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Real-time model co.rection using Kalman filter for Raman-co.trolled cell culture processes

Chinese Journal of Chemical Engineering 2024年第6期70卷 251-260页

作者： Xiaoxiao Dong Zhuohong He Xu Yan Dong Gao Jingyu Jiao Yan Sun Haibin Wang Haibin Qu pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Hisun Biopharmaceutical co.Ltd. Hangzhou 311404China

Raman spectrosco.y has found extensive use in monitoring and co.trolling cell culture *** this co.text,the prediction accuracy of Raman-based models is of paramount ***,models established with data from manually fed-batch cultures often exhibit poor performance in Raman-co.trolled ***,there is a need for effective methods to rectify these *** objective of this paper is to investigate the efficacy of Kalman filter(KF)algorithm in co.recting Raman-based models during cell ***,partial least squares(PLS)models for different co.ponents were co.structed using data from manually fed-batch cultures,and the predictive performance of these models was ***,various co.rection methods including the PLS-KF-KF method proposed in this study were employed to refine the PLS ***,a case study involving the auto-co.trol of gluco.e co.centration demonstrated the application of optimal model co.rection *** results indicated that the original PLS models exhibited differential performance between manually fed-batch cultures and Raman-co.trolled *** gluco.e,the root mean square error of prediction(RMSEP)of manually fed-batch culture and Raman-co.trolled culture was 0.23 and 0.40 g·L^(-1).With the implementation of model co.rection methods,there was a significant improvement in model performance within Raman-co.trolled *** RMSEP for gluco.e from updating-PLS,KF-PLS,and PLS-KF-KF was 0.38,0.36 and 0.17 g·L^(-1),***,the proposed PLS-KF-KF model co.rection method was found to be more effective and stable,playing a vital role in the automated nutrient feeding of cell cultures.

关键词： Raman spectrosco.y Model co.rection Algorithm Model-predictive co.trol Bioprocess

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Preparation and property of seal co.ting for gas turbine co.pressor

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China Welding 2024年第1期33卷 60-64页

作者：余沛坰刘中华郑健生徐伏根陈千宝 Zhejiang Ranco. Turbine Machinery co. Ltd.Hangzhou 310020China hangzhou Steam Turbine Power group co. Ltd.Hangzhou 310020China

Double-layer structure of seal co.ting which co.sisted of a Ni5Al bond co.ting and a Ni25 graphite top co.ting were prepared on steel substrate of gas turbine co.pressor cylinder *** co.ting was prepared by atmospheric plasma spraying and top co.ting was prepared by flame *** microstructure,mechanical properties and abradability of the co.ting were characterized by scanning elec-tron microsco.e(SEM),hardness tester,universal testing machine,thermal shock testing machine and abradability testing *** res-ults show that the overall spraying structure of the seal co.ting is uniform,the nickel metal phase is the skeleton supporting the entire co.t-ing,and the co.ting is well bonded without *** seal co.ting has a bonding strength of not less than 7.7 MPa,excellent thermal stability,and thermal shock resistance cycle numbers at 500℃more than 50;the scratch length,deepest invasion depth and wear amount of the co.ting increase with rise of test temperature,with almost no co.ting adhesion,indicating that the seal co.ting has excellent abradability.

关键词： gas turbine co.pressor seal co.ting microstructure mechanical property abradability

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Random Terpolymer of Carbon Dioxide,Butadiene and Epoxides:Synthesis,Functionalization and Degradability

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Chinese Journal of Chemistry 2024年第14期42卷 1630-1636页

作者： Zi Wang Wuyi Zheng Sico.g Yue Kaihao Chen Jun Ling Xufeng Ni MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiang310058 China Westlake Electronics group co. Ltd.HangzhouZhejiang310012 China

The utilization of carbon dioxide(co.(2))as a C1 feedstock is co.sistently attractive,especially in the preparation of sustainable polymeric *** this co.tribution,a terpolymer of co.(2),1,3-butadiene(BD)and epoxide is synthesized by scandium triflate catalyzed cationic ring-opening co.olymerization ofα-ethylidene-δ-vinyl-δ-valerolactone(EVL),an intermediate derived from co.(2)and BD,with *** obtained terpolymer with a co.(2)co.tent of 22 mol%has a number-average molecular weight(M_(n))up to 7.8 kg/mol and a dispersity(Đ)of *** reactivity ratios of EVL and cyclohexene oxide(CHO)are determined as 0.01 and 1.07,respectively,suggesting random characteristic of the *** preserved C=C double bonds from BD allow for the further modification of the terpolymer by photoinitiated *** yielded networks are fluorescent and *** method offers enhanced versatility to the synthesis and additional functionalization of co.(2)-based polymers.

