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Space-time clustering and associated risk factors of pulmonary tuberculosis in southwest China

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Infectious Diseases of Poverty 2018年第1期7卷 940-950页

作者： Li Huang Eniola Michael Abe Xin-Xu Li Robert Bergquist Lin Xu Jing-Bo Xue Yao Ruan Chun-Li Cao Shi-Zhu Li Yunnan provincial Center for Disease Control and Prevention KunmingChina National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionRuijing Er road 207Shanghai 200025China National Research Center for Tropical Disease ShanghaiChina Key Laboratory of Parasite and Vector Biology Ministry of HealthShanghaiChina WHO Collaborating Center for Tropical Diseases ShanghaiChina Center for drug Evaluation China Food and Drug AdministrationBeijingChina Ingerod BrastadSweden

Background:Pulmonary tuberculosis(PTB,both smear positive and smear negative)is an airborne infectious disease of major public health concern in China and other parts of the world where PTB endemicity is *** study aims at identifying PTB spatio-temporal clusters and associated risk factors in Zhaotong prefecture-level city,located in southwest China,where the PTB notification rate was higher than the average rate in the entire ***:Space-time scan statistics were carried out using PTB registered data in the nationwide TB online registration system from 2011 to 2015,to identify spatial *** patients diagnosed between October 2015 and February 2016 were selected and a structured questionnaire was administered to collect a set of variables that includes socio-economic status,behavioural characteristics,local environmental and biological *** on the discovery of detailed town-level spatio-temporal PTB clusters,we divided selected subjects into two groups including the cases that resides within and outside identified ***,logistic regression analysis was applied comparing the results of variables between the two ***:A total of 1508 subjects consented and participated in the *** for PTB cases were identified in 38 towns distributed over south-western *** regression analysis showed that history of chronic bronchitis(OR=3.683,95%CI:2.180-6.223),living in an urban area(OR=5.876,95%CI:2.381-14.502)and using coal as the main fuel(OR=9.356,95%CI:5.620-15.576)were independently associated with ***,not smoking(OR=0.340,95%CI:0.137-0.843)is the protection factor of spatial ***:We found PTB specially clustered in south-western *** strong associated factors influencing the PTB spatial cluster including:the history of chronic bronchitis,living in the urban area,smoking and the use of coal as the main fuel for cooking and ***,efforts should

关键词： Pulmonary tuberculosis Spatio-temporal clustering Regression analysis method Risk factors China

Clemastine in remyelination and protection of neurons and skeletal muscle after spinal cord injury

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Neural Regeneration Research 2023年第5期18卷 940-946页

作者： Ali Myatich Azizul Haque Christopher Sole Naren L.Banik Department of Microbiology and Immunology Medical University of South CarolinaCharlestonSCUSA Department of Neurosurgery Medical University of South CarolinaCharlestonSCUSA Ralph H.Johnson Veterans administration Medical Center CharlestonSCUSA Department of Health and Human Performance The CitadelCharlestonSCUSA

Spinal cord injuries affect nearly five to ten individuals per million every year. Spinal cord injury causes damage to the nerves, muscles, and the tissue surrounding the spinal cord. Depending on the severity, spinal injuries are linked to degeneration of axons and myelin, resulting in neuronal impairment and skeletal muscle weakness and atrophy. The protection of neurons and promotion of myelin regeneration during spinal cord injury is important for recovery of function following spinal cord injury. Current treatments have little to no effect on spinal cord injury and neurogenic muscle loss. Clemastine, an food and drug administration-approved antihistamine drug, reduces inflammation, protects cells, promotes remyelination, and preserves myelin integrity. Recent clinical evidence suggests that clemastine can decrease the loss of axons after spinal cord injury, stimulating the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes that are capable of myelination. While clemastine can aid not only in the remyelination and preservation of myelin sheath integrity, it also protects neurons. However, its role in neurogenic muscle loss remains unclear. This review discusses the pathophysiology of spinal cord injury, and the role of clemastine in the protection of neurons, myelin, and axons as well as attenuation of skeletal muscle loss following spinal cord injury.

