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Flexible electronics for cardiovascular healthcare monitoring

The Innovation 2023年第5期4卷 124-138页

作者： Tianqi Zhang Ning Liu Jing Xu Zeye Liu Yunlei Zhou Yicheng Yang Shoujun Li Yuan Huang Shan Jiang hangzhou ins itute of technology Xidian UniversityHangzhou 311200China Department of Gastrointestinal Surgery Hainan General HospitalHainan ffliated Hospital of Hainan Medical UniversityHaikou 570311China State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Structural Heart Disease National Center for Cardiovascular DiseaseChina&Fuwai HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBejing 100037China State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesPediatric Cardiac Surgery CenterFuwai HospitalChinese Academy ofMedical Sciencesand Peking Union Medical CollegeBejing 100037China

Cardiovascular diseases(CVDs)are one of the most urgent threats to humans worldwide,which are responsible for almost one-third of global mortality.Over the last decade,research on flexible electronics for monitoring and treatment of CVDs has attracted tremendous attention.In contrast to conventional medical instruments in hospitals that are usually bulky,hard to move,monofunctional,and time-consuming,flexible electronics are capable of continuous,noninvasive,real-time,and portable monitoring.Notable progress has been made in this emerging field,and thus a number of significant achievements and concomitant research prospects deserve attention for practical implementation.Here,we comprehensively review the latest progress of flexible electronics for CVDs,focusing on new functions provided by flexible electronics.First,the characteristics of CVDs and flexible electronics and the foundation of their combination are briefly reviewed.Then,four representative applications of flexible electronics for CVDs are elaborated:blood pressure(BP)monitoring,electrocardiogram(ECG)monitoring,echocardiogram monitoring,and direct epicardium monitoring.Their operational principles,progress,merits and demerits,and future efforts are discussed.Finally,the remaining challenges and opportunities for flexible electronics for cardiovascular healthcare are outlined.

关键词： electronics monitoring consuming

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Correlation between Toll-like Receptor Gene Polymorphisms and Idiopathic Nephrotic Syndrome in Chinese Children

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当代医学科学(英文) 2023年第3期43卷 585-591页

作者： Hui-hui GAO Wei LI Xin-yi SHOU Jian-hua MAO Department of Pediatric and Adolescent Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Clinical Laboratory Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Nephrology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

Objective Idiopathic nephrotic syndrome(ins)is the most common glomerular disease in children.Toll-like receptors(TLRs)have been reported to be associated with response to steroid treatment in children with ins.Nevertheless,the correlation between TLR genes and the progression of ins has not yet been clarified.The present study aimed to investigate the association of single-nucleotide polymorphisms(SNPs)in TLR2,TLR4,and TLR9 with susceptibility to ins as well as the clinical phenotyping of steroid responsiveness in Chinese children with ins.Methods A total of 183 pediatric inpatients with ins were included and given standard steroid therapy.Based on their clinical response to steroids,the patients were classified into three groups:steroid-sensitive nephrotic syndrome(SSNS),steroid-dependent nephrotic syndrome(SDNS),and steroid-resistant nephrotic syndrome(SRNS).A total of 100 healthy children were employed as controls.The blood genome DNA was extracted from each participant.Six SNPs(rs11536889,rs1927914,rs7869402,rs11536891,rs352140,and rs3804099)in TLR2,TLR4,and TLR9 were selected and detected by multiplex polymerase chain reaction with next-generation sequencing to assess TLR gene polymorphisms.Results Among the 183 patients with ins,89(48.6%)had SSNS,73(39.9%)had SDNS,and 21(11.5%)had SRNS.No significant difference was found in the genotype distribution between healthy children and patients with ins.However,the genotype and allele frequencies of TLR4 rs7869402 were significantly different between SRNS and SSNS.Compared with patients with the C allele and CC genotype,patients with the T allele and CT genotype had an increased risk of SRNS.Conclusion TLR4 rs7869402 affected the steroid response in Chinese children with ins.It might be a predictor for the early detection of SRNS in this population.

