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China CDC weekly 2023年第35期5卷 767-772,I0001页

作者： Yuan Li Suhong Gao Jiamei Wang Hang An Le Zhang Yali Zhang Xiaohong Liu Zhiwen Li Institute of Reproductive and Child Health Peking University/Key Laboratory of Reproductive HealthNational Health Commission of the People’s Republic of ChinaBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Child Health Beijing Haidian Maternal and Child Health HospitalBeijingChina Department of Gynaecology and Obstetrics Beijing Haidian Maternal and Child Health HospitalBeijingChina

Summary What is already known about this topic?Interpregnancy intervals(IPIs)that are either excessively long or short have been linked with an elevated risk of adverse perinatal ***,no pertinent guidelines have been established in China to provide clear direction with regard to optimal *** is added by this report?A brief interpregnancy interval may elevate the risk of miscarriage,postpartum hemorrhage,and fetal distress among expectant *** are the implications for public health practice?

关键词： pregnancy elevated distress

Investigation on Mental Health Status among High School Students at Grade 3 in haidian district of Beijing

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Journal of Contemporary Educational Research 2019年第5期3卷 15-19页

作者： Mohan Li Yonggang Li Baohua Zhang Beijing No.20 High School Haidian DistrictBeijing100085China

*** understand and analyze the mental health status of key Senior School Students at grade 3 in haidian district of Bey ing and Senior Three Students in General Schools,so as to provide basis for mental health education and psychological ***.A total of 263 senior three students were randomly selected from a general school and two key school in haidian district of Beijing.A questionnaire survey was conducted using the Mental Health Scale for Chinese Middle School Students(MSSMHS).*** the 260 students surveyed,54.2%had mental health problems,36.5%had mild problems,8.8%had moderate problems,and 0.5%had slightly and deeply serious *** first three factors about examined rates of factors of mental health were anxiety,learning and interpersonal *** detection rates accounted for 23.5%,23.1%and 18.8%*** was no significant difference in the scores of each factor between key and ordinary middle school students(P>0.05).The scores of interpersonal,depression,anxiety and emotional factors of middle school girls were higher than those of boys,with statistical significance(Phaidian district of Beijing,and female students9 are ***,families and societies should pay attention to this problem and strengthen mental health education with a focused goal.

关键词： Mental health Middle school students haidian district,Beijing,MSSMHS

Trends in the Prevalence of Births with Chromosomal Abnormalities—haidian district,Beijing Municipality,China,2013–2022

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China CDC weekly 2023年第36期5卷 791-796页

作者： Shuangbo Xia Chao Meng Xiao Cheng Duoduo Wang Yaxian Wu Zhiwen Li Yuan Wei Jufen Liu Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health Peking UniversityBeijingChina Department of Maternal Health Care Beijing Haidian Maternal and Child Health HospitalBeijingChina Department of Gynaecology and Obstetrics Peking University Third HospitalBeijingChina

Summary What is already known about this topic?The primary causes of early miscarriage and stillbirth are chromosomal abnormalities(CAs)whose prevalence has been observed to increase in recent *** is added by this report?According to data received from a hospital-based birthdefect surveillance system in the haidian district,Beijing,there was a significant increase in the prevalence of CAs along with most subtypes from 2013 to 2022.

关键词： Beijing district birth

A Hospital-Based Study on Congenital Heart Defects—haidian district,Beijing Municipality,China,2013–2022

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China CDC weekly 2023年第36期5卷 809-814页

作者： Yaxian Wu Chao Meng Jufen Liu Yuan Wei Zhiwen Li Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health Peking UniversityBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Maternal Health Care Beijing Haidian Maternal and Child Health HospitalBeijingChina Department of Gynaecology and Obstetrics Peking University Third HospitalBeijingChina

Summary What is already known about this topic?Congenital heart defects(CHDs)represent the most prevalent birth defects in China,exhibiting significant mortality and morbidity *** years have witnessed a steady increas... 详细信息

关键词： Congenital mortality rigorous

Alignment error modeling and control of a double-sided microlens array during precision glass molding

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Microsystems & Nanoengineering 2024年第2期10卷 311-322页

作者： Zihao Zeng Tianfeng Zhou Qian Yu Jia Zhou Gang Wang Qiuchen Xie Zifan Wang Xiaoqiang Yao Yubing Guo School of Medical Technology Beijing Institute of TechnologyNo.5 Zhongguancun South StreetHaidian DistrictBeijing100081China School of Mechanical Engineering Beijing Institute of TechnologyNo.5 Zhongguancun South StreetHaidian DistrictBeijing100081China

Double-sided microlens arrays(DSMLAs)include combinations of two single-sided MLAs to overcome positioning errors and greatly improve light transmissivity compared to other types of *** glass molding(PGM)is used to fabricate DSMLAs,but controlling alignment errors during this process is *** this paper,a mold assembly was manufactured with a novel combination of materials to improve the alignment accuracy of mold cores during PGM by using the nonlinear thermal expansion characteristics of the various materials to improve the DSMLA alignment *** establishing a mathematical model of the DSMLA alignment error and a thermal expansion model of the mold-sleeve pair,the relationship between the maximum alignment error of the DSMLA and the mold-sleeve gap was *** research provides a method to optimize the mold-sleeve gap and minimize the alignment error of the *** measured DSMLA alignment error was 10.56μm,which is similar to the predicted maximum alignment *** measurements showed that the uniformity of the homogenized beam spot was 97.81%,and the effective homogeneous area accounted for 91.66%of the total *** proposed method provides a novel strategy to improve the performance of DSMLAs.

