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Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice

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Food Science and Human Wellness 2024年第3期13卷 1543-1555页

作者： Xin Wang Weiye Xiu Ye Han Zhili Wang Yu Luo Yongqiang Ma Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources College of Food EngineeringHarbin University of CommerceHarbin 150028China

Type 2 diabetes mellitus(T2DM)is a metabolic disease caused by a glycolipid metabolism disorder and isletβ-cell ***-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob,an agricultural *** hypoglycemic effects of SCP-80-I on T2DM mice and its mechanisms were investigated in this ***-80-I was found to significantly reduce blood glucose and lipid deposition levels in T2DM mice,as well as decrease serum leptin and increase adiponectin ***,real time-polymerase chain reaction(RT-PCR)and Western blotting results revealed that SCP-80-I could regulate the expression of several glycolipid metabolisms and insulin secretion genes and proteins,including 5'-AMP-activated protein kinase(AMPK),carnitine palmitoyltransferase I(CPTI),and acetyl coenzyme A carboxylase(ACC)in the liver and AMPK,sirtuin1(Sirtl),peroxisome proliferator-activated receptorycoactivator-1(PGC-1α),and uncoupling protein 2(UCP2)in the *** have a hypoglycemic effect,SCP-80-1 regulated glycolipid metabolism and islet cell function in the liver by regulating the AMPK/AC C/CPT1 signaling pathway and the AMPK/Sirt1/PGC-1αand AMPK/Sirtl/UCP2 signaling *** findings improve our understanding of polysaccharides derived from sweet corncob and the use of SCP-80-I in the production of hypoglycemic foods.

关键词： Sweet corn cob polysaccharide Type 2 diabetes Signal pathway 5’-AMP-activated protein kinase(AMPK)

KH550-SiO_(2)/polyimide insulating paper preparation and characterisation

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High Voltage 2024年第2期9卷 466-473页

作者： Minghe Chi Xue Sun Xiaorui Zhang Jiahao Shi Ling Weng Yang Yu School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbinChina Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbinChina School of Materials Science and Engineering Harbin University of Science and TechnologyHarbinChina

Oil-paper insulation material is an essential component for oil-filled transformers,and polyimide(PI)insulation paper is a novel material in the field of *** improvement of insulation class for insulation paper has gained significant attention in recent *** this study,SiO_(2)nanoparticles were modified with a silane coupling agent(KH550),and the KH550-SiO_(2)was added to the fibre membrane through in situ *** chemical composition and microcosmic characteristics of the PI porous fibre membrane were characterised using FT-IR and SEM FT-IR and ***-quently,the dielectric constant of the composite paper was reduced to 2.3 upon adding 3 wt%of KH550-SiO_(2),and the dielectric strength reached its maximum value of 85 kV/*** results demonstrate that the insulation performance of the KH550-SiO_(2)/PI composite was significantly improved due to the incorporation of nano-SiO_(2).This establishes an efficient approach for achieving excellent electrical and thermal properties in practical applications using the KH550-SiO_(2)/PI fibre membrane.

关键词： composite insulation fibre

Localization for mixed near-field and far-field sources under impulsive noise

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Journal of Systems Engineering and Electronics 2024年第2期35卷 302-315页

作者： GAO Hongyuan ZHANG Yuze DU Ya’nan CHENG Jianhua CHEN Menghan College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China College of Intelligent Systems Science and Engineering Harbin Engineering UniversityHarbin 150001China

In order to solve the problem that the performance of traditional localization methods for mixed near-field sources(NFSs)and far-field sources(FFSs)degrades under impulsive noise,a robust and novel localization method is *** eliminating the impacts of impulsive noise by the weighted out-lier filter,the direction of arrivals(DOAs)of FFSs can be estimated by multiple signal classification(MUSIC)spectral peaks *** on the DOAs information of FFSs,the separation of mixed sources can be ***,the estimation of localizing parameters of NFSs can avoid two-dimension spectral peaks search by decomposing steering *** Cramer-Rao bounds(CRB)for the unbiased estimations of DOA and range under impulsive noise have been *** experiments verify that the proposed method has advantages in probability of successful estimation(PSE)and root mean square error(RMSE)compared with existing localization *** can be concluded that the proposed method is effective and reliable in the environment with low generalized signal to noise ratio(GSNR),few snapshots,and strong impulse.

