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An intravascular needle coated by ZnO nanoflowers for in vivo elimination of circulating tumor cells

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Nano Research 2023年第1期16卷 873-881页

作者： Jinqi Li Xinlei Li Yangfeng Zhang Kun Jin Ye Yuan Ruiqi Ming Yuhua Yang Tongsheng Chen MOE key laboratory of Laser Life Science&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial key laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China SCNU Qingyuan Institute of Science and Technology Innovation Co. Ltd.South China Normal UniversityQingyuan 511500China Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China State key laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterSchool of Materials Science&EngineeringSun Yat-sen UniversityGuangzhou 510275China

Circulating tumor cells(CTCs)are recognized as the main source of tumor recurrence and metastasis.Eliminating the CTCs in peripheral blood provides a new strategy to reduce the probability of recurrence or metastasis.Here,we proposed a concept to eliminate CTCs by inserting a needle in the superficial blood vessel.Using the property of ZnO and the structure of nanoflowers,we designed a medical needle coated with ZnO nanoflowers(ZNFs),which killed about 90%of captured CTCs in vitro and prevented the injecting CTCs from spreading to lung tissue in BABL/c mouse model.Results in vitro and in vivo demonstrated that the CTCs not only were captured and killed,but also detached from the needle surface after dead,enabling the ZNFs needle continually eliminate CTCs.Furthermore,a theoretical model was presented to explain the penetration mechanism of cells by nanostructures,which indicated that nanoflowers structure can puncture CTCs more easily than vertical nanowire structure.The concept of inserting an intravascular needle provides a potential strategy to lower the concentration of CTCs in blood and reduce the probability of tumor recurrence or metastasis.

关键词： ZnO nanoflowers circulating tumor cells elimination cancer treatment theoretical model

Polarization microwave-induced thermoacoustic imaging for quantitative characterization of deep biological tissue microstructures

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Photonics Research 2022年第5期10卷 1297-1306页

作者： YUJING LI SHANXIANG ZHANG LINGHUA WU ZHONGWEN CHENG ZHENHUI ZHANG HAOHAO WANG SHUXIANG ZHAO MINGYANG REN SIHUA YANG DA XING HUAN QIN MOE key laboratory of Laser Life Science&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial key laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Polarization optical imaging can be used to characterize anisotropy in biological tissue microstructures and has been demonstrated to be a powerful tool for clinical diagnosis. However, the approach is limited by an inability to image targets deeper than ~1 mm due to strong optical scattering in biological tissues. As such, we propose a novel polarization microwave-induced thermoacoustic imaging(P-MTAI) technique to noninvasively detect variations in deep tissue by exploiting the thermoacoustic signals induced by four pulsed microwaves of varying polarization orientations. The proposed P-MTAI method overcomes the penetration limits of conventional polarization optical imaging and provides submillimeter resolution over depths of several centimeters. As part of the paper, the structural characteristics of tissues were quantified using a new parameter, the degree of microwave absorption anisotropy. P-MTAI was also applied to the noninvasive detection of morphological changes in cardiomyocytes as they transitioned from ordered to disordered states, providing a potential indication of myocardial infarction.

关键词： polarization millimeter scattering

Surface-rare-earth-rich upconversion nanoparticles induced by heterovalent cation exchange with superior loading capacity

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Journal of Materials Science & Technology 2022年第2期97卷 223-228页

作者： Meifeng Wang Yiru Qin Wei Shao ZhiWang Cai Xiaoyu Zhao Yongjun Hu Tao Zhang Sheng Li Mark T.Swihart Yang Liu Wei Wei MOE&Guangdong Provincial key laboratory of Laser Life Science Guangzhou Key Laboratory of Spectral Analysis and Functional ProbesCollege of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Department of Chemical and Biological Engineering University at Buffalothe State University of New YorkBuffaloNY 14260United States Guangdong Provincial key laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and Technology&School of Life SciencesSouth China Normal UniversityGuangzhou 510631China State key laboratory Breeding Base of Green Chemistry Synthesis Technology and College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China

