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γ-Aminobutyric acid alleviates litchi thaumatin-like protein-induced inflammation and reduces gut microbial translocation

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Food Science and Human Wellness 2024年第5期13卷 3043-3053页

作者： Yao Wang Dongwei Wang Kai Wang Min Zhao Cizhou Li Yu Wang Xuwei Liu Lei Zhao Zhuoyan Hu Guangdong Provincial Key Laboratory of Food Quality and Safety College of Food ScienceSouth China Agricultural UniversityGuangzhou 510642China guangzhou Wanglaoji Lychee Industry development Co. Ltd.Guangzhou 510623China

Previous research reported litchi thaumatin-like protein(LcTLP)could lead to inflammation,which is a factor causing the adverse reactions after excessive intake of *** a main amino acid in litchi pulp,γ-aminobutyric acid(GABA)was found with anti-inflammatory ***,this study aimed to investigate the effects of GABA on LcTLP-induced inflammation through RAW264.7 macrophages and C57BL mice *** vitro study showed GABA could effectively regulate the level of inflammatory cytokines(interleukin(IL)-1β,IL-6,IL-10,and prostaglandin E2)and Ca2+in cells,and inhibit the phosphorylation of p65,IκB,p38,c-Jun N-terminal kinase(JNK)and extracellular signal-regulated kinase(ERK).These results indicate GABA alleviated inflammation through nuclear factor-κB and mitogen-activated protein kinase pathway signaling *** vivo experiment was performed to verify the anti-inflammatory effect of GABA,and the results demonstrated that GABA reduced the inflammation and oxidative stress in the liver of LcTLP-treated mice,as it down-regulated the pro-inflammatory cytokines,malondialdehyde,aspartate transferase,and alanine *** relative expression of phosphorylated p38,JNK and ERK in mice liver with GABA treatment were reduced to 65%,39%and 80%of the control group,***,GABA treatment enriched probiotic bacteria and decreased pathogenic bacteria in mice gut,which reveals GABA could effectively reduce the translocation of gut microbiota.

关键词： Anti-inflammation Gut microbiota Litchi thaumatin-like protein Mitogen-activated protein kinase pathway γ-Aminobutyric acid

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Vimentin as a potential target for diverse nervous system diseases

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Neural Regeneration Research 2023年第5期18卷 969-975页

作者： Kang-Zhen Chen Shu-Xian Liu Yan-Wei Li Tao He Jie Zhao Tao Wang Xian-Xiu Qiu Hong-Fu Wu Department of Anesthesiology Guangzhou Huadu Hospital Affiliated to Guangdong Medical University(Guangzhou Huadu District Maternal and Child Health Care Hospital)GuangzhouGuangdong ProvinceChina Dongguan City Key Laboratory of Stem Cell and Regenerative Tissue Engineering Guangdong Medical UniversityDongguanGuangdong ProvinceChina Department of Surgery the Third Hospital of Guangdong Medical University(Longjiang Hospital of Shunde District)FoshanGuangdong ProvinceChina

Vimentin is a major type Ⅲ intermediate filament protein that plays important roles in several basic cellular functions including cell migration, proliferation, and division. Although vimentin is a cytoplasmic protein, it also exists in the extracellular matrix and at the cell surface. Previous studies have shown that vimentin may exert multiple physiological effects in different nervous system injuries and diseases. For example, the studies of vimentin in spinal cord injury and stroke mainly focus on the formation of reactive astrocytes. Reduced glial scar, increased axonal regeneration, and improved motor function have been noted after spinal cord injury in vimentin and glial fibrillary acidic protein knockout(GFAPVIM) mice. However, attenuated glial scar formation in post-stroke in GFAP–/– VIM–/– mice resulted in abnormal neuronal network restoration and worse neurological recovery. These opposite results have been attributed to the multiple roles of glial scar in different temporal and spatial conditions. In addition, extracellular vimentin may be a neurotrophic factor that promotes axonal extension by interaction with the insulin-like growth factor 1 receptor. In the pathogenesis of bacterial meningitis, cell surface vimentin is a meningitis facilitator, acting as a receptor of multiple pathogenic bacteria, including E. coli K1, Listeria monocytogenes, and group B streptococcus. Compared with wild type mice, VIMmice are less susceptible to bacterial infection and exhibit a reduced inflammatory response, suggesting that vimentin is necessary to induce the pathogenesis of meningitis. Recently published literature showed that vimentin serves as a double-edged sword in the nervous system, regulating axonal regrowth, myelination, apoptosis, and neuroinflammation. This review aims to provide an overview of vimentin in spinal cord injury, stroke, bacterial meningitis, gliomas, and peripheral nerve injury and to discuss the potential therapeutic methods involving vimen

关键词： astrocytes axonal regeneration bacterial meningitis glial scar gliomas nervous system diseases peripheral nervous system injury spinal cord injury stroke vimentin

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Polyisocyanuratoesters:Renewable Linear Polyesters with High Flame Retardancy

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Journal of Renewable Materials 2018年第6期6卷 584-590页