关键词： source localization far-field source(NFS) near-field source(FFS) impulsive noise Cramer-Rao bound(CRB)

Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A

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Virologica Sinica 2024年第4期39卷 685-693页

作者： Yanyan Dong Enze Shao Siwei Li Ruiqi Wang Dan Wang Lixin Wang Hong Yang Yingxia He Tian Luan Yang Chen Yao Wang Lexun Lin Yan Wang Zhaohua Zhong Wenran Zhao Department of Cell Biology Harbin Medical UniversityHarbin 150081China Department of Microbiology Harbin Medical UniversityHarbin 150081China

Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated *** B coxsackievirus(CVB)is one of the leading causative pathogens of viral myocarditis,which primarily affects children and young *** to the lack of vaccines,the development of antiviral medicines is crucial to controlling CVB infection and the progression of *** this study,we investigated the antiviral effect of baicalein,a flavonoid extracted from Scutellaria *** results demonstrated that baicalein treatment significantly reduced cytopathic effect and increased cell viability in CVB3-infected *** addition,significant reductions in viral protein 3D,viral RNA,and viral particles were observed in CVB3-infected cells treated with *** found that baicalein exerted its inhibitory effect in the early stages of CVB3 *** also suppressed viral replication in the myocardium and effectively alleviated myocarditis induced by CVB3 *** study revealed that baicalein exerts its antiviral effect by inhibiting the activity of caspase-1 and viral protease *** together,our findings demonstrate that baicalein has antiviral activity against CVB3 infection and may serve as a potential therapeutic option for the myocarditis caused by enterovirus infection.

关键词： Baicalein Coxsackievirus B(CVB) Myocarditis 2A protease Caspase-1

Local saliency consistency-based label inference for weakly supervised salient object detection using scribble annotations

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 239-249页

作者： Shuo Zhao Peng Cui Jing Shen Haibo Liu School of Computer Science and Technology Harbin University of Science and TechnologyHarbinChina School of Computer Science and Technology Harbin Engineering UniversityHarbinChina

Recently,weak supervision has received growing attention in the field of salient object detection due to the convenience of ***,there is a large performance gap between weakly supervised and fully supervised salient object detectors because the scribble annotation can only provide very limited foreground/background ***,an intuitive idea is to infer annotations that cover more complete object and background regions for *** this end,a label inference strategy is proposed based on the assumption that pixels with similar colours and close positions should have consistent ***,k-means clustering algorithm was first performed on both colours and coordinates of original annotations,and then assigned the same labels to points having similar colours with colour cluster centres and near coordinate cluster ***,the same annotations for pixels with similar colours within each kernel neighbourhood was set *** experiments on six benchmarks demonstrate that our method can significantly improve the performance and achieve the state-of-the-art results.

关键词： label inference salient object detection weak supervision

Large-area superconducting nanowires fabricated based on laser exposure on photoresist

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Nano Research 2024年第9期17卷 8220-8225页

作者： Han Zhou Shangqing Li Yicong Huang Wenqian Liu Haohui Zhang Yao Wu Wenzhi Zhang Enhua Chen Chaoyun Zhang Xiaoliang Wang Daqian Liu Jianxin Lin Qingdao Innovation and Development Center of harbin Engineering university Qingdao 266000China College of Intelligent systems and Engineering Harbin Engineering UniversityHarbin 150000China

To realize large-scale micro/nanofabrication process in superconducting devices,the nano laser direct writing(NLDW)as a potential tool was *** this paper,thermal effect induced laser-matter(superconducting film)interaction based on laser direct writing on Nb films and laser exposure on photoresist were investigated by simulation and *** avoid nanoscale thermal effect on superconducting films,large-scale superconducting nanoarrays with the area up to 100μm×100μm based on laser exposure on photoresist were *** with laser direct writing on superconducting films,which lead to the degradation of superconducting performance such as critical current,transition temperature,the superconducting nanoarrays based on laser exposure on photoresist maintain excellent superconducting performance without *** that,by further optimizing the process parameters and the thickness of photoresist,the nanowires with the width down to nanometers are *** with the traditional electron beam and ion beam process,to some extent,the nanowires fabrication process based on NLDW provides a more efficient and cost-effective path for the fabrication of large-area superconducting devices/circuits.

