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Milk fat globule epidermal growth factor 8 alleviates liver injury in severe acute pancreatitis by restoring autophagy flux and inhibiting ferroptosis in hepatocytes

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World Journal of Gastroenterology 2024年第7期30卷 728-741页

作者： Qing Cui Hang-Cheng Liu Wu-Ming Liu Feng Ma Yi Lv Jian-Cang Ma Rong-Qian Wu Yi-Fan Ren Department of Cardiology Xi’an Central Hospital Affiliated to Xi’an Jiaotong UniversityXi’an 710003Shaanxi ProvinceChina Department of General Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina National Local Joint Engineering research center for Precision Surgery&Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Vascular Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ultimately leads to *** previous study found that milk fat globule epidermal growth factor 8(MFG-E8)alleviates acinar cell damage during SAP via binding toαvβ3/5 ***-E8 also seems to mitigate pancreatic fibrosis via inhibiting chaperone-mediated *** To speculate whether MFG-E8 could also alleviate SAP induced liver injury by restoring the abnormal autophagy *** SAP was induced in mice by 2 hly intraperitoneal injections of 4.0 g/kg L-arginine or 7 hly injections of 50μg/kg cerulein plus ***8-knockout mice were used to study the effect of MFG-E8 deficiency on SAPinduced liver ***,a specificαvβ3/5 integrin inhibitor,was used to investigate the possible mechanism of *** The results showed that MFG-E8 deficiency aggravated SAP-induced liver injury in mice,enhanced autophagy flux in hepatocyte,and worsened the degree of *** MFG-E8 reduced SAP-induced liver injury in a dose-dependent ***,MFG-E8 mitigated excessive autophagy and inhibited ferroptosis in liver *** abolished MFG-E8’s beneficial effects in SAP-induced liver *** MFG-E8 acts as an endogenous protective mediator in SAP-induced liver ***-E8 alleviates the excessive autophagy and inhibits ferroptosis in hepatocytes by binding to integrinαVβ3/5.

关键词： Autophagy flux Ferroptosis Liver injury Milk fat globule epidermal growth factor 8 αvβ3/5 integrins Acute pancreatitis

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Enhanced thermoelectric performance of Sb-doped Mg_(2)Si_(0.4)Sn_(0.6)via doping,alloying and nanoprecipitation

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Journal of Materiomics 2024年第2期10卷 285-292页

作者： Binhao Wang Haidong Zhao Jianghua Li Bin Zhang Dan Wang Chen Chen Aihua Song Wentao Hu Dongli Yu Bo Xu Yongjun Tian center for High Pressure Science State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdaoHebei066004China shaanxi University of Technology HanzhongShaanxi723000China

With the advantages of eco-friendliness,low cost,and low density,Mg_(2)(Si,Sn)solid solutions are promising candidates for thermoelectric *** this work,Sb-doped Mg_(2)Si_(0.4)Sn_(0.6)bulks were prepared with a combined method of solid-state reaction and high pressure synthesis,followed by spark plasma *** investigations show that Sb doping optimizes the carrier concentration,while Si/Sn alloying effectively suppresses the lattice thermal conductivity and induces a convergence of the two lowest-lying conduction ***,numerous coherent Sn-rich nanoprecipitates are formed within micron-sized *** these factors contribute synergistically to improving the thermoelectric properties of Mg_(2)Si_(0.4)Sn_(0.6).The optimal Mg_(2)(Si_(0.4)Sn_(0.6))_(0.985)Sb_(0.015)exhibits a power factor higher than 4000 mW·m^(-1)·K^(-2)and a lattice thermal conductivity less than 0.8 W·m^(-1)·K^(-1)at temperatures higher than 600 K,leading to the highest ZT of 1.61 at 823 *** work demonstrates an effective approach to enhancing the thermoelectric performance of n-type Mg_(2)X solid solutions through doping,alloying,and microstructure modification.

