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Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy

World Journal of Gastroenterology 2017年第4期23卷 668-675页

作者： Kouichi Sakurai Hiroko Suda Yumi Ido Takayuki Takeichi Ayako Okuda Kiwamu Hasuda Masahiro hattori hattori clinic Chuo-ku

AIMTo compare the effectiveness and safety of vonoprazan-based therapy with proton pump inhibitor (PPI)-based therapies to treat Helicobacter pylori (H. pylori).METHODSWe retrospectively analysed data from first-line (vonoprazan or PPI with 200 mg clarithromycin and 750 mg amoxicillin twice daily for 7 d) (n = 1353) and second-line (vonoprazan or PPI with 250 mg metronidazole and 750 mg amoxicillin twice daily for 7 d) (n = 261) eradication treatments for H. pylori -positive patients with associated gastrointestinal diseases from April 2014 to December 2015 at hattori clinic, Japan. The primary endpoint was the eradication rate, which was assessed with a full analysis set. The secondary endpoints were adverse events and related *** the first-line treatments, the eradication rates for vonoprazan, esomeprazol, rabeprazole, and lansoprazole were 87.9% (95%CI: 84.9%-90.5%), 71.6% (95%CI: 67.5%-75.5%), 62.9% (95%CI: 52.0%-72.9%), and 57.3% (95%CI: 50.4%-64.1%), respectively. The vonoprazan eradication rate was significantly higher than that of the PPIs (P < 0.01). Interestingly, smoking did not affect the H. pylori eradication rate in the vonoprazan group (P = 0.34), whereas it decreased the rates in the PPI groups (P = 0.013). The incidence of adverse events in the vonoprazan group was not different from the PPI group (P = 0.054), although the vonoprazan group exhibited a wider range of adverse events. Vonoprazan-based triple therapy was highly effective as a second-line treatment, with an eradication rate similar to that of PPI-based *** might be superior to PPIs in first-line H. pylori therapy, particularly for smokers. However, caution is required due to possible adverse events.

关键词： Helicobacter pylori Eradication treatment Vonoprazan Proton pump inhibitors Adverse event Smoking

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Factors associated with complicated erosive esophagitis: A Japanese multicenter, prospective, cross-sectional study

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World Journal of Gastroenterology 2017年第2期23卷 318-327页

作者： Masahiro Sakaguchi Noriaki Manabe Nobuo Ueki Jun Miwa Tomoki Inaba Norimasa Yoshida Kouichi Sakurai Masahiro Nakagawa Hajime Yamada Michiya Saito Koji Nakada Katsuhiko Iwakiri Takashi Joh Ken Haruma Department of Gastroenterology Moriguchi Keijinkai Hospital Division of Endoscopy and Ultrasonography Department of Clinical Pathology and Laboratory MedicineKawasaki Medical School Department of Internal Gastroenterology and Hepatology Tokyo Rosai Hospital Department of Gastroenterology Toshiba General Hospital Department of Gastroenterology Kagawa Prefectural Central Hospital Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital hattori clinic Department of Endoscopy Hiroshima City Hospital Department of Gastroenterology and Hepatology Shinko Hospital1 Michiya clinic1 Department of Laboratory Medicine Daisan Hospital Jikei University School of Medicine1 Department of Gastroenterology Nippon Medical School Graduate School of Medicine1 Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences1 Department of General Internal Medicine 2 Kawasaki Medical School General Medical Center

AIMTo assess the clinical characteristics of patients with complicated erosive esophagitis (EE) and their associated *** prospective, cross-sectional study included patients diagnosed with EE by upper gastrointestinal endoscopy between October 2014 and March 2015 at 106 Japanese hospitals. Data on medical history, general condition, gastrointestinal symptoms, lifestyle habits, comorbidities, and endoscopic findings were collected using a standard form to create a dedicated database. Logistic regression analysis was used to calculate adjusted odds ratios (aOR) and 95%CI for the association with complicated *** the study period, 1749 patients diagnosed with EE, 38.3% of whom were prescribed proton pump inhibitors (PPIs) were included. Of them, 143 (8.2%) had EE complications. Esophageal bleeding occurred in 84 (4.8%) patients, esophageal strictures in 45 (2.6%) patients, and 14 (0.8%) patients experienced both. Multivariate analysis showed that increased age (aOR: 1.05; 95%CI: 1.03-1.08), concomitant use of psychotropic agents (aOR: 6.51; 95%CI: 3.01-13.61), and Los Angeles grades B (aOR: 2.69; 95%CI: 1.48-4.96), C (aOR: 15.38; 95%CI: 8.62-28.37), and D (aOR: 71.49; 95%CI: 37.47-142.01) were significantly associated with complications, whereas alcohol consumption 2-4 d/wk was negatively associated (aOR: 0.23; 95%CI: 0.06-0.61). Analyzing associated factors with each EE complication separately showed esophageal ulcer bleeding were associated with increased age (aOR: 1.05; 95%CI: 1.02-1.07) and Los Angeles grades B (aOR: 3.60; 95%CI: 1.52-8.50), C (aOR: 27.61; 95%CI: 12.34-61.80), and D (aOR: 119.09; 95%CI: 51.15-277.29), while esophageal strictures were associated with increased age (aOR: 1.07; 95%CI: 1.04-1.10), gastroesophageal reflux symptom (aOR: 2.51; 95%CI: 1.39-4.51), concomitant use of psychotropic agents (aOR: 11.79; 95%CI: 5.06-27.48), Los Angeles grades C (aOR: 7.35; 95%CI: 3.32-16.25), and D (aOR: 20.34; 95%CI: 8.36-49.53) and l

