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Accurate prediction of biliary atresia with an integrated model using MMP-7 levels and bile acids

World Journal of Pediatrics 2024年第8期20卷 822-833页

作者： Yi-Jiang Han Shu-Qi Hu Jin-Hang Zhu Xiao Cai Deng-Ming Lai Bao-Hai Chen Kun Zhu Qiao Tong Xin-Rui Zhou Jia-Le Deng Jin-Fa Tou Zhuo Fang Li-Zhong Du Department of Neonatal Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Data and Analytics WuXi Diagnostics Innovation Research InstituteShanghaiChina Department of Information center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Pathology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Neonatology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina

Background Biliary atresia(BA)is a rare fatal liver disease in children,and the aim of this study was to develop a method to diagnose BA *** We determined serum levels of matrix metalloproteinase-7(MMP-7),the results of 13 liver tests,and the levels of 20 bile acids,and integrated computational models were constructed to diagnose *** Our findings demonstrated that MMP-7 expression levels,as well as the results of four liver tests and levels of ten bile acids,were significantly different between 86 BA and 59 non-BA patients(P<0.05).The computational prediction model revealed that MMP-7 levels alone had a higher predictive accuracy[area under the receiver operating characteristic curve(AUC)=0.966,95%confidence interval(CI):0.942,0.989]than liver test results and bile acid *** AUC was 0.890(95%CI 0.837,0.943)for liver test results and 0.825(95%CI 0.758,0.892)for bile acid ***,bile levels had a higher contribution to enhancing the predictive accuracy of MMP-7 levels(AUC=0.976,95%CI 0.953,1.000)than liver test *** AUC was 0.983(95%CI 0.962,1.000)for MMP-7 levels combined with liver test results and bile acid *** addition,we found that MMP-7 levels were highly correlated with gamma-glutamyl transferase levels and the liver fibrosis *** The innovative integrated models based on a large number of indicators provide a noninvasive and cost-effective approach for accurately diagnosing BA in children.

关键词： Bile aid.Biliary atresia Diagnosis Liver fibrosis Liver test MMP-7

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Low-cost portable dielectric spectrometer based on mini-vector network analyzer and open-ended coaxial probe technology

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 166-172页

作者： Zhuozhuo Zhu Xinhua Zhu Wenchuan Guo College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100ShaanxiChina School of Physics and Electronic Information Yan'an UniversityYan'an 716000ShaanxiChina shaanxi research center of Agricultural Equipment Engineering Technology Yangling 712100ShaanxiChina Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural AffairsYangling 712100ShaanxiChina shaanxi Key Laboratory of Agricultural Information Perception and Intelligent Service Yangling 712100ShaanxiChina

As a simple,fast,and non-destructive measuring technology,dielectric spectroscopy is usually used to analyze the dielectric properties of agricultural products and food,and then to predict the main components of ***,the large and expensive vector network analyzers(VNA)with expensive analysis software applied in measuring dielectric properties make research limited to the *** acquire dielectric spectra in situ,a model for solving relative complex permittivity was derived,and its performance was ***,a low-cost portable dielectric spectrometer with a mini VNA,a Raspberry Pi,and a coaxial probe as core parts was developed over the frequency range of 100-3000 *** stability and accuracy of the developed spectrometer were tested using milk and *** results indicated that the relative errors of the model were within±5%for dielectric constant(ε′)and loss factor(ε″).The coefficients of variation of measuredε′andε″by the developed spectrometer at 100-3000 MHz were less than 1%and 2%,*** with the dielectric properties obtained by using a commercial dielectric measurement system,the relative errors of measuredε′andε″were within±3.4%and±6.0%,*** study makes fast,non-destructive,and on-site food quality detection using dielectric spectra possible.