关键词： nano laser direct writing(NLDW) superconducting nanowire arrays superconducting devices light-matter interaction

A self-organization formation configuration based assignment probability and collision detection

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Journal of Systems Engineering and Electronics 2024年第1期35卷 222-232页

作者： SONG Wei WANG Tong YANG Guangxin ZHANG Peng School of harbin Engineering university Harbin 150001China Chinese Aeronautical Establishment Beijing 100010China

The formation control of multiple unmanned aerial vehicles(multi-UAVs)has always been a research *** on the straight line trajectory,a multi-UAVs target point assignment algorithm based on the assignment probability is proposed to achieve the shortest overall formation path of multi-UAVs with low complexity and reduce the energy *** order to avoid the collision between UAVs in the formation process,the concept of safety ball is introduced,and the collision detection based on continuous motion of two time slots and the lane occupation detection after motion is proposed to avoid collision between *** on the idea of game theory,a method of UAV motion form setting based on the maximization of interests is proposed,including the maximization of self-interest and the maximization of formation interest is proposed,so that multi-UAVs can complete the formation task quickly and reasonably with the linear trajectory assigned in ***,through simulation verification,the multi-UAVs target assignment algorithm based on the assignment probability proposed in this paper can effectively reduce the total path length,and the UAV motion selection method based on the maximization interests can effectively complete the task formation.

关键词： straight line trajectory assignment probability collision detection lane occupation detection maximization of interests

Transition metal clusters with precise numbers of atoms anchored on graphdiyne as multifunctional electrocatalysts for OER/ORR/HER:a computational study

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Rare Metals 2024年第7期43卷 3107-3117页

作者： Xin-Yang Liu Jing-Wei Liu Gang Li Jing-Xiang Zhao College of Chemistry and Chemical Engineering Harbin Normal UniversityHarbin 150025China

Subnanometer metal clusters play an increasingly important role in heterogeneous catalysis due to their high catalytic activity and *** this work,by means of the density functional theory(DFT) calculations,the catalytic activities of transition metal clusters with precise numbers of atoms supported on graphdiyne(TM_(1-4)@GDY,TM=V,Cr,Mn,Fe,Co,Ni,Cu,Ru,Rh,Pd,Ir,Pt) were investigated for oxygen evolution reactions(OER),oxygen reduction reactions(ORR) and hydrogen evolution reactions(HER).The computed results reveal that the Pd_(2),Pd_(4) and Pt_(1) anchored graphdiyne can serve as trifunctional catalysts for OER/ORR/HER with the overpotentials of 0.49/0.37/0.06,0.45/0.33/0.12 and 0.37/0.43/0.01 V,respectively,while Pd_(1) and Pt_(2)@graphdiyne can exhibit excellent catalytic performance for water splitting(OER/HER) with the overpotentials of 0.55/0.17 and 0.43/0.03 *** addition,Ni_(1) and Pd_(3) anchored GDY can perform as bifunctional catalysts for metal-air cells(OER/ORR) and fuels cells(ORR/HER) with the overpotentials of 0.34/0.32 and 0.42/0.04 V,***,by precisely controlling the numbers of atoms in clusters,the TM_(1-4) anchored graphdiyne can serve as promising multifunctional electrocatalysts for OER/ORR/HER,which may provide an instructive strategy to design catalysts for the energy conversation and storage devices.

关键词： Density functional theory Graphdiyne Single-cluster catalysts Multifunctional electrocatalysts Overpotential

A Dual Discriminator Method for Generalized Zero-Shot Learning

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Computers, Materials & Continua 2024年第4期79卷 1599-1612页

作者： Tianshu Wei Jinjie Huang School of Computer Science and Technology Harbin University of Science and TechnologyHarbin150006China School of Automation Harbin University of Science and TechnologyHarbin150006China

Zero-shot learning enables the recognition of new class samples by migrating models learned from semanticfeatures and existing sample features to things that have never been seen before. The problems of consistencyof different types of features and domain shift problems are two of the critical issues in zero-shot learning. Toaddress both of these issues, this paper proposes a new modeling structure. The traditional approach mappedsemantic features and visual features into the same feature space;based on this, a dual discriminator approachis used in the proposed model. This dual discriminator approach can further enhance the consistency betweensemantic and visual features. At the same time, this approach can also align unseen class semantic features andtraining set samples, providing a portion of information about the unseen classes. In addition, a new feature fusionmethod is proposed in the model. This method is equivalent to adding perturbation to the seen class features,which can reduce the degree to which the classification results in the model are biased towards the seen *** the same time, this feature fusion method can provide part of the information of the unseen classes, improvingits classification accuracy in generalized zero-shot learning and reducing domain bias. The proposed method isvalidated and compared with othermethods on four datasets, and fromthe experimental results, it can be seen thatthe method proposed in this paper achieves promising results.

关键词： Generalized zero-shot learning modality consistent discriminator domain shift problem feature fusion