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Effects of the anti-tumor composition ofthe acetoacetate extract of vitex negundoseed on the growth of human cervical carcinomaxenografts in nude mice

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The Chinese-German Journal of Clinical Oncology 2014年第3期13卷 105-109页

作者： Yanlin Cai Zhongdong Chen Aiqiong Tang Bin Jiang Zhaohua Fan Jun Bai Deparetment of Gynecolgy The First Affiliated Hospital of University of South China Deparetment of Gynecolgy Hunan Provincial Maternal and Child Health Hospital Department of Plastic Surgery The Second Affiliated Hospital of University of South China Deparetment of Obstetrics and Gynecolgy Hangzhou Red Cross Hospital

Objective： The aim of our study was to investigate the effects of the anti-tumor composition of the acetoacetate extract of Vitex Negundo Seed （EVn-50） on the growth of human cervical carcinoma HeLa cells xenografts in nude mica and its possible molecular mechanism. Methods： Models of human cervical cancer HeLa cells xenografts transplanted subcuta- neously in nude mice were established and randomly divided into 7 groups （each group including 5 nude mice）： saline group, Taxol group, EVn-50 group, comp-6 group, comp-7 group, comp-8 group and comp-10 group. The volume and weight of Xe- nograts were observed and compared. The alteration of the weight of nude mice, and the change of serum levels ofLDH, ALT, Cr and WBC counts were examined and compared. The apoptotic rate of human cervical carcinoma HeLa cells xenografts was analyzed by FCM. The expressions of P53 and Bcl-2 proteins of HeLa cells xenografts were determined by Western blot- ting. Results： EVn-50 and its fractionated extracts could significantly suppress the increasing volume and weight of human cervical carcinoma HeLa cells xenografts in nude mice models in time-dependent manner, yet had no significant effect on the weight of nude mice, the serum levels of LDH, ALT, Cr and WBC were counted. When the xenografts were treated with EVn-50 and its fractionated extracts for 16 days, the apoptotic rate of xenografts cells were significantly increased, and the expression of P53 protein was up-regulated and protein level of Bcl-2 was decreased. Conclusion： EVn-50 and its fractionated extracts could suppress the growth of human cervical carcinoma HeLa cells xenografts in nude mice, which may be related to its pro- motion on xenografts cells apoptosis through down-regulation of Bcl-2 expressionPand activation of P53 expression.

关键词： cervical cancer EVn-50 xenografts apoptosis

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Celebrating the 95th birthday of Professor Karl *** Part 1-Biography and tributes

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computer Modeling in Engineering & Sciences 2021年第12期 1077-1122页

作者： Sheila Humphreys Univ Maryland Dept Civil & Environm Engn College Pk MD 20742 USA Peter ODonnell Jr Chair computat & Appl Math Austin TX USA Aerosp Engn & Engn Mech Austin TX USA Univ Pacific Stockton CA 95211 USA Univ Maryland Glenn L Martin Prof Aerosp Engn College Pk MD 20742 USA Dev Engn Grad Grp Educ Blum Ctr Developing Econ MEng Program Chair Roscoe & Elizabeth Hughes Prof Mech Engn Product Berkeley CA USA Univ Texas Austin Oden Inst Computat Engn & Sci Cockrell Family Regents Chair Engn Austin TX 78712 USA Univ Texas Austin Aerosp Engn & Engn Mech Austin TX 78712 USA Univ Texas Austin Math Austin TX 78712 USA Univ Texas Austin Comp Sci Austin TX 78712 USA Univ Calif Berkeley Berkeley CA USA UC Santa Cruz Santa Cruz CA USA Univ Colorado Engn & Appl Sci Emeritus Lab Atmospher & Space Phys Boulder CO 80309 USA Ramon Llull Univ ESADE Business Sch Barcelona Spain Univ Stuttgart Inst Baustat & Baudynam Inst Struct Mech Stuttgart Germany Cooper Union Adv Sci & Art Strateg Initiat & Inst Effectiveness New York NY 10003 USA Univ Colorado Dept Aerosp Engn Sci Boulder CO 80309 USA Univ Colorado Aerosp Mech Res Ctr Boulder CO 80309 USA Software Engn Apple Inc Los Angeles CA USA Stanford Univ Mech Engn Stanford CA 94305 USA

Celebrating the 95th birthday of Professor Karl *** In Part 1,a biography of Professor Karl Pister is followed by seventeen individual tributes,penned by a diverse group from university presidents to an elementary school teacher,with the longest tribute by *** Humphreys focusing on Professor Pister’s endeavor to increase the enrollment of minorities in engineering.

关键词： engineering. birthday ster

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