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IndRT-GCNets: Knowledge Reasoning with Independent Recurrent Temporal Graph Convolutional Representations

Computers, Materials & Continua 2024年第1期78卷 695-712页

作者： Yajing Ma Gulila Altenbek Yingxia Yu College of Information Science and Engineering Xinjiang UniversityUrumqi830017China Xinjiang Laboratory of Multilanguage Information Technology Xinjiang UniversityUrumqi830017China The Base of Kazakh and Kirghiz Language of National Language Resource Monitoring and Research center on Minority Languages Xinjiang UniversityUrumqi830017China

Due to the structural dependencies among concurrent events in the knowledge graph and the substantial amount of sequential correlation information carried by temporally adjacent events,we propose an Independent Recurrent Temporal Graph Convolution Networks(IndRT-GCNets)framework to efficiently and accurately capture event attribute *** framework models the knowledge graph sequences to learn the evolutionary represen-tations of entities and relations within each ***,by utilizing the temporal graph convolution module in the evolutionary representation unit,the framework captures the structural dependency relationships within the knowledge graph in each ***,to achieve better event representation and establish effective correlations,an independent recurrent neural network is employed to implement auto-regressive ***,static attributes of entities in the entity-relation events are constrained andmerged using a static graph constraint to obtain optimal entity ***,the evolution of entity and relation representations is utilized to predict events in the next subsequent *** multiple real-world datasets such as Freebase13(FB13),Freebase 15k(FB15K),WordNet11(WN11),WordNet18(WN18),FB15K-237,WN18RR,yago3-10,and Nell-995,the results of multiple evaluation indicators show that our proposed IndRT-GCNets framework outperforms most existing models on knowledge reasoning tasks,which validates the effectiveness and robustness.

关键词： Knowledge reasoning entity and relation representation structural dependency relationship evolutionary representation temporal graph convolution

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Statins and Sepsis Literature Review

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Pharmacology & Pharmacy 2013年第8期4卷 573-577页

作者： Alicia Hernandez Torres Ana Belen Hernandez Cascales Pedro Pujante Alarcon Alfonso Lopez Ruiz MariaÁngeles Ibanez Gil Maria Dolores Hellin Gil Hospital University Virgen de la Arrixaca de Murcia MurciaSpain Hospital University Virgen de la Arrixaca de Murcia MurciaSpain Pharmaceutical Care Research at the University of Granada GranadaSpain health center mariano yago MurciaSpain

Recent data suggest that, in addition to improving dyslipidemia, statin may reduce the risk of infections and infection-related complications. The aim of this study is to make a review of the literature about the effects of statins on clinically relevant outcomes of patients admitted to the hospital and having an infection and/or sepsis, principally in terms of intensive care unit admissions and related death.

关键词： Statins Pravastatin Simvastatin Sepsis Bacteremia Mortality

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Pleiotropic Effects of GLP-1. Cardiovascular Evidence of Effectiveness

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Pharmacology & Pharmacy 2013年第9期4卷 647-650页

作者： Pedro Pujante Alarcon Ana Belen Hernandez Cascales Alfonso Lopez Ruiz Maria Angeles Ibanez Gil Alicia Hernandez Torres Maria Dolores Hellin Gil Endocrinology and Nutrition Service of the Hospital University Virgen de la Arrixaca MurciaSpain Pharmaceutical Care Research at the University of Granada GranadaSpain health center mariano yago YeclaMurciaSpain Infectious Internal Medicine of the Hospital University Virgen de la Arrixaca MurciaSpain

Patients with diabetes are characterized by the development of cardiovascular complications: nephropathy, retinopathy, neuropathy, ischemia or hypertensive etc. Therefore, the cardiovascular involvement is the leading cause of death in patients with Diabetes Mellitus type 2 (DM2). Despite intensive treatment on classical factors of cardiovascular disease (blood pressure levels, LDL cholesterol, etc.), patients with diabetes have a high number of cardiovascular events and the onset and prognosis of these are related to glycemic control parameters, glycosylated hemoglobin (HbA1c). On the other hand, the question of the cardiovascular protective effect of some hypoglycemic treatments has been raised, asking what he has done to know more accurately about the safety and cardiovascular effects of the treatments we have today. The two most important incretin hormones are GIP (gastric inhibitory polypeptide) and GLP-1 (glucagon-like peptide-1). Treatment based on GLP-1 is a novel weapon in T2DM that achieves a reduction in HbA1c with other metabolic effects: weight loss and extra effect in dyslipidemia and blood pressure. In the last years other beneficial actions such a protector effect against myocardium ischemia and other actions in basals were reported. In this article we will try to explain the evidence of GLP-1 treatments and its cardiovascular effects.