关键词： children idiopathic nephrotic syndrome polymorphisms Toll-like receptor genes steroid resistance

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T-cell and B-cell repertoire diversity are selectively skewed in children with idiopathic nephrotic syndrome revealed by high-throughput sequencing

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World Journal of Pediatrics 2023年第3期19卷 273-282页

作者： Qing Ye Dong-Jie Wang Bing Lan Jian-Hua Mao Department of Clinical Laboratory Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052China Department of Nephrology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052China

Background Clinical studies suggest that the dysfunction of T cells and B cells may play an essential role in the pathogenesis of idiopathic nephrotic syndrome(ins),but laboratory evidence is lacking.Therefore,this study explored T-cell receptor(TCR)and B-cell receptor(BCR)profiling in children with idiopathic nephrotic syndrome.Methods High-throughput sequencing technology was used to profile the TCR and BCR repertoires in children with ins.Peripheral blood was collected from ten ins patients,including five vinculin autoantibody-positive patients and five vin-culin autoantibody-negative patients,before and after treatment.TCR and BCR libraries were constructed by 5'-RACE and sequenced by a DNBSEQ-T7 sequencer,and sequence analyses were performed using ReSeqTools,FastP,MiXCR,and VDJtools.Results The TRA(T-cell receptorα),TRG(T-cell receptor y),and IGH(immunoglobulin heavy chain)repertoires of the ins group were occupied by highly abundant clonotypes,whereas small clonotypes occupied the healthy group,especially TRA.A significant increase in the Shannon-Weaver index was observed for the TRA and TRG repertoires after treatment in vinculin autoantibody-negative patients,but a significant increase in the IGH repertoire after treatment was observed in vinculin autoantibody-positive patients.The frequency of some V-J pairs was significantly enriched in steroid-sensitive nephrotic syndrome patients.The usage frequency of the V and J genes was skewed in patients,which seemed not related to immunosuppressive therapy.However,after effective treatment,dynamic changes in the size of the individual clonotype were observed.Conclusion T-cell and B-cell immunity contribute to the pathogenesis of different inss.

关键词： B-cell receptor repertoire Complementary determining region 3 Idiopathic nephrotic syndrome T-cell receptor repertoire

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Unveiling the grain boundary-related effects on the incipient plasticity and dislocation behavior in nanocrystalline CrCoNi medium-entropy alloy

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Journal of Materials Science & technology 2022年第32期127卷 98-107页

作者： Shuo Sun Yang Yang Chenxu Han Guixun Sun Yan Chen Hongxiang Zong Jiangjiang Hu Shuang Han Xiaozhou Liao Xiangdong Ding Jianshe Lian Key Laboratory of Automobile Materials Ministry of EducationCollege of Materials Science and EngineeringJilin UniversityChangchun 130025China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310014China School of Aerospace Mechanical and Mechatronic EngineeringThe University of SydneySydneyNSW 2006Australia

The incipient plasticity and dislocation behavior in a nanocrystalline(NC)CrCoNi medium-entropy alloy were systematically investigated in terms of pop-in events during instrumental nano-indentation tests.Quantitative statistical analysis and molecular dynamic simulations were performed to reveal the effects of grain boundaries(GBs)on initial stages of plastic deformation.Multiple pop-in events appeared during loading on the NC CrCoNi.The first pop-in that represents the initial yielding was identified to be controlled by dislocation nucleation,which is in sharp contrast to the continuous elastic-plastic transition mediated by GB mechanisms in NC pure metals.This can be attributed to the sluggish kinetics of the chemically complex GBs(CCGBs)in the NC CrCoNi that hinders diffusive GB activities but facilitates dislocation nucleation.Subsequent pop-ins were also found to be closely related to the extra dragging effects imposed by the CCGBs on dislocation propagation in the NC alloy.Moreover,the extremely small grain sizes and the consequent high-volume fraction of GBs in the NC alloy severely restrict the lengths of dislocation source and the radii of dislocation loop,giving rise to a higher critical stress,smaller activation volume and lower pop-in width as compared with its coarse-grained counterpart.These results provide new insights into the onset of nano-plasticity in concentrated multi-principal element alloys.

