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Statistical theory and Related Fields 2018年第1期2卷 14-20页

作者： Donna Spiegelman harvard t.h.chan school of public health BostonMAUSA

I commend *** and huang(Ph)for their continued and longstanding commitment to the generation of knowledge concerning the nutritional causes of chronic diseases,and in their dedication to applying their extensive,and in the case of ***,virtually unparalleled,expertise towards the development of statistical methods in this regard,to which this paper is one of a long line of such contributions.

关键词： diseases cardiovascular continued

the Influence of Secular trends in Body height and Weight on the Prevalence of Overweight and Obesity among Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2016年第12期29卷 849-857页

作者： FU Lian Guo SUN Li Li WU Shao Wei YANG Yi De LI Xiao hui WANG Zheng he WU Lu WANG Fu Zhi MA Jun Department of Preventive Medicine Bengbu Medical College Department of Environmental health Harvard T.H.Chan School of Public Health Institute of Child and Adolescent health School of Public HealthPeking University Health Science Center

Objective to explore the influence of secular trends in body height and weight on the prevalence of overweight and obesity among Chinese children and adolescents. Methods the data were obtained from five cross-sectional Chinese National Surveys on Students＇ Constitution and health. Overweight/obesity was defined as BMI-for-age Z-score of per the Wold health Organization （WhO） reference values. Body height and weight for each sex and age were standardized to those reported in 1985 （standardized height＂ ShY, standardized weight： SWY） and for each sex and year at age 7 （standardized height： ShA; standardized weight： SWA） using the Z-score method. Results the prevalence of overweight/obesity in Chinese children was 20.2% among boys and 10.7% among girls in 2010 and increased continuously from 1985 to 2010. Among boys and girls of normal weight, ShY and ShA were significantly greater than SWY and SWA, respectively （P 〈 0.001）. Among boys and girls with overweight/obesity, ShY was significantly lower than SWY （P 〈 0.001）, and showed an obvious decreasing trend after age 12. ShA was lower than SWA among overweight boys aged 7-8 years and girls aged 7-9 years. ShY/ShW and ShA/SWA among normal-weight groups were greater than among overweight and obese groups （P 〈 0.001）. Conclusion the continuous increase in the prevalence of overweight/obesity among Chinese children may be related to a rapid increase in body weight before age 9 and lack of secular increase in body height after age 12.

关键词： Obesity Children Secular trends Body height Body weight

Implementing New Approaches to tuberculosis Control

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China CDC weekly 2021年第12期3卷 256-259页

作者： Kristine M.Guinn Eric J.Rubin Department of Immunology and Infectious Diseases Harvard T.H.Chan School of Public HealthBostonMassachusettsUSA

As someone who has studied tuberculosis(tB)formany years,it is difficult for me to admit,buttuberculosis has not been the most exciting field inmedicine for a long *** vaccine that is used inmuch of the world was deve... 详细信息

关键词： tuberculosis vaccine clinical

the role of radical prostatectomy and definitive external beam radiotherapy in combined treatment for high-risk prostate cancer:a systematic review and meta-analysis

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Asian Journal of Andrology 2020年第4期22卷 383-389页

作者： Xu Cheng Zhi-hui Wang Mou Peng Zhi-Chao huang Lu Yi Yi-Jian Li Lei Yi Wen-Zhi Luo Jia-Wen Chen Yin-huai Wang Department of Urology The Second Xiangya Hospital of Central South UniversityChangsha 410011China t.h.chan school of public health Harvard UniversityBostonMA 02115USA

the first-line treatment options for high-risk prostate cancer(PCa)are definitive external beam radiotherapy(EBRt)with or without androgen deprivation therapy(ADt)and radical prostatectomy(RP)with or without adjuvant ***,few randomized trials have compared the survival outcomes of these two *** systematically evaluate the survival outcomes of high-risk PCa patients treated with EBRt-or RP-based therapy,a comprehensive and up-to-date meta-analysis was performed.A systematic online search was conducted for randomized or observational studies that investigated biochemical relapse-free survival(bRFS),cancer-specific survival(CSS),and/or overall survival(OS),in relation to the use of RP or EBRt in patients with high-risk *** summary hazard ratios(hRs)were estimated under the random effects *** identified heterogeneity between studies using Q tests and measured it using I2 *** evaluated publication bias using funnel plots and Egger's regression asymmetry *** studies(including one randomized controlled trial[RCt])of low risk of bias were selected and up to 9504 patients were *** comparing EBRt-based treatment with RP-based treatment,the pooled hRs for bRFS,CSS,and OS were 0.40(95%confidence interval[CI]:0.24–0.67),1.36(95%CI:0.94–1.97),and 1.39(95%CI:1.18–1.62),*** OS for RP-based treatment and better bRFS for EBRt-based treatment have been identified,and there was no significant difference in CSS between the two ***-based treatment is recommended for high-risk PCa patients who value long-term survival,and EBRt-based treatment might be a promising alternative for elderly patients.