关键词： GLP-1 T2DM Myocardium Ischemia

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Morbid Obesity in Diabetes Mellitus Type 2 and Exenatide

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Pharmacology & Pharmacy 2014年第2期5卷 149-152页

作者： Maria Angeles Ibanez Gil Alfonso Lopez Ruiz Alicia Hernandez Torres Ana Belen Hernandez Cascales Pedro Pujante Alarcon Maria Dolores Hellin Gil health center mariano yago YeclaSpain Pharmaceutical Care Research at the University of Granada GranadaSpain Infectious Internal Medicine of the Hospital University Virgen de la Arrixaca MurciaSpain Endocrinology and Nutrition Service of the Hospital University Virgen de la Arrixaca MurciaSpain

Worldwide, the prevalence of diabetes and obesity is increasing in recent years in developed countries. The first step of treatment is changes in lifestyle and in case of failure to initiate drug treatment. In our case, the patient with morbid obesity and glucose intolerance to metformin therapy was initiated without achieving weight loss and loss of glycemic control after 6 months of treatment. It was decided to add exenatide as an alternative to bariatric surgery. At the end of the study (12 months), it showed a weight reduction of 20.8% (Table 1), 20.83% BMI, glycosylated hemoglobin decrease of 2 points, and improved the lipid profile. So exenatide may be an acceptable option in the use of patient profile. It would be necessary to seek a new alternative treatment with minimal side effects and less healthcare costs.

关键词： Type 2 Diabetes and Obesity Exenatide

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Evolution of Biochemical Effects of Byetta<sup>®</sup>in Type 2 Diabetics with Cardiovascular Risk

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Pharmacology & Pharmacy 2013年第9期4卷 679-683页

作者： Alfonso Lopez Ruiz Maria Angeles Ibanez Gil Pedro Pujante Alarcon Alicia Hernandez Torres Ana Belen Hernandez Cascales Maria Dolores Hellin Gil Pharmaceutical Care Research at the University of Granada GranadaSpain health center mariano yago YeclaMurciaSpain Endocrinology and Nutrition Service of the Hospital University Virgen de la Arrixaca MurciaSpain Infectious Internal Medicine of the Hospital University Virgen de la Arrixaca MurciaSpain.

The objective of this study was to examine longitudinally the effects of exenatide on different physical and biochemical markers, evaluated in adult type 2 diabetic patients with cardiovascular risk. Data were recorded from 10 patients who attended the outpatient primary care health center mariano Iago Yecla, Murcia province, Spain in the period of December 2009 to October 2011 and who were treated with Byetta®. Differences were statistically significant (p 0.05) in HbA1c from the third month of treatment, and trends of decrease in body weight from the third week of treatment. There was a significant and better glycemic control. Overall effect was interpreted as a sensitizer drug of the parameters evaluated. Randomized studies are recommended with a minimum follow-up of 2 years, to see if the results are maintained over time.

关键词： Diabetes Mellitus Type 2 Exenatide Cardiovascular Risk

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Hypertension Unusual Cause

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Pharmacology & Pharmacy 2014年第1期5卷 1-3页

作者： Ana Belen Hernandez Cascales Alicia Hernandez Torres Maria Angeles Ibanez Gil Pedro Pujante Alarcon Alfonso Lopez Ruiz Maria Dolores Hellin Gil Juan Mayor Barrancos Endocrinology and Nutrition Service Hospital University Virgen de la ArrixacaMurciaSpain Infectious Internal Medicine Hospital University Virgen de la ArrixacaMurciaSpain health center mariano yago MurciaSpain University of Granada GranadaSpain Roman Alberca Psychiatric Hospital El PalmarSpain

We expose a case of a woman with hypertension and hypokalemia. The differential diagnosis should include primary hyperaldosteronism, diuretics or lazantes intake, secondary hyperaldosteronism. In this patient, additional tests performed show no cause of hormonal disruption and the whole picture is due to a high intake of licorice. Glycyrrhetinic acid, the active component of licorice, inhibits renal IIbeta-hydroxisteroid dehydrogenase. This allows cortisol to stimulate mineralocorticoid receptors. Licorice ingestion should be considered in the differential diagnosis of hypertension with hypokalemia.

