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Plant essential oils combined with organic acids restored lipopolysaccharide-induced leaky intestine via gut microbial modulation in weaned piglets

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ANIMAL NUTRITION 2024年第3期18卷 419-432页

作者： Zheng, Xiaoyu Wang, Yibo Zhou, Xuemei Deng, Tanyi Zhao, Yueqi Fu, Zhichao Wei, Yulong Ma, Wen Zhang, Shihai Guan, Wutai Chen, Fang South China Agr Univ Coll Anim Sci State Key Lab Swine & Poultry Breeding Ind Guangzhou 510642 Peoples R China South China Agr Univ Guangdong Lab Lingnan Modern Agr Guangzhou 510642 Peoples R China South China Agr Univ Coll Anim Sci Guangzhou 510642 Peoples R China South China Agr Univ Natl Engn Res Ctr Breeding Swine Ind Guangzhou 510642 Peoples R China

Intestine derived lipopolysaccharide (LPS) is closely related to systemic inflammation and disorders, yet little is known about its roles in the weanling stress of piglets and its potential as a nutritional intervention target. This study aimed to investigate the potential of essential oils (EO) and organic acids (OA) in mitigating weaning stress in piglets by modulating the circulation of intestine derived LPS. Seventytwo weaned piglets at 21 d old with body weight of 8.12 +/- 0.168 kg were randomly divided into a control group (CON) and an experimental group, each consisting of six pens with six piglets per pen, and were fed either a basal diet or a basal diet supplemented with 3 kg/t OA + 500 g/t EO (EO + OA). On the 14th day of the feeding trial, 12 weaned piglets were randomly selected from the CON group, and 6 piglets were selected from the experimental group. Based on diet composition and stress treatment, these 18 piglets were divided into the following three groups: 1) CON group. Piglets were fed a basal diet and received an intraperitoneal injection of saline as a control. 2) LPS group. Piglets were fed a basal diet and received an intraperitoneal injection of LPS (100 mg/kg body weight) to induce stress. 3) EO + OA + LPS group. Piglets were fed a basal diet supplemented with EO and OA and received an intraperitoneal injection of LPS (100 mg/kg body weight) to induce stress. The results showed that EO + OA significantly ameliorated the oxidative imbalance and inflammation disorder induced by LPS in piglets' serum and intestine by inhibiting the activation of the Toll-like receptor 4 (TLR4)/nuclear factor- kappa B (NF-kB)/mitogen-activated protein kinase (MAPK) signaling pathway. Furthermore, compared to the LPS group, supplementation with EO + OA restored LPS-induced reductions in Bcl-2 protein expression in the piglets' intestines (P P < 0.05) and mitigated morphological damage; it also enhanced both the protein expression and relative gene expression of

关键词： Weaned piglet Essential oil Organic acid Gut microbiota Lipopolysaccharide WEANING STRESS BARRIER HEALTH

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Dietary black soldier fly oil enhances growth performance, flesh quality, and health status of largemouth bass (Micropterus salmoides)

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ANIMAL NUTRITION 2024年第3期18卷 234-245页

作者： Yuan, Hailin Hu, Junru Li, Xiangce Sun, Qiuxuan Tan, Xiaohong You, Cuihong Dong, Yewei Huang, Yanhua Zhou, Meng Zhongkai Univ Agr & Engn Innovat Inst Anim Hlth Breeding Coll Anim Sci & Technol Guangzhou 510225 Guangdong Peoples R China guangzhou Key Lab Aquat Anim Dis & Waterfowl Breed Guangzhou 510225 Guangdong Peoples R China Guangdong Prov Water Environm & Aquat Prod Secur E Guangzhou 510225 Guangdong Peoples R China Guangdong Prov Key Lab Anim Breeding & Nutr Res Guangzhou 510640 Guangdong Peoples R China

