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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina guizhou Center for disease control and prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for prevention and control of Endemic and Ethnic Regional diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Epidemiological Characteristics of Rifampicin-Resistant Tuberculosis in Students——China,2015-2019

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China CDC weekly 2021年第26期3卷 549-552页

作者： Wei Su Yunzhou Ruan Tao Li Xin Du Jiawen Jiang Yuying He Renzhong Li National Center for Tuberculosis control and prevention Chinese Center for Disease Control and PreventionBeijingChina guizhou Provincial Center for disease control and prevention GuiyangGuizhouChina

Summary What is already known about this topic?The number of students with tuberculosis(TB)has been increasing since ***,the prevalence of rifampicin-resistant tuberculosis(RR-TB)among student population is *** is added by the report?The number of students with RR-TB has significantly increased from 2015 to 2019,especially in the western region of *** majority of patients were college *** with RR-TB were mainly new patients.

关键词： has since among tuberculosis

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Metabolomic Profiling of Mice Exposed toα-amanitin Using Ultra-performance Liquid Chromatography Quadrupole Time-of-flight Tandem Mass Spectrometry

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Biomedical and Environmental Sciences 2023年第3期36卷 289-294页

作者： LI Lei ZHENG Chong YE Jian Fang ZHU Kai ZHOU Yi Bing LIU Jia GAO Ming WU Yu Tian LIU Yong Ting LIU Li Ya LIN Ye LI Hai Chang ZHANG Quan GUO Hua Clinical Laboratory Guizhou Provincial Center for Disease Control and PreventionGuiyang 550004GuizhouChina Clinical Laboratory Guiyang Provincial Center for Disease Control and PreventionGuiyang 550002GuizhouChina

Numerous instances of poisoning caused by the ingestion of mushrooms are reported annually worldwide,with most mushroom poisoning deaths caused by the ingestion of toxic amanita *** is the main toxic component of aman... 详细信息

关键词： Metab ani annually

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Serological Survey of Zika Virus in Humans and Animals in Dejiang Prefecture, guizhou Province,China

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Biomedical and Environmental Sciences 2019年第12期32卷 875-880页

作者： LI Fan ZHOU Jing Zhu ZHOU Lei FU Shi Hong TIAN Zhen Zao WANG Qi SHAO Nan LI Dan HE Ying LEI Wen Wen TANG Guang Peng LIANG Guo Dong WANG Ding Ming ZHANG Yan Ping WANG Huan Yu NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory for Infectious disease prevention and control Chinese Center for Disease Control and PreventionBeijing 102206China guizhou Center for disease control and prevention Guiyang 550004China Public Health Emergency Center Chinese Center for Disease Control and PreventionBeijing 102206China

Objective The current outbreak of Zika virus(ZIKV)poses a severe threat to human *** ZIKV strains were isolated from mosquitoes collected from the Dejiang prefecture in China in 2016,which was the first isolation of ZIKV in nature in *** In this study,serum samples were collected from 366 healthy individuals and 104 animals from Dejiang prefecture in 2017,and the plaque reduction neutralization test(PRNT)was used to evaluate the seroprevalence of *** None of the 366 residents from whom the samples were collected were seropositive for *** of the 11 pigs from whom the samples were collected were seropositive for ZIKV,while 1 of 63(1.59%)chickens and 2 of 30(6.67%)sheep were seropositive for *** The extremely low seropositivity rate of ZIKV antibodies in animals in the Dejiang prefecture,guizhou province in this study indicates that ZIKV can infect animals;however,there is a low risk of ZIKV circulating in the local population.

