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Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry

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International Journal of ophthalmology(English edition) 2025年第2期18卷 258-267页

作者： Li-Jun Ji Jin-Yu Hu Yan-Mei Zeng Qian Ling Jie Zou Cheng Chen Liang-Qi He Xiao-Yu Wang Hong Wei Xu Chen Yi-Xin Wang Yi Shao Yao Yu department of ophthalmology Dahua HospitalShanghai 200237China department of Endocrine and Metabolic the First Affiliated Hospital of Nanchang UniversityJiangxi Clinical Research Centre for Endocrine and Metabolic DiseaseJiangxi Branch of National Clinical Research Center for metabolic DiseaseNanchang 330006Jiangxi ProvinceChina department of ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg Provinciethe Netherlands school of optometry and vision science Cardiff UniversityCardiffCF244HQWalesUK department of ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage(DVH)and its correlation with clinical ***:Twenty-one individuals with DVH(male/female 12/9;mean age 52.29±11.66y)were selected,alongside 21 appropriately matched controls with diabetes mellitus(DM).Voxel-based morphometry(VBM)techniques were employed to identify aberrant functional regions in the *** operating characteristic(ROC)curves were utilized for classification based on the average VBM values of the two groups,and Pearson correlation analysis was conducted to assess the relationship between average VBM values in distinct brain regions and clinical ***:Relative to the DM controls,DVH patients exhibited reduced VBM values in the right superior temporal pole,the right superior temporal gyrus,the right medial orbital frontal gyrus,and the left superior frontal ***,ROC curve analysis of these four brain regions in DVH patients demonstrated a high degree of accuracy,as indicated by the area under the *** average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale(HADS).CONCLUSION:Pathological alterations in four distinct brain regions are observed in patients with DVH,potentially reflecting neuropathological changes associated with this condition.

关键词： diabetic vitreous hemorrhage voxel-based morphometry Hospital Anxiety and Depression Scale brain areas

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Augmented Reality Based Navigation System for Endoscopic Transnasal Optic Canal Decompression

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Journal of Shanghai Jiaotong university(Science) 2025年第1期30卷 34-42页

作者： FU Hang XU Jiangchang LI Yinwei ZHOU Huifang CHEN Xiaojun Institute of Biomedical Manufacturing and Life Quality Engineering State Key Laboratory System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China department of ophthalmology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Institute of medical Robotics Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011China

Endoscopic transnasal optic nerve decompression surgery plays a crucial role in minimal invasive treatment of complex traumatic optic ***,a major challenge faced during the procedure is the inability to visualize the optic nerve *** address this issue,an endoscopic image-based augmented reality surgical navigation system is developed in this *** system aims to virtually fuse the optic nerve onto the endoscopic images,assisting surgeons in determining the optic nerve’s position and reducing surgical ***,a calibration algorithm based on a checkerboard grid of immobile points is proposed,building upon existing calibration ***,to tackle accuracy issues associated with augmented reality technology,an optical navigation and visual fusion compensation algorithm is proposed to improve the intraoperative tracking *** evaluate the system’s performance,model experiments were meticulously designed and *** results confirm the accuracy and stability of the proposed system,with an average tracking error of(0.99±0.46)*** outcome demonstrates the effectiveness of the proposed algorithm in improving the augmented reality surgical navigation system’s ***,the system successfully displays hidden optic nerves and other deep tissues,thus showcasing the promising potential for future applications in orbital and maxillofacial surgery.

