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Targeted therapy for capillary-venous malformations

Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela protic Clément hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot denise MAdams Tristan Mirault laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

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Immunoprophylaxis failure and vaccine response in infants born to mothers with chronic hepatitis B infection in Djibouti

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World Journal of hepatology 2024年第7期16卷 1039-1050页

作者： Sahal Darar Dirir Ambroise D Ahouidi Aboubacry Drame Warsama Osman Abdi Guelleh Youssouf Kayad Mohamed houmed Aboubakar Makhtar Camara Coumba Toure Kane halimatou Diop Ndiaye laboratoire Medical de la caisse National de SécuritéSocial de Djibouti Caisse National de SécuritéSocial de DjiboutiDjibouti BP 696Senegal Parasitology Institut de Recherche en santéde Surveillanceépidémiologique et de FormationDakar 7325Senegal Ecole Doctoral UniversitéAlioune Diop de BambeyDakar 7325Senegal department of des Soins Caisse National de Securite SocialDjibouti 696Senegal Centre de Soin Caisse National de Securite SocialDjibouti 696Senegal laboratoire Medical Mer Rouge Djibouti 99399Senegal Centre hospitalier Universitaire Aristide le Dantec Laboratoire Bactériologie-Virologie-Hôpital Aristide le DantecDakar 7325Senegal department of Virology Institut de Recherche en Santéde Surveillanceépidémiologique et de FormationDakar 7325Senegal Bacteriology and Virology laboratory Le Dantec University Teaching HospitalDakar BP 7325Senegal

BACKGROUND In endemic areas,vertical transmission of hepatitis B virus(hBV)remains a major source of the global reservoir of infected *** mother-to-child transmission(MTCT)of hBV is at the heart of World health Organization’s goal of reducing the incidence of hBV in children to less than 0.1%by *** screening for hepatitis B during pregnancy and neonatal vaccination are the main preventive *** To evaluate the efficacy of hBV vaccination combined with one dose of immunoglobulin in children born to hepatitis B surface antigen(hBsAg)-positive mothers in Djibouti *** We conducted a study in a prospective cohort of hBsAg-positive pregnant women and their *** study ran from January 2021 to May 2022,and infants were followed up to 7 mo of *** serological markers and viral load in pregnant women were measured using aVidas microparticle enzyme-linked immunosorbent assay(Biomérieux,Paris,France)and the automated Amplix platform(Biosynex,Strasbourg,France).All infants received hepatitis B immunoglobulin and were vaccinated against hBV at *** infants were closely monitored to assess their seroprotective response and for failure of *** logistic regression was also used to identify risk factors associated with immunoprophylaxis failure and poor vaccine *** statistical analyses were performed with version 4.0.1 of the R *** Of the 50 pregnant women recruited,the median age was 31 years,ranging from 18 years to 41 *** MTCT rate in this cohort was 4%(2/50)in hBsAg-positive women and 67%(2/3)in hepatitis B e antigen-positive women with a viral load>200000 IU/*** the 48 infants who did not fail immunoprophylaxis,8(16%)became poor responders(anti-hBhBV vaccination and hepatitis B immunoglobulin,while 40(84%)infants achieved a good level of seroprotection(anti-hB>100 mIU/mL).Factors associated with this failure of immunoprophylaxis were maternal hBV DNA lev

关键词： hepatitis B surface antigen Infants hepatitis B immunoglobulin hepatitis vaccine Djibouti

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Visceral Leishmaniasis at the National Reference University hospital Center of N’Djamena (Chad): Epidemiological, Clinical, Diagnostic, Therapeutic and prognostic Aspects

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Advances in Infectious Diseases 2024年第2期14卷 478-486页

作者： Joseph Mad-Toïngué Mahamat Ali Ahmat Oumaïma Mahamat Djarma Alifa Adjibera Philippe Ali Mahamat Moussa Ngakoutou Rangar Choua Ouchemi Mahamat Ali Bolti Djiddi Ali Sougoudi Mamissou Didi Mahamat Doungous Atim Service des Maladies Infectieuses CHU de Référence Nationale N’Djamena Chad Service de Gastroentérologie et Médecine Interne CHU de Référence Nationale N’Djamena Chad Service de Pneumologie et Phtisiologie CHU de Référence Nationale N’Djamena Chad Service de Chirurgie viscérale CHU de Référence Nationale N’Djamena Chad Service de Médecine CHU de la Renaissance N’Djamena Chad