关键词： sided alignment error

Study on damage mechanism and damage distribution of the rear plate under impact of debris cloud

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Defence Technology（防务技术） 2024年第5期35卷 151-167页

作者： Chenyang Wu Xiaowei Chen Qiguang He State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyHaidian DistrictBeijing 100081China School of Mechatronical Engineering Beijing Institute of TechnologyHaidian DistrictBeijing 100081China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621900SichuanChina

The debris cloud generated by the hypervelocity impact(HVI)of orbiting space debris directly threatens the spacecraft.A full understanding of the damage mechanism of rear plate is useful for the optimal design of protective *** this study,the hypervelocity yaw impact of a cylindrical aluminum projectile on a double-layer aluminum plate is simulated by the FE-SPH adaptive method,and the damage process of the rear plate under the impact of the debris cloud is analyzed based on the debris cloud *** damage process can be divided into the main impact stage of the debris cloud and the structural response of the rear *** main impact stage lasts a short time and is the basis of the rear plate *** the stage of structure response,the continuous deformation and inertial motion of the rear plate dominate the perforation of the rear *** further analyze the damage mechanism and damage distribution characteristics of the rear plate in ***,the connection between velocity space and position space of the debris cloud is established,which promotes the general analysis of the damage law of debris *** on the relationship,the features of typical damage areas are identified by the localized fine *** the cumulative effect and structural response cause the perforation of rear plate;in the non-perforated area,cratering by the impact of hazardous fragments is the main damage mode of the rear plate.

关键词： Damage of rear plate Debris cloud Secondary impact Hypervelocity yaw impact FE-SPH adaptive method

Molecular Mechanisms of Intracellular Delivery of Nanoparticles Monitored by an Enzyme‑Induced Proximity Labeling

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Nano-Micro Letters 2024年第6期16卷 14-37页

作者： Junji Ren Zibin Zhang Shuo Geng Yuxi Cheng Huize Han Zhipu Fan Wenbing Dai Hua Zhang Xueqing Wang Qiang Zhang Bing He Department of Pharmaceutics School of Pharmaceutical Sciences Peking University38 Xueyuan RdHaidian DistrictBeijing 100191People’s Republic of China

Achieving increasingly finely targeted drug delivery to organs,tissues,cells,and even to intracellular biomacromolecules is one of the core goals of *** the delivery destination is refined to cellular and subcellular targets,it is essential to explore the delivery of nanomedicines at the molecular ***,due to the lack of technical methods,the molecular mechanism of the intracellular delivery of nanomedicines remains unclear to ***,we develop an enzyme-induced proximity labeling technology in nanoparticles(nano-EPL)for the real-time monitoring of proteins that interact with intracellular ***(lactic-co-glycolic acid)nanoparticles coupled with horseradish peroxidase(HRP)were fabricated as a model(HRP(+)-PNPs)to evaluate the molecular mechanism of nano delivery in *** adding the labeling probe biotin-phenol and the catalytic substrate H_(2)O_(2)at different time points in cellular delivery,nano-EPL technology was validated for the real-time in situ labeling of proteins interacting with ***-EPL achieves the dynamic molecular profiling of 740 proteins to map the intracellular delivery of HRP(+)-PNPs in macrophages over *** on dynamic clustering analysis of these proteins,we further discovered that different organelles,including endosomes,lysosomes,the endoplasmic reticulum,and the Golgi apparatus,are involved in delivery with distinct participation *** importantly,the engagement of these organelles differentially affects the drug delivery efficiency,reflecting the spatial–temporal heterogeneity of nano delivery in *** summary,these findings highlight a significant methodological advance toward understanding the molecular mechanisms involved in the intracellular delivery of nanomedicines.