关键词： Zika Virus Serological survey Humans Animals China Plague reduction neutralization test

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The Impact of COVID-19 Epidemic on Tuberculosis Reports Among Students — guizhou Province, China, 2020

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China CDC weekly 2022年第11期4卷 216-219页

作者： Yuying He Tao Li Lijie Zhang Renzhong Li Zaiping Chen Yunzhou Ruan Wei Su Jinlan Li Institute for Tuberculosis control Guizhou Center for Disease Control and PreventionGuiyangGuizhouChina National Center for Tuberculosis control and prevention Chinese Center for Disease Control and PreventionBeijingChina Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?In 2020,the implementation of non-medical interventions during the coronavirus disease 2019(COVID-19)epidemic has created a negative impact on tuberculosis(TB)*** is unclear if the prevalence of TB among students in guizhou Province was also *** is added by this report?Among TB cases,the proportion of student TB patients was 19.91%in the back-to-school period in 2020,which was higher than the 13.37%registered in 2017–2019,but this decreased in the COVID-19 pandemic *** time interval between symptom onset and care-seeking of the student TB patients was the shortest in the back-to-school and physical checkup *** are the implications for public health practice?TB active screening was effective for timely detection and diagnosis of TB among students,which could prevent TB outbreaks in schools.

关键词： guizhou seeking Impact

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Coverage of 13-Valent Pneumococcal Conjugate Vaccine Among Children 0–15 Months of Age—9 Provinces,China,2019–2021

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China CDC weekly 2023年第17期5卷 379-384页

作者： Lijun Liu Zhaonan Zhang Xixi Zhang Changsha Xu Yifan Song Li Li Jiakai Ye Zhiguo Wang Hui Liang Weiyan Zhang Ling Lin Ning Li Shujun Zhang Qianli Ma Wen Du Yongzhuo Jiao Lingsheng Cao Qi Qi Lei Cao Wenzhou Yu Sichuan Center for disease control and prevention Chengdu CitySichuan ProvinceChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Suqian Center for disease control and prevention Suqian CityJiangsu ProvinceChina Jiangsu Center for disease control and prevention Nanjing CityJiangsu ProvinceChina Zhejiang Center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Shandong Center for disease control and prevention Jinan CityShandong ProvinceChina Anhui Center for disease control and prevention Hefei CityAnhui ProvinceChina Hubei Center for disease control and prevention Wuhan CityHubei ProvinceChina Hunan Center for disease control and prevention Changsha CityHunan ProvinceChina guizhou Center for disease control and prevention Guiyang CityGuizhou ProvinceChina Gansu Center for disease control and prevention Lanzhou CityGansu ProvinceChina

Summary What is already known on this topic?Limited data exist regarding the coverage of the 13-valent pneumococcal conjugate vaccine(PCV13)in China.A lack of official statistics,coupled with an insufficient body of published literature,hinders the accurate depiction of the current *** is added by this report?This study investigated the utilization of PCV13 and estimated its coverage in nine provinces across eastern,central,and western China between 2019 and *** an annual increase in PCV13 usage during this period,the overall coverage remained suboptimal.

关键词： spite coverage hinder

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Epidemiological Survey of First Human Brucellosis Outbreak Caused by the Sika Deer(Cervus nippon)—guizhou Province,China,2019

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China CDC weekly 2021年第14期3卷 301-303页

作者： Zhongfa Tao Zhangping Yang Yishan Chen Shufeng Yang Jingchao Xu Yue Wang Mingyu Lei Yun Gou Qiulan Chen Yan Huang guizhou Provincial Center for disease control and prevention GuiyangGuizhouChina Division of Infectious disease Key Laboratory of Surveillance and Early Warning on Infectious DiseaseChina Center for Disease Control and PreventionBeijingChina China Field Epidemiology Training Project BeijingChina Qiandongnan Prefecture Center for disease control and prevention KailiGuizhouChina Emory University America Leishan County Center for disease control and prevention LeishanGuizhouChina Qiannan Prefecture Center for disease control and prevention DuyunGuizhouChina.

Summary What is already known on this topic?Brucellosis is a zoonotic infectious disease caused by Brucella *** main source of infection in human brucellosis is sick animals,mainly including sheep,goat,and cattle,but sika deer(Cervus nippon)can also cause human *** first human brucellosis case in guizhou Province was reported in 2009,and no brucellosis outbreak was reported caused by sika deer ever before.