Introduction: leishmaniasis is a group of parasitic diseases caused by a parasite of the genus Leishmania transmitted by the bite of an infected vector called a sandfly. There are four forms. Visceral leishmaniasis is the most severe form. The aim of our work is to study the epidemiological, clinical, diagnostic, therapeutic and prognostic aspects of the disease in the Infectious Diseases department of the Centre hospitalier Universitaire de Référence nationale in N'Djaména. Methodology: Patients were recruited on the basis of clinical signs suggestive of visceral leishmaniasis, i.e. prolonged fever, splenomegaly and altered general condition. Biological confirmation was performed with a rapid diagnostic test using recombinant K39 parasite antigen, which is known to have good specificity and sensitivity. Epidata version 3.1 software was used to process patient data. Results: From 05/04/21 to 15/12/23, 153 positive cases were managed. The mean age of patients was 18 years, with a sex ratio of 9.2. Of these patients, 103 (67.3%) had recently stayed at gold mining sites. Patients testing positive were treated with sodium stibogluconate combined with paromomycin for 17 days. The mortality rate was 13.2%. Conclusion: Leishmaniasis is a serious and little-known disease in Chad. In order to respond to the disease, it is necessary to reinforce the capacities of health structures and to carry out appropriate actions in the outbreaks.

关键词： Visceral Leishmaniasis Gold Mining Sites Chad

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Evaluation of the Strategy and Efficacy of Treatment of Chronic Viral hepatitis C with the Sofosbuvir/Daclatasvir Combination in a Resource-Limited Country

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Open Journal of Gastroenterology 2024年第7期14卷 233-240页

作者： Mayanna habkreo Ali Mahamat Moussa Adama Ahmed Ngare Abdraman Kossou Tahir Mahamat Saleh Maire dehainsala Mahamat Ali hachim Mahamat Ali Bolti Oumaima Djarma Joseph Madtoingue Service de Gastroentrologie/Mdecine Interne du Centre hospitalier Universitaire la Rfrence nationale NDjamena Chad Service de Gastroentrologie du Centre hospitalier Universitaire la Renaissance NDjamena Chad Service de Maladies Infectieuses du Centre hospitalier Universitaire la Renaissance NDjamena Chad Service de Maladies Infectieuses du Centre hospitalier Universitaire la Rfrence nationale NDjamena Chad

Introduction: The treatment of viral hepatitis C (hCV), a major public health problem, has evolved considerably since the introduction of direct-acting anti-virals (DAAs). The aim of this study was to evaluate the strategy for initiating treatment with Sofosbuvir/Daclatasvir, and also to assess its efficacy. Patients and Methods: Included were patients aged at least 15 years, with detectable hepatitis C viremia and treated with a pan-genotypic Sofosbuvir/Daclatasvir regimen at the Centre “hospitalier Universitaire la Référence nationale de N’Djamena” between October 2019 and October 2023. The AprI score was used to assess fibrosis. Cure was defined by an undetectable viral load 12 weeks after the end of treatment. Results: A total of 835 patients were included (sex ratio 1.55, mean age 50.5 ± 13.73, extremes 20 and 84 years). The 60 - 69 age group was the most represented. The mean AprI score was 0.42 ± 0.29, with extremes of 0.019 and 1.84. The mean viral load was 2,316,193.086 IU/mL. All subjects had good renal function. Cytolysis was absent in 70% of cases. Without genotyping, a pan-genotypic regimen was used in all patients: Sofosbuvir (400 mg)/Daclatasvir (60 mg). The cure rate was 99.4%, with good tolerability. however, four cases of failure were recorded out of the 668 patients who underwent follow-up hCV-PCR testing after 12 weeks of treatment. Conclusion: The Sofosbuvir/Daclatasvir regimen is highly effective, with an excellent safety profile. however, the still high cost of these molecules limits their accessibility to a large proportion of patients.

关键词： Efficacy Tolerance Sofosbuvir/Daclatasvir hCV Chad

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Eradication Treatment of helicobacter pylori Infection: Evaluation of Therapeutic Strategies in N’Djamena

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Open Journal of Gastroenterology 2024年第2期14卷 59-67页

作者： Mayanna habkréo Ali Mahamat Moussa Tahir Mahamat Saleh Djerabet Franckly Fany haby Mairé dehainssala Adama Ngaré Mahamat Ali hachim Service de Medecine Interne et Gastroenterologie Centre Hospitalier Universitaire La Reference Nationale N’Djamena Tchad Service de Medecine Interne Centre Hospitalier Universitaire La Renaissance N’Djamena Tchad Service de Médecine Hopital de l’Amitié Tchad-Chine N’Djamena Tchad

