检索结果-南通市图书馆

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

引用

Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease co.trol and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina co.laborative Innovation Center for Prevention and co.trol of Endemic and Ethnic Regional Diseases co.co.structed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-gluco.e deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-gluco.e deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

One Novel hydraulic Actuating System for the Lower-Body Exoskeleton

引用

Chinese Journal of Mechanical Engineering 2021年第1期34卷 20-29页

作者： Maowen Sun Xiaoping Ouyang Jouni Mattila Huayong Yang Gang Hou State Key Laboratory of Fluid Power&Mechatronic Systems Zhejiang UniversityHangzhou 310027China Department of Intelligent hydraulics and Automation Tampere University33101 TampereFinland guiyang hyc hydraulic co. LtdGuiyang 550018China

The hydraulic exoskeleton is one research hotspot in the field of robotics,which can take heavy load due to the high power density of the hydraulic ***,the traditional hydraulic system is normally centralized,inefficient,and bulky during application,which limits its development in the *** improving the robot's performance,its hydraulic actuating system should be optimized *** this paper a novel hydraulic actuating system(HAS)based on electric-hydrostatic actuator is proposed,which is applied to hip and knee *** HAS integrates an electric servo motor,a high-speed micro pump,a specific tank,and other co.ponents into a *** specific parameters are obtained through relevant simulation acco.ding to human motion data and load *** dynamic models of the HAS are built,and validated by the system *** of trajectory tracking and human-exoskeleton interaction are carried out,which demonstrate the proposed HAS has the ability to be applied to the *** with the previous prototype,the total weight of the HAS in the robot is reduced by about 40%,and the power density is increased by almost 1.6 times.

关键词： hydraulic actuating system(HAS) Lower-body exoskeletons Lightweight and integrated System identification Working mode test

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

引用

Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng co.lege of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are co.monly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver co.ld represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico.approaches

引用

Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive co.ponents and underlying mechanisms have not been *** objective of this study was to identify the active co.ponents and potential mechanisms of SMW by integrating pharmaco.ogical experimentation,serum pharmaco.hemistry,network pharmaco.ogy and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmaco.ynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive co.ponents present in SMW-co.taining *** pharmaco.ogy and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and gluco.e metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 co.pounds detected in SMW-co.taining serum were identified as potential active co.ponents,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 co.responding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active co.pounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated gluco.e transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).co.clusion:S

关键词： hyperuricemia network pharmaco.ogy serum pharmaco.hemistry Simiaowan UPLC-Q-Exactive-MS/MS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic simulation and experimental study of the effect of one-dimensional vibration on the packing of wood powder particles

引用

Particuology 2024年第11期94卷 294-304页

作者： Xiaoneng Chen Fuqiang He Fajiang Chen Yuan Dai School of Mechanical Engineering Guizhou UniversityGuiyang550025China Guizhou Jingmu Building Materials co. Guiyang550025China

In the industry of production of high-density fiberboards without adhesive,applying vibration to the particle packing system before pressing and molding is an effective way to improve the uniformity of particle packing and reduce *** this work,physical experiments co.bined with numerical simulations are used to systematically investigate the packing structure behavior of wood powder particles under different vibration *** and microsco.ic properties such as porosity,co.rdination number,radial distribution function,and co.tacts are characterized and *** results indicate that when the vibration frequency is 72 Hz and the vibration amplitude is 1 mm,the porosity of wood powder particles closely packed is *** results of the Discrete Element Method show that the distribution of the co.rdination number is approximately *** the vibration co.ditions change,the packing structure beco.es tighter,but the main peak of the radial distribution function beco.es blurred or even *** does not significantly change the type of co.tact in the packing *** co.clusions can provide more co.prehensive vibration co.ditions and microsco.ic theories for the uniform spreading of wood powder particles before pressing,ensuring that the finished panels have excellent mechanical and physical properties.

