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CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO SUN QINGHUA SONG HUA LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

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Treatment implications of posterior fossa ependymoma subgroups

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Chinese Journal of Cancer 2016年第11期35卷 563-566页

作者： Vijay Ramaswamy Michael D.Taylor Division of haematology/Oncology Hospital for Sick Children Division of Neurosurgery Hospital for Sick Children

Posterior fossa ependymoma comprises two distinct molecular entities,ependymoma_posterior fossa A(EPN_PFA)and ependymoma_posterior fossa B(EPN_PFB),with differentiable gene expression *** yet,the response of the two entities to treatment is *** determine the relationship between the two molecular subgroups of posterior fossa ependymoma and treatment,we studied a cohort of 820 patients with molecularly profiled,clinically annotated posterior fossa *** found that the strongest predictor of poor outcome in patients with posterior fossa ependymoma across the entire age spectrum was molecular subgroup EPN_PFA,which was recently reported in the paper entitled "Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era:a retrospective multicohort analysis" in the Journal ofClinical *** with incompletely resected EPN_PFA tumors had a very poor outcome despite receiving adjuvant radiation therapy,whereas a substantial proportion of patients with EPN_PFB tumors can be cured with surgery alone.

关键词： Posterior fossa ependymoma Genomics Radiation PFA

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Prenatal Diagnosis of Sirenomelia by Two-Dimensional and Three-Dimensional Skeletal Imaging Ultrasound

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2015年第6期35卷 928-931页

作者：刘蓉陈欣林杨小红马慧静 deparment of Medical Ultrasound Hubei Maternal and Children Health Hospital deparment of Medical Ultrasound the First Clinical Hospital of Three Gorges University (Yichang Central People's Hospital) Department of Computerized Tomography Wuhan Children's Hospital

Summary： This study sought to evaluate the contribution of two-dimensional ultrasound （2D-US） and three-dimensional skeletal imaging ultrasound （3D-SUIS） in the prenatal diagnosis of sirenomelia. Be- tween September 2010 and April 2014, a prospective study was conducted in a single referral center using 3D-SU1S performed after 2D-US in 10 cases of sirenomelia. Diagnostic accuracy and detailed findings were compared with postnatal three-dimensional helical computed tomography （3D-HCT）, radiological findings and autopsy. Pregnancy was terminated in all 10 sirenomelia cases, including 9 singletons and I conjoined twin pregnancy, for a total of 5 males and 5 females. These cases of sirenomelia were deter- mined by autopsy and/or chromosomal examination. Initial 2D-US showed that there were 10 cases of oligohydranmios, bilateral renal agenesis, bladder agenesis, single umbilical artery, fusion of the lower limbs and spinal abnormalities; 8 cases of dipus or monopus; 2 cases of apus; and 8 cases of cardiac abnormalities. Subsequent 3D-SUIS showed that there were 9 cases of scoliosis, l0 cases of sacrococ- cygeal vertebra dysplasia, 3 cases of hemivertebra, 1 case of vertebral fusion, 3 cases of spina bifida, and 5 cases of rib abnormalities. 3D-SUIS identified significantly more skeletal abnormalities than did 2D-US, and its accuracy was 79.5% （70/88） compared with 3D-HCT and radiography. 3D-SUIS seems to be a useful complementary method to 2D-US and may improve the accuracy of identifying prenatal skeletal abnormalities related to sirenomelia.

关键词： sirenomelia three-dimensional skeletal imaging ultrasound three-dimensional helicalcomputed tomography

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Metastatic colorectal cancer-past,progress and future

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World Journal of Gastroenterology 2007年第28期13卷 3806-3815页

作者： Kathryn Field Lara Lipton Department of Medical Oncology and Clinical haematology Western HospitalFootscray 3011VictoriaAustralia

The clinical management of metastatic （stage IV） colorectal cancer （CRC） is a common challenge faced by surgeons and physicians. The last decade has seen exciting developments in the management of CRC, with significant improvements in prognosis for patients diagnosed with stage IV disease. Treatment options have expanded from 5-fluorouracil alone to a range of pharmaceutical and interventional therapies, improving survival, and providing a cure in selected cases. Enhanced understanding of the biologic pathways most important in colorectal carcinogenesis has led to a new generation of drugs showing promise in advanced disease. It is hoped that in the near future the treatment paradigm of metastatic CRC will be analogous to that of a chronic illness, rather than a rapidly terminal condition. This overview discusses the epidemiology of advanced CRC and currently available therapeutic options including medical, surgical, ablative and novel modalities in the management of metastatic colorectal cancer.