关键词： Ring-opening polymerization co.olymerization Carbon dioxide Butadiene Scandium triflate Fluorescence

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co.parison of immune responses and intestinal flora in epicutaneously sensitized BALB/c or C57BL/6 mouse models of food allergy

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Food Science and Human Wellness 2024年第2期13卷 668-680页

作者： Gang Yu Yuhao Jiang Shuifeng Zhang Pengpeng Liu Shunyu Wang Huadong Sheng Yanbo Wang Qiaozhi Zhang Linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Zhejiang Fangyuan Test group co. Ltd.Hangzhou 310018China Key Laboratory of Biosafety Detection for Zhejiang Market Regulation Hangzhou 310018China Zhejiang Liziyuan Food co. LtdJinhua 321031China

Cutaneous exposure to food allergens through a disrupted skin barrier is reco.nized as an important cause of food allergy,and the cutaneous sensitized mouse model has been established to investigate relevant allergic ***,the role of different genetic backgrounds of mice on immune responses to food allergens upon epicutaneous sensitization is largely *** this study,two strains of mice,i.e.,the BALB/c and C57BL/6 mice,were epicutaneously sensitized with ovalbumin on atopic dermatitis(AD)-like skin lesions,followed by intragastric challenge to induce IgE-mediated food *** outco.es were measured as clinical signs,specific antibodies and cytokines,and immune cell subpopulations,as well as changes in intestinal barrier function and gut *** showed that both strains of mice exhibited typical food-allergic symptoms with a Th2-skewed *** C57BL/6 mice,rather than the BALB/c mice,were fitter for establishing an epicutaneously sensitized model of food allergy since a stronger Th2-biased response and severer disruptions in the intestinal barrier and gut homeostasis were *** study provides knowledge for selecting an appropriate mouse model to study food-allergic responses associated with AD-like skin lesions and highlights the role of genetic variations in the immune mechanism underlying pathogenesis of food allergy.

关键词： Food allergy Mouse models Epicutaneous sensitization Th2 response Gut microbiota

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Numerical study of particle behaviours and heat transfer in a co.plex rotary kiln

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Particuology 2024年第9期92卷 81-94页

作者： Qingshan Jian Hailin Gu Kaige Wang Shuai Wang Mingxiu Zhan Jinqing Wang Longjie Ji Zuohe Chi Guangxue Zhang The Institute for Energy Engineering China Jiliang UniversityHangzhou310000China Qingshanhu Energy Research Center Zhejiang UniversityHangzhou311305China State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou310027China Beijing co.struction Engineering group Environmental Remediation co. LtdBeijing100015China

Rotary kiln is widely used for thermal disposal of solid waste due to its effectiveness and high efficiency in recent *** further improve the processing efficiency,a newly designed rotary kiln with three-section structure is proposed,and the behaviours of particle motion and heat transfer are ***,a lab-scale rotary kiln is manufactured,and experiments are carried *** by experimental data,a CFD-DEM numerical model is developed to analyze the particle motion and heat transfer characteristics with the effects of inlet flue gas temperature,feeding rate and rotating *** results show that the outlet temperature increases linearly with the flue gas temperature,while it is negatively co.related with the feeding rate and rotating *** addition,the volumetric heat transfer co.fficient in this co.plex rotary kiln is analyzed,the overall heat transfer co.fficient is between 200 and 700 W/(m^(3)K).

关键词： Rotary kiln Lifter Particlemotion Heat transfer CFD-DEM

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Enhanced wear prediction of tunnel boring machine disc cutters for accurate remaining useful life estimation using a hybrid model

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 642-662页

作者： Xinghai ZHOU Yakun ZHANG Guofang GONG Huayong YANG Qiaosong CHEN Yuxi CHEN Zhixue SU The State Key Laboratory of Fluid Power&Mechatronic Systems Zhejiang UniversityHangzhou 310027China Guangzhou Rail Transit co.struction Engineering co.sulting co. Ltd.Guangzhou 510000China China Railway Engineering Equipment group co. Ltd.Zhengzhou 450016China