关键词： Magnesium silicide High pressure synthesis Alloy scattering Band convergence

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A simple modification to the classical SIR model to estimate the proportion of under-reported infections using case studies in flu and COVID-19

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Infectious Disease Modelling 2024年第4期9卷 1147-1162页

作者： Leonid Kalachev Jon Graham Erin L.Landguth Mathematical Sciences University of MontanaMissoulaUSA center for Population health research School of Public and Community Health SciencesUniversity of MontanaMissoulaUSA

Background:Under-reporting and,thus,uncertainty around the true incidence of health events is common in all public health reporting *** the problem of underreporting is acknowledged in epidemiology,the guidance and methods available for assessing and correcting the resulting bias are ***:We aim to design a simple modification to the Susceptible e Infected e Removed(SIR)model for estimating the fraction or proportion of reported infection ***:The suggested modification involves rescaling of the classical SIR model producing its mathematically equivalent version with explicit dependence on the reporting parameter(true proportion of cases reported).We justify the rescaling using the phase plane analysis of the SIR model system and show how this rescaling parameter can be estimated from the data along with the other model ***:We demonstrate how the proposed method is cross-validated using simulated data with known disease cases and then apply it to two empirical reported data sets to estimate the fraction of reported cases in Missoula County,Montana,USA,using:(1)flu data for 2016e2017 and(2)COVID-19 data for fall of ***:We establish with the simulated and COVID-19 data that when most of the disease cases are presumed reported,the value of the additional reporting parameter in the modified SIR model is close or equal to one,so that the original SIR model is appropriate for data ***,the flu example shows that when the reporting parameter is close to zero,the original SIR model is not accurately estimating the usual rate parameters,and the re-scaled SIR model should be *** research demonstrates the role of under-reporting of disease data and the importance of accounting for underreporting when modeling simulated,endemic,and pandemic disease *** reporting the“true”number of disease cases will have downstream impacts on predictions of disease dynamics.A simple parameter adjustment

关键词： Modeling of epidemics SIR type models flu and COVID-19 Under-reporting parameter Proportion of reported disease cases

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Continuous age-and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease

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World Journal of Pediatrics 2024年第9期20卷 949-956页

作者： Zhao-Yuan Wu Si-Wei Chi Liu-Jian Ouyang Xiao-Qin Xu Jing-Nan Chen Bing-Han Jin Rahim Ullah Xue-Lian Zhou Ke Huang Guan-Ping Dong Zhe-Ming Li Ying Shen Jie Shao Yan Ni Jun-Fen Fu Qiang Shu Wei Wu Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou310051China Department of Data and Information Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Child health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Thoracic&Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical Center3333 Binsheng RoadHangzhou310051China

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(<50 U/L)were developed by laboratories and have not been validated in populations with a large nu... 详细信息

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(healthy *** This study collected venous blood and anthropometric data from a total of 13,287 healthy children aged 3 months to 18 years who underwent routine physical examinations in the Department of Pediatric *** applied the least mean square algorithm to establish age-and sex-related reference percentiles of serum levels of *** validation,we recruited 4276 children and adolescents with obesity/overweight who underwent evaluation and metabolic tests in the *** receiver operating characteristic curves,we determined age-and sex-specific upper limit percentiles of liver enzymes for fatty liver *** This study revealed a significant correlation between serum transaminase levels and age and sex(P<0.01).These transaminase levels exhibited age-and sex-specific *** individuals in the non-alcoholic fatty liver disease(NAFLD)cohort,elevated ALT levels displayed a positive association with clinical markers of disease severity,including homeostatic model assessment of insulin resistance,waist-hip ratio,and serum uric acid levels(P<0.01).According to the receiver operating characteristic curves,ALT levels at the 92.58th percentile for boys and the 92.07th percentile for girls yielded the highest accuracy and *** This study provides age-and sex-specific reference ranges for ALT,aspartate aminotransferase,andγ-glutamyltransferase in Chinese children and adolescents,making it the largest population study to ***,the study establishes a precise upper limit for ALT levels,facilitating their use in NAFLD screening.