关键词： Enzyme-induced proximity labeling Intracellular delivery Nano-protein interaction Dynamic molecule profiling Macrophages

Perinatal prevalence of birth defects in the Mainland of China,2000–2021:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第7期20卷 669-681页

作者： Liang-Yu Kang Zi-Rui Guo Wei-Jing Shang Gui-Ying Cao Yi-Ping Zhang Qiao-Mei Wang Hai-Ping Shen Wan-Nian Liang Min Liu Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityNo.38Xueyuan RoadHaidian DistrictBeijing100191China Vanke School of Public Health Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Department of Maternal and Child Health National Health Commission of the People’s Republic of ChinaNo.1Xizhimenwai South RoadXicheng DistrictBeijingChina Institute of Healthy China Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of Education BeijingNo.38Xueyuan RoadHaidian DistrictBeijing100191China

Background Although birth defects are of great concern globally,the latest national prevalence has not yet been quantified in *** conducted a systematic review and meta-analysis to estimate the perinatal prevalence of birth defects in the Mainland of China between 2000 and *** We performed a systematic literature search of six databases for relevant articles published between January 1,2000,and March 1,*** included published studies that reported data on the perinatal prevalence of birth defects in the Mainland of *** DerSimonian and Laird random-effects models were used to estimate the pooled prevalence and its 95%confidence interval(CI).We also conducted subgroup analyses and univariable meta-regressions to explore differences in prevalence by time period,geographic region,and other *** We included 254 studies reporting the perinatal prevalence of birth defects and 86 studies reporting only the prevalence of specific types of birth *** on 254 studies covering 74,307,037 perinatal births and 985,115 cases with birth defects,the pooled perinatal prevalence of birth defects was 122.54(95%CI 116.20–128.89)per 10,000 perinatal births in the Mainland of China during 2000–***,the perinatal prevalence of birth defects increased from 95.60(86.51–104.69)per 10,000 in 2000–2004 to 208.94(175.67–242.22)per 10,000 in 2020–*** were also significant disparities among different geographical *** heart defects(33.35 per 10,000),clefts of the lip and/or palate(13.52 per 10,000),polydactyly(12.82 per 10,000),neural tube defects(12.82 per 10,000),and inborn errors of metabolism(11.41 per 10,000)were the five most common types of birth *** perinatal prevalence among males was significantly higher than that among females(β=2.44×10^(−3),P=0.003);a higher perinatal prevalence of birth defects was observed among perinatal births whose mothers were≥35 years(β=4.34×10^(−3),P<0.001).Conclusion Compreh

关键词： Birth defects China Perinatal Prevalence

Coordinated Capacitor Voltage Balancing Method for Cascaded H-bridge Inverter with Supercapacitor and DC-DC Stage

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CES Transactions on Electrical Machines and Systems 2024年第2期8卷 191-201页

作者： Ye Zhang Zixin Li Fanqiang Gao Cong Zhao Yaohua Li IEEE Key Laboratory of High Density Electromagnetic Power and Systems(Chinese Academy of Sciences) Institute of Electrical EngineeringChinese Academy of SciencesHaidian District University of Chinese Academy of Sciences Shijingshan District

Cascaded H-bridge inverter(CHBI) with supercapacitors(SCs) and dc-dc stage shows significant promise for medium to high voltage energy storage applications. This paper investigates the voltage balance of capacitors within the CHBI, including both the dc-link capacitors and SCs. Balance control over the dc-link capacitor voltages is realized by the dcdc stage in each submodule(SM), while a hybrid modulation strategy(HMS) is implemented in the H-bridge to balance the SC voltages among the SMs. Meanwhile, the dc-link voltage fluctuations are analyzed under the HMS. A virtual voltage variable is introduced to coordinate the balancing of dc-link capacitor voltages and SC voltages. Compared to the balancing method that solely considers the SC voltages, the presented method reduces the dc-link voltage fluctuations without affecting the voltage balance of SCs. Finally, both simulation and experimental results verify the effectiveness of the presented method.

关键词： Cascaded H-bridge inverter(CHBI) Hybrid modulation strategy(HMS) Capacitor voltage balancing DClink voltage fluctuation Supercapacitor(SC)

The Chinese Reception of Western Marxism:From Wary Onlookers to Confident Participants on the World Stage

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Fudan Journal of the Humanities and Social Sciences 2024年第1期17卷 1-22页

作者： Roland Boer School of Philosophy Renmin University of China59 Zhongguancun StreetHaidian DistrictBeijing 100872China

This study presents an analytic overview of forty years of study of Western Marxism by Chinese *** into four main sections,it begins with an emphasis on the wider institutional context of this Chinese ***,I deal with the beginnings of research on Western Marxism in China and outline the two main periods of this research,which turn on the important educational reforms of *** next section focuses on the initial period of research on Western Marxism,from the early 1980s to the education reforms,which may be characterised in terms of the work of“wary onlookers”writing introductions and surveys of Western Marxist *** following section covers the last two decades after the 2005 education *** period is of most interest,so more attention is devoted to developments during this *** has been a time of increasingly confident participants on the world stage,who focus on core issues,realistic demands,and problem-based *** final section concerns assessments of the limitations of Western Marxism,which have been identified through the in-depth research of the second *** conclusion,while Western Marxism may be seen as a legitimate development of Marxism in a capitalist context,it is a tributary from the mainstream.

关键词： Western Marxism Chinese scholarship 2005 education reforms Wary onlookers Confident global participants Mainstream and tributary