关键词： Complication Erosive esophagitis Proton pump inhibitor Esophageal ulcer bleeding Esophageal stricture

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日本人结肠直肠癌中新生癌的比例研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 23-23页

作者： Goto H. Oda Y. Murakami Y. 刘丽娜 hattori GI Endoscopy and Oncology clinic Kumamoto Japan

Background &Aims: Adenomatous polyps are main precursors of colorectal cancers (CRCs). In Japan, de novo cancers, which do not arise from preexisting adenomas, are considered to account for a substantial number of CRCs, but the relative importance of de novo carcinogenesis remains controversial. This study estimated the proportion of de novo cancers among CRCs in Japan. Methods: The subjects were persons 40-79 years of age who were relatively similar to those in the general population. The subjects underwent colonoscopy between 1997 and 2001. Early cancers among CRCs detected in this study were classified as de novo cancers or polyp cancers derived from adenomas. The age-specific incidence of the early CRCs was calculated, and the proportion of de novo cancers was estimated. The lifetime risk of early CRCs was estimated. Results: The study group comprised 14,817 persons. CRCs were diagnosed in 189 subjects, including 83 early cancers. There were no differences with regard to size and location between de novo cancers and polyp cancers, but morphology differed. Eighty-four percent (16/19) of de novo cancers were flat elevated or depressed. The expected lifetime risk of developing early CRCs was 5.27%for men and 3.21%for women. Among persons with early cancers, the expected probabilities of developing de novo cancer were 18.6%for men, 27.4%for women. Conclusions: De novo cancers account for a considerable proportion in Japan. This information suggests that the recommended interval for colonoscopic examination in Japan should be shorter than that in the United States.

关键词：结肠直肠癌腺瘤性息肉促癌作用年龄分组早期癌结肠镜检查癌前病变息肉样受试人群风险度

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Relationship between Respiratory Muscle Strength and Static Balance in Older People Requiring Support and Care

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Open Journal of Therapy and Rehabilitation 2023年第3期11卷 90-97页

作者： Yutaro Hyodo Takumi Jiroumaru Kenji Mori Tomoka hattori Yasumasa Oka Minoru Kuroda Takamitsu Fujikawa Kanazawa Orthopaedic and Sports Medicine clinic 881 Ono Ritto Japan Department of Physical Therapy Bukkyo University Kyoto Japan Department of Applied Biology Graduate School of Science and Technology Kyoto Institute of Technology Kyoto Japan Department of clinical Nursing Division of Psychiatric and Mental Health Nursing Shiga University Otsu Japan

Purpose: This study aimed to clarify the relationship between respiratory muscle strength and balance in older people requiring support or nursing care. Methods: Thirty-seven older subjects aged 65 years or older who were certified as requiring nursing care or support were included in the study. Maximal inspiratory pressure (PIMAX), maximal expiratory pressure (PEMAX), and one-leg standing time were measured. Additionally, the Functional Reach Test (FRT) was performed. Pearson correlation coefficient and multiple regression analyses were performed. Results: One-leg standing time was positively correlated with PEMAX, and was particularly correlated with PIMAX, while FRT score was not correlated with respiratory muscle strength. Multiple regression analysis with one-leg standing time as the dependent variable and PIMAX and PEMAX as independent variables showed that only PIMAX was significantly correlated with one-leg standing time. Conclusion: Focusing on expiratory and inspiratory muscle strength is important for improving one-leg standing ability and thus preventing falls in older people.