Background: helicobacter pylori (hp) infection is the most widespread bacterial infection in the world. The infection is generally acquired in childhood, but can persist into adulthood. Eradication therapy has undergone several modifications. The aim of this study was to evaluate the different therapeutic strategies used in the eradication of helicobacter pylori infection in the Centre hospitalier Universitaire la Reference nationale of N’Djaména. Patients and Methods: This was a prospective, descriptive analytical study spread over one year, from September 2021 to September 2022. Patients at least 15 years of age presenting with dyspeptic symptoms, seen consecutively in a hepato-gastroenterology consultation and with a positive stool test for h. pylori infection, were included in the study. Equally, 1/3 of patients were treated with dual or triple therapy. The remaining third received quadritherapy. Results: A total of 268 patients were included in the study (mean age 38.40 ± 14.66 with extremes of 16 and 80 years). Males predominated in 58% of cases. Overall therapeutic efficacy was 88.9%. According to different therapeutic strategies, efficacy was 90.75% for dual therapy with PPI (Rabeprazole) and Amoxicillin. On the other hand, efficacy was 87% and 88.88% for PPI-based triple therapy and dual antibiotic therapy, and for PPI-based quadruple therapy and triple antibiotic therapy. Conclusion: h. pylori infection is a common disease in Chad. Dual therapy with rabeprazole combined with a high dose of amoxicillin over a period of at least two weeks showed similar if not better efficacy than triple or quadruple therapy.

关键词： helicobacter pylori Therapeutic Strategies Eradication Dyspepsia Chad

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determinants of the Low proportion of pregnant Women Seen for First-Trimester prenatal Care at KoudougouUrban Medical Center, Burkina-Faso

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Open Journal of Nursing 2024年第8期14卷 421-432页

作者： Swanfani Talardia André Thiombiano Nestor Bationo Ziemlé Clément Meda Iliassa Sawadogo Léa Yameogo Cécile Sanou Dieudonné Soubeiga Institut de Formation et de Recherche Interdisciplinaire en Science de la Sant et de lEducation (IFRISSE) Ouagadougou et Ecole Nationale de Sant Publique (ENSP) Bobo-Dioulasso Burkina Faso department of Public health Universit Joseph Ki-ZERBO Ouagadougou Burkina-Faso Institut suprieur des Sciences de la Sant (INSSA) de lUniversit Nazi Boni et Centre hospitalier Universitaire Souro Sanou (ChUSS) Bobo Dioulasso Burkina Faso Direction Rgionale de la Sant et de lhygine Publique des hauts Bassins Bobo Dioulasso Burkina Faso Direction Rgionale de la Sant et de lhygine Publique du Centre Ouest Koudougou Burkina Faso Ecole nationale de Sant Publique Direction Rgionale de Bobo-Dioulasso Bobo-Dioulasso Burkina Faso

Introduction: Antenatal care (ANC) contributes to the reduction of maternal and neonatal morbidity and mortality. The study aimed to investigate the determinants of the low proportion of pregnant women seen for first antenatal care in the first trimester of pregnancy at the urban medical center of Koudougou, Burkina Faso. Materials and Methods: This was a cross-sectional study with data collection from June 08 to August 18, 2021. It involved a sample of 302 participants including 280 pregnant women and 22 maternity providers. Semi-structured individual interviews, non-participant observation, and a literature review were used. Results: pregnant women age 20 and over, knowledge of the date of their last menstrual period, and knowledge of the antenatal care calendar were associated with coming into contact (1) with Antenatal care in the first trimester of pregnancy. In addition, there was a lack of availability of antenatal care services, inadequate reception of clients, and shortages of health products. Conclusion: There is a need to revisit strategies for communicating with women about ANC, reorganizing ANC services, and improving ANC services.

关键词： Least Risk Maternity Maternal and Neonatal health Maternal and Neonatal Mortality Maternal and Neonatal Morbidity Reception

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Nonaqueous potassium-ion full-cells:Mapping the progress and identifying missing puzzle pieces

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Journal of Energy Chemistry 2024年第6期93卷 384-399,I0010页

作者： Badre larhrib Louiza larbi Lénaïc Madec Universite de Pau et des Pays de l’Adour E2S UPPACNRSIPREMPauFrance Universitéde haute-Alsace Institut de Science des Matériaux de Mulhouse(IS2M)CNRS UMR 7361F-68100 MulhouseFrance Universitéde Strasbourg F-67081 StrasbourgFrance Réseau sur le Stockage Electrochimique de l’Energie CNRS FR3459AmiensFrance Institut des Matériaux Jean Rouxel(IMN) CNRS UMR 6502Univ.Nantes44322 Cedex 3 NantesFrance