关键词： Medium-entropy alloy Nanocrystalline Nanoindentation Incipient plasticity Grain boundary

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rGO空间限域生长超薄ins纳米片用于构建高效准一维SbSe基异质结光阴极(英文)

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Science China Materials 2022年

作者：成宇飞孙倩李秋洁张文婉刘恩周樊君谢海姣苗慧胡晓云 School of Chemical Engineering Northwest University School of Physics Northwest University hangzhou Yanqu Information technology Co. Ltd.

硒化锑(SbSe)属于窄带隙半导体材料,具有良好的光吸收特性,已逐渐应用于光电催化领域.独特的一维(SbSe)n带状结构单元连接方式,使其载流子传输具有高度各向异性.本文通过气相输运沉积法和原位水热法成功构建了还原氧化石墨烯(rGO)修饰...

硒化锑(SbSe)属于窄带隙半导体材料,具有良好的光吸收特性,已逐渐应用于光电催化领域.独特的一维(SbSe)n带状结构单元连接方式,使其载流子传输具有高度各向异性.本文通过气相输运沉积法和原位水热法成功构建了还原氧化石墨烯(rGO)修饰的准一维SbSe@ins光陷阱异质结.研究结果表明,在rGO空间限域效应下,原位生长的非层状ins纳米片厚度从30 nm减小到10 nm,显著增加了光电极的电化学活性比表面积,进一步增强了光陷阱纳米结构对光的捕获能力. rGO和超薄ins纳米片共同修饰的准一维毛刷状SbSe@ins-rGO纳米棒光电极在0 V(相对于可逆氢电极)的外加偏压下,光电流密度可达1.169 mA cm,约是SbSe@ins和单体SbSe的2倍和16倍,且稳定性良好,在中性条件下平均产氢速率为16.59μmol cmh.实验结果和理论计算均表明, II型异质结电荷传输方式是其光电化学增强的物理机制.以上工作为设计基于rGO修饰的复合光电极用于光电化学领域的研究提供了崭新的思路.

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The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility

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Science China(Life Sciences) 2023年第7期66卷 1459-1481页

作者： Xin Wang Di-Hang Lin Yue Yan An-Hui Wang Jiaoyang Liao Qian Meng Wen-Qing Yang Heng Zuo Min-Min Hua Fengjuan Zhang Hongwen Zhu Hu Zhou Tian-Yu Huang Rui He Guangyong Li Yue-Qiu Tan Hui-Juan Shi Lan-Tao Gou Dangsheng Li Ligang Wu Yonggang Zheng Xiang-Dong Fu Jinsong Li Rujuan Liu Guo-Hui Li Mo-Fang Liu Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310024China State Key Laboratory of Molecular Biology State Key Laboratory of Cell BiologyShanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai200031China Laboratory of Molecular Modeling and Design State Key Laboratory of Molecular Reaction DynamicsDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Life Science and technology ShanghaiTech UniversityShanghai201210China NHC Key Lab of Reproduction Regulation(Shanghai institute for Biomedical and Pharmaceutical Technologies) Fudan UniversityShanghai200032China Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education School of Basic Medical SciencesNingxia Medical UniversityYinchuan750004China Department of Urology General Hospital of Ningxia Medical UniversityNingxia Medical UniversityYinchuan750004China institute of Reproductive and Stem Cell Engineering College of Basic of MedicineCentral South UniversityChangsha410000China Department of Physiology Howard Hughes Medical InstituteUniversity of Texas Southwestern Medical CenterDallasTX75390USA Westlake Laboratory of Life Sciences and Biomedicine School of Life SciencesWestlake UniversityHangzhou310024China