关键词： optic nerve decompression endoscopy augmented reality surgical navigation

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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa Zhang department of ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina department of ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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Potential of ultrasound stimulation and sonogenetics in vision restoration:a narrative review

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Neural Regeneration Research 2025年第12期20卷 3501-3516页

作者： Jie Ji Chen Gong Gengxi Lu Junhang Zhang Baoqiang Liu Xunan Liu Junhao Lin Patrick Wang Biju B.Thomas Mark S.Humayun Qifa Zhou department of Biomedical Engineering University of Southern CaliforniaLos AngelesCAUSA USC Roski Eye Institute Keck School of Medicine of University of Southern CaliforniaLos AngelesCAUSA Thomas Lord department of Computer Science University of Southern CaliforniaLos AngelesCAUSA harvard Westlake school Studio CityCAUSA

Vision restoration presents a considerable challenge in the realm of regenerative medicine,while recent progress in ultrasound stimulation has displayed potential as a non-invasive therapeutic *** narrative review offers a comprehensive overview of current research on ultrasound-stimulated neuromodulation,emphasizing its potential as a treatment modality for various nerve *** examining of the efficacy of different types of ultrasound stimulation in modulating peripheral and optic nerves,we can delve into their underlying molecular ***,the review underscores the potential of sonogenetics in vision restoration,which involves leveraging pharmacological and genetic manipulations to inhibit or enhance the expression of related mechanosensitive channels,thereby modulating the strength of the ultrasound *** also address how methods such as viral transcription can be utilized to render specific neurons or organs highly responsive to ultrasound,leading to significantly improved therapeutic outcomes.

关键词： neuromodulation non-invasive optic nerve injury retinal degeneration sonogenetics ultrasound stimulation visual restoration

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Advancements in diabetic retinopathy:Insights and future directions

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World Journal of Methodology 2025年第2期15卷 21-26页

作者： Chun-Yao Cheng Wen-Rui Hao Tzu-Hurng Cheng department of ophthalmology Cathay General HospitalTaipei 10633TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328TaiwanChina

This editorial discusses recent advancements and ongoing challenges in diabetic retinopathy,as reviewed by Morya et al in their comprehensive *** their review,Morya et al discussed the pathophysiology of diabetic retinopathy and explored novel treatment *** editorial highlights the importance of these advancements and emphasizes the need for continued research and innovation for the enhanced management of diabetic *** also reflects upon the implications of the authors’review findings for clinical practice and future research directions,underscoring the potential of emerging therapies for improving patient outcomes and providing a deeper understanding of disease mechanisms.

关键词： Diabetic retinopathy Pathophysiology Novel treatments Review analysis Clinical implications

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Enhancing the outcomes of diabetic vitrectomy with pharmacological adjuvants

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World Journal of Methodology 2025年第2期15卷 15-20页

作者： Chun-Yao Cheng Wen-Rui Hao Tzu-Hurng Cheng department of ophthalmology Cathay General HospitalTaipei 10633TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung City 404328TaiwanChina

This editorial offers insights from a minireview by Venkatesh et al,who explored pharmacological adjuvants for diabetic ***,they synthesized current knowledge and evaluated the efficacy of various adjunctive therapies in improving the outcomes of diabetic retinopathy and managing associated ***,we highlight the key roles of pharmacological adjuvants in optimizing surgical techniques,minimizing intraoperative challenges,and enhancing postoperative *** further discuss the potential implications of this approach for clinical practice and future research directions in this evolving ***,this editorial underscores the importance of incorporating pharmacological adjuvants into standard diabetic vitrectomy care to improve surgical outcomes and thus patients’quality of life.

关键词： Diabetic vitrectomy Pharmacological adjuvants Surgical outcomes Diabetic retinopathy Clinical implications

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Healthcare providers’perspectives on factors influencing their critical care decision-making during the COVID-19 pandemic:An international pilot survey

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World Journal of Critical Care Medicine 2025年第1期14卷 100-110页

作者： Sonali Vadi Neha Sanwalka Pramod Thaker department of Critical Care Medicine Kokilaben Dhirubhai Ambani Hospital and Medical Research InstituteMumbai 400053MahārāshtraIndia department of Statistics HCJMRIJehangir HospitalPune 411001MahārāshtraIndia medical Ethics Fellowship Harvard Medical SchoolBostonMA 02138United States

