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A Blind Batch Encryption and Public Ledger-Based Protocol for Sharing Sensitive Data

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China Communications 2024年第1期21卷 310-322页

作者： Zhiwei Wang Nianhua Yang Qingqing Chen Wei Shen Zhiying Zhang School of Computer Sciences Nanjing University of Posts and TelecommunicationsNanjing 210023China Dept.of Intelligent Science and Information Law East China University of Political Science and LawShanghai 201620China Key Laboratory of Computational Science and Application of Hainan Province Hainan Normal UniversityHaikou 571158China State Key Laboratory of Public Big Data Guizhou UniversityGuizhou 550025China Yunnan Key Laboratory of Blockchain Application Technology Yunnan Innovation Research Institute of Beijing University of Aeronautics and AstronauticsKunming 650233

For the goals of security and privacy preservation,we propose a blind batch encryption-and public ledger-based data sharing protocol that allows the integrity of sensitive data to be audited by a public ledger and allows privacy information to be *** owners can tightly manage their data with efficient revocation and only grant one-time adaptive access for the fulfillment of the *** prove that our protocol is semanticallly secure,blind,and secure against oblivious requesters and malicious file *** also provide security analysis in the context of four typical attacks.

关键词： blind batch encryption data sharing onetime adaptive access public ledger security and privacy

Bioinformatics comprehensive analysis confirmed the potential involvement of SLC22A1 in lower-grade glioma progression and prognosis

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BIOCELL 2024年第5期48卷 803-815页

作者： JING HUI NANA SUN YONG LIU CHUNBO YU YONG KE YONG CAO ANXIAO YU QINGHONG KONG YUN LIU guizhou Provincial College-Based Key Lab for Tumor Prevention and Treatment with DistinctiveMedicines Zunyi Medical UniversityZunyi563000China College of Basic Medicine Zunyi Medical UniversityZunyi563000China Department of Dermatology Guizhou Province Cosmetic Plastic Surgery HospitalAffiliated Hospital of Zunyi Medical UniversityZunyi563000China School of Forensic Medicine Zunyi Medical UniversityZunyi563000China

Background:Although it has been established that the human Solute Carrier Family 22(SLC22)functions as a cationic transporter,influencing cellular biological metabolism by modulating the uptake of various cations,its impact on cancer prognosis remains ***:We conducted a comprehensive analysis utilizing data from The Cancer Genome Atlas(TCGA)and other databases to assess the prognostic value and functional implications across various *** of SLC22A1 RNA in glioma U251 cells was performed to access the impact of SLC22A1 on lowergrade glioma(LGG)***:Our findings demonstrated a significant correlation between SLC22A1 expression and the survival time of patients with various cancers(p0.8).Cell proliferation and clone formation experiment proved that decreased expression of SLC22A1 in glioma U251 cells inhibited glioma cell ***:Our findings suggest SLC22A1 has huge prospects as a promising biomarker and therapeutic target for LGG ***22A1 has only been proved to support cellular function *** findings demonstrated a robust connection between the tumor microenvironment and functional proteins that maintain basal cell metabolism,which gifts unique tumor immune characteristics of ***,we provide a highly practical prediction model for estimating the survival rate of LGG patients.

关键词： SLC22A1 LGG prognosis immune nomogram

The Bright Single Pulse Emission from PSR B1133+16

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Research in Astronomy and Astrophysics 2024年第4期24卷 253-261页

作者： Jun Tan Zhi-Gang Wen Zhen Wang Xue-Feng Duan Hong-Guang Wang Na Wang Vishal Gajjar Jian-Ping Yuan Rai Yuen Wen-Ming Yan Jian-Ling Chen Wei Han Hui Wang Cheng-Bing Lyu Ai-Jun Dong Maths and Information Technology School Yuncheng UniversityYuncheng 044000China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China Space Science Laboratory University of CaliforniaBerkeley 94710USA Department of Physics and Electronic Engineering Yuncheng UniversityYuncheng 044000China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China