关键词： Alanine aminotransferase Childhood Fatty liver diseases

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Food-derived protein hydrolysates and peptides:anxiolytic and antidepressant activities,characteristics,and mechanisms

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Food Science and Human Wellness 2024年第3期13卷 1168-1185页

作者： Wenhui Li Yu Xi Junru Wang Yinxiao Zhang He Li Xinqi Liu Beijing Advanced Innovation center for Food Nutrition and Human health Beijing Engineering and Technology Research Center of Food AdditivesNational Soybean Processing Industry Technology Innovation CenterBeijing Technology and Business UniversityBeijing 100048China

Globally,the prevalence of anxiety and depression has reached epidemic ***-derived protein hydrolysates and peptides delivered through dietary supplementation can avoid the negative risks associated with traditional pharmaceuticals while delivering superior anxiolytic and antidepressant *** review summarizes current research on food-derived anxiolytic and antidepressant protein hydrolysates and peptides,and subsequently analyses their physicochemical characteristics and elaborates on their *** aim of this work is to contribute to the in-depth study and provide a theoretical foundation for the development of related products to better serve patients with anxiety and depression.

关键词： Anxiolytic Antidepressant Peptides Protein hydrolysates Neurotransmitter

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Bispecific antibody drug conjugates:Making 1+1>2

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1965-1986页

作者： Yilin Gu Zhijia Wang Yuxi Wang Targeted Tracer research and Development Laboratory Institute of Respiratory HealthFrontiers Science Center for Disease-Related Molecular NetworkNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China Frontiers Medical center Tianfu Jincheng LaboratoryChengdu 610212China

Bispecific antibody‒drug conjugates(BsADCs)represent an innovative therapeutic category amalgamating the merits of antibody‒drug conjugates(ADCs)and bispecific antibodies(BsAbs).Positioned as the next-generation ADC approach,BsADCs hold promise for ameliorating extant clinical challenges associated with ADCs,particularly pertaining to issues such as poor internalization,off-target toxicity,and drug ***,ten BsADCs are undergoing clinical trials,and initial findings underscore the imperative for ongoing *** review initially delves into specific design considerations for BsADCs,encompassing target selection,antibody formats,and the linker–payload *** sections delineate the extant progress and challenges encountered by BsADCs,illustrated through pertinent case *** amalgamation of BsAbs with ADCs offers a prospective solution to prevailing clinical limitations of ***,the symbiotic interplay among BsAb,linker,and payload necessitates further optimizations and coordination beyond a simplistic“1+1”to effectively surmount the extant challenges facing the BsADC domain.

关键词： Bispecific antibody drug conjugates Antibody drug conjugates Bispecific antibody Targeted therapy Safety HER2 EGFR

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Synthesis of boron nitride nanorod and its performance as a metalfree catalyst for oxidative desulfurization of diesel fuel

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Chinese Journal of Chemical Engineering 2024年第4期68卷 120-132页

作者： Tanaz Ghanadi Gholamreza Moradi Alimorad Rashidi Catalyst research center Faculty of Chemical and Petroleum EngineeringRazi UniversityKermanshahIran Nanotechnology research center Research Institute of Petroleum Industry(RIPI)TehranIran

In order to reduce the sulfur compounds in diesel fuel,boron nitride(BN)has been used as a novel metal-free catalyst in the present *** nanocatalyst was synthesized via template-free approach followed by heating treatment at 900℃ in nitrogen atmosphere that the characteristics of the sample were identified by the X-ray diffraction,Fourier-transform infrared spectroscopy,Raman spectroscopy,field emission scanning electron microscopy,transmission electron microscopy,atomic force microscopy,and N2 adsorption-desorption *** results of structural and morphological analysis represented that BN has been successfully *** efficacy of the main operating parameters on the process was studied by using response surface methodology based on the Box-Behnken design *** prepared catalyst showed high efficiency in oxidative desulfurization of diesel fuel with initial sulfur content of 8040 mg·kg^(-1)*** statistical analysis,a significant quadratic model was obtained to predict the sulfur removal as a function of efficient *** maximum efficiency of 72.4%was achieved under optimized conditions at oxidant/sulfur molar ratio of 10.2,temperature of 71℃,reaction time of 113 min,and catalyst dosage of 0.36 ***,the reusability of the BN was studied,and the result showed little reduction in activity of the catalyst after 10 times ***,a plausible mechanism was proposed for oxidation of sulfur compounds on the surface of the *** present study shows that BN materials can be selected as promising metal-free catalysts for desulfurization process.