BACKGROUND Understanding a patient's clinical status and setting priorities for their care are two aspects of the constantly changing process of clinical *** analytical technique that can be helpful in uncertain situations is clinical *** must deal with contradictory information,lack of time to make decisions,and long-term factors when emergencies *** To examine the ethical issues healthcare professionals faced during the coronavirus disease 2019(COVID-19)pandemic and the factors affecting clinical *** This pilot study,which means it was a preliminary investigation to gather information and test the feasibility of a larger investigation was conducted over 6 months and we invited responses from clinicians worldwide who managed patients with *** survey focused on topics related to their professional roles and personal *** examined five core areas influencing critical care decision-making:Patients'personal factors,family-related factors,informed consent,communication and media,and hospital administrative policies on clinical *** collected data were analyzed using the χ^(2) test for categorical *** A total of 102 clinicians from 23 specialties and 17 countries responded to the *** was a significant factor in treatment planning(n=88)and ventilator access(n=78).Sex had no bearing on how decisions were *** doctors reported maintaining patient confidentiality regarding privacy and informed *** 50%of clinicians reported a moderate influence of clinical work,with many citing it as one of the most important factors affecting their health and *** from developing countries had a significantly higher score for considering a patient's financial status when creating a treatment plan than their counterparts from developed *** personal experiences,some respondents noted that treatment plans and preferences ch

关键词： Survey Clinical decision-making COVID-19 pandemic

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Clinical biomarkers of perioperative neurocognitive disorder:initiation and recommendation

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Science China Life Sciences 2025年

作者： Jianhui Liu Cheng Li Junyan Yao Lei Zhang Xuan Zhao Xin Lv Zhiqiang Liu Changhong Miao Yingwei Wang Hong Jiang Weifeng Yu Tianlong Wang Dongxin Wang E Wang Xiaoping Gu Hailong Dong Junli Cao Yuan Shen Weihong Song Shengdi Chen Yanjiang Wang Guanghui Liu Zhongcong Xie Lize Xiong Jialin C.Zheng department of Anesthesiology Shanghai Ninth People’s Hospital School of Medicine Shanghai Jiao Tong University department of Anesthesiology Shanghai Renji Hospital Shanghai Jiao Tong University School of Medicine department of Anesthesiology Xuanwu Hospital Capital Medical University department of Anesthesiology and Critical Care Medicine Peking University First Hospital department of Anesthesiology Xiangya Hospital of Central South University department of Anesthesiology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School department of Anesthesiology Xijing Hospital Fourth Military Medical University Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University department of Anesthesiology The Affiliated Hospital of Xuzhou Medical University Shanghai Mental Health Center of Shanghai Jiao Tong University department of Anesthesiology Tongji Hospital School of Medicine Tongji University Anesthesia and Brain Research Institute Tongji University Oujiang Laboratory Key Laboratory of Alzheimer’s Disease of Zhejiang Province Zhejiang Provincial Clinical Research Center for Mental Disorders Institute of Aging School of Mental Health Affiliated Kangning Hospital The Second Affiliated Hospital Yuying Children’s Hospital Wenzhou Medical University department of Neurology Ruijin Hospital Shanghai Jiao Tong University School of Medicine department of Neurology Daping Hospital Third Military Medical University State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Geriatric Anesthesia Research Unit Department of Anesthesia Critical Care and Pain Medicine Massachusetts General Hospital Harvard Medical School Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Clinical Research Center for Anesthesiology and Perioperative Medicine Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital School of Medicine Tongji University Center for Tr

Perioperative neurocognitive disorder(PND) is a significant neurological complication in aging perioperative patients that impacts postoperative cognition. PND is currently diagnosed through cognitive function testing, which is limited by its subjectivity and time requirements. Thus, the identification of biomarkers to assess PND onset is a priority to identify at-risk individuals and enable interventions and treatments to patient outcomes. This article synthesizes expert perspectives on brain aging and PND, presents the latest clinical evidence on PND biomarkers(imaging, electroencephalography, and molecular biomarkers), and delves into the relationship between PND and other age-related cognitive disorders. Thorough review of PND research identified several biomarkers with high sensitivity and specificity,offering a solid scientific foundation to predict and diagnose PND. These biomarkers not only enhance diagnostic accuracy for clinicians but also provide opportunities for earlier intervention and more effective treatment, potentially enhancing patient outcomes and quality of life.