PIWI-clade proteins harness pi RNAs of 24–33 nt in length.Of great puzzles are how PIWI-clade proteins incorporate pi RNAs of different sizes and whether the size matters to PIWI/pi RNA function.Here we report that a PIWI-ins module unique in PIWIclade proteins helps define the length of pi RNAs.Deletion of PIWI-ins in Miwi shifts MIWI to load with shorter pi RNAs and causes spermiogenic failure in mice,demonstrating the functional importance of this regulatory module.Mechanistically,we show that longer pi RNAs provide additional complementarity to target m RNAs,thereby enhancing the assembly of the MIWI/e IF3f/Hu R super-complex for translational activation.Importantly,we identify a c.1108C>T(p.R370W)mutation of HIWI(human PIWIL1)in infertile men and demonstrate in Miwi knock-in mice that this genetic mutation impairs male fertility by altering the property of PIWI-ins in selecting longer pi RNAs.These findings reveal a critical role of PIWI-ins-ensured longer pi RNAs in fine-tuning MIWI/pi RNA targeting capacity,proven essential for spermatid development and male fertility.

关键词： PIWI piRNAs PIWI-ins translational activation spermatid development male fertility

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A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-ins29, Leads to a Hypothesis of Viral Transmission in South China

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Genomics, Proteomics & Bioinformatics 2003年第2期1卷 101-107页

作者： E‘deQin XiongleiHe WeiTian YongLiu WeiLi JieWen Bingyinsi YongwuHu WenmingPeng LinTaug TaoJiang JianpingShi JiaJia YuZhang JiaYe Cui’eWang YujunHan JingqiangWang BaochangFan QingfaWu GuohuiChang WuchunCao ZuyuanXu RuifuYang JmgWang ManYu YanLi JingXu JunZhou YajumDeng XiaoyuLi JianfeiHu CaipingWang ChunxiaYan QingrunZhang JingyueBao GuoqingLi HaiqingZhang YilinZhang HuiZhao XiaoweiZhang ShuangliLi XiaoJieCheng XiuqingZhang BinLiu ChangqingZeng HuanmingYang WeijunChen LinFang ChangfengLi MengLei DaweiLi WeiTong XiangjunTian JianWang BoZhang SonggangLi XuehaiTan SiqiLiu WeiDong JunWang GaneKa-ShuWong JunYu QingyuZhu instituteofMicrobiologyandEpidemiology ChineseAcademyofMilitaryMedicalSciencesBeijing100071China BeijingGenomicsinstitute ChineseAcademyofSciencesBeijing101300JamesD.WatsonInstituteofGenomeSciencesZhijiangCampusZhejiangUniversityHangzhou310008China

We report a complete genomic sequence of rare isolates (minor genotype) of the SARS-CoV from SARS patients in Guangdong, China, where the first few cases emerged. The most striking discovery from the isolate is an extra 29-nucleotide sequence located at the nucleotide positions between 27,863 and 27,864 (referred to the complete sequence of BJ01) within an overlapped region composed of BGI-PUP5 (BGI-postulated uncharacterized protein 5) and BGI-PUP6 upstream of the N (nucleocapsid) protein. The discovery of this minor genotype, GD-ins29, suggests a significant genetic event and differentiates it from the previously reported genotype, the dominant form among all sequenced SARS-CoV isolates. A 17-nt segment of this extra sequence is identical to a segment of the same size in two human mRNA sequences that may interfere with viral genome replication and transcription in the cytosol of the infected cells. It provides a new avenue for the exploration of the virus-host interaction in viral evolution, host pathogenesis, and vaccine development.