关键词： Desulfurization Boron nitride(BN)nanostructure Experimental design BoxeBehnken

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Shaping global health promotion:a comprehensive analysis of the 10 Global Conferences on health Promotion Conferences(1986-2021)

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Global health Journal 2024年第2期8卷 91-96页

作者： Shiyu Liu Meichen Sun Na Zhang Zhaozhang Sun Xiangyang Tian Liming Li Youfa Wang Global health Institute School of Public HealthXi'an Jiaotong UniversityXi'anShaanxiChina School of Nursing Health Science CenterXi'an Jiaotong UniversityXi'anShaanxiChina Department of culture Media and Creative IndustriesKing's College LondonLondonUnited Kingdom Chinese center for health Education BeijingChina School of Public health Peking UniversityBeijingChina

Objective This study analyzed how the 10 Global Conferences on health Promotion have played a significant role in shaping and promoting a worldwide consensus and actions on health promotion,effectively addressing diverse health challenges that evolved over different *** The textual analysis method was used in this study and text encoding was conducted to systematically examine the declarations and reports presented by the 10 Global Conferences on health Promotion held during *** summarized the themes and key achievements,and key vocabulary in the conference declarations was extracted and analyzed to construct the global health promotion consensus and *** The fundamental principles of the conferences are to foster consensus and initiate actions in the realm of health promotion on a global *** primary purpose and goal are to promote health from regional to ***,our findings highlight a transition in the primary actors driving health *** underscores a shift in health promotion from being driven primarily by organizations like the World health Organization,governments,and international bodies,to a more inclusive approach involving non-governmental organizations and the general *** development implies that health promotion has evolved into a collective global endeavor,demanding the proactive involvement of various stakeholders,and forging new alliances in public ***,the coronavirus disease 2019(COVID-19)pandemic has further shaped the landscape of health promotion,underscoring the need for intensified focus on areas including disease prevention,health education,and the integration of digital health technologies,and emphasizing the importance of a multidimensional,responsive approach in public health *** Sustained collaboration and innovative strategies are pivotal to advancing health promotion ***,together with public and private entities,should intensi

关键词： Global conference on health promotion health promotion Consensus and actions

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Anti-inflammatory effects and mechanism of triterpene alcohols from camellia oil

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Food Science and Human Wellness 2024年

作者： Yonglin Li Shengmin Zhou Jie Qiang Yongsheng Cao Huijun Yang Yuan Gao Qi Li Xiuzhu Yu Engineering research center of Grain and Oil Functionalized Processing Universities of shaanxi Province， College of Food Science and Engineering， Northwest A&F University Wilmar (Shanghai) Biotechnology research & Development center Co.Ltd shaanxi Guanzhongyoufang Oil Co.， Ltd