关键词： Respiratory Muscle Strength PIMAX PEMAX One-Leg Standing Older Person

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Possibilities of Assessing Respiratory Muscle Strength and Trunk Muscle Mass in the Prevention of Sarcopenia in Older People Living in the Community

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Open Journal of Therapy and Rehabilitation 2023年第3期11卷 82-89页

Objective: The purpose of this study was to clarify the relationship between respiratory muscle strength and skeletal muscle mass (trunk, upper limbs, and lower limbs) in older people who were certified as requiring nursing or supportive care. Methods: Thirty-five older people (65 years or older) who were certified as requiring nursing care or support were included in the study. The subjects were divided into a non-sarcopenic group (n = 12) and a sarcopenic group (n = 23) according to the sarcopenia diagnostic criteria proposed by the Asian Working Group for Sarcopenia. Maximum inspiratory pressure, maximum expiratory pressure, skeletal muscle mass (trunk, upper and lower limbs), and hand grip strength were measured. Pearson’s correlation coefficient and multiple regression analysis were used for statistical processing. Results: In the non-sarcopenic group, both expiratory muscle strength and hand grip strength were correlated with skeletal muscle mass. In the sarcopenia group, expiratory muscle strength was not correlated with skeletal muscle mass, and only hand grip strength was correlated with upper limb muscle mass. Multiple regression analysis revealed that, in the non-sarcopenic group, trunk muscle mass was the primary factor in expiratory muscle strength and upper limb muscle mass was the primary factor in hand grip strength. In the sarcopenia group, upper limb muscle mass was found to be the main factor in hand grip strength. Conclusion: Our results highlight the importance of assessing expiratory muscle strength and trunk muscle mass before sarcopenia develops in older people who require support and nursing care.

关键词： Respiratory Strength PIMAX PEMAX Trunk Muscle Mass Skeletal Muscle Mass

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Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018

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Burns & Trauma 2019年第1期7卷 356-395页

作者： Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi Department of Plastic Reconstructive and Aesthetic SurgeryNippon Medical School1-1-5 Sendagi Bunkyo-kuTokyo 113-8603Japan Department of Plastic Surgery Wound Repair and RegenerationFukuoka UniversityFukuoka 814-0180Japan Department of Plastic Surgery Nippon Medical School Musashikosugi Hospital1-396 KosugichoNakahara-kuKawasaki-shiKanagawa 211-8533Japan Department of Plastic and Reconstructive Surgery Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo 160-8582Japan Department of Plastic and Reconstructive Surgery Faculty of Medicine and Graduate School of MedicineHokkaido UniversityKita-15Nishi-7Kita-kuSapporo 060-8638Japan Department of Plastic Surgery Tokai University School of Medicine4-1-1 KitakanameHiratsukaKanagawa 259-1292Japan Department of Plastic and Reconstructive Surgery Tokyo Medical University6-7-1 NishishinjukuShinjuku-kuTokyo 160-0023Japan Department of Plastic and Reconstructive Surgery Osaka Saiseikai Nakatsu Hospital2-10-39 ShibataKita-kuOsaka 530-0012Japan Department of Plastic Reconstructive and Aesthetic SurgeryIwate Medical University School of Medicine19-1 UchimaruMoriokaIwate 020-8505Japan Department of Plastic Surgery Oita University Hospital1-1 IdaigaokaHasamamachiYufu-shiOita 879-5503Japan Department of Plastic Surgery Showa University Fujigaoka Hospital1-30 FujigaokaAoba-kuYokohamaKanagawaJapan Department of Plastic and Reconstructive Surgery Japanese Red Cross Fukui Hospital2-4-1 TsukimiFukui 918-8501Japan Division of Dermatology and Dermatopathology Nippon Medical School Musashikosugi Hospital1-396KosugichoNakahara-kuKawasaki-shiKanagawa 211-8533Japan Faculty of Pharmaceutical Sciences Teikyo Heisei University4-21-2 NakanoNakano-kuTokyo 164-8530Japan Wakamatsu-cho Mental and Skin clinic 9-4 Wakamatsu-choShinjyuku-kuTokyo 162-0056Japan Department of Radiation Oncology Nippon Medical School HospitalTokyo 113-8603Japan

There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic *** is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these *** contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be *** ethnic disparity also means that countries vary in terms of their differential diagnostic *** lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven *** overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature *** tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected *** tool is simple and easy to *** a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their *** JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment *** guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment *** Consensus Document is provided in this *** describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these *** believe that t

关键词： Keloid Hypertrophic scars Pathological scars Guideline Pathology Surgery Radiotherapy Steroid Laser

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