We have conducted a comprehensive investigation into the bright single pulse emission from PSR B1133+16using the Giant Metrewave Radio *** time resolution data(61μs)were obtained at a center frequency of 322 MHz with a bandwidth of 32 MHz over a continuous observation period of 7.45 hr.A total of 1082 bright pulses were sporadically detected with peak flux densities ranging from 10 to 23 times stronger than the average pulse ***,no giant pulse-like emission with a relative pulse energy larger than 10 and extremely short duration was detected,indicating that these bright pulses cannot be categorized as giant pulse *** majority of these bright pulses are concentrated in pulse phases at both the leading and trailing windows of the average pulse profile,with an occurrence ratio of approximately *** pulse energy distribution for all individual pulses can be described by a combination of two Gaussian components and a cutoff power-law with an index of α=-*** updated nulling fraction of 15.35%±0.45% was determined from the energy *** emission of individual pulses follows a log-normal distribution in peak flux density *** is imperative that regular phase drifting in bright pulse sequence is identified in both the leading and trailing components for the first *** physical mechanisms are discussed in detail to provide insights into these observations.

关键词： (stars:)pulsars:general (stars:)pulsars:individual(PSR B1133+16) methods:observational methods:data analysis

The Role of ZNF207 in Liver Hepatocellular Carcinoma:Expression analysis and Prognostic Implications

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Proceedings of Anticancer Research 2024年第4期8卷 20-29页

作者： Chengrui Peng Linfei Wu Xiaofang Yang Hanyun Yao Yan Xie First Clinical College Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina School of Public Health Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

Objective:To analyze the expression and clinical significance of the zinc finger protein ZNF207 gene in liver hepatocellular carcinoma(LIHC)based on The Cancer Genome Atlas(TCGA)***:The mRNA sequencing data of 371 cases of primary liver cancer,50 cases of normal tissues,and 3 cases of recurrent liver cancer were downloaded from the TCGA *** corresponding clinical information of the 371 cases of hepatocellular carcinoma was subsequently *** difference in ZNF207 expression between normal and tumor tissues was analyzed using the UALCAN online *** impact of ZNF207 expression on survival prognosis was assessed using the Kaplan-Meier method in R *** GO and KEGG pathways of ZNF207 were *** Cox proportional hazards model was used to evaluate the prognostic factors of patients with ***-qPCR was employed to verify the expression of ZNF207 in LIHC ***:ZNF207 was highly expressed in LIHC tissues and HepG2 cells,with a significant difference(Panalysis revealed that patients with high ZNF207 expression had a significantly shorter overall survival time compared to those with low ZNF207 expression(HR=1.466,95%CI:1.011-2.126,Panalysis suggested that ZNF207 may influence the onset and progression of hepatocellular carcinoma by regulating mRNA splicing and mRNA transcription processing through the *** pathway enrichment analysis indicated that ZNF207 might affect the onset and progression of hepatocellular carcinoma through mitophagy,mRNA surveillance,homologous recombination,spliceosome,and nuclear-cytoplasmic ***:The expression of ZNF207 may be an independent predictor of the prognosis of patients with LIHC and could influence the development of hepatocellular carcinoma through various gene functions and *** has the potential to serve as a novel molecular marker for predicting the prognosis of hepatocellular carcinoma.

关键词： ZNF207 Hepatocellular carcinoma TCGA database

Efficacy and safety of B-ultrasound-guided radiofrequency ablation in the treatment of primary liver cancer: Systematic review and metaanalysis

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2986-2995页

作者： Xiong Zhang Hong-Yi Zhu Ming Yuan Department of Nursing Guizhou Nursing Vocational CollegeGuiyang 550025Guizhou ProvinceChina Department of Hepatobiliary Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina

BACKGROUND Primary liver cancer is one of the most lethal malignancies in the ***-tional treatment methods have limitations in terms of efficacy and ***-diofrequency ablation(RFA)guided by B-ultrasound,as a minimally invasive treatment,has attracted increasing attention in the treatment of primary liver cancer in recent *** To study the efficacy and safety of RFA were compared with those of traditional surgery(TS)for treating small liver *** At least 2 people were required to search domestic and foreign public databases,including foreign databases such as EMBASE,PubMed and the Cochrane Library,and Chinese databases such as the China National Knowledge Infrastructure database,China Biomedical Literature database,Wanfang database and VIP *** trials of RFA vs conventional surgery for small liver cancer were retrieved from January 2008 to January *** were screened and eva-luated according to the quality evaluation criteria in the Cochrane Handbook of Systematic *** meta-analysis was performed using RevMan 5.3 *** A total of 10 studies were included in this study,including 1503 patients in the RFA group and 1657 patients in the surgery *** results of the meta-ana-lysis showed that there was no significant difference in 1-year overall survival between the two groups(P>0.05),while the 3-year and 5-year overall survival rates and 1-year,3-year and 5-year tumor-free survival rates in the surgery group were greater than those in the RFA group(P<0.05).In terms of complications,the incidence of complications in the RFA group was lower than that in the surgery group(P<0.05).CONCLUSION In terms of long-term survival,TS is better than RFA for small liver cancer ***,RFA has fewer complications and is safer.

关键词： Survival prognosis Small liver cancer Radiofrequency ablation Traditional surgical resection Meta-analysis

Flexible capacitive pressure sensor based on interdigital electrodes with porous microneedle arrays for physiological signal monitoring

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Nanotechnology and Precision Engineering 2024年第1期7卷 18-31页

作者： Jiahui Xu Minghao Wang Minyi Jin Siyan Shang Chuner Ni Yili Hu Xun Sun Jun Xu Bowen Ji Le Li Yuhua Cheng Gaofeng Wang School of Electronics&Information MOE Engineering Research Center of Smart Microsensors and MicrosystemsHangzhou Dianzi UniversityHangzhou 310018China Wenzhou Institute of Hangzhou Dianzi University Wenzhou 310018China Key Laboratory of Intelligent Operation and Maintenance Technology&Equipment for Urban Rail Transit of Zhejiang Province College of EngineeringInstitute of Precision Machinery and Smart StructureZhejiang Normal UniversityJinhua 321004China Institute of guizhou Aerospace Measuring and testing Technology Guiyang 550009China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

Flexible pressure sensors have many potential applications in the monitoring of physiological signals because of their good biocompatibil-ity and ***,their relatively low sensitivity,linearity,and stability have hindered their large-scale commercial ***,aﬂexible capacitive pressure sensor based on an interdigital electrode structure with two porous microneedle arrays(MNAs)is *** porous substrate that constitutes the MNA is a mixed product of polydimethylsiloxane and *** to its porous and interdigital structure,the maximum sensitivity(0.07 kPa-1)of a porous MNA-based pressure sensor was found to be seven times higher than that of an imporous MNA pressure sensor,and it was much greater than that of aﬂat pressure sensor without a porous MNA ***-element analysis showed that the interdigital MNA structure can greatly increase the strain and improve the sensitivity of the *** addition,the porous MNA-based pressure sensor was found to have good stability over 1500 loading cycles as a result of its bilayer parylene-enhanced conductive electrode *** importantly,it was found that the sensor could accurately monitor the motion of aﬁnger,wrist joint,arm,face,abdomen,eye,and Adam’s ***,preliminary semantic recognition was achieved by monitoring the movement of the Adam’s ***,multiple pressure sensors were integrated into a 33 array to detect a spatial pressure distribu-×*** to the sensors reported in previous works,the interdigital electrode structure presented in this work improves sensitivity and stability by modifying the electrode layer rather than the dielectric layer.