关键词： Colorectal cancer Metastases Chemotherapy Oncology Biological therapies

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Adjuvant therapies for colorectal cancer

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World Journal of Gastroenterology 2007年第28期13卷 3799-3805页

作者： Suzanne Kosmider Lara Lipton Department of Medical Oncology and Clinical haematology Western HospitalFootscray 3011VictoriaAustralia

The management of colon and rectal cancer has changed dramatically over the last 25 years. The use of adjuvant therapies has become standard practice in locally advanced （stage M and selected stage 11） colorectal cancer. Improved surgical techniques, chemotherapeutics and radiotherapy are resulting in higher cure rates and the development of agents targeting proliferative and angiogenic pathways offer further promise. Here we explore risk factors for local and distant recurrence after resection of colon and rectal cancer, and the role of adjuvant treatments. Discussion will focus on the evidence base for adjuvant therapies utilised in colorectal cancer, and the treatment of sub-groups such as the elderly and stage 11 disease. The role of adjuvant radiotherapy in rectal cancer in reduction of recurrence will be explored and the role and optimal methods for surveillance post-curative resection with or without adjuvant therapy will also be addressed.

关键词： Colon cancer Rectal cancer Chemotherapy Radiotherapy Adjuvant treatment

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Electrochemiluminescence immunoassay method underestimates cortisol suppression in ulcerative colitis patients treated with oral prednisone

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World Journal of Gastroenterology 2014年第31期20卷 10895-10899页

作者： Francesco Manguso Raffaele Bennato Giovanni Lombardi Assunta Viola Elisabetta Riccio Livio Cipolletta Division of Gastroenterology Cardarelli Hospital Division of haematology and Stem Cell Transplantation Unit Cardarelli Hospital

AIM: To evaluate cortisolemia by using conventional electrochemiluminescence immunoassay (ECLIA) method compared to liquid chromatography-tandem mass spectrometry (LC-MS/MS) method in active ulcerative colitis (UC) pa... 详细信息

关键词： Cortisol Immunoassay Liquid chromatography Prednisone Tandem mass spectrometry Ulcerative colitis

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Effects of PPAR-y in the Myocardium on the Development of Ventricular Septation

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Current Medical Science 2020年第2期40卷 313-319页

作者： Lun ZHOU Zhao-zhao WANG Zhi-chao XIAO Ling TU deparment of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong Universiry of Science and TechnologyWthan 430030China deparment of Cardiovascular Medicine Tongji HospitalTongji Medical CollegeHuazhong Universiry of Science and TechnologyWuhan 430030China

Ventricular septum defects(VSDs)are common types of congenital heart diseases caused by developmental defect;they contribute to 25%-30%of all adult congenital heart *** peroxisome proliferator-activated receptor gamma(PPAR-y)is widely expressed in mammalian tissues and in the immune system,regulating cell differentiation and immune and inflammatory *** PPAR-y gene has recently been found crucial for heart development,but the mechanism of action is not *** study aims to investigate the effects of the PPAR-y gene in the myocardium on the development of ventricular *** this study,we applied Cre-loxP recombination enzyme(CRE)technology to downregulate the expression of the PPAR-y gene in different cardiac tissues,RT-PCR to examine the expression of the c-fos and TGF-B!genes,and histology staining to check the defect of embryonic heart at embryonic day 14.5(E14.5).We found that the downregulation of the PPAR-p gene resulted in a ventricular membranous septation defect of the embryonic heart at ***,only conversion of a Tnt:Cre,but not Mef2c:Cre,Tie2:Cre,or Wnt:Cre PPAR-T floxed allele to a null allele resulted in ***-/mi-Orv+embryos showed increascs in atrioventricular(AV)-cushion cells and the expression of c-fos gene but no change in the expression of TGF-B1 at *** study demonstrates PPAR-N in the myocardium is required for ventricular septation through regulation of AV-cushion cell proliferation by a Tntc-fos signal.