关键词： Vibration Wood powder particle Dynamic simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Task Offloading Strategy Based on Multi-Agent Deep Reinforcement Learning for Offshore Wind Farm Scenarios

引用

co.puters, Materials & co.tinua 2024年第10期81卷 985-1008页

作者： Zeshuang Song Xiao Wang Qing Wu Yanting Tao Linghua Xu Yaohua Yin Jianguo Yan Department of Electrical Engineering Guizhou UniversityGuiyang550025China Powerchina guiyang Engineering co.poration Limited Guiyang550081China Powerchina Guizhou Engineering co. Ltd.Guiyang550001China

This research is the first application of Unmanned Aerial Vehicles(UAVs)equipped with Multi-access Edge co.puting(MEC)servers to offshore wind farms,providing a new task offloading solution to address the challenge of scarce edge servers in offshore wind *** proposed strategy is to offload the co.putational tasks in this scenario to other MEC servers and co.pute them proportionally,which effectively reduces the co.putational pressure on local MEC servers when wind turbine data are ***,the task offloading problem is modeled as a multi-intelligent deep reinforcement learning problem,and a task offloading model based on MultiAgent Deep Reinforcement Learning(MADRL)is *** Adaptive Genetic Algorithm(AGA)is used to explore the action space of the Deep Deterministic Policy Gradient(DDPG),which effectively solves the problem of slow co.vergence of the DDPG algorithm in the high-dimensional action *** simulation results show that the proposed algorithm,AGA-DDPG,saves approximately 61.8%,55%,21%,and 33%of the overall overhead co.pared to local MEC,random offloading,TD3,and DDPG,*** proposed strategy is potentially important for improving real-time monitoring,big data analysis,and predictive maintenance of offshore wind farm operation and maintenance systems.

关键词： Offshore wind MEC task offloading MADRL AGA-DDPG

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Using a modified direct shear apparatus to explore gap and size effects on shear resistance of co.rse-grained soil

引用

Particuology 2015年第6期13卷 82-89页

作者： Wenxi Fu Xing Zheng Xiaozhang Lei Jianhui Deng State Key Laboratory of hydraulic and Mountain River Engineering Sichuan University Chengdu 610065 China Civil Engineering Hydrochina Guiyang Engineering Corporation LTD Guiyang 550081 China

This work used a modified direct shear apparatus, created newly by the authors, to explore effects of the gap between shear box halves and specimen size on the shear resistance of co.rse-grained soil. The shear boxes of this apparatus were assembled from a series of steel structures capable of superimposition and nesting. Such characteristics facilitated variation of specimen size in both diameter and height. The new device can also maintain a co.stant gap during shearing. We performed a series of gap-effect and size-effect tests for two uniformly graded, co.rse^grained soil samples. The test results showed that both the gap space and specimen size bad significant influences on shear resistance of the co.rse-grained soil. Further, analysis of variations in shear strength indices led to a reasonable gap dimension and specimen size of the two soil samples.

关键词： Direct shear apparatus Gap effectSize effect Shear resistance co.rse-grained soil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Abrasion test of flexible protective materials on hydraulic structures

引用

Water Science and Engineering 2014年第1期7卷 106-116页

作者： Xin WANG Shao-ze LUO Guang-sheng LIU Lu-chen ZHANG Yong WANG State Key Laboratory of Hydrology-Water Resources and hydraulic Engineering Nanjing Hydraulic Research Institute Beijing Oriental Yuhong Waterproof Technology co. Ltd.

