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China CDC weekly 2024年第13期6卷 254-260页

作者： Bihui Su Guanghong Du Shuiping Hou Zongqiu Chen Xiaoying Wu Gang He Jun Yuan Chaojun Xie Tuberculosis Management and Treatment Department Guangzhou Chest HospitalGuangzhou CityGuangdong ProvinceChina School of Public Health Guangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina guangzhou center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Office of the Director Huadu District Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina

What is already known about this topic?S.1,4,[5],12:i:-and *** are emerging serotypes of Salmonella that require close monitoring for antimicrobial resistance and containment of their *** is added by this report?The study aimed to identify antimicrobial resistance genes(ARGs)in S.1,4,[5],12:i:-and *** strains isolated from environmental sewage in guangzhou City,Guangdong Province,China.A phylogenetic tree was constructed using single nucleotide polymorphism data to assess genetic relatedness among strains,offering insights for Salmonella infection outbreak investigations in the *** are the implications for public health practice?It is crucial to implement strategies,such as integrating different networks,to control the spread of drugresistant *** technologies must be utilized to disinfect sewage and eliminate *** food safety and proper sewage disinfection are essential to curb the dissemination of Salmonella.

关键词： Whole offering integrating

Acceptance and Factors Associated With Participation in Functional Cure–Related Trials Among People Living With HIV: A Cross-sectional Study in Southern China

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Infectious Microbes & diseases 2024年第1期6卷 11-19页

作者： Zhaomin Deng Minjuan Shi Yue Yuan GuangjinCao Chunyan Wen Lijuan Chen Xueying Fan Linan Wu Jianhui Yuan Huachun Zou Linghua Li Caijun Sun School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenChina Department of diseases control Panyu District Center for Disease Control and PreventionGuangzhouChina Infectious disease center Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Nanshan district center for disease control and prevention ShenzhenChina Key Laboratory of Tropical disease control(Sun Yat-sen University) Ministry of EducationGuangzhouChina

HIV remains a global health challenge,and research efforts directed towards a functional cure require people living with HIV(PLHIV)in-volvement in clinical *** study assessed willingness to participate in HIV functional cure–related clinical trials and associated factors among PLHIV in guangzhou,China,using a questionnaire survey *** analyzed responses from 718 questionnaires,finding that 71.2%were willing to participate in Phase Ⅲtrials,while 51.7%were willing to participate in Phase I trials and 42.9%expressed acceptability for analytic treatment *** logistic regression demonstrated that male PLHIV,those with awareness of functional cure,and PLHIV,who had been on antiretroviral therapy(ART)for less than 1 year,were more willing to partic-ipate in Phase Ⅲ*** with a body mass index greater than 24,and those without resistance to ART drug were more willing to participate in Phase I *** major motivations for participation in Phase Ⅲtrials were access to cutting-edge treatments(62.6%)and supporting research(55.3%).Safety was the main concern contributing to *** study revealed a high willingness to participate in HIV functional cure–related trials among PLHIV in guangzhou,China,and willingness varied across different trial phases and was influenced by multiple *** study provides valuable references for future clinical trial recruitment strategies and public health policy formulation.

关键词： people living with HIV functional cure clinical trials willingness

Aqueous-phase formation of N-containing secondary organic compounds affected by the ionic strength

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Journal of Environmental Sciences 2024年第4期138卷 88-101页

作者： Yuqi Gan Xiaohui Lu Shaodong Chen Xinghua Jiang Shanye Yang Xiewen Ma Mei Li Fan Yang Yewen Shi Xiaofei Wang Shanghai Key Laboratory of Atmospheric Particle Pollution and prevention Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China Shanghai Institute of Pollution control and Ecological Security Shanghai 200092China Guangdong Provincial Observation and Research Station for Coastal Atmosphere and Climate of the Great Bay Area Southern University of Science and TechnologyShenzhen 518055China Institute of Mass Spectrometry and Atmospheric Environment Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air PollutionJinan UniversityGuangzhouChina Environmental Monitoring Station of Pudong New district Shanghai 201200China Shanghai Municipal center for disease control&prevention Shanghai 200336China

