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BTG2 interference ameliorates high glucose-caused oxidative stress, cell apoptosis, and lipid deposition in hK-2 cells

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BIOCELL 2024年第9期48卷 1379-1388页

作者： WENJUAN ZhU ZhENGZhENG JU FAN CUI Department of Blood Transfusion The First People’s Hospital of WuhuWuhu241000China Department of Clinical Laboratory The First People’s Hospital of WuhuWuhu241000China

Objective:Diabetic nephropathy(DN)is a deleterious microangiopathy of diabetes,constituting a critical determinant of fatality in diabetic *** work is purposed to disclose the effects and modulatory mechanism of BTG anti-proliferation factor 2(BTG2)during the pathological process of ***:BTG2 expression in kidney tissues of diabetic mice and high glucose(hG)-exposed human proximal tubular cell line hK-2 was assessed with Western blot and *** diabetic mice model was constructed by streptozotocin injection and confirmed by the blood glucose level beyond 16.7 mmol/*** and eosin(h&E)staining and measurement of kidney function hallmarks were conducted to assess kidney *** counting kit(CCK)-8 method and TUNEL assay appraised cell activity and *** red O staining assayed lipid *** commercial kits were used to estimate oxidative stress-related ***-immunoprecipitation(Co-IP)assay testified the binding relationship of BTG2 with protein arginine methyltransferase 1(PRMT1).Results:BTG2 expression was significantly raised in renal tissues of diabetic mice and hK-2 cells exposed to ***2 deficiency improved viability and extenuated the apoptosis,lipid deposition as well as oxidative stress in hK-2 cells following hG *** addition,PRMT1 was also overexpressed in hK-2 cells exposed to ***2 interacted with PRMT1 and positively modulated PRMT1 *** effects of BTG2 interference on viability,apoptosis,lipid deposition,and oxidative stress in hG-challenged hK-2 cells were partially abrogated by PRMT1 ***:Altogether,BTG2 might aggravate hK-2 cell injury in response to hG by binding with PRMT1,providing a novel target for the therapeutic strategy of DN.

关键词： BTG2 Diabetic nephropathy Lipid deposition Oxidative stress PRMT1

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seamless morphing trailing edge flaps for UAs-s45 using high-fidelity aerodynamic optimization

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Chinese Journal of Aeronautics 2024年第2期37卷 12-29页

作者： Mir hossein NEGAhBAN Musavir BAshIR Victor TRAIsNEL Ruxandra Mihaela BOTEZ LARCAsE Laboratory of Applied Research in Active Controls Avionics and AeroservoelasticityEcole de Technologie SuperieureUniversite du QuebecMontreal H3C1K3Canada

The seamless trailing edge morphing flap is investigated using a high-fidelity steady-state aerodynamic shape optimization to determine its optimum configuration for different flight conditions,including climb,cruise,and gliding descent.A comparative study is also conducted between a wing equipped with morphing flap and a wing with conventional hinged *** optimization is performed by specifying a certain objective function and the flight performance goal for each flight *** the climb rate,extending the flight range and endurance in cruise,and decreasing the descend rate,are the flight performance goals covered in this *** optimum configurations were found for the morphing wing by determining the optimum morphing flap deflection for each flight condition,based on its objective function,each of which performed better than that of the baseline *** was shown that by using optimum configuration for the morphing wing in climb condition,the required power could be reduced by up to 3.8%and climb rate increases by 6.13%.The comparative study also revealed that the morphing wing enhances aerodynamic efficiency by up to 17.8%and extends the laminar ***,the optimum configuration for the gliding descent brought about a 43%reduction in the descent rate.

关键词： seamless morphing trailing edge flap Aerodynamic optimization Gradient-based optimiza-tion Climb flight condition Gliding descent Flight range Endurance

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12.6μm-Thick Asymmetric Composite Electrolyte with superior Interfacial stability for solid-state Lithium-Metal Batteries

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Nano-Micro Letters 2024年第9期16卷 397-409页