关键词： guizhou nippon break

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Coverage of the Combined DTaP-IPV/Hib Vaccine Among Children Aged 2-18 Months—9 PLADs,China,2019-2021

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China CDC weekly 2024年第19期6卷 418-423,I0001页

作者： Li Li Hui Liang Yifan Song Zhaonan Zhang Jing An Ning Li Huifeng Sun Ying Bao Leijin Mao Lin Ding Jie Yan Zhiguo Wang Lei Cao Jiakai Ye Wenzhou Yu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Zhejiang Center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Gansu Center for disease control and prevention Lanzhou CityGansu ProvinceChina Hubei Center for disease control and prevention Wuhan CityHubei ProvinceChina Shandong Center for disease control and prevention Jinan CityShandong ProvinceChina Sichuan Center for disease control and prevention Chengdu CitySichuan ProvinceChina Anhui Center for disease control and prevention Hefei CityAnhui ProvinceChina guizhou Center for disease control and prevention Guiyang CityGuizhou ProvinceChina Hunan Center for disease control and prevention Changsha CityHunan ProvinceChina Jiangsu Center for disease control and prevention Nanjing CityJiangsu ProvinceChina

Summary What is already known on this topic?In China,there is limited data available on the use and coverage of the non-program,combined diphtheria,tetanus toxoid,acellular pertussis adsorbed,inactivated poliovirus and haemophilus influenzae type b(DTaPIPV/Hib)pentavalent vaccine,and its role as a substitute for the separately administered standalone program vaccines.

关键词： vaccine Hib DTaP

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Public Awareness and Mask Usage during the COVID-19 Epidemic:A Survey by China CDC New Media

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Biomedical and Environmental Sciences 2020年第8期33卷 639-645页

作者： SUN Cheng Xi HE Bin MU Di LI Pei Long ZHAO Hong Ting LI Zhi Li ZHANG Mu Li FENG Lu Zhao ZHENG Jian Dong CHENG Ying CUI Ying LI Zhong Jie Shandong Center for disease control and prevention Jinan 250014ShandongChina Health Communication Center Chinese Centre for Disease Control and PreventionBeijing 102206China Division of Infectious disease Key Laboratory of Surveillance and Early-warning on Infectious DiseaseChinese Centre for Disease Control and PreventionBeijing 102206China Division of Epidemiology National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

An online survey conducted March 18–19,2020 on the official China CDC WeChat account platform was used to evaluate the effect of public education about masks usage during the new coronavirus disease 2019(COVID-19)*** nationals older than 18 were eligible for the *** survey collected 5,761 questionnaires from the 31 provinces,municipalities,and autonomous regions of China's Mainland.99.7%and 97.2%of the respondents answered correctly that respiratory droplets and direct contact were the main transmission routes.73.3%of the respondents considered COVID-19 to be‘serious’or‘very serious’.

关键词： mainland autonomous education

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Molecular Detection of Tick-borne Pathogens in Ticks Collected from Hainan Island,China

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Biomedical and Environmental Sciences 2021年第7期34卷 581-586页

作者： LU Miao TANG Guang Peng BAI Xiao Song QIN Xin Cheng WANG Wen GUO Wen Ping LI Kun State Key Laboratory of Infectious disease prevention and control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesDepartment of ZoonosesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China guizhou Center for disease control and prevention Guiyang 550000GuizhouChina Congjiang Center for disease control and prevention Qiandongnan Autonomous Prefecture 557400GuizhouChina Department of Pathogenic Biology College of Basic MedicineChengde Medical UniversityChengde 067000HebeiChina

Pathogens like bacteria and protozoa,which affect human and animal health worldwide,can be transmitted by vectors like *** investigate the epidemiology and genetic diversity of bacteria and protozoans carried by ticks in Chengmai county of Hainan province,China,285 adult hard ticks belonging to two species[Rhipicephalus sanguineus(sensu lato):183,64.21%and Rhipicephalus microplus:102,35.79%]from dogs,cattle,and goats were *** families were identified in these ticks by amplifying the 18 S r RNA,16 S r RNA(rrs),citrate synthase(glt A),and heat shock protein(gro EL)*** data revealed the presence of four recognized species and two Candidatus *** Anaplasmataceae and *** sum,these data reveal an extensive diversity of Anaplasmataceae bacteria,Coxiellaceae bacteria,Babesiidae,and Hepatozoidae in ticks from Hainan Island,highlighting the need to understand the tickborne pathogen infection in local animals and humans.

关键词： Ticks Rickettsiales bacteria Protozoa Coxiellaceae bacteria Tick-borne disease China

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