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HPLC Method Research of Picoplatin-a New Platinum Anti-cancer Drug and Its Impurities

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贵金属 2012年第A01期33卷 253-257页

作者： LUAN Chunfang coNG Yanwei ZHANG Qi QIU Xueweng BEI Yuxiang PU Shaoping Kunming guiyan Pharmaceutical co.Ltd. Kunming 650106China.

Purpose: To establish a HPLC testing method of the content of bulk picoplatin and its impurities. Method: the separation was perform on a C18 column(4.6 mm×250 mm, 5 m) with potassium dihydrogen phosphate-aceton-itrile as the mobile phase at a flow rate of 1.0 mL/min. The detecting wavelength was set at 210 nm, and the column temperature was set at 30℃. Result: in the method validation, the linear relationship modulus of picoplatin is 0.9999, the systemic precision is 0.44%, the method precision is 0.74%, the average recovery rate is 99.62%, the LOD and LOQ of picoplatin is 0.2 ng and 1.0 ng. The average resolution of picoplatin and its impurities is more than 2. conclusion: The established method is good specificity, high sensitivity, and good repeatability which could provide scientific evidence for the quality control of picoplatin and its impurities.

关键词： platinum-based anti-cancer drug picoplatin HPLC

control the Silver content in the Preparation Process of Platinum Group Anti-cancer Drugs

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贵金属 2012年第A1期33卷 243-245页

作者： HE Jian ZHU Zhebin LI Xuejie LUAN Chunfang PENG Juan WANG Qinkun PU Shaopin Kunming guiyan Pharmaceutical co. Ltd.Kunming 650106China

In order to control the silver content in the preparation process of platinum group anti-cancer drugs, we put two kinds of color reagent to color in the production process of the platinum anti-cancer drugs by UV spectra measurement to control drugs production of platinum anticancer, thus we could control the silver content in the drugs so that it meets the pharmacopoeia standards of US and

关键词： silver platinum anti-cancer drugs

Improved Synthesis of Miriplatin

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贵金属 2012年第A1期33卷 281-283页

作者： WANG Qingkun PU Shaoping LIU Zhudong LIU Liangmeng LIAO Yunxing JIN Ji Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug Kunming Guiyan Pharmaceutical Co.Ltd.Kunming 650106China

Miriplatin, a novel lipophilic platinum complex has been developed to treat hepatocellular carcinoma. An improvd synthetic route was designed and used to prepare the target compound. The intermediate Pt(C6H14N2)(I) 2 was synthesized from K 2 PtCl 4 , KI and (1R,2R)-1,2-cyclohexanediamine, Pt(C 6 H 14 N 2 )(I) 2 was reacted with AgNO 3 to prepare Pt(C 6 H 14 N 2 )(H 2 O) 2 (NO 3 ) 2 solution then was subsequently reacted with CH 3 (CH 2 ) 12 coONa in n-butanol to give target compound with satisfied yield 81%(based on Pt(C 6 H 14 N 2 )I 2 ). The structure of the target compound was identified by elemental analysis, ESI-MS, FT-IR, 1H-NMR, thermal analysis, the structure was consistent with the target compound.

关键词： antitumor drug miriplatin improved synthesis