关键词： high risk prostatectomy prostatic neoplasms radiotherapy survival

COVID-19 Vaccine Allocation: Modeling health Outcomes and Equity Implications of Alternative Strategies

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Engineering 2021年第7期7卷 924-935页

作者： Maddalena Ferranna Daniel Cadarette David E.Bloom harvard t.h.chan school of public health BostonMA 02115USA

Given the scarcity of safe and effective COVID-19 vaccines,a chief policy question is how to allocate them among different sociodemographic *** paper evaluates COVID-19 vaccine prioritization strategies proposed to date,focusing on their stated goals;the mechanisms through which the selected allocations affect the course and burden of the pandemic;and the main epidemiological,economic,logistical,and political issues that arise when setting the prioritization *** paper uses a simple,agestratified susceptible–exposed–infectious–recovered model applied to the United States to quantitatively assess the performance of alternative prioritization strategies with respect to avoided deaths,avoided infections,and life-years *** demonstrate that prioritizing essential workers is a viable strategy for reducing the number of cases and years of life lost,while the largest reduction in deaths is achieved by prioritizing older adults in most scenarios,even if the vaccine is effective at blocking viral *** regarding this property and potential delays in dose delivery reinforce the call for prioritizing older ***,we investigate the strength of the equity motive that would support an allocation strategy attaching absolute priority to essential workers for a vaccine that reduces infectionfatality risk.

关键词： Vaccine allocation COVID-19 Equity SEIR model

Implementing a vector surveillanceresponse system for chagas disease control:a 4-year field trial in Nicaragua

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Infectious Diseases of Poverty 2017年第1期6卷 154-165页

作者： Kota Yoshioka Doribel tercero Byron Perez Jiro Nakamura Lenin Perez Doctor of public health Program Harvard T.H.Chan School of Public HealthBostonUSA school of tropical Medicine and Global health Nagasaki UniversityNagasakiJapan Former Chagas Disease Control Project Japan International Cooperation AgencyManaguaNicaragua Department of Disease Prevention Ministry of Health in NicaraguaManaguaNicaragua

Background:Chagas disease is one of the neglected tropical diseases(NtDs).International goals for its control involve elimination of vector-borne *** American countries face challenges in establishing sustainable vector control programmes,since the main vector,triatoma dimidiata,cannot be *** 2012,the Ministry of health in Nicaragua started a field test of a vector surveillance-response system to control domestic vector *** paper reports the main findings from this pilot ***:this study was carried out from 2012 to 2015 in the Municipality of *** Japan International Cooperation Agency provided technical cooperation in designing and monitoring the surveillance-response system until *** system involved 1)vector reports by householders to health facilities,2)data analysis and planning of responses at the municipal health centre and 3)house visits or insecticide spraying by health personnel as a *** registered all vector reports and responses in a digital *** collected data were used to describe and analyse the system performance in terms of amount of vector reports as well as rates and timeliness of ***:During the study period,*** was reported 396 *** analysis identified some high-risk *** houses reported to be infested were visited by health personnel in 2013 and this response rate dropped to 39%in *** of insecticide spraying rose above 80%in 2013 but no spraying was carried out in the following 2 *** timeliness of house visits improved significantly after the responsibility was transferred from a vector control technician to primary health care ***:We argue that the proposed vector surveillance-response system is workable within the resourceconstrained health system in *** to the primary health care services was a key to improve the system *** efforts are necessary to keep adap

关键词： Chagas disease triatoma dimidiata Vector control Surveillance-response system Programme integration Nicaragua

Comprehensive analysis of the expression and prognosis for APOE in malignancies: A pan-cancer analysis

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Oncology Research 2022年第1期30卷 13-22页

作者： ShOUKAI YU LINGMEI QIAN JUN MA hongqiao International Institute of Medicine&Clinical Research Center Tongren HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Clinical Research Institute Shanghai Jiao Tong University School of MedicineShanghaiChina harvard t.h.chan school of public health Harvard UniversityBostonUSA