This review addresses the growing interest for potassium-ion full-cells(KIFCs)in view of the transition from potassium-ion half-cells(KIhCs)toward commercial K-ion batteries(KIBs).It focuses on the key parameters of KIFCs such as the electrode/electrolyte interfaces challenge,major barriers,and recent advancements in *** strategies for enhancing KIFC performance,including interfaces co ntrol,electrolyte optimization,electrodes capacity ratio,electrode material screening and electrode design,are *** review highlights the need to evaluate KIBs in full-cell configurations as half-cell results are strongly impacted by the K metal *** also emphasizes the importance of understanding solid electrolyte interphase(SEI)formation in KIFCs and explores promising nonaqueous as well as quasiand all-solid-state electrolytes *** review thus paves the way for practical,cost-effective,and scalable KIBs as energy storage systems by offering insights and guidance for future research.

关键词： K-ion full-cells Potassium-ion batteries Cross-talk Solid-state batteries Potassium reactivity Electrolyte design Electrode design

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Phytochemical Analysis and Antimicrobial Activity of lawsonia inermis Leaf Extracts from Burkina Faso

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American Journal of Plant Sciences 2024年第7期15卷 552-576页

作者： Ollo Youl Soumaïla Konaté Ernest N. Sombié Rainatou Boly Boukaré Kaboré Moumouni Koala Arouna Zoungrana Saybou Savadogo Christian Marc Tahita Innocent Valea halidou Tinto Adama hilou Maminata Traoré-Coulibaly laboratoire de Biochimie et de Chimie Applique (laBIOCA) Universit de Ouagadougou Ouagadougou Burkina Faso Agence nationale Pour la Scurit Sanitaire de lEnvironnement de lAlimentation du Travail et des Produits de Sant (ANSSEAT) Ouagadougou Burkina Faso laboratoire de Recherche-Dveloppement de Phytomdicaments et Mdicaments (L-RD/PM) Institut de Recherche en Sciences de la Sant (IRSS-CNRST) Ouagadougou Burkina Faso laboratoire de Chimie Organique et de Physique Applique (LCOPA) cole Doctorale Sciences et Technologie Universit Joseph KI-ZERBO Ouagadougou Burkina Faso laboratoire Sciences de la Vie et de la Terre (laSVT) cole Doctorale Sciences et Technologie Universit Norbert ZONGO Koudougou Burkina Faso Unit de Recherche Clinique de Nanoro Institut de Recherche en Sciences de la Sant (IRSS-CNRST) Nanoro Burkina Faso

lawsonia inermis is a hairless plant growing in various regions of North Africa, the Indian subcontinent, and the Middle East. It possesses many medicinal attributes, including curative properties against infectious dermatoses. This study was carried out to evaluate the phytochemical profile of the crude ethanolic extract of the plant leaves and its fractions as well as their antimicrobial activities. The phytochemical profile was performed using high-performance thin-layer chromatography (hPTLC), gas chromatography-mass spectrometry (GC-MS), and high-performance liquid chromatography (hPLC). Additionally, the phenolic and flavonoid contents were determined using the Folin-Ciocalteu spectrophotometric and the aluminum trichloride methods. Antimicrobial activity was tested using disc diffusion and microdilution methods. The presence of flavonoids, tannins, sterols, and triterpenes was revealed. GC-MS detected twelve compounds main compounds consisting of saturated and unsaturated fatty acids and phenolic and terpenoid compounds among twenty-seven components. hPLC also detected high contents of phenolic acids and flavonoids. The most abundant triterpene and sterols were ursolic acid (around 43.14 g/100g DW, 13.9 g/100g dry weight (DW), and 0.68 g/100g DW) in the crude ethanolic extract of leaves (FeLi), hexane fraction (FhLi) and dichloromethane fraction (FDLi), respectively and, β-sitosterol in FeLi (56.7 mg/100g DW), FhLi (10.55 g/100g DW), FDLi (106.1 mg/100g DW) and butanol fraction (FBLi) (357.4 mg/100g DW). Among the flavonoids, rutin = 3.24 g/100g and quercetin = 0.63 g/100g in the ethanolic extract, rutin = 15.73 g/100g in the dichloromethane fraction, and rutin = 0.23 g/100g) in the aqueous fraction;and among phenolic compounds, caffeic acid (37.65 g/100g DW) and vanillic acid (22.70 g/100g DW) were the most important in the ethyl acetate fraction (FAeLi). All organic fractions exhibited interesting antibacterial and antifungal activities against the tested s

关键词： lawsonia inermis Phytochemical profile hPLC GC-MS Analysis Antimicrobial Activity

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habits on Social Networks at Workplace: A Survey of Motivations and Behaviour