The study aimed to assess the effects of dietary black soldier fly oil (BSFO) on the growth performance, flesh quality, and health status of largemouth bass (Micropterus salmoides). Six iso-nitrogenous and isolipid diets were formulated by substituting fish oil and soybean oil (1/2, wt/wt) with BSFO in percentages of 0%, 20%, 40%, 60%, 80%, and 100%, respectively. The diets were fed to 960 fish (initial body weight = 16.5 g) in four replicates for 8 weeks. Indicators related to growth performance, body composition, hematology, flesh quality, expression of genes related to inflammatory cytokines and apoptosis, and the response of fish to Aeromonas veronii challenge were analyzed. The results showed that the weight gain rate was numerically improved in all BSFO substitution groups, ranging from 9.3% to 44.0% compared to the control group. The highest survival rate and the lowest hepatosomatic index and condition factor were observed in the BFSO20 group. In terms of flesh quality, the water-holding capacity of the dorsal muscle was elevated with higher levels of dietary BSFO. However, significant changes in texture properties (cohesiveness, gluing, and chewiness) were observed in the BSFO20 group (P < 0.05). Six hematological parameters related to glycolipid and liver function were optimized in most of the BFSO substitution groups. Furthermore, the expressions of six inflammation- and apoptosis-related genes (IL-1 beta, Bcl-xl, BAX, caspase8, TNF-alpha, and IL-10) were significantly affected by dietary BSFO (P < 0.05). Following bacterial challenge, the seven-day cumulative survival rates of fish were considerably increased from 10.0% in the control group to 60.0% and 66.7% in the BSFO80 and BSFO100 groups, respectively. One-variable linear regression analysis revealed that various parameters related to fish growth, flesh quality, and health status were significantly influenced by dietary BSFO substitution levels in a dose-dependent manner (P < 0.05). In conclusion, su

关键词： Micropterus salmoides Black soldier fly oil (BSFO) Growth performance Flesh quality Health status FATTY-ACID PROFILES HERMETIA-ILLUCENS RAINBOW-TROUT SOYBEAN OIL CELL-DEATH CASPASES FILLETS LARVAE MEAL

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Reaction Mechanism of Actin ATP Hydrolysis Studied by QM/MM Calculations

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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 849-855页

作者： Wang, Yiwen Lin, Lirui Xu, Li-Yan Li, En-Min Dong, Geng Shantou Univ med coll Dept Biochem & Mol Biol Shantou 515041 Peoples R China Shantou Univ med coll Guangdong Higher Educ Inst Key Lab Mol Biol High Canc Incidence Coastal Area Shantou 515041 Peoples R China Shantou Univ med coll Med Informat Res Ctr Shantou 515041 Peoples R China Shantou Univ med coll Guangdong Prov Key Lab Infect Dis & Mol Immunopath Shantou 515041 Peoples R China Shantou Univ med coll Dept Bioinformat Shantou 515041 Peoples R China Shantou Univ med coll Canc Res Ctr Shantou 515041 Peoples R China

Actin fibers are an important part of the cytoskeleton, providing vital support for the plasma membrane. This function is driven by its ATPase (ATP: adenosine triphosphate) activity, i.e., ATP+H2O -> ADP+Pi. This seemingly simple reaction has attracted much attention because the hydrolysis of ATP provides energy to support life processes. However, the reaction mechanism of ATP hydrolysis in actin is not clear. In order to gain deep insights into the functions of actin, it is essential to elucidate the reaction mechanism of the actin ATP hydrolysis. In this paper, we have studied the reaction mechanism of the ATP hydrolysis in actin by the combined quantum mechanical and molecular mechanics (QM/MM) calculations. Our results show that 1) bond cleavage of the P gamma-OS of ATP and bond formation between oxygen of the lytic water and P gamma atoms take place simultaneously, and this is the rate-limiting step of the hydrolysis; 2) the proton on the lytic water transfers to the phosphate to form H2P gamma O4-via one bridge water. The energy barrier of the complete reaction is 17.6 kcal/mol (1 kcal=4.184 kJ), which is in high agreement with the experimental value.

关键词： Actin Adenosine triphosphate (ATP) hydrolysis Quantum mechanical and molecular mechanics (QM/MM) Reaction mechanism MOLECULAR-DYNAMICS SIMULATIONS APPROXIMATION QUANTUM

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Influencing factors of anxiety in isolated population under COVID-19 and clinical observation of acupuncture intervention

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China medical Abstracts(Internal medicine) 2024年第1期41卷 9-10页

作者：周夏芸 7th Clin med coll Guangzhou TCM UnivShenzhen 518101

Objective To investigate the anxiety of isolated people under the epidemic of 2019-novel coronavirus infection,analyze its related factors,and evaluate the clinical efficacy of acupuncture intervention in isolated peo... 详细信息

关键词： acupuncture clinical acute

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Sandpaper-templated Stretchable Immunosensing Electrodes for Sub-picomolar Progesterone Detection

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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 874-880页

作者： Li, Zhaoxian Meng, Xingyu Fang, Chuyao Yi, Zhenkai Wu, Yaoyao Liu, Xuanxuan Zhong, Wei Zhang, Limei Xie, Zhuang Sun Yat sen Univ Sch Mat Sci & Engn Key Lab Polymer Composite & Funct Mat Minist Educ Guangzhou 510275 Peoples R China Sun Yat sen Univ Affiliated Hosp 1 Reprod Med Ctr Dept Obstet & Gynecol Guangzhou 510080 Peoples R China