The reaction of carbonyl-to-imine/hemiaminal conversion in the atmospheric aqueous phase is a critical pathway to produce the light-absorbing N-containing secondary organic compounds(SOC).The formation mechanism of these compounds has been wildly investigated in bulk solutions with a low ionic ***,the ionic strength in the aqueous phase of the polluted atmosphere may be *** is still unclear whether and to what extent the inorganic ions can affect the SOC *** we prepared the bulk solution with certain ionic strength,in which glyoxal and ammonium were mixed to mimic the aqueous-phase *** characterization by High-resolution Mass Spectrometry was performed to identify the N-containing products,and the light absorption of the mixtures was measured by ultraviolet-visible ***-nine N-containing compounds were identified and divided into four categories(N-heterocyclic chromophores,high-molecular-weight compounds with N-heterocycle,aliphatic imines/hemiaminals,and the unclassified).It was observed that the longer reaction time and higher ionic strength led to the formation of more N-heterocyclic chromophores and the increasing of the lightabsorbance of the *** added inorganic ions were proposed to make the aqueous phase somewhat viscous so that the molecules were prone to undergo consecutive and intramolecular reactions to form the *** general,this study revealed that the enhanced ionic strength and prolonged reaction time had the promotion effect on the lightabsorbing SOC *** implies that the aldehyde-derived aqueous-phase SOC would contribute more light-absorbing particulate matter in the industrial or populated area where inorganic ions are abundant.

关键词： Ionic strength Carbonyl-to-imine/hemiaminal Heterocyclic Brown carbon Mass spectrometry Aqueous-phase reaction

Early Detection of the Emerging SARS-CoV-2 BA.2.86 Lineage Through Wastewater Surveillance Using a Mediator Probe PCR Assay—Shenzhen City,Guangdong Province,China,2023

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China CDC weekly 2024年第15期6卷 332-338,I0008,I0009页

作者： Chen Du Yuejing Peng Ziquan Lyu Zhijiao Yue Yulin Fu Xiangjie Yao Jinzhen Tang Guixian Luo Chenxi Gao Shisong Fang Xiaolu Shi Chengsong Wan Yinghui Li Qinghua Hu Shenzhen center for disease control and prevention Shenzhen CityGuangdong ProvinceChina BSL-3 Laboratory(Guangdong) Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou CityGuangdong ProvinceChina Department of Public Health Laboratory Sciences School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang CityHunan ProvinceChina School of Public Health Shanxi Medical UniversityTaiyuan CityShanxi ProvinceChina

Introduction:The emergence of the new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron sublineage,BA.2.86,has sparked global public health concerns for its potential heightened transmissibility and immune *** data from Shenzhen’s city-wide wastewater surveillance system,we highlight the presence of the BA.2.86 lineage in ***:A mediator probe polymerase chain reaction(PCR)assay was developed to detect the BA.2.86 lineage in wastewater by targeting a specific mutation(Spike:A264D).Between September 19 and December 10,2023,781 wastewater samples from 38 wastewater treatment plants(WWTPs)and 9 pump stations in ten districts of Shenzhen were *** multiple short-amplicon sequencing,three positive samples were ***:The BA.2.86 lineage was identified in the wastewater of Futian and Nanshan districts in Shenzhen on December 2,*** December 2 to 10,a total of 21 BA.2.86-positive wastewater samples were found across 6 districts(Futian,Nanshan,Longhua,Baoan,Longgang,and Luohu)in *** weighted average viral load of the BA.2.86 lineage in Shenzhen’s wastewater was 43.5 copies/L on December 2,increased to 219.8 copies/L on December 4,and then decreased to approximately 100 copies/L on December 6,8,and ***:The mediator probe PCR assay,designed for swift detection of low viral concentrations of the BA.2.86 lineage in wastewater samples,shows promise for detecting different SARS-CoV-2 *** surveillance could serve as an early detection system for promptly identifying specific SARS-CoV-2 variants as they emerge.

关键词： wastewater Wastewater district

Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021

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China CDC weekly 2021年第27期3卷 584-586页

作者： Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li Guangdong Provincial center for disease control and prevention GuangzhouGuangdongChina Guangdong Provincial Institute of Public Health GuangzhouGuangdongChina School of Public Health Southern Medical UniversityGuangzhouGuangdongChina guangzhou center for disease control and prevention GuangzhouGuangdongChina Foshan center for disease control and prevention GuangzhouGuangdongChina Maoming center for disease control and prevention GuangzhouGuangdongChina Zhanjiang center for disease control and prevention GuangzhouGuangdongChina guangzhou liwan district center for disease control and prevention GuangzhouGuangdongChina guangzhou Panyu district center for disease control and prevention GuangzhouGuangdongChina guangzhou Haizhu district center for disease control and prevention GuangzhouGuangdongChina guangzhou Yuexiu district center for disease control and prevention GuangzhouGuangdongChina Foshan Nanhai district center for disease control and prevention GuangzhouGuangdongChina Maoming Dianbai district center for disease control and prevention GuangzhouGuangdongChina National Institute for Communicable disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina Chinese center for disease control and prevention BeijingChina