关键词： myocardium c-fos peroxisome proliferator-activated receptor-y2 ventricular septum defect

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Acute appendicitis: What is the gold standard of treatment?

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World Journal of Gastroenterology 2013年第47期19卷 8799-8807页

作者： Cesare Ruffolo Alain Fiorot Giulia Pagura Michele Antoniutti Marco Massani Ezio Caratozzolo Luca Bonariol Francesco Calia di Pinto Nicolò Bassi Ⅱ deparment of Surgery (Ⅳ Unit) Regional Hospital "Ca’ Foncello"31100 TrevisoItaly

McBurney’s procedure represented the gold-standard for acute appendicitis until 1981,but nowadays the number of laparoscopic appendectomies has progressively increased since it has been demonstrated to be a safe procedure,with excellent cosmetic results and it also allows a shorter hospitalization,a quicker and less painful postoperative *** aim of this editorial was to perform a review of the literature in order to address controversial issues in the treatment of acute appendicitis.

关键词： Acute appendicitis Surgery Laparoscopy

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Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions： finding of 18F-FDG PET/CT

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Frontiers of Medicine 2017年第3期11卷 440-444页

作者： Zhan Su Fengyu Wu Weiyu Hu Xiaodan Liu Shaoling Wu Xianqi Feng Zhongguang Cui Jie Yang Zhenguang Wang Hongzai Guan Hongguo Zhao Wei Wang Chunting Zhao jun Peng Department of haematology Qilu Hospital Shandong University Jinan 250012 China Department of haematology The Affiliated Hospital of Qingdao University Qingdao 266000 China PET/CT Center The Affiliated Hospital of Qingdao University Qingdao 266000China Department of Hepatobiliary Surgery The Affiliated Hospital of Qingdao University Qingdao 266000 China Department of haematology Qingdao University Medical College Qingdao 266071 China

Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguish from the blast phase of chronic myeloid leukemia. As a myeloid neoplasm, rare cases of this leukemia manifest multiple soft-tissue tumors or bone lyric lesions. In this paper, we describe a 49-year-old male patient who had an abrupt onset with sharp chest pain, fever, fatigue, emaciation, and splenomegaly. 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography （18F-FDG PET/CT） result showed diffuse and uneven hypermetabolic lesions in the bone marrow with peripheral bone marrow expansion, multiple soft tissue neoplasms with high 18F-FDG uptake, and lyric bone lesions. Bone marrow smear and biopsy detected aberrant blast cells expressing myeloid rather than lymphoid immunophenotype marker. For the existence of Philadelphia chromosome and BCR-ABL1 fusion gene together with complex chromosome abnormalities, a diagnosis of Philadelphia-positive acute myeloid leukemia was made, although the type （de novo or blast crisis） remained unclear.

关键词： Philadelphia chromosome acute myeloid leukemia mass osteolysis positron emission tomography

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CART trials are going ahead

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Science China(Life Sciences) 2017年第11期60卷 1276-1279页

作者： jianshu wei weidong han deparment of molecules&immunology chinese pla general hospitalmedical college of plaBeijing 100853China

For a long time,unresectable tumors were mainly controlled by chemotherapy,radiation therapy or kinase inhibitors,with which complete and durable remission was infrequent despite great advances *** recently,together with checkpoint inhibitors,chimeric antigen receptor modified T(CART)therapies have made immunotherapy percolated into the mainstream of cancer treatment due to astonishing clinical results.

关键词： CART trials going ahead

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