Surface modification of different functional molecules onto NaREF_(4)(RE=rare earth)upconversion nanoparticles(UCNPs)impart their multiple functionalities.functional molecules can be loaded onto NaREF_(4) UCNPs through the formation of coordination bonds between the surface-exposed RE^(3+) ions and the appropriate chemical groups of functional molecules.The density of surface RE^(3+) ions directly determines the loading efficiency of Na REF4 UCNPs.However,NaREF_(4) is a binary cation system,rendering the surface-distributed Na;and RE^(3+) ions remains a mystery.Here,we develop an effective strategy to significantly enhance the density of surface RE^(3+) ions,thus maximizing the loading capacity of NaREF_(4) UCNPs.This strategy is based on a heterovalent cation exchange(HCE)reaction in the surface region in which Na^(+)ions are replaced by RE^(3+) ions.The density of surface ligands enhances from 3.6 to 8.8 molecules/nm^(2) after reaction,suggesting that the loading efficiency increases by approximately 150%.Benefiting from the improved loading capacity,we demonstrate such surface-RE-rich nanoparticles have the ability to offer higher colloidal stability and more desirable photodynamic therapy(PDT)efficacy.This work not only advances our understanding of cation exchange reactions in RE-based nanoparticles,but also provides significant value for considerable applications such as sensing,bioimaging,and therapy.

关键词： Heterovalent cation exchange Surface-rare-earth-rich Upconversion nanoparticles Superior loading capacity

Prospects of microwave-induced thermoacoustic imaging

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电子科技学刊:英文版 2023年第3期21卷 21-37页

作者： Xing-Hua Wang Huan Qin key laboratory of Laser Life Science(Ministry of Education)&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou510631China Guangdong Provincial key laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou510631China guangzhou key Lab of spectral analysis and functional probes College of BiophotonicsSouth China Normal UniversityGuangzhou510631China

Microwave-induced thermoacoustic imaging(MTAI)has advantages including the large imaging depth,high imaging resolution,high imaging contrast,and fast imaging speed.The thermoacoustic(TA)group of South China Normal University has dedicated to developing TA imaging for more than a decade and has made many breakthroughs.This review introduces these breakthroughs from two aspects including the improvement in techniques and the exploration of applications.On the technological level,there are ultrashort microwave pulse(USMP)-induced􀀁TA imaging that can improve the imaging resolution,nonlinear thermoacoustic imaging(NTAI)that can improve the imaging contrast,polarized microwave-induced􀀁thermoacoustic imaging(P-MTAI)that can obtain cellular-level alignment information,and more convenient and accurate handheld and multimodal probes.On the application side,the optimization and expansion have been carried out,mainly concentrating on breast and myocardial imaging.Finally,several current research directions are introduced,including the application of P-MTAI on joint imaging and research on whole-body imaging of small animals.

关键词： Applications in biomedical field Microwave-induced thermoacoustic imaging(MTAI) Nonlinear thermoacoustic imaging(NTAI) Polarized microwave-induced thermoacoustic imaging(P-MTAI) Ultrashort microwave pulse (USMP)-induced thermoacoustic imaging

Label-free breast cancer detection and classification by convolutional neural network-based on exosomes surface-enhanced raman scattering

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Journal of Innovative Optical Health Sciences 2023年第2期16卷 3-15页

作者： Xiao Ma Honglian Xiong Jinhao Guo Zhiming Liu Yaru Han Mingdi Liu Yanxian Guo Mingyi Wang Huiqing Zhong Zhouyi Guo MOE key laboratory of Laser Life Science&Institute of Laser Life Science SATCM Third Grade laboratory of Chinese Medicine and Photonics Technology&Guangdong Provincial key laboratory of Laser Life Science Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of Biophotonics South China Normal University guangzhou 510631 P.R.China Department of Physics and Optoelectronic Engineering Foshan University Guangdong 528011P.R.China

Because the breast cancer is an important factor that threatens women's lives and health,early diagnosis is helpful for disease screening and a good prognosis.Exosomes are nanovesicles,secreted from cells and other body fluids,which can reflect the genetic and phenotypic status of parental cells.Compared with other methods for early diagnosis of cancer(such as circulating tumor cells(CTCs)and circulating tumor DNA),exosomes have a richer number and stronger biological stability,and have great potential in early diagnosis.Thus,it has been proposed as promising biomarkers for diagnosis of early-stage cancer.However,distinguishing different exosomes remain is a major biomedical challenge.In this paper,we used predictive Convolutional Neural model to detect and analyze exosomes of normal and cancer cells with surface-enhanced Raman scattering(SERS).As a result,it can be seen from the SERS spectra that the exosomes of MCF-7,MDA-MB-231 and MCF-10A cells have similar peaks(939,1145 and 1380 cm^(-1)).Based on this dataset,the predictive model can achieve 95%accuracy.Compared with principal component analysis(PCA),the trained CNN can classify exosomes from different breast cancer cells with a superior performance.The results indicate that using the sensitivity of Raman detection and exosomes stable presence in the incubation period of cancer cells,SERS detection combined with CNN screening may be used for the early diagnosis of breast cancer in the future.

