adrenergic receptor *** overstimulated and sustained activation ofβ-adrenergic receptors has been reported to induce biochemi-cal and physiological alterations and ultimately result in cardiac *** has been used for decades to induce acute myocardial ***,the use of low doses and chronic administration of ISP have been shown to induce cardiac fibrosis;this practice has increased in recent *** or subcutaneous ISP has been widely used in preclinical studies to induce cardiac remodeling manifested by fibrosis and *** induced oxidative stress with subsequent perturbations in cellular signaling cascades through triggering the release of free radicals is consid-ered the initiating mechanism of myocardial *** is consistently used to induce fibrosis in laboratory animals and in cardiomyocytes isolated from *** recent years,numerous phytochemicals and synthetic molecules have been evaluated in ISP-induced cardiac *** present review exclusively provides a comprehensive summary of the pathological biochemical,histological,and molecular mechanisms of ISP in inducing cardiac fibrosis and *** also summarizes the ap

关键词： cardiac fibrosis catecholamines experimental models isoproterenol myocardial fibrosis phytochemicals β-adrenergic receptors

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Microbiological contamination in IVF laboratories: A narrative review

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Asian pacific Journal of Reproduction 2025年第1期14卷 7-12页

作者： Sudheer Singh Nancy Nair Akash More Neeraj Vishwakarma Avanti Kalbande Clinical Embryology School of Allied Health SciencesDatta Meghe Institute of Higher Education and ResearchHingna RoadWanadongriNagpurMaharashtraIndia Department of Clinical Embryology School of Allied Health SciencesDatta Meghe Institute of Higher Education and Research(DU)SawangiMeghe WardhaIndia Department of Clinical Embryology School of Allied Health SciencesDatta Meghe Institute of Higher Education and Research(DU)WanadongriMaharashtraIndia

In vitro fertilization(IVF)is one of the most used assisted reproductive technology(ART)techniques ***,the success of IVF procedures heavily relies on maintaining a sterile environment in *** narrative review examines the effects of microbiological contamination in IVF laboratories,exploring its sources,impacts on IVF outcomes,and preventive *** conducted a complete literature search using databases such as PubMed and Google Scholar,focusing on studies published within the last fifteen *** findings highlight that microbiological contamination can significantly impair embryo quality,reduce implantation and pregnancy rates,and increase the risk of miscarriage and *** review also discusses current best practices for contamination prevention and identifies areas for future *** work emphasizes the critical importance of stringent sterility protocols in IVF laboratories and calls for continued vigilance and innovation in maintaining optimal conditions for assisted reproduction.

关键词： In vitro fertilization Assisted reproductive technologies Microbial contamination Embryonic arrest Infertility

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