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Open Journal of Applied Sciences 2024年第8期14卷 2154-2168页

作者： Thomas Kakou Kouassi Douatia Koné Aliou Bamba Aladji Kamagaté Olivier Asseu Yvon Kermarrec laboratoire des Sciences et Technologies de lInformation et de la Communication (laSTIC) Ecole Superieure Africaine des TIC (ESATIC) Abidjan Cte dIvoire Institut National Polytechnique houphout Boigny (INPhB) Yamoussoukro Cte dIvoire departement de Mathematiques Physique et Chimie Universit Plforo Gon Coulibaly (UPGC) Korhogo Cte dIvoire Agence nationale de la Recherche (ANR) Paris France laboratoire des Sciences et Techniques de linformation de la Communication et de la Connaissance (lab-STICC) IMT Atlantique Brest France

This article explores the use of social networks by workers in Abidjan, Côte d’Ivoire, with particular emphasis on a descriptive or quantitative analysis aimed at understanding motivations and methods of use. More than five hundred and fifty questionnaires were distributed, highlighting workers’ preferred digital channels and platforms. The results indicate that the majority use social media through their mobile phones, with WhatsApp being the most popular app, followed by Facebook and LinkedIn. The study reveals that workers use social media for entertainment purposes and to develop professional and social relationships, with 55% unable to live without social media at work for recreational activities. In addition, 35% spend on average 1 to 2 hours on social networks, mainly between 12 p.m. and 2 p.m. It also appears that 46% believe that social networks moderately improve their productivity. These findings can guide marketing strategies, training, technology development and government policies related to the use of social media in the workplace.

关键词： Social Network Social Media Applications Poisson’s law Statistics Digital Supports Workers productivity

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Women Breast Cancer: Knowledge, Attitudes, practices and Factors Associated with Early Screening in the Municipality of Abomey-Calavi in Benin in 2018

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Open Journal of Epidemiology 2024年第1期14卷 131-156页

作者： Stéphane Arold Bidossessi Senahoun Nicolas hamondji Amegan Mahougnon hugues Serge Dohou hermann Comlanvi Agbedjinou Lucresse Corine Fassinou Tècle Edwige Korogone Armand Ibikounle Dieudonné Fambo Joël Gamêlé Mikponhoué Christiane Tshabu Aguemon Ecole Doctorale des Sciences de la Santé Université d’Abomey-Calavi Cotonou Bénin Ecole de Santé Publique de l’Université de Montréal Québec Canada Unité de Formation et de Recherche en Médecine Cardiovasculaire Faculté de Médecine de l’Université de Parakou Parakou Bénin Ecole de Santé Publique Université Libre de Bruxelles Bruxelles Belgique Ecole nationale des Techniciens Supérieurs en Santé Publique et en Surveillance Epidémiologique Université de Parakou Parakou Bénin Faculté des Sciences de la Santé Université d’Abomey-Calavi Cotonou Bénin

Background: Breast cancer is the dominant cancer in women in both developed and developing countries. The objective of this study was to assess the knowledge, attitudes, practices and factors associated with early breast cancer screening among women in the Municipality of Abomey-Calavi in Benin. Methods: This was a cross-sectional, descriptive, analytical study with prospective data collection from October 1 to 8, 2018, involving 1740 women in the Municipality of Abomey-Calavi, aged 18 years or older and selected by WhO four-stage random cluster sampling. Consenting women who were mentally competent, 18 years of age or older at the time of the survey, and residing continuously in the Municipality of Abomey-Calavi for the last six months prior to the survey were included. On the other hand, women who belonged to a breast cancer prevention service, women in whom secondary screening was noted, or non-consenting women were not included. The initial minimum size was estimated by the Schwartz formula with a cluster effect of k = 2. Information was collected by questionnaire survey, entered with Epidata 3.1. Fr and analyzed with R Studio 3.5.1. software. Results: The mean age of the women surveyed was 32.0 ± 11.5 years with a range of 18 and 71 years. Regarding knowledge, the clinical manifestation known by the majority of women was the presence of a nodule (68.50%). In the series, 1308 (75.17%) declared having heard about breast cancer once before, either on the radio, television or from friends and 726 (55.50%) had heard about breast cancer screening. Five hundred and twelve (70.52%) of the 726 who had heard of breast cancer said they knew that breast cancer could be screened earlier. Breast self-examination was the most cited screening method (67.58%). The disease is of natural origin according to 37.84% of them. Regarding attitudes and practices, the prevalence of early breast cancer screening was 12.93%, of which 11.67% declared that they had checked themselves to kno

关键词： Breast Cancer Early Screening Knowledge practices Attitudes Associated Factors

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