关键词： axonal damage clemastine myelination neuronal death oligodendrocytes skeletal muscle spinal cord injury

RNA干扰技术沉默STAT3对人前列腺癌细胞生长的抑制作用

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中华男科学杂志 2005年第1期11卷 29-33,37页

作者：高丽芳徐德启邵月婷赵丹赵雪俭吉林大学基础医学院病理生理学科 Laboratory of Enteric and Sexually Transmitted Diseases Center for Biologics Evaluation and Research Food and Drug Administration Bethesda MD 20892 USA

目的:探讨RNA干扰技术沉默STAT3基因表达对人前列腺癌细胞PC3及LNCaP的生长抑制作用.方法:针对STAT3 mRNA序列设计合成3对编码小干扰RNA(siRNA)的DNA模板,构建pSilencer 1.0-U6-siRNA-STAT3重组质粒,转染PC3及LNCaP细胞;采用Western印迹、Northern印迹等技术观察重组质粒对STAT3基因表达的影响;用MTT法观察重组质粒对PC3及LNCaP细胞体外生长抑制作用;用流式细胞术(FCM)及吖啶橙染色检测重组质粒诱导细胞凋亡.结果:成功构建pSilencer1.0-U6-siRNA-STAT3重组质粒,并成功转染PC3及LNCaP细胞;Western印迹,Northern印迹结果证实重组质粒在mRNA及蛋白水平分别显著抑制STAT3基因表达,抑制率为60%～75%;MTT及FCM结果证明上述重组质粒可显著抑制PC3及LNCaP细胞的体外生长并诱导PC3细胞凋亡.结论:pSilencer1.0-U6-siRNA-STAT3可抑制STAT3在人前列腺癌细胞中的表达,并抑制肿瘤细胞的生长,促进其凋亡.

关键词：前列腺癌 RNA干扰 STAT3 凋亡

Hydroxyl,hydroperoxyl free radicals determination methods in atmosphere and troposphere

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Journal of Environmental Sciences 2021年第1期33卷 324-335页

作者： Guoying Wang Yves Iradukunda Gaofeng Shi Pascaline Sanga Xiuli Niu Zhijun Wu School of Petrochemical Engineering Lanzhou University of TechnologyLanzhou 730050China Gansu food Inspection and Research Institute Lanzhou 730050China State Key Joint Laboratory of Environment Simulation and Pollution Control(Peking University) College of Enuironmental Sciences and EngineeringPeking UniversityBeijing 100871China

The hydroxyl radical(·OH)has a crucial function in the oxidation and removal of many atmospheric compounds that are harmful to ***,high reactivity,low atmospheric abundance,determination of hydroxyl,and hydroperoxyl radical’s quantity is very *** the atmosphere and troposphere,hydroperoxyl radicals(HO_(2))are closely demanded in the chemical oxidation of the *** advances in technology have allowed researchers to improve the determination methods on the research of free radicals through some spectroscopic *** far,several methods such as laser-induced fluorescence(LIF),high-performance liquid chromatography(HPLC),and chemical ionization mass spectroscopy have been identified and mostly used in determining the quantity of hydroxyl and hydroperoxyl *** this systematic review,we have advised the use of scavenger as an advance for further researchers to circumvent some of these problems caused by free *** primary goal of this review is to deepen our understanding of the functions of the most critical free radical(·OH,HO_(2))and also understand the currently used methods to quantify them in the atmosphere and troposphere.

关键词： Atmosphere Determination method Hydroxyl radical Hydroperoxyl radical Troposphere

4-Methyloxazole-5-carbonitrile,90-day oral toxicity study in rats after gavage administration

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4-Methyloxazole-5-carbonitrile,90-day oral toxicity study in...

Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars

作者： OUYANG Zhao-he LI Lei-ning GAO Xiao-xing QU Wen-shen WANG He-mei HAN Gang GUAN Yong-biao DING Ri-gao National Beijing Center for drug Safety Evaluation & Research Beijing Institute of Pharmacology and Toxicology

OBJECTIVE To evaluate the toxicity of 4-methyloxazole-5-carbonitrile(cyanomethyloxazol,CMO) in rats. METHODS Four groups of Sprague-Dawley(SD) rats,each consisting of 10 males and 10 females were dosed daily via oral gavage for 90 consecutive *** of ten animals per group per sex remained untreated for 14 d prior to euthanasia to evaluate recovery from *** article was dissolved in propylene glycol for *** dose levels were 0 (propylene glycol for gavage),2,10 and 50 mg·kg~(-1).Examinations were conducted on the rats with respect to general demeanor,clinical signs,mortality,body weights/total body weight gains,food consumption,ophthalmologic changes, urinalysis,hematology,serum chemistry,gross necropsy,absolute and relative organ weights,and histopathology. RESULTS One male of the mid dose group and one male and one female of the high dose group died during the study. Gross pathology findings showed that the death of the mid dose male was the result of a gavaging *** on the necropsy findings(haemorrhage in the lungs),the deaths in the high dose group were considered to be accidental and caused by respiratory *** lethargy was the major clinical sign seen in the high dose group caused by CMO and found in both *** was reversible after cessation of *** clinical signs were seen in the mid and low dose *** ocular finding was attributed to the administration of test article during the *** were no treatment -related differences between the vehicle control group and rats receiving CMO for mean body weight,mean body weight gains and food consumption during the *** relevant findings were seen in haematology,clinical chemistry and *** were no test article-related changes in absolute organ weights,organ weight to body weight ratios, or macroscopic and microscopic *** Based upon the results from this study,the no observed adverse effect level of CMO in rats was established at

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Science China(Life Sciences) 2020年第1期63卷 116-124页

作者： Wenjie Tang Jian Wu Shunshun Jin Liuqin He Qinlu Lin Feijun Luo Xingguo He Yanzhong Feng Binsheng He Pingping Bing Tiejun Li Yulong Yin Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionChangsha 410125China National Engineering Laboratory for Deep Process of Rice and Byproducts Hunan Key Laboratory of Grain-oil Deep Process and Quality ControlHunan Key Laboratory of Processed Food for Special Medical PurposeCollege of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha 410004China Academics Working Station at The First Affiliated Hospital Changsha Medical UniversityChangsha 410219China Sichuan Academy of Animal Sciences Animal Breeding and Genetics Key Laboratory of Sichuan ProvinceChengdu 610066China ^Changsha Green LecrfBiotechnology Co. Ltd.Changsha 610066Hunan Heilongjiang Academy of Agricultural Sciences Harbin 150086China

Several potential oxidative agents have damaging effects on mammalian reproductive *** study was conducted to investigate the effects of glutamate(Glu)and aspartate(Asp)supplementation on antioxidant enzymes and immune defense systems in the outer scrotum of boars injected with H2O2.A total of 24 healthy boars were randomly divided into 4 treatment groups:control(basal diet,saline-treated),H2O2(basal diet,H2O2-challenged outer scrotum(1 m L kg^–1 BW)),Glu(basal diet+2%Glu,H2O2-challenged),and Asp(basal diet+2%Asp,H2O2-challenged).Our results showed that both Glu and Asp supplementation improved testicular morphology and decreased the genital index in the H2O2-treated *** and Asp administration increased the antioxidant enzyme activities and affected the testicular inflammatory cytokine secretion but had no effect on sex hormone ***,the m RNA expression of CAT,Cu Zn SOD,and GPx4 was altered in the testes and epididymis of boars treated with Asp and *** and Asp supplementation also modulated the expression of TGF-β1,IL-10,TNF-α,IL-6 and IL-1βin the testis and *** results indicate that dietary Glu and Asp supplementation might enhance antioxidant capacity and regulate the secretion and expression of inflammatory cytokines to protect the testes and epididymis of boars against oxidative stress.