关键词： Capacitive pressure sensor Microneedle array Porous PDMS Interdigital electrode

Quantitative Evaluation of Heavy Metal Pollution and Its Influencing Factors in Water Bodies of Karst Areas

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Meteorological and Environmental Research 2024年第1期15卷 75-82页

作者： Dijin MU Shizhen XIAO School of Karst Science Guizhou Normal UniversityGuiyang 550001China

At present, there is relatively little research on the synergistic effects of heavy metals in soil, sediment, and bedrock on heavy metal pollution in water bodies. In this paper, heavy metals in soil, sediment, bedrock, and water of a typical karst watershed in southwest China were investigated. The results indicated that the average values of heavy metals in soil and sediment were relatively higher than those in bedrock except for Ni and As. During the research period, As and Cd were the main heavy metal elements polluting the soil and sediment in the study area, while water bodies were mainly polluted by Ni, As, and Cd. The pollution assessment indicated that there were instances of poor or very poor water quality in the study area during the study period;the soil as a whole was slightly polluted by Cd and As;sediment was subject to moderate Cd pollution and mild As pollution. analysis of geochemical form for heavy metals showed that heavy metals in soil and sediment were mainly in residual form, and the proportions of exchangeable As and Cd were relatively high. Multiple statistical analysis showed that heavy metals in sediment, soil, and bedrock explained 23.8%, 16.8%, and 16.2% of the changes in heavy metals of water, respectively. The research results can provide scientific basis for the prevention and control of heavy metal pollution in water bodies.

关键词： Water body Sediment Soil Bedrock Speciation forms Pollution Influence factor

Exact satisfiability and phase transition analysis of the regular(k,d)-CNF formula

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Frontiers of Computer Science 2024年第1期18卷 263-265页

作者： Guoxia NIE Daoyun XU Xi WANG Zaijun ZHANG College of Computer Science and Technology Guizhou UniversityGuiyang 550025China School of Mathematics and Statistics Qiannan Normal University for NationalitiesDuyun 558000China Key Laboratory of Industrial Automation and Machine Vision of Qiannan Duyun 558000China

1Introduction The satisfiability(SAT)problem has been considered the"seed"of other NP-complete *** regular partial exact(k,d)-SAT problem is an important extension of the SAT *** any(k,d)-CNF formula with a variable set V,V'is a proper subset of V,the problem involves determining whether a truth assignment set on V'exists such that only a literal in each clause is *** V'=V,it is a regular exact(k,d)-SAT ***,both experimental verifications and theoretical analyses of k-SAT problem have shown that the ratioα(clause constraint density)of the number of clauses m to the number of variables n is an important parameter affecting the satisfiability of the formula[1].However,the regular(k,d)-SAT problem has the same clause constraint density d/k.

关键词： formula constraint exact

Study on the Mechanism of Action of Glyasperin A in the Treatment of Atherosclerosis Based on Network Pharmacology and Molecular Docking

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Agricultural Biotechnology 2024年第2期13卷 53-57页

作者： Na LI Xiang PU Yihui CHAI Yuqi YANG Lailai LI guizhou University of Traditional Chinese Medicine Guiyang 550025China

[Objectives] This study was conducted to investigate the mechanism of action of glyasperin A in the treatment of atherosclerosis using a network pharmacology approach. [Methods] Targets related to atherosclerosis were searched in GeneCards database. An active ingredient-disease-target network was constructed by Cytoscape 3.7.1. A target protein interaction network was constructed by String database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the DAVID database. [Results] Glyasperin A acted on 36 atherosclerosis-related targets, and the biofunctional and pathway enrichment analyses showed that it was mainly involved in response to xenobiotic stimulus, drug transport across blood-brain barrier, lipid oxidation, barrier, and lipid oxidation, etc. The results showed that glyasperin A acted on 36 atherosclerosis-related targets. The biofunctional and pathway enrichment analyses showed that it was mainly involved in response to xenobiotic stimulus, drug transport across blood-brain barrier, lipid oxidation, positive regulation of protein localization to nucleus, and hepoxilin biosynthetic process, and it played an anti-fatigue role through signal pathways such as serotonergic synapse, efferocytosis, arachidonic acid metabolism, chemical carcinogenesis-receptor activation and platelet activation. [Conclusions] Glyasperin A has multi-target and multi-pathway effects in the treatment of atherosclerosis. This study provides reference for further research on glyasperin A in the treatment of atherosclerosis.

关键词： Glyasperin A Atherosclerosis Network pharmacology Mechanism of action