关键词： coaxial probe mini vector network analyzer low-cost portable dielectric spectrometer

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Surface deterioration dependent on the crystal facets of spinel LiNi_(0.5)Mn_(1.5)O_(4) cathode active material

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Journal of Energy Chemistry 2024年第10期97卷 757-766,I0016页

作者： Qian Li Yan Zhao Jifu Zhu Wujiu Zhang Yi Liu Yaru Cui Chao Shen Keyu Xie School of Metallurgical Engineering Xi'an University of Architecture and TechnologyXi'an 710055ShaanxiChina State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsNorthwestern Polytechnical University and Shaanx joint Laboratory of Graphene(NPU)Xi'an 710072ShaanxiChina shaanxi Union research center of University and Enterprise for Cathode Materials of LIBs Xi'an 710072ShaanxiChina CRRC Zhu Zhou Institute Co. Ltd.Zhuzhou 412000HunanChina

The spinel LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)cathode active materials(CAMs)are considered a promising alternative to commercially available cathodes such as layered and polyanion oxide cathodes,primarily due to their notable safety and high energy density,particularly in their single-crystal ***,the industrial application of the LNMO CAMs is severely inhibited due to the interfacial deterioration and corrosion under proton-rich and high-voltage *** study successfully designed and synthesized two typical types of crystal facets-exposed single-crystal LNMO *** tracking the electrochemical deterioration and chemical corrosion evolution,this study elucidates the surface degradation mechanisms and intrinsic instability of the LNMO,contingent upon their crystal ***(111)facet,due to its elevated surface energy,is found to be more susceptible to external attack compared to the(100)and(110)*** study highlights the electrochemical corrosion stability of crystal plane engineering for spinel LNMO CAMs.

关键词： LiNi_(0.5)Mn_(1.5)O_(4) Crystal facets Electrochemical degradation Chemical corrosion Surface energy

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Gp78 regulates PMP22 and causes ER stress and autophagy in EV71-VP1-overexpressing mouse Schwann cells

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BIOCELL 2024年第4期48卷 653-664页

作者： DANPING ZHU GUANGMING LIU KUAN FENG SUYUN LI DANDAN HU SIDA YANG PEIQING LI Pediatric Emergency Department Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina Department of Child health Care Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina Pediatric Neurology Department Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouChina

Background:During Enterovirus type 71(EV71)infection,the structural viral protein 1(VP1)activates endoplasmic reticulum(ER)stress associated with peripheral myelin protein 22(PMP22)accumulation and induces ***,the speciﬁc mechanism behind this process remains ***:In this research,we used the VP1-overexpressing mouse Schwann cells(SCs)models co-transfected with a PMP22 silencing or Autocrine motility factor receptor(AMFR/gp78)overexpressing vector to explore the regulation of gp78 on PMP22 and its relationship with autophagy and ***:The activity of gp78 could be inﬂuenced by EV71-VP1,leading to a decrease in the ubiquitination and degradation of PMP22,resulting in PMP22 accumulation in *** VP1-overexpressing mouse SCs,all three ER stress sensors,including pancreatic endoplasmic reticulum kinase(PERK),activating transcription factor 6(ATF6)and inositol-requiring enzyme 1(IRE1)and the related downstream signals(C/EBP-homologous protein(CHOP)and Caspase 12)were activated,as well as the ER-resident chaperone Glucose-regulated protein 78(GRP78).In addition,VP1 upregulated the autophagy marker Microtubule-associated protein 1 light chain 3 beta(LC3B),while PMP22 silencing or gp78 overexpression reversed the ***,PMP22 silencing or gp78 overexpression increased proliferation of EV71-VP1-transfected mouse ***:Gp78 could regulate PMP22 accumulation through ubiquitination degradation and cause ER stress and autophagy in EV71-VP1-overexpressing mouse ***,the gp78/PMP22/ER stress axis might emerge as a promising therapeutic target for myelin and neuronal damage induced by EV71 infection.

关键词： Enterovirus type 71 AMFR/gp78 PMP22 Autophagy Schwann cells

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Identification of Shell Color-Associated Genes Using Mantle Branch-Specific RNA Sequencing of Yellow-Colored Line of Pearl Oyster Pinctada fucata martensii

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Journal of Ocean University of China 2024年第4期23卷 1076-1086页

作者： PENG Haiming LIAO Yongshan YANG Chuangye MKUYE Robert DENG Yuewen YUE Chenyang Fisheries College Guangdong Ocean UniversityZhanjiang 524088China Pearl research Institute Guangdong Ocean UniversityZhanjiang 524088China Guangdong Science and Innovation center for Pearl culture Zhanjiang 524088China Pearl Breeding and Processing Engineering Technology research center of Guangdong Province Zhanjiang 524088China Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and healthy culture Zhanjiang 524088China

