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聚乙二醇干扰素α-2a(派罗欣)联合利巴韦林治疗hiv感染患者的慢性丙型肝炎的疗效

世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 2-3页

作者： Torriani F.J. Rodr.guez-TorresM. Rockstroh J.K. 陈云茹 University of california San DiegoAntiViral Research Center 150 W. Washington St.San Diego CA 92103 United States

BACKGROUND: Hepatitis C virus (HCV) infection is highly prevalent and is associated w.th substantial morbidity and mortality among persons infected w.th the human immunodeficiency virus (hiv). w. compared the efficacy and safety of pegylated interferon alfa-2a (peginterferon alfa-2a) plus either ribavirin or placebo w.th those of interferon alfa-2a plus ribavirin for the treatment of chronic HCV infection in patients w.o w.re also infected w.th ***: A total of 868 persons w.o w.re infected w.th both hiv and HCV and w.o had not previously been treated w.th interferon or ribavirin w.re randomly assigned to receive one of three regimens: peginterferon alfa-2a (180 μ g per w.ek) plus ribavirin (800 mg per day),peginterferon alfa-2a plus placebo, or interferon alfa-2a(3 million IU three times a w.ek) plus ribavirin. Patients w.re treated for 48 w.eks and follow.d for an additional 24 w.eks. The primary end point w.s a sustained virologic response (defined as a serum HCV RNA level below.50 IU per milliliter at the end of follow.up, at w.ek 72). RESULTS:The overall rate of sustained virologic response w.s significantly higher among the recipients of peginterferon alfa-2a plus ribavirin than among those assigned to interferon alfa-2a plus ribavirin (40 percent vs. 12 percent, Pw.th HCV genotype 1, the rates of sustained virologic response w.re 29 percent w.th peginterferon alfa-2a plus ribavirin, 14 percent w.th peginterferon alfa-2a plusplacebo, and 7 percent w.th interferon alfa-2a plus *** corresponding rates among patients infected w.th HCV genotype 2 or 3 w.re 62 percent, 36 percent,and 20 percent. Neutropenia and thrombocytopenia w.re more common among patients treated w.th regimens that contained peginterferon alfa-2a, and anemia w.s more common among patients treated w.th regimens containing ribavirin. CONCLUSIONS: Among patients infected w.t

关键词：慢性丙型肝炎 hiv感染患者干扰素α 派罗欣持续病毒学应答干扰素联合丙型肝炎病毒安慰剂应答率临床试验

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hiv阳性神经认知损害患者的尾状核血流和体积减少

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世界核心医学期刊文摘(神经病学分册) 2006年第10期 47-47页

作者： Ances B.M. Roc A.C. 郭俊 hiv neurobehavioral research center 150 w. washington san diego ca 92119 united states dr.

Objective: To evaluate the effects of hiv- associated neurocognitive impairment on caudate blood flow.and volume. Methods: The authors performed continuous arterial spin labeled MRI on 42 hiv+ patients (23 subsyndr.mic and 19 hiv neurosymptomatic) on highly active antiretroviral therapy and 17 seronegative controls. They compared caudate blood flow.and volume among groups. Results: A stepw.se decrease in both caudate blood flow.and volume w.s observed w.th increasing hiv- associated neurocognitive impairment. Compared w.th seronegative controls, baseline caudate blood flow.w.s reduced in hiv+ neurosymptomatic patients (p = 0.001) w.th a similar decreasing trend for subsyndr.mic hiv+ patients (p = 0.070). Differences in caudate volume w.re observed only for neurosymptomatic hiv+ patients compared w.th controls (p = 0.010). A Jonckheere- Terpstra test for trends w.s significant for both caudate blood flow.and volume for each of the three subgroups. Pearson product moment correlation coefficients w.re not significant betw.en caudate blood flow.and volume for each group. Conclusions: Decreasing trends in caudate blood flow.and volume w.re associated w.th significantly increasing hiv- associated neurocognitive impairment (HNCI), w.th the greatest decreases observed for more severely impaired patients. How.ver, reductions in caudate blood flow.and volume w.re poorly correlated. Changes in residual caudate blood flow.may act as a surrogate biomarker for classifying the degree of HNCI.

关键词：尾状核纹状体血流神经认知患者阳性

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