On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in liwan district,guangzhou City,Guangdong Province,*** number of infection... 详细信息

关键词： Guangdong fir break

The Associated Factors of SARS-CoV-2 Reinfection by Omicron Variant—Guangdong Province,China,December 2022 to January 2023

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China CDC weekly 2023年第18期5卷 391-396页

作者： Chunsheng Cai Yihong Li Ting Hu Rongwei Liang Kaibin Wang Congrui Guo Yan Li Meng Zhang Min Kang Guangdong Field Epidemiology Training Program Guangzhou CityGuangdong ProvinceChina Zhongshan center for disease control and prevention Zhongshan CityGuangdong ProvinceChina Guangdong Provincial center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Huaiji County center for disease control and prevention Zhaoqing CityGuangdong ProvinceChina Tianhe district center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Futian district center for disease control and prevention Shenzhen CityGuangdong ProvinceChina

Summary What is already known about this topic?Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reinfection by variants is being reported commonly and has caused waves of epidemic in many *** of dynamic zero policy,the SARSCoV-2 reinfection was less reported in *** is added by this report?SARS-CoV-2 reinfections were observed in Guangdong Province between December 2022 and January *** study estimated that the reinfection incidence was 50.0%for the original strain primary infections,35.2%for the Alpha or Delta variants,and 18.4%for the Omicron variant;The reinfection incidence within 3-6 months after primary infection by Omicron variant was 4.0%.Besides,96.2%reinfection cases were symptomatic while only 7.7%sought medical *** are the implications for public health practice?These findings suggest a reduced likelihood of an Omicron-driven epidemic resurgence in the short term but emphasize the importance of maintaining vigilant surveillance of emerging SARS-CoV-2 variants and conducting population-based antibody level surveys to inform response preparedness.

关键词： policy Guangdong conducting

Incidence and risk factors of tuberculosis among the elderly population in China:a prospective cohort study

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Infectious diseases of Poverty 2020年第1期9卷 64-76页

作者： Jun Cheng Yan-Ni Sun Can-You Zhang Yan-Ling Yu Li-Hong Tang Hong Peng Ying Peng Yu-Xia Yao Shuang-Yi Hou Jian-Wei Li Jin-Ming Zhao Lan Xia Lin Xu Yin-Yin Xia Fei Zhao Li-Xia Wang Hui Zhang National center for Tuberculosis control and prevention Chinese Center for Disease Control and PreventionBeijingChina National center for Population Health and Epidemiology CanberraAustralia Heilongjiang Provincial center for disease control and prevention HarbinChina Minhang district center for disease control and prevention ShanghaiChina Jiangsu Provincial center for disease control and prevention NanjingChina Zhejiang Provincial center for disease control and prevention HangzhouChina Henan Provincial center for disease control and prevention ZhengzhouChina Hubei Provincial center for disease control and prevention WuhanChina center for Tuberculosis control of Guangdong Province GuangzhouChina GuangXi center for disease prevention and control NanningChina Sichuan Provincial center for disease control and prevention ChengduChina Yunnan Provincial center for disease control and prevention KunmingChina

Background:China is facing challenges of the shifting presentation of tuberculosis(TB)from younger to elderly due to an ageing population,longer life expectancy and reactivation ***,the burden of elderly TB and influence factors are not yet *** fill the gap,we generated a cohort study to measure the magnitude of TB incidence and associated factors among the elderly population aged 65 years and above in ***:In this cohort established in 2013 through a prevalence survey conducted in selected sites,a total of 34076 elderlies without TB were enrolled into two-year *** used both active and passive case findings to find out all TB patients among *** person-year(PY)incidence rates for both bacteriologically positive TB and active TB were *** proportional regression model was performed to test effect of risk factors,and the population attributable fraction(PAF)of each risk factor contributing to incident TB among elderlies was ***:Over the two-year follow-up period,a total of 215 incident active TB were identified,62 of which were bacteriologically *** incidence rates for active TB and bacteriologically positive TB were 481.8 per 100000 PY(95%CI:417.4–546.2 per 100000 PY)and 138.9 per 100000 PY(95%CI:104.4–173.5 per 100000 PY),*** cases detected by active case finding were significantly higher(Pdisease,implying that National TB Program(NTP)needs to prioritize f

关键词： Tuberculosis Elderly tuberculosis Active case finding Incidence Risk factor Follow up China

Prevalence,Incidence,and Characteristics of Tuberculosis Among Known Diabetes Patients—A Prospective Cohort Study in 10 Sites,2013–2015

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China CDC weekly 2022年第3期4卷 41-46页

