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Levels of plasma des-γ-carboxy protein C and prothrombin in patients with liver diseases

World Journal of Gastroenterology 2004年第20期10卷 3073-3075页

作者： Xiao-FanHe Zhi-Binwen Min-JuanLiu HuiZhang QunLi Shi-LinHe haemostasisphysiologylaboratory DepartmentofPhysiologyXiangyaMedicalCollegeCentralSouthUniversityChangsha410078HunanProvinceChina SecondAffiliatedHospitalofGuangzhouMedicalCollege Guangzhou510260GuangdongProvinceChina XiangyaHospital CentralSouthUniversityChangsha410008HunanProvinceChina

AIM: To study the plasma des-γ-carboxy protein C activity, antigen and prothrombin levels in patients with liver diseases and their clinical significance. METHODS: Plasma protein C activity (PC:C) was detected by chromogenic assay and antigen (PC:Ag) and des-γ-carboxy protein C (DCPC) were detected by ELISA. Total prothrombin and unabsorbed prothrombin in plasma were detected by ecarin chromogenic assay. RESULTS: Compared with the control, the levels of PC:C and PC:Ag in patients with hepatocellular carcinoma (HCC) and liver cirrhosis (LC) were lower (PCC: 104.65±23.0%,62.50±24.89%, 56.75±20.14%, PC:Ag: 5.31±1.63 μg/mL, 2.28±1.15 μg/mL, 2.43±0.79 μg/mL, P0.05). The levels of DCPC in patients with HCC were remarkably higher (0.69±0.29 μg/mL,1.18±0.63 μg/mL, 0.45±0.21 μg/mL, P<0.05) and its averagewas up to 50% of total PC:Ag. But those of DCPC in patients with AVH were not significantly different from the control. The levels of total prothrombin were lower in patients with LC, but higher in patients with HCC. The levels of unabsorbed prothrombin were predominantly higher than those of other groups. CONCLUSION: PC:C and PC:Ag in patients with liverdiseases (except PC:C in AVH) were lower. The total prothrombin was lower in patients with LC. The higher level of unabsorbed prothrombin may be used as a scanning marker for HCC. DCPC may be used as a complementary marker in the diagnosis of HCC.

关键词：血浆脱-γ-羧基蛋白质C 凝血素肝脏疾病肝癌肿瘤

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