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Genetic Variations and Nonalcoholic Fatty Liver Disease:Field Synopsis,Systematic Meta-Analysis,and Epidemiological Evidence

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Biomedical and Environmental Sciences 2024年第7期37卷 762-773页

作者： Yamei Li Xiang Xiao Jie Wang Yixu Liu Xiongfeng Pan Haibin Yu Jiayou Luo Miyang Luo Department of Epidemiology and health statistics School of Public HealthUniversity of South ChinaHengyang 421001HunanChina Department of Maternal and Child health Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina Supervision and Inspection Department of Shanghai healthcare Security Bureau Shanghai 200003China Department of Epidemiology and health statistics Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina

Objective To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease(NAFLD).Methods Literature from Web of Science,PubMed,and Embase between January 1980 and September 2022 was systematically ***-analyses of the genetic variants were conducted using at least five data *** epidemiologic credibility of the significant associations was graded using the Venice *** Based on literature screening,399 eligible studies were included,comprising 381 candidate gene association,16 genome-wide association,and 2 whole-exome sequencing *** identified 465 genetic variants in 173 genes in candidate gene association studies,and 25 genetic variants in 17 genes were included in the *** meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD,with cumulative epidemiological evidence of an association graded as strong for two variants in two genes(HFE,TNF),moderate for four variants in three genes(TM6SF2,GCKR,and ADIPOQ),and weak for five variants in five genes(MBOAT7,PEMT,PNPLA3,LEPR,and MTHFR).Conclusion This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD,which may help understand the genetic architecture of NAFLD risk.

关键词： Nonalcoholic fatty liver disease Genetic association study Genetic variant Systematic review Meta-analysis

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Reproductive Characteristics and Trends of Major Pregnancy Outcomes of Women at Different Parities-Beijing Municipality,China,2013-2022

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China CDC weekly 2024年第31期6卷 786-792页

作者： Zhaoxia Jia Yongxian Zhao Lei Wang Qingqing Wu Moning Guo Jianpeng Zheng Lili Huang Junhua Wang Zhao Wang Di Zhang Minghui Wu Department of information and statistics Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijingChina Department of data resources and statistics Beijing Municipal Health Big Data and Policy Research CenterBeijingChina

Summary What is already known about this topic?With socioeconomic development,the increase of older pregnancies and multiparas has brought risks to mothers and *** is added by this report?As parities increased,the proportion of women of advanced maternal age(AMA)and non-local domicile increased,while the proportion of women with higher education levels *** with≥3 parities are more likely to have preterm birth(PTB)and *** are the implications for public health practice?A comprehensive analysis of pregnancy traits among women at different parities offers a robust foundation for tailored strategies against adverse pregnancy outcomes.

关键词： mother pregnancy likely

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A New Class of Strong Orthogonal Arrays of Strength Three

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Journal of Systems Science & Complexity 2024年第3期37卷 1233-1250页

作者： WANG Chunyan LIU Min-Qian YANG Jinyu Center for Applied statistics and School of statistics Renmin University of ChinaBeijing 100872China School of statistics and Data Science LPMC&KLMDASRNankai UniversityTianjin 300071China

Strong orthogonal arrays(SOAs) were recently introduced and studied as a class of spacefilling designs for computer experiments. To surely realize better space-filling properties, SOAs of strength three or higher are desirable. In addition, orthogonality is also an important property for designs of computer experiments, because it guarantees that the estimates of the main effects are uncorrelated. This paper first provides a systematic study on the construction of(nearly) orthogonal strength-three SOAs with better space-filling properties. The newly proposed strength-three SOAs enjoy almost the same space-filling properties of strength-four SOAs, and can accommodate much more columns than the latter. Moreover, they are(nearly) orthogonal and flexible in run sizes. The construction methods are straightforward to implement, and their theoretical supports are well established. In addition to the theoretical results, many designs are tabulated for practical needs.

关键词： Computer experiment orthogonality space-filling property strong orthogonal array

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Construction of Optimal Mixed-Level Uniform Designs

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Journal of Systems Science & Complexity 2024年第2期37卷 841-862页

作者： CHATTERJEE Kashinath LIU Min-Qian QIN Hong YANG Liuqing Department of Population health Sciences Division of Biostatistics and Data ScienceAugusta UniversityGA 30912USA NITFID LPMC&KLMDASRSchool of Statistics and Data ScienceNankai UniversityTianjin 300071China School of statistics and Mathematics Zhongnan University of Economics and LawWuhan 430073China

The theory of uniform design has received increasing interest because of its wide application in the field of computer *** generalized discrete discrepancy is proposed to evaluate the uniformity of the mixed-level factorial *** this paper,the authors give a lower bound of the generalized discrete discrepancy and provide some construction methods of optimal mixed-level uniform designs which can achieve this lower *** methods are all deterministic construction methods which can avoid the complexity of stochastic *** saturated mixed-level uniform designs and supersaturated mixed-level uniform designs can be obtained with these ***,the resulting designs are also χ^(2)-optimal and minimum moment aberration designs.

关键词： Generalized discrete discrepancy Hadamard matrix mixed-level design orthogonal array supersaturated design

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Exclusive Hypothesis Testing for Cox's Proportional Hazards Model

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Journal of Systems Science & Complexity 2024年第5期37卷 2157-2172页

作者： WU Qiang TONG Xingwei DUAN Xiaogang School of statistics Beijing Normal University

Exclusive hypothesis testing is a new and special class of hypothesis testing. This kind of testing can be applied in survival analysis to understand the association between genomics information and clinical information about the survival time. Besides, it is well known that Cox's proportional hazards model is the most commonly used model for regression analysis of failure time. In this paper,the authors consider doing the exclusive hypothesis testing for Cox's proportional hazards model with right-censored data. The authors propose the comprehensive test statistics to make decision, and show that the corresponding decision rule can control the asymptotic Type Ⅰ errors and have good powers in theory. The numerical studies indicate that the proposed approach works well for practical situations and it is applied to a set of real data arising from Rotterdam Breast Cancer Data study that motivated this study.