In this study, several kinds of flexible protective materials sprayed with polyurea elastomers （hereinafter referred to as polyurea elastomer protective material） were adopted to meet the abrasion resistance requirement of hydraulic structures, and their abrasion resistances against the water flow with suspended load or bed load were studied systematically through tests. Natural basalt stones were adopted as the abrasive for simulation of the abrasion effect of the water flow with bed load, and test results indicate that the basalt stone is suitable for use in the abrasion resistance test of the flexible protective material. The wear process of the polyurea elastomer protective material is stable, and the wear loss is linear with the time of abrasion. If the wear thickness is regarded as the abrasion resistance evaluation factor, the abrasion resistance of the 351 pure polyurea is about twice those of pure polyurea with a high level of hardness and aliphatic polyurea, and over five times that of high-performance abrasion-resistant co.crete under the abrasion of the water flow with suspended load. It is also about 50 times that of high-performance abrasion-resistant co.crete under the abrasion of the water flow with bed load. Overall, the abrasion resistance of pure polyurea presented a decreasing trend with increasing hardness. Pure polyurea with a Shore hardness of D30 has the best abrasion resistance, which is 60 to 70 times that of high-performance abrasion-resistant co.crete under the abrasion of the water flow with bed load, and has been reco.mended, among the five kinds of pure polyurea materials with different hardness, in anti-abrasion protection of hydraulic structures.

关键词： flexible protective material polyurea elastomer material abrasion resistance hardness influence hydraulic structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-Objective Image Optimization of Product Appearance Based on Improved NSGA-II

引用

co.puters, Materials & co.tinua 2023年第9期76卷 3049-3074页

作者： Yinxue Ao Jian Lv Qingsheng Xie Zhengming Zhang Key Laboratory of Advanced Manufacturing Technology of the Ministry of Education Guizhou UniversityGuiyang550025China Potevio Logistics Technology co. Ltd.Guiyang550025China

A seco.d-generation fast Non-dominated Sorting Genetic Algorithm product shape multi-objective imagery optimization model based on degradation(DNSGA-II)strategy is proposed to make the product appearance optimization scheme meet the co.plex emotional needs of users for the ***,the semantic differential method and K-Means cluster analysis are applied to extract the multi-objective imagery of users;then,the product multidimensional scale analysis is applied to classify the research objects,and again the reference samples are screened by the semantic differentialmethod,and the samples are parametrized in two dimensions by using elliptic Fourier analysis;finally,the fuzzy dynamic evaluation function is used as the objective function of the algorithm,and the co.rdinates of key points of product co.tours Finally,with the fuzzy dynamic evaluation function as the objective function of the algorithm and the co.rdinates of key points of the product profile as the decision variables,the optimal product profile solution set is solved by *** validity of the model is verified by taking the optimization of the shape scheme of the hospital co.nection site as an *** co.parison with DNSGA-II,other multi-objective optimization algorithms are also *** evaluate the performance of each algorithm,the performance evaluation index values of the five multi-objective optimization algorithms are calculated in this *** results show that DNSGA-II is superior in improving individual diversity and has better overall performance.

关键词： Product appearance optimization NSGA-II multi-objective optimizations perceptual image semantic differential method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alternative 3D Modeling Approaches Based on co.plex Multi-Source Geological Data Interpretation

引用

Transactions of Tianjin University 2014年第1期20卷 7-14页

作者：李明超韩彦青缪正建高伟 State Key Laboratory of hydraulic Engineering Simulation and Safety Tianjin University Tianjin Dredging co. Ltd

Due to the co.plex nature of multi-source geological data, it is difficult to rebuild every geological structure through a single 3D modeling method. The multi-source data interpretation method put forward in this analysis is based on a database-driven pattern and focuses on the discrete and irregular features of geological data. The geological data from a variety of sources co.ering a range of accuracy, resolution, quantity and quality are classified and integrated acco.ding to their reliability and co.sistency for 3D modeling. The new interpolation-approximation fitting co.struction algorithm of geological surfaces with the non-uniform rational B-spline(NURBS) technique is then presented. The NURBS technique can retain the balance among the requirements for accuracy, surface co.tinuity and data storage of geological structures. Finally, four alternative 3D modeling approaches are demonstrated with reference to some examples, which are selected acco.ding to the data quantity and accuracy specification. The proposed approaches offer flexible modeling patterns for different practical engineering demands.

关键词： multi-source data geological data interpretation interpolation-approximation fitting 3D geological sur-face modeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：