作者： Zijian Chen Rui Hou Jianbing Cheng Fengjie Fang Donglin Tang Guangzhao Zhang School of Materials Science and Engineering South China University of Technology381 Wushan RoadTianhe DistrictGuangzhou 510640P.R.China

Biobased urea nowadays attracts increasing attention as a biomass resource with giant potential,which benefits from the development of biobased ammonia and ecological sanitation *** is an ideal feedstock for chemical industry and developing new urea-based polymer materials can take advantage of the urea *** this work,a class of renewable linear polyesters,namely polyisocyanuratoesters(PICEs)were synthesized from a urea-based monomer bis(2-carbomethoxyethyl)isocyanurate and biobased aliphatic *** with conventional aliphatic polyesters,PICEs containing isocyanurate rings in the polymer chain backbone exhibit outstanding flame retardancy that both PICE-4(the number‘4’refers to the number of methylene in diols,e.g.4 for butylene and 6 for hexylene)and PICE-6 have high limiting oxygen index values over 30%.In the UL 94 tests,PICE-6 reaches V-1 rating;while V-2 is found for *** PICEs exhibit similar pyrolysis behavior that the temperatures of 5%weight loss are around 320°*** are found to have glass transition among 20°C-45°*** crystallization behavior is observed without annealing except for PICE-10,which can crystallize even at room temperature.

关键词： Urea isocyanurate ring aliphatic diol linear polyester flame retardancy

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Oxidation of diclofenac by permanganate: Kinetics, products and effect of inorganic reductants

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Chinese Chemical Letters 2023年第4期34卷 378-383页

作者： Run Huang Chaoting Guan Qin Guo Zhen Wang Hanping Pan Jin Jiang Key Laboratory for City Cluster Environmental Safety and Green development of the Ministry of Education School of EcologyEnvironment and ResourcesGuangdong University of TechnologyGuangzhou 510006China Southern Marine Science and Engineering Guangdong Laboratory(guangzhou) Guangzhou 511458China

The large consumption and discharge of diclofenac(DCF) lead to its frequent detection in surface water and groundwater, posing great threats to humans and ecosystems. This study explored the oxidation kinetics of DCF by permanganate(Mn(Ⅶ)), and expounded the underlying reason for the unusual p Hdependency that was unclear in previous studies. The kinetics of DCF analogues(i.e., aromatic secondary amines) by Mn(Ⅶ) oxidation were comparatively investigated. Then, a tentative kinetic model involving the formation of an intermediate between Mn(Ⅶ) and DCF or its analogues was proposed to fit the p H-rate profile. Since DCF contained two chloro groups, and a carboxyl group which could be ionized by negative electrospray ionization, a precursor ionization scanning approach was used for the first time for detection of N-containing chlorinated oxidation products. New degradation pathways of DCF containing ring opening, carboxylation, carbonylation, electrophilic addition, hydroxylation and dehydrogenation were proposed based on the identified oxidation products. Moreover, it was demonstrated that the introduction of various reducing agents such as Mn(Ⅱ), Fe(Ⅱ) and bisulfite significantly improved the oxidation kinetics of DCF by Mn(Ⅶ). The positive effects of Mn(Ⅱ) and Fe(Ⅱ) were mainly attributed to the accelerated formation of MnO_(2)that acted as a catalyst or co-oxidizer contributing to DCF degradation. The presence of bisulfite caused two-stage kinetics, where a sharp drop of DCF concentration followed by a slowdown of DCF removal. In the first stage, potent reactive manganese species(e.g., Mn(Ⅲ), Mn(V), and Mn(VI)) and sulfate radical were generated during reaction of bisulfite with Mn(Ⅶ), whereas bisulfite was depleted fast due to excess Mn(Ⅶ) concentrations and the system became the Mn(Ⅶ)/MnO_(2)system in the second stage. These results provide new insight into reaction mechanism of DCF with Mn(Ⅶ)as well as propose a feasible strategy for enhancing the treatment of D

关键词： Permanganate Diclofenac Aromatic secondary amines Precursor ionization scanning Reductant activation

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A Lightweight Compact Lithium-Ion Battery Thermal Management System Integratable Directly with EV Air Conditioning Systems

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Journal of Thermal Science 2022年第6期31卷 2363-2373页

作者： LIN Bichao CEN Jiwen JIANG Fangming Laboratory of Advanced Energy Systems Guangzhou Institute of Energy ConversionChinese Academy of SciencesGuangzhou510640China CAS Key Laboratory of Renewable Energy Guangzhou 510640China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and development Guangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China

This paper discusses an improved thermal management system to ameliorate the performance of lithium-ion battery storage systems for electric vehicles(EVs) applications. A compact and lightweight cold plate is designed and fabricated to fit 18650-type lithium-ion batteries, using aluminum-finned copper tubes. A dynamic temperature PID(proportional, integral, differential) control algorithm for electronic expansion valves is developed to study using EV air conditioning refrigerant, R134a, to control battery modules’ temperature with this compact and lightweight thermal management system. The experimental results show that the proposed battery thermal management system can effectively control the battery module’s temperature. In addition, during 1C discharge, when the PID temperature algorithm control scheme is used, the maximum temperature difference across the battery module peaks at less than 4℃, and the maximum temperature within the battery module is less than 36℃.

