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data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

health data science—A New science Partner Journal Dedicated to Promoting data for Better health

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health data science 2021年第1期2021卷 157-158页

作者： Qimin Zhan National Institute of health data science at Peking University China

health data and cutting-edge technologies empower medicine and improve *** has become even more true during the COVID-19 *** coronavirus data sharing and worldwide collaboration,the speed of vaccine development for COVID-19 is *** and data technologies were quickly adopted during the pandemic,showing how those technologies can be harnessed to enhance public health and healthcare.A wide range of digital data sources are being utilized and visually presented to enhance the epidemiological surveillance of *** contact tracing mobile apps have been adopted by many countries to control community *** learning has been utilized to achieve various solutions for COVID-19 disruption,including outbreak prediction,virus spread tracking.

关键词： utilized health prediction

Posttraumatic stress symptoms among Chinese university students during the COVID-19 pandemic:Prevalence,correlates,and mental health help-seeking

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World Journal of Psychiatry 2025年第1期15卷 145-152页

作者： Rui-Yao Wu Lin-Feng Ge Bao-Liang Zhong Department of Psychiatry The Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong University of Science&TechnologyWuhan 430012Hubei ProvinceChina Department of Psychiatry Wuhan Mental Health CenterWuhan 430012Hubei ProvinceChina

BACKGROUND Revisiting the epidemiology of posttraumatic stress symptoms(PTSSs)among university students during the coronavirus disease 2019(COVID-19)pandemic as well as understanding the mental health help-seeking behavior of individuals with PTSSs has critical implications for public mental health strategies in future medical *** To investigate the prevalence and correlates of PTSSs among university students during the first wave of the COVID-19 pandemic in China and to examine mental health help-seeking behaviors among these *** A total of 2507 Chinese university students were recruited via snowball *** students completed the Seven-item Screening Scale for Post-traumatic Stress Disorder during the first wave of the COVID-19 pandemic in ***-graphic characteristics,pandemic-related characteristics,and mental health help-seeking behaviors of students with PTSSs were also *** The prevalence of PTSSs among the participants was 28.0%.Seven significant correlates of PTSSs were identified(odds ratio=1.23-3.65,P≤0.024):Female sex,being 19 years old or older,living with others or alone,a low level of family economic status,fair or poor interpersonal relationships,severe or very severe local pandemic,and having family members diagnosed with ***,only 3.28%of the students with PTSSs reported seeking help from mental health *** the 23 students who sought help from mental health specialists,13 opted for online or telephone-based psychological *** Our data suggest that there was a high risk of PTSSs among university students and a high level of unmet mental health needs during the COVID-19 *** delivery of mental health services online or via telephone is a promising approach to address these unmet needs.

关键词： Posttraumatic stress symptoms University students COVID-19 Mental health help-seeking China

Social Determinants,data science,and Decision Making:The 3-D Approach to Achieving health Equity in Asia

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health data science 2022年第1期2022卷 39-40页

作者： Luxia Zhang Sabina Faiz Rashid Gabriel Leung National Institute of health data science Peking UniversityBeijingChina Advanced Institute of Information Technology Peking UniversityHangzhouZhejiang ProvinceChina Renal Division Department of MedicinePeking University First HospitalBeijingChina BRAC James P Grant School of Public health BRAC UniversityDhakaBangladesh WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public HealthLKS Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Laboratory of data Discovery for health Hong Kong Science and Technology ParkHong Kong Special Administrative RegionChina

Improving population health by creating more equitable health systems is a major focus of health policy and planning ***,before we can achieve equity in health,we must first begin by leveraging all we have learned,and are continuing to discover,about the many social,structural,and environmental determinants of *** must fully consider the conditions in which people are born,grow,learn,work,play,and *** study of social determinants of health has made tremendous strides in recent *** the same time,we have seen huge advances in how health data are collected,analyzed,and used to inform action in the health *** is time to merge these two fields,to harness the best from both and to improve decision-making to accelerate evidence-based action toward greater health equity.