Female hormone detection, particularly non-invasive monitoring progesterone (P4) levels in body fluids, plays a critical role in female health management and disease diagnosis. However, the challenge still exists because of the ultralow abundance of P4 (mol/L. Notably, the stretchable electrode exhibits stable electrochemical performance, enabling the detection of P4 at sub-picomolar levels even under mechanical strain of 30%. This innovative electrochemical sensor holds significant promise for non-invasive, on-site monitoring of P4 levels in healthcare, as well as hormone detection in food safety and environment surveillance.

关键词： Progesterone Immunosensor Microstructured electrode Stretchable biosensor Electrochemical sensing ELECTROCHEMICAL SENSOR BIOSENSOR ESTRADIOL HORMONES

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Linker gadolinium as charge channel and singlet oxygen activation site in graphitic carbon nitride for enhancing photocatalytic decomposition of tetracycline

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Journal of Rare Earths 2024年第5期42卷 827-837,I0001页

作者： Jianmin Luo Wenqin Li Xinglei Wang Eric Lichtfouse Donglan Huang Xiaoyuan Chen Yi Zhang Lejie Zhu Chuanyi Wang college of Chemistry and Civil Engineering Shaoguan UniversityShaoguan512005China Key Laboratory of Pollutant Chemistry and Environmental Treatment College of Chemistry and Environmental ScienceYili Normal UniversityYining 835000China college of Chemistry and Environmental Science Kashi UniversityKashi844006China CNRS IRDINRAEColl FranceCEREGEAix-Marseille UniversityAix en Provence13100France guangzhou Institute of Industrial Intelligence(GIl) Guangzhou511400China

Reactive oxygen species are essential in photocatalytic water *** this paper,Gd doped carbon nitride(CN)photocatalysts were prepared by simple thermal polymerization for the photocatalytic degradation of tetracycline under visible light *** photodegradation rate of *** is as high as 95%in 18 min,and the photocatalytic performance is much higher than that of *** improvement of photocatalytic performance is mainly attributed to the fact that Gd ion implantation directly provides active sites for oxygen activation and induces the formation of N *** results of characterizations show that the introduction of Gd in CN can improve the conversion ability of activated oxygen,carrier separation and energy band structure ***,1.0GdCN photocatalyst can be employed for efficient photocatalytic synthesis of ***,three ways of photocatalytic degradation of tetracycline were revealed by high performance liquid chromatographymass *** work provides insights into the doping strategy of CN to improve the production of reactive oxygen species for environmental remediation.

关键词： Photocatalysis Tetracycline Hydrogen peroxide Gd doped CN Singlet oxygen Rare earths

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Particle segregation mechanism of S-D system in a rotating drum

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PARTICUOLOGY 2024年第10期93卷 300-308页

作者： Xiao, Erliang Zhang, Wei Chi, Zhipeng Li, Ran Yang, Hui Univ Shanghai Sci & Technol Sch Opt Elect & Comp Engn Shanghai 200093 Peoples R China Shanghai Univ med & Hlth Sci Coll Med Instrumentat Shanghai 201318 Peoples R China

Complex segregation occurs in a binary particle system with differing particle sizes and densities, particularly when the larger particles are heavier (S-D system, i.e., size minus density system). Predicting the segregation pattern driven by multiple mechanisms simultaneously is often challenging. This study explores the segregation mechanisms in a quasi-2D circular drum containing a S-D system, realizing a transition between the S-core and Core-and-band patterns by adjusting the drum rotation speed. During the transition of the segregation pattern, only the S-core pattern chiefly driven by the percolation mechanism is initially observed. As the rotation speed increases, the buoyancy mechanism and particle diffusion gradually strengthen, jointly driving the formation of the Core-and-band pattern. A dimensionless strength ratio, l 1/4 H=h, where H and h respectively represent the diffusion and buoyancy strengths at length scales, is introduced to elucidate this transition. The Core-and-band pattern emerges when l reached 1.4. (c) 2024 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Particle segregation S -D system Segregation mechanisms competition Segregation pattern Rotating drum GRANULAR MIXTURES DRIVEN SEGREGATION SIZE SEGREGATION DENSITY RATIO PERCOLATION BEHAVIOR SPEED

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Study on after-effect of electroacupuncture with different time intervals on corticospinal excitability in primary motor cortex