关键词： Licorice Glycyrrhizic Acid Glycyrrhizinic Acid Induced Hypertension Hypokalemia

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Review: Surgical Treatment of Type 2 Diabetes

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Pharmacology & Pharmacy 2014年第1期5卷 24-29页

作者： Maria Dolores Hellin Gil Pedro Pujante Alarcon Alfonso Lopez Ruiz Maria Angeles Ibanez Alicia Hernandez Torres Ana Belen Hernandez Cascales Nutrition Service Hospital University Virgen de la Arrixaca de MurciaMurciaSpain Endocrinology and Nutrition Service Hos-pital University Virgen de la Arrixaca de MurciaMurciaSpain Community Pharmacy Bullas(Murcia)Spain health center Mar-iano yago Yecla(Murcia)Spain Infectious Internal Medicine Hospital University Virgen de la Arrixaca de MurciaMurciaSpain

In the last decades we have witnessed a significant increase in the incidence of type 2 diabetes mellitus, and obesity in parallel. So 90% of patients with Diabetes Mellitus type 2 (DM2) are obese. Changes in lifestyle (diet and exercise), behavioral therapies or the use of certain anti-obesity drugs have shown a limited effect and are not maintained over time. Currently, bariatric surgery is the most effective anti-obesity treatment, which is durable and resolves associated comorbidities. The surgical treatment of obesity for the modification of the anatomy of the digestive system is to produce gastric capacity constraints alone or associate with varying degrees of intestinal malabsorption and reduce body weight, improve and maintain the comorbidities associated weight loss by reduced food intake alone or in combination with malabsorption of this. The development of these surgical techniques has occurred in stages. With these techniques, setting to bariatric surgery is an effective, safe and proven procedure for the treatment of obesity and its complications especially DM2, as their post surgery referral mechanisms provide us with information for potential therapeutic treatment aimed at optimizing the control DM2 patients metabolic obese. In this review, we expose the evidence in treatment of DM2 with bariatric surgery and the actual hypothesis trying to explain how it is possible.

关键词： DM2 Bariatric Surgery Gastric Bypass

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Medical consultation in ulcerative colitis:Key elements for improvement

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World Journal of Gastroenterology 2023年第6期29卷 917-925页

作者： yago González-Lama Elena Ricart Ana Cábez Pilar Fortes Susana Gómez Francesc Casellas Inflammatory Bowel Disease Unit Department of Gastroenterology and HepatologyHospital Universitario Puerta de Hierro-MajadahondaMadrid 28222Spain Inflammatory Bowel Disease Unit Department of GastroenterologyHospital ClínicBarcelona 08036Spain Biomedical Research Networking center in Hepatic and Digestive Diseases(CIBERehd) Barcelona 08036Spain Department of Medical Pfizer SpainMadrid 28108Spain Servicio de Reumatología Hospital Universitario de SalamancaSalamanca 37007Spain Department of Gastroenterology Vall d'Hebron Research InstituteBarcelona 08035Spain

Ulcerative colitis(UC)is a chronic inflammatory disease with a high *** order to improve patient outcomes,the clinician-patient relationship in daily practice is *** guidelines provide a framework for UC diagnosis and ***,standard procedures and the medical content focused upon medical consultations in UC patients has not yet been ***,UC is a complex disease,given that patient characteristics and patient needs have been proven to vary during clinical consultation since establishing the diagnosis and upon the course of the *** this article,we have discussed the key elements and specific objectives to consider in medical consultation,such as diagnosis,first visits,follow-up visits,active disease patients,patients on topical therapies,new treatment initiation,refractory patients,extra-intestinal manifestations,as well as challenging *** key elements have been mentioned to comprise effective communication techniques,motivational interviewing(MI),as well as information and educational aspects,or organizational *** key elements to be implemented in daily practice were reported to comprise several general principles like duly prepared consultations,in addition to honesty and empathy with patients,as well as effective communication techniques,MI,information and educational points,or organizational *** role of other healthcare professionals such as specialized nurses,psychologists,or the use of checklists was also discussed and commented on.