Camellia oil， which contains a high content of triterpene alcohol， is known for a series of bioactivities including anti-inflammation. Amyrins are recognized as high bioactivity of anti-inflammation. However， no comparative study on triterpene alcohols from camellia oil. In this study， four high content triterpene alcohols from camellia oil， namely β-amyrin， ψ-taraxasterol， parkeol， and butyrospermol were evaluated through lipopolysaccharide induced RAW 264.7 cell inflammation. The results showed that butyrospermol exhibited the highest anti-inflammatory activity， surpassing that of β-amyrin. Characterization of signaling pathways showed that butyrospermol inhibited TLR4， NF-κB and MAPK pathways， suppressing the transcription of Tlr4， expression of p65， IκBα， ERK， JNK， and p38， and the phosphorylation of p65， IκBα， ERK， and p38. The anti-inflammatory effect of butyrospermol was further validated by phorbol 12-myristate 13-acetate induced mouse ear edema. The results in mouse showed that butyrospermol could inhibit the increase of TNF-α， IL-1β， p-JNK， p-p38， p-IκBα， and their corresponding mRNA levels. Our study provides new perspective on the anti-inflammatory role of different triterpene alcohols and explaining the bioactivity of camellia oil.

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Ambient Air Particulate Matter and Hospital Admissions for Chronic Kidney Disease in China:A Nationwide Case-Crossover Study

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Environment & health 2024年第8期2卷 553-562页

作者： Juan Chen Huimeng Liu Ge Li Lijun Bai Yunxing Jiang Jinxi Wang Chen Wei Yinxiang Li Jian Lei Furong Deng Luxia Zhang Xinbiao Guo Shaowei Wu Department of Occupational and Environmental health School of Public HealthXi’an Jiaotong University Health Science CenterXi’anShaanxi 710061China Key Laboratory of Environment and Genes Related to Diseases Ministry of EducationXi’anShaanxi 710061China Key Laboratory of Trace Elements and Endemic Diseases in Ministry of health Xi’anShaanxi 710061China Key Laboratory for Disease Prevention and Control and health Promotion of shaanxi Province Xi’anShaanxi 710061China shaanxi Provincial Institute for Endemic Disease Control Xi’anShaanxi 710003China Yunyi health Technology Co.Ltd. Beijing 102629China China-Europe Association for Technical and Economic Cooperation Beijing 101318China Renal Division Department of MedicinePeking University First HospitalPeking University Institute of NephrologyBeijing 100034China Advanced Institute of Information Technology Peking UniversityHangzhou 311200China National Institutes of health Data Science at Peking University Beijing 100191China

Incident chronic kidney disease(CKD)may be accelerated(could be indicated by repeated admissions to the hospital)by environmental triggers such as ambient particulate matter(PM).Additionally,hospital admission is a sensitive proxy reflecting the disease ***,the association of PM exposure with hospital admissions for CKD is still unknown,let alone the excess risks(ERs)in hospital admissions for CKD due to high PM level *** this study,a two-stage time-stratified case-crossover study was conducted to investigate the association of ambient air PM exposure with hospital admission for CKD in 282 Chinese cities of prefecture-level or above during 2013–***-specific associations of single and cumulative 0–3 days lagged exposure to fine particulate matter(PM_(2.5))and inhalable particles(PM_(10))with hospital admissions for total CKD and its subtypes were evaluated by the conditional logistic regression model,then were pooled using the random-effect model.A total of 3,490,416 hospital admissions for CKD were *** found that per interquartile range(IQR)increment in PM_(2.5) at lag02 and per IQR increment in PM_(10) at lag03 were associated with increases of 2.36%(95%CI:1.58%,3.14%)and 2.87%(95%CI:1.91%,3.85%)in hospital admissions for total CKD,*** to control concentrations(PM_(2.5):35μg/m^(3);PM_(10):50μg/m^(3)),the largest ERs in hospital admissions for total CKD were 2.63%(95%CI:2.15%–3.11%)and 4.45%(95%CI:3.85%–5.06%)in association with exposure to heavily excessive PM_(2.5)(≥75μg/m^(3))and PM_(10)(≥150μg/m^(3)),***,the attributable fractions(AFs)for CKD admissions were 2.83%for PM_(2.5) and 3.46%for PM_(10) during the study *** findings suggested that exposure to PM_(2.5) and PM_(10) is associated with substantially increased risk and burden of CKD admissions.

关键词： particulate matter hospital admission chronic kidney disease excess risks case-crossover

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