关键词： Exosomes surface-enhanced Raman scattering(SERS) breast cancer convolutional neural model label-free

Microwave-induced thermoacoustic imaging with functional nanoparticles

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Journal of Innovative Optical Health Sciences 2023年第2期16卷 92-107页

作者： Xiaoyu Tang Jia Fu Huan Qin MOE key laboratory of Laser Life Science&Institute of Laser Life Science College of Biophotonics South China Normal University Guangzhou 510631P.R.China Guangdong Provincial key laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631P.R.China guangzhou key Lab of spectral analysis and functional probes College of Biophotonics South China Normal UniversityGuangzhou 510631P.R.China

As an emerging hybrid imaging modality,microwave-induced thermoacoustic imaging(MTAI),using microwaves as the excitation source and ultrasonic signals as the information carrier for combining the characteristics of high contrast of electromagnetic imaging and high resolution of ultrasound imaging,has shown broad prospects in biomedical and clinical applications.The imaging contrast depends on the microwave-absorption coe±cient of the endogenous imaged tissue and the injected MTAI contrast agents.With systemically introduced functional nanoparticles,MTAI contrast and sensitivity can be further improved,and enables visualization of biological processes in vivo.In recent years,functional nanoparticles for MTAI have been developed to improve the performance and application range of MTAI in biomedical applications.This paper reviews the recent progress of functional nanoparticles for MTAI and their biomedical applications.The challenges and future directions of microwave thermoacoustic imaging with functional nanoparticles in theeld of translational medicine are discussed.

关键词： Microwave thermoacoustic imaging nanomaterials nanoprobe

Quantitative tracing of bioprobes by simultaneously monitoring radiative and nonradiative relaxations

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创新光学健康科学杂志(英文) 2023年第4期16卷 40-47页

作者： Hongjiang Chen Xiaoyu Tang Guangshuai Nie Zhen Wang Jia Hu Jun Hu Huan Qin Department of Orthopaedics The First Affiliated Hospital of Shantou University Medical College Shantou 515041Guangdong ProvinceP.R.China MOE key laboratory of Laser Life Science&Institute of Laser Life Science College of Biophotonics South China Normal University Guangzhou 510631P.R.China Guangdong Provincial key laboratory of Laser Life Science College of Biophotonics South China Normal University Guangzhou 510631P.R.China guangzhou key Lab of spectral analysis and functional probes College of Biophotonics South China Normal University Guangzhou 510631P.R.China

Bioprobe based on fluorescence is widely used in biological and medical research due to its high sensitivity and selectivity.Yet,its quantification in vivo is complicated and often compromised by the interaction between the fluorophore with the environmental factors,as well as the optical scattering and absorption by the tissue.A high florescence quantum yield and minimal interference by the environment are key requirements for designing an effective bioprobe,and the prerequisitions severely limit the available options.We propose that a comprehensive evaluation of potential bioprobe can be achieved by simultaneously measuring both radiative and nonradiative transitions,the two fundamental and complementary pathways for the energy de-excitation.This approach will not only improve the accuracy of the quantification by catching the information from a broader spectrum of the energy,but also provide additional information of the probe environment that often impacts the balance between the two forms of the energy transition.This work first analyzes the underlying mechanism of the hypothesis.The practical feasibility is then tested by means of simultaneous measurements of photoacoustic signal for the non-radiative and fluorescence for the radiative energy processes,respectively.It is demonstrated that the systematic evaluation of the probe energy de-excitation results in an improved quantitative tracing of a bioprobe in complex environment.