关键词： glutamate aspartate boars oxidative stress inflammatory cytokines

Seasonal variation characteristics of hydroxyl radical pollution and its potential formation mechanism during the daytime in Lanzhou

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Journal of Environmental Sciences 2020年第9期32卷 58-64页

作者： Guoying Wang Shiming Jia Ruihong Li Shangrong Ma Xuefu Chen Zhijun Wu Gaofeng Shi Xiuli Niu School of Petrochemical Engineering Lanzhou University of TechnologyLanzhou 730050China State Key Joint Laboratory of Environment Simulation and Pollution Control(Peking University) College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Gansu food Inspection and Research Institute Lanzhou 730030China

Hydroxyl free radicals(OH radicals) play the main role in atmospheric chemistry and their involving reactions are the dominant rate determining step in the formation of secondary fine particulate matter and in the removal of air pollutants from the *** this paper,we studied the seasonal variation characteristics of OH radicals during the daytime in Lanzhou and explored the potential formation mechanism of high concentration OH *** found that the OH radicals in four seasons was 2.7×106,2.6×106,3.1×106, and2.2×106 cm-3,*** the rainfall was concentrated in summer,the wet deposition had a significant effect on removing OH *** the four pollutants(including ozone(O3),volatile organic compounds(VOCs),nitrogen dioxide(NO2) and fine particulate matter(PM2.5)),the variation of OH radicals were closely related to ozone concentration especially in spring and *** autumn,the correlation between PM2.5 and OH radicals were the closest among the observing pollutants and its formation mechanism was different conventional regeneration *** Event 1,high concentration of ozone was the main source of OH radicals;under the high humidity condition,except for ozone,the multiple factors including VOCs,NO2 and PM2.5 interplayed and leaded to the Event 2.

关键词： pollution ozone radicals

Spirulina platensis aqueous extracts ameliorate colonic mucosal damage and modulate gut microbiota disorder in mice with ulcerative colitis by inhibiting inflammation and oxidative stress

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第6期23卷 481-501页

作者： Jian WANG Liqian SU Lun ZHANG Jiali ZENG Qingru CHEN Rui DENG Ziyan WANG Weidong KUANG Xiaobao JIN Shuiqing GUI Yinghua XU Xuemei LU Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances School of Life Science and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China Intensive Care Unit Shenzhen Second People’s Hospitalthe First Affiliated Hospital of Shenzhen UniversityShenzhen 518031China Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products National Institutes for Food and Drug ControlBeijing 102629China

Ulcerative colitis(UC)is a chronic and recurrent inflammatory bowel disease(IBD)that has become a major gastroenterologic problem during recent *** complicating factors are involved in UC development such as oxidative stress,inflammation,and microbiota *** factors exacerbate damage to the intestinal mucosal *** platensis is a commercial alga with various biological activity that is widely used as a functional ingredient in food and beverage ***,there have been few studies on the treatment of UC using *** aqueous extracts(SP),and the underlying mechanism of action of SP against UC has not yet been ***,we aimed to investigate the modulatory effect of SP on microbiota disorders in UC mice and clarify the underlying mechanisms by which SP alleviates damage to the intestinal mucosal *** sulfate sodium(DSS)was used to establish a normal human colonic epithelial cell(NCM460)injury model and UC animal *** mitochondrial membrane potential assay 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and staining with Annexin V-fluorescein isothiocyanate(FITC)/propidium iodide(PI)and Hoechst 33258 were carried out to determine the effects of SP on the NCM460 cell injury ***,hematoxylin and eosin(H&E)staining,transmission electron microscopy(TEM),enzyme-linked immunosorbent assay(ELISA),quantitative real-time polymerase chain reaction(qPCR),western blot,and 16S ribosomal DNA(rDNA)sequencing were used to explore the effects and underlying mechanisms of action of SP on UC in C57BL/6 *** vitro studies showed that SP alleviated DSS-induced NCM460 cell *** also significantly reduced the excessive generation of intracellular reactive oxygen species(ROS)and prevented mitochondrial membrane potential reduction after DSS *** vivo studies indicated that SP administration could alleviate the severity of DSS-induced colonic mucosal damage compared with the cont

关键词： Spirulina platensis aqueous extracts Ulcerative colitis Oxidative stress Inflammation Antioxidant Gut microbiota

4-Methyloxazole-5-carbonitrile,90-day oral toxicity study in rats after gavage administration

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4-Methyloxazole-5-carbonitrile,90-day oral toxicity study in...