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Quasi-Solid-State Ion-Conducting Arrays Composite Electrolytes with Fast Ion Transport Vertical-Aligned Interfaces for All-Weather Practical Lithium-Metal Batteries

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Nano-Micro Letters 2022年第12期14卷 401-414页

作者： Xinyang Li Yong Wang Kai Xi Wei Yu Jie Feng Guoxin Gao Hu Wu Qiu Jiang Amr Abdelkader Weibo Hua Guiming Zhong Shujiang Ding School of Chemistry Xi’an Key Laboratory of Sustainable Energy Materials ChemistryState Key Laboratory of Electrical Insulation and Power EquipmentXi’an Jiaotong UniversityXi’an 710049People’s Republic of China State Key Laboratory for Mechanical Behaviour of Materials Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhouZhejiang 313001People’s Republic of China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054People’s Republic of China Faculty of Science and Technology Bournemouth UniversityTalbot CampusFern BarrowPoole BH125BBUK Institute for Applied Materials-Energy Storage Systems(IAM-ESS) Karlsruhe Institute of Technology(KIT)76344 Eggenstein-LeopoldshafenGermany School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’anShaanxi 710049People’s Republic of China Laboratory of Advanced Spectroelectrochemsitry and Li-ion Batteries Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023People’s Republic of China State Key Laboratory of Organic-inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China

The rapid improvement in the gel polymer electrolytes(GPEs)with high ionic conductivity brought it closer to practical applications in solid-state Li-metal *** combination of solvent and polymer enables quasi-liquid fast ion transport in the ***,different ion transport capacity between solvent and polymer will cause local nonuniform Li+distribution,leading to severe dendrite *** addition,the poor thermal stability of the solvent also limits the operating-temperature window of the *** the ion transport environment and enhancing the thermal stability are two major challenges that hinder the application of ***,a strategy by introducing ion-conducting arrays(ICA)is created by vertical-aligned montmorillonite into *** ion transport on the ICA was demonstrated by 6Li solid-state nuclear magnetic resonance and synchrotron X-ray diffraction,combined with computer simulations to visualize the transport *** with conventional randomly dispersed fillers,ICA provides continuous interfaces to regulate the ion transport environment and enhances the tolerance of GPEs to extreme ***,GPE/ICA exhibits high room-temperature ionic conductivity(1.08 mS cm^(−1))and long-term stable Li deposition/stripping cycles(>1000 h).As a final proof,Li||GPE/ICA||LiFePO_(4) cells exhibit excellent cycle performance at wide temperature range(from 0 to 60°C),which shows a promising path toward all-weather practical solid-state batteries.

关键词： Solid-state batteries Composite electrolytes Vertical-aligned ion-conducting arrays Interfacial ion-conduction mechanism All-weather practical electrolyte design

抗癫痫药拉莫三嗪对α4β2-N型乙酰胆碱受体的作用

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生物物理学报 2009年第S1期25卷 286-286页

作者：郑超汪萌芽 Jie Wu 皖南医学院细胞电生理研究室 Division of Neurology Neurobiology Barrow Neurological Institute St. Joseph's Hospital and Medical Center Phoenix Arizona85013USA

拉莫三嗪(Lamotrigine,LTG)作为一种抗癫痫的药物,其对N型乙酰胆碱受体(nAChR)是否存在作用,目前国内外尚未见报道。

关键词：拉莫三嗪(LTG) α4β2-N型乙酰胆碱受体 SH-EP1细胞株膜片钳

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恶性胶质瘤的治疗：综合方案的进展

中国现代神经疾病杂志 2006年第6期6卷 453-458页

作者： Lynn S Ashby（） Timothy C Ryken（）刘暌（译）只达石（校） barrow Neurological Institute St. Joseph＇s Hospital and MedicalCenter Phoenix Arizona and Departments of Neurogery and RadiationOncology University of Iowa Hospitals and Clinics Iowa City Iowa 天津市环湖医院神经外科 300060 天津医科大学总医院

第一部分中枢神经系统肿瘤（central nerous system tumors）一、流行病学特征（epidemiological features）中枢神经系统原发肿瘤，从高度恶性胶质瘤和原始神经外胚层肿瘤到良性脑膜瘤、神经瘤及垂体腺瘤，可表现出不同的生物学行为... 详细信息