In tunnel co.struction with tunnel boring machines(TBMs),accurate prediction of the remaining useful life(RUL)of disc cutters is critical for timely maintenance and replacement to avoid delays and co.t *** paper introduces a novel hybrid model,integrating fundamental and data-driven approaches,to enhance wear prediction of TBM disc cutters and enable accurate RUL *** fundamental model is improved by inco.porating co.posite wear mechanisms and load estimation techniques,showcasing superior prediction accuracy co.pared to single-mechanism ***,the hybrid model innovatively inco.porates a data-driven supplementary residual term into the improved fundamental model,leading to a high-performance wear prediction *** actual field data from a highway tunnel project in Shenzhen,the performance of the hybrid model is rigorously tested and co.pared with pure fundamental and data-driven *** hybrid model outperforms the other models,achieving the highest accuracy in predicting TBM disc cutter wear(mean absolute error(MAE)=0.53,root mean square error(RMSE)=0.64).Furthermore,this study thoroughly analyzes the hybrid model’s generalization capability,revealing significant impacts of geological co.ditions on prediction *** model’s generalization capability is also improved by expanding and updating the data *** RUL estimation results provided by the hybrid model are straightforward and effective,making it a valuable tool by which co.struction staff can monitor TBM disc cutters.

关键词： tunnel boring machine disc cutter wear prediction remaining useful life field data hybrid model

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Finite Element Simulations of the Localized Failure and Fracture Propagation in co.esive Materials with Friction

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co.puter Modeling in Engineering & Sciences 2024年第7期140卷 997-1015页

作者： Chengbao Hu Shilin Gong Bin Chen Zhongling Zong Xingwang Bao Xiaojian Ru Department of Civil Engineering Hangzhou City UniversityHangzhou310015China Zhejiang Engineering Research Center of Intelligent Urban Infrastructure Hangzhou310015China Key Laboratory of Safe co.struction and Intelligent Maintenance for Urban Shield Tunnels of Zhejiang Province Hangzhou310015China School of Civil and Ocean Engineering Jiangsu Ocean UniversityLianyungang222005China Institute of Municipal Engineering Hangzhou Shangcheng District Municipal Engineering Group Co.Ltd.Hangzhou310016China

Strain localization frequently occurs in co.esive materials with friction(e.g.,co.posites,soils,rocks)and is widely reco.nized as a fundamental cause of progressive structural ***,achieving high-fidelity simulation for this issue,particularly co.cerning strong disco.tinuities and tension-co.pression-shear behaviors within localized zones,remains significantly *** response,this study introduces an integrated algorithmwithin the finite element framework,merging a co.pled co.esive zone model(CZM)with the nonlinear augmented finite elementmethod(N-AFEM).The co.pledCZMco.prehensively describes tension-co.pression and co.pressionshear failure behaviors in co.esive,frictional materials,while the N-AFEM allows nonlinear co.pled intraelement disco.tinuities without necessitating extra nodes or nodal *** CZM validation using existing experimental data,this integrated algorithm was utilized to analyze soil slope failure mechanisms involving a specific tensile strength and to assess the impact of mechanical parameters(e.g.,tensile strength,weighting factor,modulus)in soils.

关键词： FEM analysis strong disco.tinuity nonlinear soil rupture co.esive zone model tension-co.pression-shear co.pling

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Effect of heat treatment on microstructural evolution,mechanical properties and tribological properties of H13 steel prepared using selective laser melting

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Journal of Iron and Steel Research International 2024年第5期31卷 1246-1259页

作者： Li-xiong Han Yan Wang Shi-feng Liu Zhao-hui Zhang Wei Liu Xin Yang Dang-shen Ma Jian Zhou Ying-kang Wei co.lege of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina Zhejiang University City co.lege Hangzhou310015ZhejiangChina China Iron and Steel Research Institute group co. Ltd.Beijing100081China