作者： Zheng Zhang Jingren Gou Kaixuan Cui Xin Zhang Yujian Yao suqing Wang haihui Wang Beijing Key Laboratory for Membrane Materials and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084People’s Republic of China school of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510000People’s Republic of China

solid-state lithium metal batteries(ssLMBs)show great promise in terms of high-energy-density and high-safety ***,there is an urgent need to address the compatibility of electrolytes with high-voltage cathodes/Li anodes,and to minimize the electrolyte thickness to achieve highenergy-density of ***,we develop an ultrathin(12.6μm)asymmetric composite solid-state electrolyte with ultralight areal density(1.69 mg cm^(−2))for *** electrolyte combining a garnet(LLZO)layer and a metal organic framework(MOF)layer,which are fabricated on both sides of the polyethylene(PE)separator separately by tape *** PE separator endows the electrolyte with flexibility and excellent mechanical *** LLZO layer on the cathode side ensures high chemical stability at high *** MOF layer on the anode side achieves a stable electric field and uniform Li flux,thus promoting uniform Li^(+)*** to the well-designed structure,the Li symmetric battery exhibits an ultralong cycle life(5000 h),and high-voltage ssLMBs achieve stable cycle *** assembled pouch cells provided a gravimetric/volume energy density of 344.0 Wh kg^(−1)/773.1 Wh L^(−1).This simple operation allows for large-scale preparation,and the design concept of ultrathin asymmetric structure also reveals the future development direction of ssLMBs.

关键词： solid-state lithium metal batteries Composite solid-state electrolyte Ultrathin asymmetric structure Pouch cells

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The emerging role of exercise as a cancer treatment

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Journal of sport and health science 2024年第4期13卷 443-444页

作者： Kerry s.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmontonAlbertaT6G 2H9Canada

Over the past few decades,exercise oncology has emerged as an important subfield within exercise *** that time,substantial progress has been made in understanding the role of exercise in people newly diagnosed with ca... 详细信息

关键词： cancer treatment exercise

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Polarizable Additive with Intermediate Chelation strength for stable Aqueous Zinc‑Ion Batteries

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Nano-Micro Letters 2024年第5期16卷 41-55页

作者： Yuting Xia Rongao Tong Jingxi Zhang Mingjie Xu Gang shao hailong Wang Yanhao Dong Chang‑An Wang state Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084People’s Republic of China school of Materials science and Engineering Zhengzhou UniversityZhengzhou 450001HenanPeople’s Republic of China

Aqueous zinc-ion batteries are promising due to inherent safety,low cost,low toxicity,and high volumetric ***,issues of dendrites and side reactions between zinc metal anode and the electrolyte need to be solved for extended storage and cycle ***,we proposed that an electrolyte additive with an intermediate chelation strength of zinc ion—strong enough to exclude water molecules from the zinc metal-electrolyte interface and not too strong to cause a significant energy barrier for zinc ion dissociation—can benefit the electrochemical stability by suppressing hydrogen evolution reaction,overpotential growth,and den-drite ***-sodium diethylene-triaminepentaacetic acid salt was selected for such a *** has a suitable chelating ability in aqueous solutions to adjust solvation sheath and can be readily polarized under electrical loading conditions to further improve the ***||Zn symmetric cells can be stably operated over 3500 h at 1 mA cm^(-2).Zn||Nh4V4O10 full cells with the additive show great cycling stability with 84.6%capacity retention after 500 cycles at 1 A g^(-1).since the additive not only reduces h2 evolution and corrosion but also modifies Zn2+diffusion and deposition,highlyreversible Zn electrodes can be achieved as verified by the experimental *** work offers a practical approach to the logical design of reliable electrolytes for high-performance aqueous batteries.

关键词： Aqueous zinc-ion batteries Electrolyte additives DTPA-Na Chelation strength

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Different bactericidal abilities of plasma-activated saline with various reactive species prepared by surface plasma-activated air and plasma jet combinations

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Plasma science and Technology 2024年第1期26卷 50-61页

作者：贾怡康李甜会张瑞赵鹏瑜王子丰陈旻郭莉刘定新 state Key Laboratory of Electrical Insulation and Power Equipment Center for Plasma BiomedicineXi’an Jiaotong UniversityXi’an 710049People’s Republic of China school of Life science and Technology Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China