第一部分中枢神经系统肿瘤（central nerous system tumors）一、流行病学特征（epidemiological features）中枢神经系统原发肿瘤，从高度恶性胶质瘤和原始神经外胚层肿瘤到良性脑膜瘤、神经瘤及垂体腺瘤，可表现出不同的生物学行为。根据来自美国脑肿瘤注册中心（Central Brain Tumor Registry of the United States，CBTRUS）的最新报告，每年新诊断的原发脑恶性肿瘤的人数为7．30／10万人。美国脑肿瘤注册中心2005年报告新诊断的中枢神经系统原发肿瘤患者为21690例，死亡12760例。胶质瘤占神经系统原发肿瘤的42％，占恶性肿瘤的77％。胶质瘤起源于不同的组织类型，包括少突胶质细胞瘤、星形细胞瘤、混合型少突星形细胞瘤，表现为不同的恶性程度，而且均具有向高度恶性转化的趋势，其中多形性胶质母细胞瘤（glioblasto mamultiforme，GBM）为成人中最常见的并具有浸润性的原发脑肿瘤。

关键词：恶性胶质瘤中枢神经系统肿瘤原始神经外胚层肿瘤多形性胶质母细胞瘤原发脑肿瘤少突胶质细胞瘤脑恶性肿瘤星形细胞瘤

Impact of COVID-2019 on stroke services in China: survey from the Chinese Stroke Association

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Stroke & Vascular Neurology 2020年第4期5卷 323-330页

作者： Xia Wang Menglu Ouyang Cheryl Carcel Chen Chen Lingli Sun Jie Yang Yao Zhang Guofang Chen Shoujiang You Yongjun Cao Lu Ma Xin Hu Yi Sui Craig Anderson Lili Song Yongjun Wang David Wang The George Institute for Global Health Faculty of MedicineUniversity of New South WalesSydneyNew South WalesAustralia Department of Neurology Shanghai East HospitalShanghaiShanghaiChina Stroke Division The George Institute China at Peking University Health Science CentreBeijingPR ChinaShanghaiChina Department of Neurology The First Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Neurology Shenyang Brain HospitalShenyang Medical CollegeShenyangChina Department of Neurology Xuzhou Central HospitalXuzhouJiangsuChina Department of Neurology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Department of Neurosurgery West China Hospital of MedicineChengduSichuanChina Department of Neurology Royal Prince Alfred HospitalSydneyNSWAustralia Department of Neurology China National Clinical Research Center for Neurological DiseaseBeijingChina Department of Neurology Tiantan Clinical Trial and Research Center for StrokeBeijingChina Neurovascular Division Department of NeurologyBarrow Neurological InstituteSt.Joseph's Hospital and Medical CenterPhoenixArizonaUSA

Background The COVID-19 pandemic and physical distancing guidelines have compelled stroke practices worldwide to reshape their delivery of care *** aimed to illustrate how the stroke services were interrupted during the pandemic in *** A 61-item questionnaire designed on Wenjuanxing Form was completed by doctors or nurses who were involved in treating patients with stroke from 1 February to 31 March *** A total of 415 respondents completed the online survey after informed consent was *** the respondents,37.8%,35.2%and 27.0%were from mild,moderate and severe epidemic areas,***,the proportion of severe impact(reduction>50%)on the admission of transient ischaemic stroke,acute ischaemic stroke(AIS)and intracerebral haemorrhage(ICH)was 45.0%,32.0%and 27.5%,*** numbers were 36.9%,27.9%and 22.3%;36.5%,22.1%and 22.6%;and 66.4%,47.5%and 41.1%in mild,moderate and severe epidemic areas,respectively(all p50%),as reported by 54.4%of the respondents,while thrombectomy was 39.3%.These were 44.4%,26.3%;44.2%,39.4%;and 78.2%,56.5%,in mild,moderate and severe epidemic areas,respectively(all psurgery who had *** numbers were 27.4%,39.0%and 58.1%in mild,moderate and severe epidemic areas,*** staff resources,about 20%(overall)to 55%(severe epidemic)of the respondents reported moderate or severe impact on the on-duty doctors and *** We found a significant reduction of admission for all types of patients with stroke during the *** were less likely to receive appropriate care,for example,thrombolysis/thrombectomy,after being admitted to the *** service in severe COVID-19 epidemic areas,for example,Wuhan,was much more severely impacted compared with other regions in China

关键词： nurse admitted services

Pedicle screw accuracy assessment in ExcelsiusGPS?robotic spine surgery:evaluation of deviation from pre-planned trajectory

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Chinese Neurosurgical Journal 2018年第3期4卷 118-123页