The yellow-colored line of pearl oyster Pinctada fucata martensii displays a yellow prismatic layer and a white nacreous layer that can be used as an ideal model for research on shell color ***-Raman spectroscopy and transcriptome analyses were performed to explore the potential molecular mechanism underlying the phenotype *** micro-Raman spectroscopy results indicate that the prismatic layer exhibits distinct characteristic peaks of carotenoids,while these peaks are not prominent in the nacreous *** the transcriptome comparison of the central zone of mantle and mantle edge tissue,which function in nacreous and prismatic layer formation,respectively,935 significantly differentially expressed genes(DEGs)were identified,with 385 genes upregulated and 227 genes downregulated(|log_(2)(Fold change)|>1 and false discovery rate<0.05)in the mantle edge *** these genes,some were associated with melanoma/melanogenesis,such as tyrosinase,zinc metalloprotease,glutathione S-transferase,and ATP-binding cassette sub-family;some were associated with the carotenoid-related pathway,including scavenger receptors,cytochrome P450 and lipoprotein *** associated with porphyrin metabolism,including porphobilinogen deaminase,and copper/zinc superoxide dismutase,and genes associated with shell matrix protein,including amorphous calcium carbonate binding protein,shematrin,PIF,and collagen,also exhibited significantly different *** is speculated that the different colours between prismatic layer and nacreous layer in the yellow-colored line of *** might be resulted from melanin,carotenoids and porphyrin metabolism,while genes related to shell structure and biomineralization might also affect *** results provide new insights to understand the mechanism of shell color formation in mollusca.

关键词： Pinctada fucata martensii shell coloration transcriptome

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PLAU plays a functional role in driving lung squamous cell carcinoma metastasis

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Genes & Diseases 2024年第2期11卷 554-557页

作者： Pengbo Ning Fuyu Du Xiaocheng Gong Jingtong Yuan Caixia Ding Xilian Zhao Wei Li School of Life Science and Technology Xidian UniversityXi'anShaanxi 710071China Engineering research center of Molecular & Neuroimaging Ministry of EducationXi'anShaanxi 710071China Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pathology Shaanxi Provincial Tumor HospitalXi'an Jiaotong UniversityXi'anShaanxi 710061China

The high mortality of patients with lung squamous cell carcinoma(LUSC)results from metastasis rather than primary tumors,1 whereas the molecular pathogenesis of cancer metastasis remains poorly *** encodes urokinase-type plasminogen activator(uPA)which is closely related to tumor diagnosis,treatment target,and prognosis of patients.2.3 We previously predicted that PLAU is a key gene negatively associated with overall survival by integrated multidimensional analyses of The Cancer Genome Atlas(TCGA)datasets from 504 samples of LUSC tumor tissues and 46 samples of adjacent non-tumorous lung tissues.4 However,whether the role of PLAU contributes to the metastasis of LUC remains ***,we analyzed the association between uPA levels and LUSC and found that uPA levels were associated with pathological variations in LUSC patients.

关键词： metastasis lung squamous

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Ultra-low loss Rayleigh scattering enhancement via light recycling in fiber cladding

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Photonics research 2024年第8期12卷 1813-1819页

作者： PENGTAO LUO FENGYI CHEN RUOHUI WANG XUEGUANG QIAO School of Physics Northwest UniversityXi’an 710127China Engineering research center of Optical Fiber Well Logging Technology for Oil and Gas Resources Universities of Shaanxi ProvinceXi’an 710127China

Rayleigh backscattering enhancement(RSE)of optical fibers is an effective means to improve the performance of distributed optical fiber *** laser direct-writing techniques have been used to modulate the fiber core for ***,in-core modulation loses more transmission light,thus limiting the sensing *** this work,a cladding-type RSE(cl-RSE)structure is proposed,where the femtosecond laser is focused in the fiber cladding and an array of scatterers is written parallel to the *** refractive-index modulation structure redistributes the light in the cladding,and the backward scattered light is recovered,which enhances the Rayleigh backscattered signal with almost no effect on the core light.