关键词： Comprehensive test statistics Cox’s proportional hazards model exclusive hypothesis testing right-censored data Type I error

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Controllability of Semilinear Integrodifferential Degenerate Sobolev Equations

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Journal of Systems Science & Complexity 2024年第5期37卷 1923-1936页

作者： GE Zhaoqiang School of Mathematics and statistics Xi’an Jiaotong University

In this paper, the approximate controllability of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions is investigated in the sense of integral solution in Hilbert spaces. Some sufficient and necessary conditions are obtained. Firstly, the existence and uniqueness of integral solutions of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions are considered by GE-evolution operator theory and Sadovskii's fixed point theorem, the existence and uniqueness theorem of solutions is given. Secondly, the approximate controllability of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions is studied in the sense of integral solution. The criterion for approximate controllability is provided. The obtained results have important theoretical and practical value for the study of controllability of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions.

关键词： Approximate controllability GE-evolution operator integral solution Sadovskii’s fixed point theorem semilinear integrodifferential degenerate Sobolev equations

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Prescribed-time stabilization and inverse optimal control of stochastic high-order nonlinear systems

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Science China(Information Sciences) 2024年第2期67卷 144-156页

作者： Ran LIU Hui WANG Wuquan LI School of Mathematics and statistics Science Ludong University

This paper investigates the prescribed-time state-feedback stabilization and prescribed-time inverse optimality problems for stochastic high-order nonlinear systems. First, a time-varying controller is designed by developing scaled quartic Lyapunov functions, which can guarantee that the system has a unique strong solution almost surely on the prescribed interval for any system initial conditions and that the states and the control converge to the origin in a mean-square form within the prescribed time. Then, the controller is redesigned to address the problem of prescribed-time inverse optimal mean-square stabilization. Finally,a concrete example is provided to confirm the efficiency of the proposed design schemes.

关键词： stochastic high-order nonlinear systems prescribed-time stabilization the scaled design inverse optimality

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Analyzing the Dissemination of News by Model Averaging and Subsampling

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Journal of Systems Science & Complexity 2024年第5期37卷 2104-2131页

作者： ZOU Jiahui School of statistics Capital University of Economics and Business

The dissemination of news is a vital topic in management science, social science and data science. With the development of technology, the sample sizes and dimensions of digital news data increase remarkably. To alleviate the computational burden in big data, this paper proposes a method to deal with massive and moderate-dimensional data for linear regression models via combing model averaging and subsampling methodologies. The author first samples a subsample from the full data according to some special probabilities and split covariates into several groups to construct candidate models. Then, the author solves each candidate model and calculates the model-averaging weights to combine these estimators based on this subsample. Additionally, the asymptotic optimality in subsampling form is proved and the way to calculate optimal subsampling probabilities is *** author also illustrates the proposed method via simulations, which shows it takes less running time than that of the full data and generates more accurate estimations than uniform subsampling. Finally,the author applies the proposed method to analyze and predict the sharing number of news, and finds the topic, vocabulary and dissemination time are the determinants.

关键词： Asymptotic optimality dissemination of news linear regression models model averaging optimal subsampling

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Nonsingularity of grain-like cascade feedback shift registers subject to fault attacks

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Science China(Information Sciences) 2024年第9期67卷 184-195页

作者： Haitao LI Zhaoqi LIU Wenrong LI School of Mathematics and statistics Shandong Normal University

Feedback shift registers(FSRs) are pivotal in generating pseudorandom sequences for stream ciphers and play a crucial role in error detection and code correction. This paper investigates the resilience of grain-like cascade FSRs(GLC-FSRs) against two types of fault attacks: hard and soft. First, we introduce a new criterion for assessing the nonsingularity of GLC-FSRs using the structure matrices of feedback functions,which enable the measurement of the number of nonsingular GLC-FSRs. Second, we demonstrate that GLC-FSRs subject to hard fault attacks become singular as determined by this new criterion. Ultimately,by constructing a soft fault bit set, we discuss the resilience of GLC-FSRs to soft fault attacks. Results demonstrate that singular GLC-FSRs remain singular after being injected by soft fault attacks. Conversely,for nonsingular GLC-FSRs, suitable soft fault attacks are designed to maintain their nonsingular status.

关键词： grain-like cascade feedback shift register fault attack nonsingularity semi-tensor product

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Optimal Model Average Prediction in Orthogonal Kriging Models

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Journal of Systems Science & Complexity 2024年第3期37卷 1080-1099页

作者： WANG Jun HE Jiabei LIANG Hua LI Xinmin School of Mathematics and statistics Qingdao UniversityQingdao 266071China Department of statistics George Washington UniversityWashington DC 20052USA

The main objective of this paper is to consider model averaging methods for kriging *** paper proposes a Mallows model averaging procedure for the orthogonal kriging model and demonstrate the asymptotic optimality of the model averaging estimators in terms of mean square *** studies are conducted to evaluate the performance of the proposed method and compare it with the competitors to demonstrate its *** authors also analyse a real dataset for an illustration.

关键词： Asymptotic optimality Mallows criterion optimal model averaging orthogonal kriging model

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