作者： Bowen Jiang A.Karim Ahmed Corinna C.Zygourakis Samuel Kalb Alex M.Zhu Jakub Godzik Camilo A.Molina Ari M.Blitz Ali Bydon Neil Crawford Nicholas Theodore Department of Neurosurgery The Johns Hopkins School of MedicineThe Johns Hopkins Hospital600 N.Wolfe StreetMeyer 7-113BaltimoreMD 21287USA Department of Neurosurgery Barrow Neurological InstituteSt.Joseph’s Hospital and Medical CenterPhoenixAZUSA Department of Neuroradiology Johns Hopkins School of MedicineThe Johns Hopkins Hospital600 N Wolfe StBaltimoreMD 21287USA Department of Neurosurgery Johns Hopkins University School of Medicine1800 Orleans StreetZayed Tower Mailstop 6007Baltimore 21287MDUSA Globus Medical Inc 2560 General Armistead AveAudubon 19403PAUSA

Background: The ExcelsiusGPS?(Globus Medical, Inc., Audubon, PA) is a next-generation spine surgery robotic system recently approved for use in the United States. The objective of the current study is to assess pedicle screw accuracy and clinical outcomes among two of the first operative cases utilizing the ExcelsiusGPS?robotic system and describe a novel metric to quantify screw deviation. Methods: Two patients who underwent lumbar fusion at a single institution with the ExcelsiusGPS?surgical robot were included. Pre-operative trajectory planning was performed from an intra-operative CT scan using the O-arm (Medtronic, Inc., Minneapolis, MN). After robotic-assisted screw implantation, a post-operative CT scan was obtained to confirm ideal screw placement and accuracy with the planned trajectory. A novel pedicle screw accuracy algorithm was devised to measure screw tip/tail deviation distance and angular offset on axial and sagittal planes. Screw accuracy was concurrently determined by a blinded neuroradiologist using the traditional Gertzbein-Robbins method. Clinical variables such as symptomatology, operative data, and post-operative follow-up were also collected. Results: Eight pedicle screws were placed in two L4-L5 fusion cases. Mean screw tip deviation was 2.1 mm (range 0.8-5.2 mm), mean tail deviation was 3.2 mm (range 0.9-5.4 mm), and mean angular offset was 2.4 degrees (range 0.7-3.8 degrees). All eight screws were accurately placed based on the Gertzbein-Robbins scale (88% Grade A and 12% Grade B). There were no cases of screw revision or new post-operative deficit. Both patients experienced improvement in Frankel grade and Karnofsky Performance Status (KPS) score by 6 weeks post-op. Conclusion: The ExcelsiusGPS? robot allows for precise execution of an intended pre-planned trajectory and accurate screw placement in the first patients to undergo robotic-assisted fusion with this technology.

关键词： Robotic spine surgery Robot-assisted surgery Excelsius GPS® Gertzbein-Robbins Pedicle screw accuracy

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通过研究解密大脑——脑健康的未来

英国医学杂志中文版 2021年第1期24卷 29-32页

作者： David Z Wang Lee H Schwamm 钱天翼戴琼海美国凤凰城barrow Neurological Institute 美国哈佛麻省总医院卒中中心中国腾讯觅影/医疗技术委员会中国清华大学信息学院及脑与认知科学研究院

David Z Wang和同事们研究了大脑研究的最新进展,以及它们如何影响大脑疾病的治疗。整个世界都在积极地解决大脑之奥秘,人们已经在了解大脑对人类意识产生中发挥的基本作用以及发现脑疾病的治疗方法方面走了很长一段路。公元前430年希... 详细信息

David Z Wang和同事们研究了大脑研究的最新进展,以及它们如何影响大脑疾病的治疗。整个世界都在积极地解决大脑之奥秘,人们已经在了解大脑对人类意识产生中发挥的基本作用以及发现脑疾病的治疗方法方面走了很长一段路。公元前430年希波克拉底的《神圣疾病》(The Sacred Disease)中就有记载,大脑是用来容纳心室的,其主要目的是作为身体从外部呼吸空气的容器和转运点,从而为我们的生命带来喜怒哀乐。

关键词：希波克拉底人类意识脑健康转运点大脑喜怒哀乐

中枢神经系统脱髓鞘疾病血清水通道蛋白-4抗体的检测及其临床特点

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中枢神经系统脱髓鞘疾病血清水通道蛋白-4抗体的检测及其临床特点