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China medical Abstracts(Internal medicine) 2024年第1期41卷 6-7页

作者：谢萌萌 Clin med Sch Acupunct-Moxib&RehabGuangzhou CM UnivGuangzhou 510405

Objective To compare the effects of electroacupuncture (EA) with different time intervals on corticospinal excitability of the primary motor cortex(M1) and the upper limb motor function in healthy subjects and observe... 详细信息

关键词： acupuncture cortex electroacupuncture

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Integrating multi-omics data of childhood asthma using a deep association model

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Fundamental Research 2024年第4期4卷 738-751页

作者： Kai Wei Fang Qian Yixue Lia Tao Zeng Tao Huang Bio-med Big Data Center CAS Key Laboratory of Computational BiologyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Guoke Ningbo Life Science and Health Industry Research Institute Ningbo 315000China guangzhou National Laboratory Guangzhou 510000China GMU-GIBH Joint School of Life Sciences The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and DiseasesGuangzhou LaboratoryGuangzhou Medical UniversityGuangzhou 510000China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Childhood asthma is one of the most common respiratory diseases with rising mortality and *** multi-omics data is providing a new chance to explore collaborative biomarkers and corresponding diagnostic models of childhood *** capture the nonlinear association of multi-omics data and improve interpretability of diagnostic model,we proposed a novel deep association model(DAM)and corresponding efficient analysis ***,the Deep Subspace Reconstruction was used to fuse the omics data and diagnostic information,thereby correcting the distribution of the original omics data and reducing the influence of unnecessary data ***,the Joint Deep Semi-Negative Matrix Factorization was applied to identify different latent sample patterns and extract biomarkers from different omics data ***,our newly proposed Deep Orthogonal Canonical Correlation Analysis can rank features in the collaborative module,which are able to construct the diagnostic model considering nonlinear correlation between different omics data *** DAM,we deeply analyzed the transcriptome and methylation data of childhood *** effectiveness of DAM is verified from the perspectives of algorithm performance and biological significance on the independent test dataset,by ablation experiment and comparison with many baseline methods from clinical and biological *** DAM-induced diagnostic model can achieve a prediction AUC of o.912,which is higher than that of many other alternative ***,relevant pathways and biomarkers of childhood asthma are also recognized to be collectively altered on the gene expression and methylation *** an interpretable machine learning approach,DAM simultaneously considers the non-linear associations among samples and those among biological features,which should help explore interpretative biomarker candidates and efficient diagnostic models from multi-omics data analysis for human complexdiseases.

关键词： Deepsub space reconstruction Deepnon-negative matrix factorization Deepcanonical correlationanalysis Multi-omics Interpretable machine learning Childhood asthma

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Data error propagation in stacked bioclimatic envelope models

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Integrative Zoology 2024年第2期19卷 262-276页

作者： Xueyan LI Babak NAIMI Peng GONG Miguel B.ARAÚJO Guangdong Provincial Key Laboratory of Remote Sensing and Geographical Information System Guangdong Open Laboratory of Geospatial Information Technology and ApplicationGuangzhou Institute of GeographyGuangdong Academy of ScienceGuangzhouChina ‘Rui Nabeiro’Biodiversity Chair CHANGE-MED InstituteUniversity ofÉvoraÉvoraPortugal Department of Geography and Department of Earth Sciences University of Hong KongHong KongChina Department of Biogeography and Global Change National Museum of Natural SciencesCSICMadridSpain

Stacking is the process of overlaying inferred species potential distributions for multiple species based on outputs of bioclimatic envelope models(BEMs).The approach can be used to investigate patterns and processes of species *** data limitations on individual species distributions are inevitable,but how do they affect inferences of patterns and processes of species richness?We investigate the influence of different data sources on estimated species richness gradients in *** fitted BEMs using species distributions data for 334 bird species obtained from(1)global range maps,(2)regional checklists,(3)museum records and surveys,and(4)citizen science data using presence-only(Mahalanobis distance),presence-background(MAXENT),and presence–absence(GAM and BRT)*** species predictions were stacked to generate species richness ***,we show that different data sources and BEMs can generate spatially varying gradients of species *** environmental predictors that best explained species distributions also differed between data *** using citizen-based data had the highest accuracy,whereas those using range data had the lowest *** richness patterns estimated by GAM and BRT models were robust to data *** multiple data sets exist for the same region and taxa,we advise that explicit treatments of uncertainty,such as sensitivity analyses of the input data,should be conducted during the process of modeling.

关键词： richness patterns species distribution stacked bioclimatic envelope models uncertainty

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