Plasma-activated water(PAW),as an extended form of cold atmospheric-pressure plasma,greatly expands the application of plasma-based *** biological effects of PAW are closely related to the aqueous reactive species,which can be regulated by the activation *** this study,surface plasma-activated air(sAA)and a he+O_(2)plasma jet(Jet)were parallelly combined(the sAA+Jet combination)or sequentially combined(the sAA→Jet combination and the Jet→sAA combination)to prepare plasma-activated saline(PAs).The PAs activated by the combinations exhibited stronger bactericidal effects than that activated by the sAA or the Jet *** concentrations of h_(2)O_(2)and NO_(2)^(-)were higher in the PAs activated by the Jet→sAA combination,while ONOO^(-)concentrations were close in the three kinds of PAs and^(1)O_(2)concentrations were higher in the PAs activated by the sAA+Jet *** analysis of scavengers also demonstrated that h_(2)O_(2),^(1)O_(2),and ONOO^(-)in the PAs activated by the sAA+Jet combination,and^(1)O_(2)in the PAs activated by the Jet→sAA combination played critical roles in bactericidal ***,the effective placement time of the three PAs varied,and the PAs activated by the Jet→sAA combination could also inactivate 2.6-log_(10)of MRsA cells after placement for more than 60 *** regulation of reactive species in plasma-activated water via different combinations of plasma devices could improve the directional application of plasma-activated water in the biomedical field.

关键词： plasma-activated water surface plasma-activated air plasma jet bactericidal effect reactive species

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Gliding arc discharge in combination with Cu/Cu_(2)O electrocatalysis for ammonia production

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Plasma science and Technology 2024年第7期26卷 67-73页

作者：刘学张佳伟何弈黄嘉敏马晓萍张潇漫卢曼婷辛煜 Jiangsu Key Laboratory of Thin Films School of Physical Science and TechnologySoochow UniversitySuzhou 215006People’s Republic of China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123People’s Republic of China

highly efficient and green ammonia production is an important demand for modern *** this study,a two-step ammonia production method is developed using a gliding arc discharge in combination with Cu/Cu_(2)O *** this method,NO_(x)is provided by the gliding arc discharge and then electrolyzed by Cu/Cu_(2)O after alkaline *** electrical characteristics,the optical characteristics and the NO_(x)production are investigated in discharges at different input voltage and the gas *** dependence of ammonia production through Cu/Cu_(2)O electrocatalysis on ph value and reduction potential are determined by colorimetric *** our study,two discharge modes are *** high input voltage and low gas flow,the discharge is operated with a stable plasma channel which is called the steady arc gliding discharge mode(A-G mode).As lowering input voltage and raising gas flow,the plasma channel is destroyed and high frequency breakdown occurs instead,which is known as the breakdown gliding discharge mode(B-G mode).The optimal NO_(x)production of 7.34 mmol h^(-1)is obtained in the transition stage of the two discharge *** ammonia yield reaches0.402 mmol h^(-1)cm^(-2)at ph value of 12.7 and reduction potential of-1.0 V versus reversible hydrogen electrode(RhE).

关键词： gliding arc discharge nitrogen fixation Cu/Cu_(2)O catalyst electrocatalytic reduction of nitrite

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Targeting cytokine and chemokine signaling pathways for cancer therapy

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signal Transduction and Targeted Therapy 2024年第8期9卷 3381-3428页

作者： Ming Yi Tianye Li Mengke Niu haoxiang Zhang Yuze Wu Kongming Wu Zhijun Dai Department of Breast surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310000People's Republic of China Department of Gynecology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000People's Republic of China Department of Oncology Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030People's Republic of China Department of hepatopancreatobiliary surgery Fujian Provincial HospitalFuzhou 350001People's Republic of China

Cytokines are critical in regulating immune responses and cellular behavior,playing dual roles in both normal physiology and the pathology of diseases such as *** molecules,including interleukins,interferons,tumor necrosis factors,chemokines,and growth factors like TGF-β,VEGF,and EGF,can promote or inhibit tumor growth,influence the tumor microenvironment,and impact the efficacy of cancer *** advances in targeting these pathways have shown promising therapeutic potential,offering new strategies to modulate the immune system,inhibit tumor progression,and overcome resistance to conventional *** this review,we summarized the current understanding and therapeutic implications of targeting cytokine and chemokine signaling pathways in *** exploring the roles of these molecules in tumor biology and the immune response,we highlighted the development of novel therapeutic agents aimed at modulating these pathways to combat *** review elaborated on the dual nature of cytokines as both promoters and suppressors of tumorigenesis,depending on the context,and discussed the challenges and opportunities this presents for therapeutic *** also examined the latest advancements in targeted therapies,including monoclonal antibodies,bispecific antibodies,receptor inhibitors,fusion proteins,engineered cytokine variants,and their impact on tumor growth,metastasis,and the tumor ***,we evaluated the potential of combining these targeted therapies with other treatment modalities to overcome resistance and improve patient ***,we also focused on the ongoing research and clinical trials that are pivotal in advancing our understanding and application of cytokine-and chemokine-targeted therapies for cancer patients.