关键词： fiber scattering cladding

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Novel strategy of multidimensional information encryption via multi-color carbon dots aggregation-induced emission

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Nano research 2024年第6期17卷 5680-5687页

作者： Liu Ding Xilang Jin Yuchong Gao Shouwang Kang Haiyan Bai Xuehao Ma Taotao Ai Hongwei Zhou Weixing Chen shaanxi Key Laboratory of Photoelectric Functional Materials and Devices Engineering research center of Light Stabilizers for Polymer Materials Universities of shaanxi Province School of Materials and Chemical EngineeringXi’an Technological UniversityXi’an 710021China School of Material Science and Engineering Shaanxi University of TechnologyHanzhong 723000China Department of Materials Science and Engineering University of PennsylvaniaPhiladelphia 19104USA

Carbon dots(CDs)with aggregation-induced emission(AIE)have sparked significant interest in multidimensional anti-counterfeiting due to their exceptional fluorescence ***,the preparation of AIE CDs with multicolor solid-state fluorescence remains a formidable challenge due to its complicated *** the present work,a novel class of multicolor AIE CDs(M-CDs)were fabricated using selected precursor(salicylic acid,thiosalicylic acid,and 2,2'-dithiodibenzoic acid),with an eco-friendly,low-cost one-pot solvothermal *** the dilute organic solution,M-CDs manifested blue emission,but upon aggregation in the presence of water,the red,yellow,green,and blue emissions were displayed due to the AIE *** analysis,coupled with theoretical calculations,revealed that the increase in the size of sp2 domains would lower the Eg and cause a red-shift emission ***,the continuous emission of M-CDs from blue to red can be utilized as ink for multimode printing,enabling the creation of a variety of school badges and quick response *** findings hold promising implications for multi-information encryption applications.

关键词： aggregation-induced emission(AIE) luminescence mechanism multi-color emission information encryption.

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An artificial intelligence approach for particle transport velocity prediction in horizontal flows

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Particuology 2024年第9期92卷 234-250页

作者： Haoyu Chen Zhiguo Wang Hai Huang Jun Zhang College of Petroleum Engineering Xi'an Shiyou UniversityXi'an710065China shaanxi Key Laboratory of Carbon Dioxide Sequestration and Enhanced Oil Recovery Xi'an710065China College of New Energy Xi'an Shiyou UniversityXi'an710065China Engineering research center of Smart Energy and Carbon Neutral in Oil&Gas Field Universities of Shaanxi ProvinceChina The Erosion/Corrosion research center The University of TulsaOK74104United States

Particle entrainment is an inevitable phenomenon in pipeline systems,especially during the development and extraction phases of oil and gas *** predicting the critical velocity for particle transport is a key focus for implementing effective sand control *** work presents a semi-supervised learning–deep hybrid kernel extreme learning machine(SSL-DHKELM)model for predicting the critical velocity,which integrates multiple machine learning theories including the deep learning approach,which is adept at advanced feature ***,the SSL framework enhances the model's capabilities when data availability is *** improved slime mould algorithm is also employed to optimize the model's *** proposed model has high accuracy on both the sample dataset and out-of-sample *** trained with only 10%of the data,the model's error still did not increase ***,this model achieves superior predictive accuracy compared to existing mechanistic models,demonstrating its impressive performance and robustness.

关键词： Particle transport Critical velocity Deep learning Semi-supervised learning Extreme learning machine

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The current situation of semen analysis in China,based on a survey of 296 laboratories

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Asian Journal of Andrology 2024年第2期26卷 220-221页

作者： Long-Long Fu Ying Liu Xiao-Wei Wang Fang Zhou Ying Guo Wen-Hong Lu Yi-Qun Gu National health Commission Key Laboratory of Male Reproductive health Reproductive Health Research CenterNational Research Institute for Family PlanningBeijing 100081China Institute of Pediatric research Children's Hospitalof Soochow UniversitySuzhou 215025China

Dear Editor,Semen analysis is a basic test to assess male fertility and is a fundamental test in assisted reproductive *** the first publication of World health Organization(WHO)Laboratory Manual of Human Semen and Sperm-Cervical Mucus Interaction in 1980,to the publication of the WHO Manual,6th edition in 2021,these 40 years have been recognized as providing a global standard that is widely used in research and clinical laboratories *** WHO Manual,6th edition in Chinese,which we have been authorized by the WHO to translate,will be published soon.

关键词： technology. analysis translate

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