关键词： Severe Acute Respiratory Syndrome (SARS) genotype GD-ins29

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Complete Genome Sequences of the SARS-CoV: the BJ Group (Isolates BJ01-BJ04)

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Genomics, Proteomics & Bioinformatics 2003年第3期1卷 180-192页

作者： ShengliBi E‘deQin ZuyuanXu WeiLi JingWang YongWuHu YongLiu ShuminDuan JianfeiHu YujunHan JingXu YanLi YaoYi YongdongZhou WeiLin1 JieWen HongXu RuanLi ZizhangZhang HaiyanSun JinguiZhu ManYu BaochangFan QingfaWu WeiLin2 LinTang Bao’anYang GuoqingLi WenmingPeng WenjieLi TaoJiang YajunDeng BohuaLiu JianpingShi YongqiangDeng WeiWei HongLiu ZongzhongTong FengZhang YuZhang Cui‘eWang YuquanLi JiaYe YonghuaGan JiaJi XiaoyuLi XiangjunTian FushuangLu GangTan RuifuYang BinLiu SiqiLiu SonggangLi JunWang JianWang WuchunCao JunYu XiaopingDong HuanmingYang CenterofDiseaseControlandPrevention Beijing100050China instituteofMicrobiologyandEpidemiology ChineseAcademyofMilitaryMedicalSciencesBeijing100071China JamesD.WatsoninstituteofGenomeSciences ZhijiangCampusZhejiangUniversityandHangzhouGenomicsInstituteHangzhou310008China BeijingGenomicsinstitute ChineseAcademyofSciencesBeijing101300China CollegeofLifeSciences PekingUniversityBeijing100871China WenzhouMedicalCollege Wenzhou325003China PekinaUnionMedicalColleqeHospital ChineseAcademyofMedicalSciencesBeijing100730China CollegeofMaterialsScienceandChemicalEngineering YuquanCampusZhejiangUniversityHangzhou310027China

Beijing has been one of the epicenters attacked most severely by the SARS-CoV (severe acute respiratory syndrome-associated coronavirus) since the first patient was diagnosed in one of the city's hospitals. We now report complete genome sequences of the BJ Group, including four isolates (Isolates BJ01, BJ02, BJ03, and BJ04) of the SARS-CoV.It is remarkable that all members of the BJ Group share a common haplotype, consisting of seven loci that differentiate the group from other isolates published to date. Among 42 substitutions uniquely identified from the BJ group, 32 are non-synonymous changes at the amino acid level. Rooted phylogenetic trees, proposed on the basis of haplotypes and other sequence variations of SARS-CoV isolates from Canada, USA, Singapore, and China, gave rise to different paradigms but positioned the BJ Group, together with the newly discovered GD01 (GD-ins29) in the same clade, followed by the H-U Group (from Hong Kong to USA) and the H-T Group (from Hong Kong to Toronto), leaving the SP Group (Singapore) more distant. This result appears to suggest a possible transmission path from Guangdong to Beijing/Hong Kong, then to other countries and regions.

关键词： SARS SARS-CoV haplotype substitution phylogeny

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Asynchronous Fusion in Positioning of Mobile Robot based on Vision-aided Inertial Navigation

Asynchronous Fusion in Positioning of Mobile Robot based on ...

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第36届中国控制会议

作者： Dai Yating Cheng Lei Peng Rui Nong Xiaoqi Xu Wenxia Chen Yang Wu Huaiyu Wu Qiuxuan School of information science and engineering Wuhan university of science and technology School of automation Hangzhou dianzi university School of computer science and engineering Wuhan institute of technology

ISBN: (纸本)9781538629185

This paper presents a binocular vision-aided inertial navigation system of mobile robot for positioning and navigation in the GPS-denied environment with fuzzy map.The system consists of two common cameras and a low-cost inertial measurement unit（IMU）.The stereo camera inertial measurement unit（SC-IMU） hardware is designed and fixed on the mobile robot to collect related data.A novel fusion method is proposed according to the two modules operating at different data rates,which fuses the current position of robot acquired by the IMU and the binocular camera system,and achieves the intermittent correction for the localization of inertial navigation system（ins）.We show experimental results to validate the reliability and effectiveness of the proposed algorithm.

关键词： Mobile robot Stereo vision Asynchronous Kalman filter Vision-aided inertial navigation system

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