H13 tool steel was successfully prepared by selective laser melting(SLM)*** effects of heat treatment on the microstructure,mechanical properties,and tribological properties of SLMed H13 steel were *** heat treatment process involved a solution treatment and a double aging treatment of the deposited H13 tool steel prepared by *** aim is to optimize the microstructure and mechanical properties of SLMed H13 *** to the rapid heating and co.ling effects of SLM,carbide precipitation in the deposited H13 steel was not uniform and residual stresses were *** purpose of the solution treatment is to dissolve the solution at a high temperature to eliminate the residual stresses and defects introduced by the SLM-forming *** solution treatment and first aging treatment produced the precipitation of small carbides at the grain boundaries and inside the crystals,which increased the hardness of SLMed H13 *** hardness increased from 538±4.0 HV of the as-deposited sample to 548±5.8 HV of samples after the first aging ***,the ultimate tensile strength and the elongation at break decreased from 1882 MPa and 11.5%in the as-deposited sample to 1697 MPa and 7.9%in those after the first aging treatment,***,the friction co.fficient and wear rate in the as-deposited sample decreased from 0.5160 and 2.36×10^(–6)mm^(−3)N^(−1)m^(−1)to 0.4244 and 1.04×10^(–6)mm^(−3)N^(−1)m^(−1),***,the distribution of carbides inside the crystals was not *** seco.d aging treatment adjusted the morphology of carbide precipitation and made it more uniform,but the precipitation of carbides grew and settled at the bottom of the grain *** hardness decreased to 533±6.7 HV co.pared with that with the first aging treatment,but the ultimate tensile strength and plasticity reached a balance(1807 MPa,14.05%).Acco.dingly,the friction co.fficient and wear rate also showed a stable and decreasin

关键词： Selective laser melting H13 steel Solution aging Double aging Friction and wear Retained austenite

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Evolutionary Multi-Tasking Optimization for High-Efficiency Time Series Data Clustering

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Tsinghua Science and Technology 2024年第2期29卷 343-355页

作者： Rui Wang Wenhua Li Kaili Shen Tao Zhang Xiangke Liao Xiangjiang Laboratory Changsha 410205China co.lege of Systems Engineering National University of Defense TechnologyChangsha 410073China Ant group co. Ltd.Hangzhou 310000China co.lege of co.puter Science and Technology NUDTChangsha 410073China

Time series clustering is a challenging problem due to the large-volume,high-dimensional,and warping characteristics of time series *** clustering methods often use a single criterion or distance measure,which may not capture all the features of the *** paper proposes a novel method for time series clustering based on evolutionary multi-tasking optimization,termed i-MFEA,which uses an improved multifactorial evolutionary algorithm to optimize multiple clustering tasks simultaneously,each with a different validity index or distance ***,i-MFEA can produce diverse and robust clustering solutions that satisfy various preferences of *** on two artificial datasets show that i-MFEA outperforms single-objective evolutionary algorithms and traditional clustering methods in terms of co.vergence speed and clustering *** paper also discusses how i-MFEA can address two long-standing issues in time series clustering:the choice of appropriate similarity measure and the number of clusters.

关键词： time series clustering evolutionary multi-tasking multifactorial optimization clustering validity index distance measure

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A review on the chemical speciation and influencing factors of heavy metals in Municipal Solid Waste landfill humus

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Waste Disposal and Sustainable Energy 2024年第2期6卷 209-218页

作者： Qiongyu Sun Bo Sun Defeng Wang Yuyuan Pu Mingxiu Zhan Xu Xu Jinqing Wang Wentao Jiao co.lege of Metrology and Measurement Engineering China Jiliang UniversityHangzhou 310018Zhejiang ProvinceChina Zhongke Hualu Soil Remediation Engineering co. LtdDezhou 253011Shandong ProvinceChina Zhejiang Environmental Protection group co. LtdHangzhou 310020Zhejiang ProvinceChina Institute for Thermal Power Engineering Zhejiang UniversityHangzhou 310027Zhejiang ProvinceChina Research Center for Eco.Environmental Sciences Chinese Academy of SciencesHaidian District18 Shuangqing RoadBeijing 100085China

Heavy metal pollution in landfill humus can cause serious environmental problems and may endanger soil eco.ystems and human *** biological toxicity of heavy metals is not only related to their total amount but also influenced to a greater extent by the distribution of their chemical *** the different chemical speciation and proportions of heavy metals can provide a more co.prehensive and accurate understanding of the pollution characteristics and biological toxic-ity of heavy metals in landfill *** on a review of the relevant literature,this paper systematically summarizes the recent research status of typical heavy metal chemical speciation in landfill *** chemical speciation is diverse and *** instance,heavy metals in residual states and organically bound states have little impact on organisms,while heavy metals in exchangeable states and Fe-Mn oxide states can easily migrate and *** chemical speciation of heavy metals is affected by many factors,among which the soil pH and organic matter co.tent are some of the most important ***,the existing gaps in the current research on the chemical speciation of heavy metals in landfills are described and future research directions are *** work provides a theoretical reference for researching the restoration of heavy metal-co.taminated humus soil and the resource utilization of humus soil.

关键词： Landflls Humus soil co.taining heavy metal-Chemical speciation Distribution characteristics Influencing factors

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