Apolipoprotein E(APOE),a gene identiﬁed as one of the strongest genetic factors contributing to the risk determinant of developing late-onset Alzheimer’s disease(AD),may also contribute to the risk of ***,no pan-cancer analysis has been conducted speciﬁcally for the APOE *** this study,we investigated the oncogenic role of the APOE gene across cancers by GEO(Gene Expression Omnibus)and tCGA(the Cancer Genome Atlas).Based on the available data,we found that most cancer types overexpress APOE,and clear associations exist between the expression level of APOE and prognosis in tumor *** expression of APOE also correlates with certain gender-associated tumors including,ovarian cancer,uterine carcinosarcoma,and breast ***,there is a signiﬁcant negative association between cancer-associatedﬁbroblast inﬁltration levels and the expression level of APOE in testicular germ cell ***,acute inﬂammatory response and protein-activation cascade-associated functions play an important role in the functional mechanisms of *** present pan-cancer analysis of APOE shows that the protein phosphorylation,DNA methylation,and genetic alterations of APOE have a signiﬁcant clinical relevance for survival prognosis and immune cell inﬁ*** novel pan-cancer study outlines the current understanding of APOE oncogenic roles across thirty-three cancers and highlights the complex association between AD and cancers.

关键词： APOE Pan-cancer Bioinformatics Alzheimer’s disease

Insight into interactions of olivine-scCO_2-water system at 140C and15 MPa during CO_2 mineral sequestration

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Geoscience Frontiers 2018年第6期9卷 1945-1955页

作者： Zijing Li Jilong Guo Zhao Dong Jiawei Chen State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China school of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Department of Environmental health Havard T.H.Chan School of Public HealthBostonMA02115USA

CO_2 mineral sequestration(in ultrabasic or basaltic rocks) has been considered as a promising long-term and stable approach to reduce CO_2 in the atmosphere and would counteract the effect of global ***, clays are widely found in ultrabasic reservoirs. In our study, clays were observed in natural olivine samples, which were used for laboratory experiments in a supercritical CO_2 system at 140C and15 MPa. Initial olivine samples were crushed into two sizes which were large grains of w850-1000 mm and powder particles of w75-150 mm, with the durations of 400 and 1000 h for the powder and grains,respectively. the results showed amorphous silica was newly formed and this passivating layer could mitigate the water-rock interaction to some extent, but it would not play a long-term prohibited effect on secondary mineral carbonate formation as it is a Fe(III) free silica coating. More interestingly, the secondary carbonates were observed to form near the surface sites where locates more clays. Our findings provide insights into the reaction mechanisms of olivine-scCO_2-water interaction process in natural ultrabasic rocks.

关键词： Carbon storage CO2 mineral sequestration Olivine Magnesite Clay mineral

the associations between Parkinson’s disease and cancer: the plot thickens

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translational Neurodegeneration 2015年第1期4卷 160-173页

作者： Danielle D.Feng Waijiao Cai Xiqun Chen MassGeneral Institute for Neurodegenerative Disease Department of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Epidemiology Harvard T.H.Chan School of Public HealthBostonMAUSA Key Laboratory of Cellular and Molecular Biology Huashan HospitalFudan UniversityShanghai 200040China

Epidemiological studies support a general inverse association between the risk of cancer development and Parkinson’s disease(PD).In recent years however,increasing amount of eclectic evidence points to a positive association between PD and cancers through different temporal analyses and ethnic *** positive association has been supported by several common genetic mutations in SNCA,PARK2,PARK8,AtM,p53,PtEN,and MC1R resulting in cellular changes such as mitochondrial dysfunction,aberrant protein aggregation,and cell cycle ***,we review the epidemiological and biological advances of the past decade in the association between PD and cancers to offer insight on the recent and sometimes contradictory findings.

关键词： cancer PARK thick

Prevalence of dementia and the attributable contributions of modifiable risk factors in China

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General Psychiatry 2023年第3期36卷 193-197页

作者： hui Chen Yuhui huang Xiaozhen Lv Xin Xu Yuan Ma huali Wang changzheng Yuan school of public health the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Bejing Dementia Key Lab National Clinical Research Center for Mental DisordersNHC Key Laboratory of Mental HealthPeking University Institute of Mental Health(Sixth Hospital)BeijingChina Department of Epidemiology Harvard T.H.Chan School of Public HealthBostonMassachusettsUSA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMassachusettsUSA

With the largest ageing population in the world,China is faced with the huge chal-lenge of dementia.-however,previously reported estimates on the prevalence of dementia among Chinese older adults were inconsistent,varying from 2%to 13%.5°It is crucial for dementia prevention to determine the number of cases that could be delayed or prevented,but how to do this remains *** address these research gaps,we aimed to provide population estimates of the prevalence of dementia in China and estimate the population attributable fractions(PAFs)of potentially modifiable risk factors.

关键词： prevention attributable estimates