关键词： Ulcerative colitis Patient experience Shared decision making Medical consultation Motivational interviewing Patient education

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Enterobacteria and Vibrio from Macrobrachium amazonicum prawn farming in Fortaleza,Ceará,Brazil

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 24-28页

作者： Débora de Souza Collares Maia Castelo-Branco Jamille Alencar Sales Raimunda Samia Nogueira Brilhante Glaucia Morgana de Melo Guedes yago Brito de Ponte Celia Maria de Souza Sampaio Tereza de Jesus Pinheiro Gomes Bandeira José Luciano Bezerra Moreira Lucas Pereira de Alencar Manoel de Araújo Neto Paiva Rossana de Aguiar Cordeiro André Jalles Monteiro Waldemiro de Aquino Pereira-Neto José Júlio Costa Sidrim Marcos Fábio Gadelha Rocha Department of Pathology and Legal Medicine Postgraduate Program in Medical MicrobiologySpecialized Medical Mycology CenterFederal University of Ceará School of Veterinary Medicine Postgraduate Program in Veterinary SciencesState University of Ceará Department of Statistics and Applied Mathematics Federal University of Ceará

Objective:To investigate the isolation of enterobacteria associated with Macrobrachium amazonicum(***) farming and evaluate the in vitro antimicrobial susceptibility of Vibrio ***:Strains were isolated from female *** prawns and environmental and hatchery *** assays were used to identify bacterial genera and those belonging to the genus Vibrio were submitted to further analyses for species identification,through Vitek 2 automated system and *** test was performed according to Clinical Laboratory Standards ***:The following genera of enlerobacteria were recovered:Enterobacter(n=11),Citrobacter(n=10),Proteus(n=2),Serratia(n=2),Kluyvera(n=2),Providencia(n=2),Cedecea(n=1),Escherichia(n=1).Edwardsiella(n=1) and BulliauxeUa(n=1).As for Vibrio,three species were identified:Vibrio cholerae non-O1/non-O139(n=4).Vibrio vulnificus(***)(n=1) and Vibrio mimicus(n=1).Vibrio *** minimum inhibitory concentrations values within the susceptibility range established by Clinical Laboratory Standards Institute for almost all antibiotics,except for ***,which presented intermediate profile to ***:Enterobacteria do not seem to be the most important pathogens associated with *** farming,whereas the recovery of Vibrio *** larviculture,with emphasis on Vibrio cholerae and ***,deserves special attention due to their role as potentially zoonotic aquaculture-associated ***,the intermediate susceptibility of *** to ampicillin reflects the importance of monitoring drug use in prawn farming.

关键词： Prawn Water Enterobacteria Vibrio Antibiotics

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Vibrio *** Macrobrachium amazonicum prawn farming are inhibited by Moringa oleifera extracts

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Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 899-902页

作者： Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Celia Maria de Souza Sampaio Francisco Geraldo Barbosa Manoel de Araujo Neto Paiva Glaucia Morgana de Melo Guedes Lucas Pereira de Alencar yago Brito de Ponte Tereza de Jesus Pinheiro Gomes Bandeira Jose Luciano Bezerra Moreira Debora de Souza Collares Maia Castelo-Branco Waldemiro de Aquino Pereira-Neto Rossana de Aguiar Cordeiro Jose Julio Costa Sidrim Marcos Fabio Gadelha Rocha Department of Pathology and Legal Medicine Postgraduate Program in Medical MicrobiologySpecialized Medical Mycology CenterFederal University of Ceara School of Veterinary Medicine Postgraduate Program in Veterinary SciencesState University of Ceara Department of Organic and Inorganic Chemistry Federal University of Ceara

Objective:To investigate the in vitro antimicrobial potential of extracts of stem,leaves,flowers,pods and seeds of Moringu okifera(***) against Vibrio *** hatchery water and the prawn Mmrobrachium ***:The ethanol extracts of stem,leaves,pods and seeds and chloroform extract of flowers of *** were tested against Vibrio cholerue(***) serogroups non-O1/non-O139(n=4).Vibrio vulnificus(n=l) and Vibrio mimicus(n=1).Escherichia coli(***)(ATCC(?) 25922) was used as quality *** species were obtained from Macmbrachium amazonicum prawns and from hatchery water from prawn *** Minimum Inhibitory Concentration(MIC) was determined by broth microdilution ***:The best result was obtained with the ethanol extract of pods,which inhibited three strains of the ***,Vibrio vulnificus,Vibrio minimis and ***(MIC range 0.312-5.000 mg/mL).The chloroform extract of flowers was effective against all *** strains and ***(MIC range 0.625-1.250 mg/mL).However,the ethanol extracts of stem and seeds showed low effectiveness in inhibiting the bacterial ***:The extracts of pods,flowers and leaves of *** have potential for the control of Vibrio *** studies are necessary to isolate the bioaetive compounds responsible for this antimicrobial activity.

关键词： Prawn Macrobrachium amazonicum Moringa oleifera Vi

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