关键词： Bioprobe fluorescence photoacoustic

The suppression of cervical cancer ferroptosis by macrophages:The attenuation of ALOX15 in cancer cells by macrophages-derived exosomes

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药学学报:英文版 2023年第6期13卷 2645-2662页

作者： Yanlin Luo Yibing Chen Huan Jin Benxin Hou Hongsheng Li Xiang Li Lingfeng Liu Yuan Zhou Yonghua Li Yong Sang Song Quentin Liu Zhengzhi Zou Department of Gynecologic Oncology the Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450001China MOE key laboratory of Laser Life Science&Institute of Laser Life Science Guangdong Provincial Key Laboratory of Laser Life ScienceCollege of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Institute of Clinical Pharmacology School of Basic Medical ScienceAcademy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Genetic and Prenatal Diagnosis Center Department of Gynecology and ObstetricsFirst Affiliated HospitalZhengzhou UniversityZhengzhou 450001China Department of General Surgery the Third People's Hospital of Hainan ProvinceSanya 572000China Department of Breast Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou 510095China Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China Department of Obstetrics and Gynecology Cancer Research InstituteCollege of MedicineSeoul National UniversitySeoul 03080South Korea State key laboratory of Oncology in South China Cancer CenterSun Yat-sen UniversityGuangzhou 510631China Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Induction of cancer cell ferroptosis has been proposed as a potential treatment in several cancer types.Tumor-associated macrophages(TAMs)play a key role in promoting tumor malignant progression and therapy resistance.However,the roles and mechanisms of TAMs in regulating tumor ferroptosis is still unexplored and remains enigmatic.This study shows ferroptosis inducers has shown therapeutic outcomes in cervical cancer in vitro and in vivo.TAMs have been found to suppress cervical cancer cells ferroptosis.Mechanistically,macrophage-derived miRNA-660-5p packaged into exosomes are transported into cancer cells.In cancer cells,miRNA-660-5p attenuates ALOX15 expression to inhibit ferroptosis.Moreover,the upregulation of miRNA-660-5p in macrophages depends on autocrine IL4/IL13-activated STAT6 pathway.Importantly,in clinical cervical cancer cases,ALOX15 is negatively associated with macrophages infiltration,which also raises the possibility that macrophages reduce ALOX15 levels in cervical cancer.Moreover,both univariate and multivariate Cox analyses show ALOX15 expression is independent prognostic factor and positively associated with good prognosis in cervical cancer.Altogether,this study reveals the potential utility of targeting TAMs in ferroptosis-based treatment and ALOX15 as prognosis indicators for cervical cancer.

关键词： Cervical cancer Tumor-associated macrophage ALOX15 Ferroptosis Exosome miRNA-660-5p Macrophages infiltration STAT6

Chemical Linkage and Passivation at Buried Interface for Thermally Stable Inverted Perovskite Solar Cells with Efficiency over 22%

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CCS Chemistry 2023年第8期5卷 1802-1814页

作者： Ying Tan Xueqing Chang Jun-Xing Zhong Wenhuai Feng Meifang Yang Tian Tian Li Gong Wu-Qiang Wu MOE key laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510006 Instrumental analysis Research Center Sun Yat-sen UniversityGuangzhou 510275

Poly[bis(4-phenyl)-(2,4,6-trimethylphenyl)amine](PTAA)has been developed as one of the most popular hole transport layer(HTL)materials in inverted perovskite solar cells(PSCs).However,the efficiency,thermal stability,and reproducibility of PTAA-based devices are still largely limited by underoptimized chemical interaction,energy level alignment,and contact affinity at the PTAA/perovskite interface.To this end,we introduced a bilateral chemical linker to simultaneously achieve favorable chemical interaction with the PTAA underlayer and form robust coordination bonding with the buried perovskite bottom layer,which beneficially improved the contact affinity,facilitated the hole extraction,well-passivated the interfacial defects,and relieved the nonradiative charge recombination at the HTL/perovskite buried interface.The inverted PSCs modified with interfacial chemical linker exhibited consistently higher power conversion efficiencies and performance reproducibility than that of the PTAA-only devices.Combined with the blade-coated FA0.4MA0.6PbI3 perovskite layer,a champion efficiency of 22.23%has been achieved,which is one of the highest reported values for the inverted PSCs based on the bilayer HTL.The targeted device showed enhanced thermal stability under continuous heating at 85℃ owing to suppressed composition segregation with robust interfacial linkage and consolidation.This work offers a new insight towards making efficient,thermally stable,and reproducible perovskite photovoltaics.

关键词： perovskite solar cells hole extraction charge recombination defect passivation thermal stability