关键词： cytokine chemokine overcome

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Dielectric barrier discharge plasma-assisted catalytic ammonia synthesis:synergistic effect of Ni-MOF-74 catalyst and nanosecond pulsed plasma

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Plasma science and Technology 2024年第6期26卷 40-49页

作者：徐晓芳孙萌宋勤龙吴璇陈冲冲陈强张海宝 Laboratory of Plasma Physics and Materials Beijing Institute of Graphic CommunicationBeijing 102600People’s Republic of China

Ammonia is one of the most important chemical raw materials in both manufacture and life of *** haber-Bosch method for ammonia synthesis involves high temperature and high pressure conditions,leading to significant energy consumption and environmental ***-thermal plasma(NTP) is a promising alternative approach to ammonia synthesis at low temperature and atmospheric *** this study,the synergistic effect of nanosecond pulsed dielectric barrier discharge(np-DBD) and Ni-MOF-74 catalyst was investigated in ammonia synthesis by utilizing nitrogen and hydrogen as *** results demonstrated that the plasma catalytic-synthesis process parameters play a crucial role in the synthesis process of *** highest ammonia synthesis rate of 5145.16 μmol·g^(-1)·h^(-1)with an energy efficiency of 1.27 g·kWh^(-1)was observed in the presence of the Ni-MOF-74 catalyst,which was3.7 times higher than that without Ni-MOF-74 *** synergistic effect of Ni-MOF-74catalyst and nanosecond pulsed plasma was explored by in-situ plasma discharge diagnostics.

关键词： ammonia synthesis low-temperature plasma nanosecond pulsed power source Ni-MOF-74

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Intestinal anti-inflammatory effect of a plant sterol food supplement in experimental murine colitis and cell co-culture models

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Food science and human Wellness 2024年

作者： Mussa Makran Antonio Cilla Rosa María Giner María Carmen Recio Luisa Tesoriere Alessandro Attanzio Guadalupe Garcia-Llatas Nutrition and Food science Area， Faculty of Pharmacy and Food sciences， University of Valencia.Av.Vicente Andrés Estellés s/n Department of Pharmacology， Faculty of Pharmacy and Food sciences， University of Valencia.Av.Vicente Andrés Estellés s/n Department of Biological， Chemical and Pharmaceutical sciences and Technologies， University of Palermo

The potential of a plant sterol food supplement （Ps-Fs） in addressing intestinal inflammation in vivo and in vitro was evaluated. As in vivo model， C57BL/6J mice were exposed to 1.5% dextran sulfate sodium in three 5-day periods， with 10-day rest intervals in between， daily reciving Ps-Fs （35 mg Ps/kg）. The in vitro approach involved a bi-cameral system with 8-day-differentiated Caco-2 （apical） and RAW264.7 cells （basolateral）. The bioaccessible fraction of Ps-Fs， obtained after INFOGEsT 2.0 simulated gastrointestinal digestion， was added to the apical part （90 min）， followed by stimulation with lipopolysaccharide （1 μg/mL， 24 h）. Ps-Fs alleviated rectal bleeding and rebalanced pro- (tumor necrosis factor α， interleukin （IL）-6， and IL-8) and anti-inflammatory cytokines （IL-10）. Additionally， Ps-Fs ameliorated histopathological damage and enhancing occludin expression. A reduction in oxidative stress was evidenced by decreased myeloperoxidase activity and reactive oxygen species production. The anti-inflammatory mechanism included suppressing cyclooxygenase 2 expression， reducing prostaglandin E2production， and inhibiting the phosphorylation and nuclear translocation of the nuclear factor κB p65 subunit. This study reveals the potential of Ps-Fs as a therapeutic intervention for colitis. The alignment between in vivo and in vitro outcomes substantiates the appropriateness of the co-culture model to evaluate the anti-inflammatory activity of foods.

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