关键词： action today equity

Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

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science China Mathematics 2025年第1期 223-252页

作者： Weidong Liu Dennis Leung Qi-Man Shao School of Mathematical sciences Shanghai Jiao Tong University School of Mathematics and Statistics University of Melbourne Department of Statistics and data science SICMSouthern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model,the number of pairwise comparisons can become large even with a moderate number of *** by this,we consider a regime with a growing number of groups and prove that,when testing pairwise comparisons,the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries,despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) *** Tukey's perspective that the difference between the means of any two groups cannot be exactly zero,our main result provides control over the directional false discovery rate and directional false discovery proportion.A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR *** analysis does not rely on conventional assumptions such as normality,variance homogeneity,or a balanced design,thereby offering a theoretical foundation for applications in more general settings.

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Record-breaking bifunctional oxygen electrocatalyst accomplished by a data-driven approach for zinc-air batteries

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Journal of Energy Chemistry 2025年第1期100卷 144-145页

作者： Deviprasath Chinnadurai Zhi Wei Seh Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A*STAR)

Rechargeable zinc-air batteries(ZABs) have recently drawn great attention in energy research due to their high theoretical capacity,low costs, and inherently safe nature [1–3]. However, the sluggish cathode reactions necessitate the development of bifunctional oxygen electrocatalysts with lower ΔE indicator values. The ΔE indicator is commonly employed to quantitatively evaluate the electrocatalytic activity of a bifunctional oxygen electrocatalyst,representing the overall overpotential from oxygen reduction reaction(ORR) to oxygen evolution reaction(OER).

关键词： data-driven approach Bifunctional oxygen electrocatalyst Record breaking performance Zinc-air batteries

Effects of short-range attraction on Jamming transition

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Chinese Physics B 2021年第6期30卷 409-413页

作者： Zhenhuan Xu Rui Wang Jiamei Cui Yanjun Liu Wen Zheng Institute of Public-safety and Big data College of Data ScienceTaiyuan University of TechnologyTaiyuan 030060China Center for Big data Research in health Changzhi Medical CollegeChangzhi 046000China

Enormous progresses to understand the jamming transition have been driven via simulating purely repulsive particles which were somehow idealized in the past two decades. While the attractive systems are both theoretical and practical compared with repulsive systems. By studying the statistics of rigid clusters, we find that the critical packing fraction φ_(c) varies linearly with attraction μ for different system sizes when the range of attraction is short. While for systems with long-range attractions, however, the slope of φ_(c) appears significantly different, which means that there are two distinct jamming scenarios. In this paper, we focus our main attention on short-range attractions scenario and define a new quantity named "short-range attraction susceptibility" χ_(p), which describes the degree of response of the probability of finding jammed states pjto short-range attraction strength μ. Our central results are that χ_(p) diverges in the thermodynamic limit as χ_(p) ∝|φ-φ_(c)^(∞)|^(-γ_(p)), where φ_(c)^(∞) is the packing fraction at the jamming transition for the infinite system in the absence of attraction. χ_(p) obeys scaling collapse with a scaling function in both two and three dimensions, illuminating that the jamming transition can be considered as a phase transition as proposed in previous work.

关键词： short-range attraction Jamming transition short-range attraction susceptibility

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

Estimation and Inference in Semi-Functional Partially Linear Measurement Error Models

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Journal of Systems science & Complexity 2020年第4期33卷 1179-1199页

作者： ZHU Hanbing ZHANG Riquan ZHU Gen School of Statistics East China Normal UniversityShanghai 200241China Department of Biostatistics and data science School of Public Healththe University of Texas Health Science Center at HoustonHouston 77030USA

This article studies the estimation and statistical inference problems of semi-functional partially linear regression models when the covariates in the linear part are measured with additive error. To obtain the estimation of the parametric component, a corrected profile least-squares based estimation procedure is developed. Asymptotic properties of the proposed estimators are established under some mild assumptions. To test hypothesis on the parametric part, the authors propose a novel test statistic based on the difference between the corrected residual sums of squares under the null and alternative hypotheses, and show that its limiting distribution is a weighted sum of independent standard χ12. Finally, the authors illustrate the finite sample performance of the methods with some simulation studies and a real data application.

关键词： estimation corrected parametric