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Bivalirudin for anticoagulation in elderly acute coronary syndrome:Effects on myocardial microcirculation and adverse events

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World Journal of Clinical Cases 2025年第13期13卷 47-51页

作者： Chun-Yao Cheng Wen-Rui Hao Tzu-Hurng Cheng department of ophthalmology Cathay General HospitalTaipei 10633Taiwan department of medical Education National Taiwan University HospitalTaipei 100225Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei City 11002Taiwan department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung City 404328Taiwan

The management of acute coronary syndrome(ACS)in older patients remains challenging because standard anticoagulants often fail to yield optimal ***,a direct inhibitor of thrombin,serves as an alternative to traditional *** drug is particularly effective in enhancing myocardial microcircu-lation and reducing adverse events after clinical *** present article explores the findings of a recent study that highlighted the clinical benefits of bivalirudin by investigating its effects on myocardial microcirculation and adverse cardiac events after percutaneous coronary intervention in older patients with *** with unfractionated heparin,bivalirudin markedly reduced the emergency response time and improved cardiac function *** further mitigated the risks of cardiovascular events and recurrent myocardial *** findings suggest that bivalirudin can enhance myocardial perfusion and reduce bleeding complications,thus serving as a safe,effective anticoagulation agent for older patients with ***,further large-scale,high-quality trials are needed to establish optimal usage guidelines and assess long-term *** bivalirudin into ACS treatment protocols for older patients may help optimize patient care,balancing efficacy and *** research and consensus building are necessary for the widespread clinical application of bivalirudin and the improvement of ACS outcomes in older patients.

关键词： Bivalirudin Acute coronary syndrome Myocardial microcirculation Elderly patients Anticoagulation

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Genetic insights in infectious diseases:Insights from a case report and implications for personalized medicine

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World Journal of Clinical Cases 2025年第13期13卷 1-6页

作者： Suryasnata Bhowmik Adrija Hajra Dhrubajyoti Bandyopadhyay department of Medicine Nilratan Sircar Medical CollegeKolkata 700156West BengalIndia department of Medicine Brigham and Women’s Hospital/Mass General BrighamBostonMA 02115United States department of Cardiovacular Imaging Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States

The relationship between genetics and infectious diseases is important in shaping our understanding of disease susceptibility,progression,and *** research shows the impact of genetic variations,such as heme-oxygenase promoter length,on diseases like malaria and sepsis,revealing both protective and inconclusive *** on vaccine responses highlight genetic markers like human leukocyte antigens,emphasizing the potential for personalized immunization *** ongoing battle against drug-resistant tuberculosis(TB)illustrates the complexity of genomic variants in predicting resistance,highlighting the need for integrated diagnostic ***,genome-wide association studies reveal antibiotic resistance mechanisms in bacterial genomes,while host genetic polymorphisms,such as those in solute carrier family 11 member 1 and vitamin D receptor,demonstrate their role in TB *** techniques like metagenomic next-generation sequencing promise detailed pathogen detection but face challenges in cost and accessibility.A case report involving a highly virulent Mycobacterium TB strain with the pks1 gene further highlights the need for genetic insights in understanding disease severity and developing targeted *** evolving landscape emphasizes the role of genetics in infectious diseases,while also addressing the need for standardized studies and accessible technologies.

关键词： Genetic profiling Infectious diseases Tuberculosis virulence pks1 gene Genetic polymorphisms Personalized medicine

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