作者： Jun Cheng Yanling Yu Qiongjin Ma Zhijian Wang Qingrong Zhou Guolong Zhang Shuangyi Hou Lin Zhou Feiying Liu Lan Xia Lin Xu Canyou Zhang Yinyin Xia Hui Chen Hui Zhang Lixia Wang National center for Tuberculosis control and prevention China CDCBeijingChina Heilongjiang Provincial center for disease control and prevention HarbinHeilongjiangChina Minhang district center for disease control and prevention ShanghaiChina center for disease control and prevention of Danyang County DanyangJiangsuChina center for disease control and prevention of Jiangshan city JiangshanZhejiangChina Henan Provincial center for disease control and prevention ZhengzhouHenanChina Hubei Provincial center for disease control and prevention WuhanHubeiChina center for Tuberculosis control of Guangdong Province GuangzhouGuangdongChina Guangxi center for disease prevention and control NanningGuangxi Zhuang Autonomous RegionChina Sichuan Provincial center for disease control and prevention ChengduSichuanChina Yunnan Provincial center for disease control and prevention KunmingYunnanChina

Summary What is already known about this topic?The association of diabetes mellitus(DM)with both increased risk of tuberculosis(TB)and unfavorable treatment outcomes has been identified by many studies(1).However,epidemic data for TB cases in DM patients is absent in *** is added by this report?This current population-based prospective cohort study,conducted in ten counties located in eastern,central,and western China during 2013–2015,revealed a high prevalence and incidence of TB in known DM *** TB cases were captured by active case-finding and a much higher presence of being asymptomatic among TB/DM patients was *** are the implications for public health practice?Active case-finding should be carried out in DM patients and populations at high risk for developing TB.A TB symptom screening-based case-finding strategy is not enough;chest radiography check should be done once a year for these patients.

关键词： finding Diabetes Patients

An Imported Case and an Infected Close Contact of the Omicron Variant of SARS-CoV-2—Guangdong Province,China,December 13,2021

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China CDC weekly 2022年第5期4卷 96-97页

作者： Kuibiao Li Zhonghua Zheng Xiang Zhao Qing Zeng Tengfei Zhou Qianfang Guo Yao Hu Wenbo Xu Zhoubin Zhang Baisheng Li Institute of Public Health Guangzhou Medical University&Guangzhou Center for Disease Control and PreventionGuangzhouGuangdongChina Guangdong Provincial center for disease control and prevention GuangzhouGuangdongChina National Institute for Viral disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina

On November 27,2021,a 67-year-old male returning from Canada via airplane was transferred to the central isolation hotel in *** the quarantine,his 1st,4th,7th,and 14th days of specimens returned negative for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19).On December 11,he completed 14 days of centralized isolation and returned to guangzhou from Shanghai via airplane,then he was closed-loop transferred to Yuexiu district for a 7-day home *** December 12,the local Community Health Service center routinely collected his throat swab and the result returned to COVID-19 positive on December 13,*** was transported to the guangzhou Eighth People’s Hospital for isolated treatment by negative pressure ambulance on the same *** patient had two inflamed lungs according to the chest computed tomography(CT)examination,but his most recently updated condition was *** estimated 600 close contacts were identified and were placed in centralized *** December 16,one of the close contacts,a 70-year-old female also tested positive for *** lived on the lower floor of the same type of apartment as the imported case and spent 19 hours in the same building.

关键词： transferred Canada guangzhou

Genome Characterization of the First Outbreak of COVID-19 Delta Variant B.1.617.2——guangzhou City,Guangdong Province,China,May 2021

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China CDC weekly 2021年第27期3卷 587-589页

作者： Zhencui Li Kai Nie Kuibiao Li Yao Hu Yang Song Min Kang Meng Zhang Xiaoling Deng Jun Yuan Wenbo Xu Baisheng Li Guangdong Provincial center for disease control and prevention GuangzhouGuangdongChina Guangdong Workstation for Emerging Infectious disease control and prevention Chinese Academy of Medical SciencesGuangzhouGuangdongChina National Institute for Viral disease control and prevention China CDCBeijingChina guangzhou center for disease control and prevention GuangzhouGuangdongChina

On May 20,2021,75-year-old female(Case A)went to a local hospital due to pharyngeal pain and low-grade fever in liwan district,guangzhou City,Guangdong *** oropharyngeal swab from Case A tested preliminarily positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)/coronavirus disease 2019(COVID-19)virus using a quantitative real-time reverse transcription polymerase chain reaction(RT-qPCR)method after a hospital visit.

关键词： Province. guangzhou Guangdong