关键词： electric vehicles air conditioning system battery thermal management finned tube two-phase flow

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Preparation of double perovskite-type oxide LaSrFeCoO_6 for chemical looping steam methane reforming to produce syngas and hydrogen

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Journal of Rare Earths 2016年第10期34卷 1032-1041页

作者：赵坤沈阳何方黄振魏国强郑安庆李海滨赵增立 Key Laboratory of Renewable Energy Chinese Academy of Sciences Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510640 China Guangdong Key Laboratory of New and Renewable Energy Research and development Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510640 China Universiiy of Chinese Academy of Sciences Beijing 100049 China

Double-perovskite type oxide LaSrFeCoO_6 was used as oxygen carrier for chemical looping steam methane reforming（CL-SMR） due to its unique structure and reactivity. Solid-phase, amorphous alloy, sol-gel and micro-emulsion methods were used to prepare the LaSrFeCoO_6 samples, and the as-prepared samples were characterized by means of X-ray diffraction（XRD）, hydrogen temperature-programmed reduction（H_2-TPR）, X-ray photoelectron spectroscopy（XPS）, Brunauer-Emmett-Teller（BET） surface area. Results showed that the samples made by the four different methods exhibited pure crystalline perovskite structure. The ordered double perovskite LaSrFeCoO_6 was regarded as a regular arrangement of alternating FeO_6 and CoO_6 corner-shared octahedra, with La and Sr cations occupying the voids in between the octahedral. Because the La^（3＋） and Sr^（2＋） ions in A-site did not take part in reaction, the TPR patterns showed the reductive properties of the B-site metals. The reduction peaks at low temperature revealed the reduction of adsorbed oxygen on surface and combined with the reduction of Co^（3＋） to Co^（2＋） and to Co^0, while the reduction of Fe^（3＋） to Fe^（2＋） and the partial reduction of Fe^（2＋） to Fe^0 occurred at higher temperatures. From the point of view of the oxygen-donation ability, resistance to carbon formation, as well as hydrogen generation capacity, the sample made by micro-emulsion method exhibited the best reactivity. Its redox reactivity was very stable in ten successive cycles without deactivation. Compared to the single perovskite-type oxides LaFeO_3 and LaCoO_3, the double perovskite LaSrFeCoO_6 exhibited better syngas and hydrogen generation capacity.

关键词： double-perovskite CL-SMR micro-emulsion oxygen species redox rare earths

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In situ formed Mg(BH_(4))_(2) for improving hydrolysis properties of MgH_(2)

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Journal of Magnesium and Alloys 2024年第3期12卷 1204-1214页

作者： Yongyang Zhu Mili Liu liming Zeng Yin Wang Daifeng Wu Rui Li Qing Zhou Renheng Tang Fangming Xiao Institute of Resources Utilization and Rare Earth development Guangdong Provincial Key Laboratory of Rare Earth Development and ApplicationGuangdong Academy of SciencesGuangzhou 510650China School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510641China

The hydrolysis of MgH_(2) delivers high hydrogen capacity(15.2 wt%),which is very attractive for real-time hydrogen ***,the formation of a surface passivation Mg(OH)_(2) layer and the large excess of H_(2)O required to ensure complete hydrolysis are two key challenges for the MgH_(2) hydrolysis ***,a low-cost method is reported to synthesize MgH_(2)@Mg(BH_(4))_(2) composite via ball-milling MgH_(2) with cheap and widely available B_(2)O_(3)(or B(OH)_(3)).By adding small amounts of B_(2)O_(3),the in-situ formed Mg(BH_(4))_(2) could significantly promote the hydrolysis of MgH_(2).In particular,the MgH_(2)–10 wt%B_(2)O_(3) composite releases 1330.7 mL·g^(−1) H_(2)(close to 80%theoretical hydrogen generation H_(2))in H_(2)O and 1520.4 mL·g^(−1) H_(2)(about 95%)in 0.5 M MgCl_(2) in 60 min at 26℃ with hydrolysis rate of 736.9 mL·g^(−1)·min^(−1) and 960.9 mL·g^(−1)·min^(−1) H_(2) during the first minute of the hydrolysis,*** addition,the MgCl_(2) solution allows repeated use by filtering and exhibits high cycle stability(20 cycles),therefore leading to much reduced capacity loss caused by the excess H_(2)*** show that by introducing B_(2)O_(3) and recycling the 0.5 M MgCl_(2) solution,the system hydrogen capacity can approach 5.9 wt%,providing a promising hydrogen generation scheme to supply hydrogen to the fuel cells.

关键词： Hydrolysis MgH_(2) Mg(BH_(4))_(2) Hydrogen generation B_(2)O_(3) MgCl_(2)

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Oil cracking: An important way for highly efficient gen- eration of gas from marine source rock kitchen

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Chinese Science Bulletin 2005年第22期50卷 2628-2635页

作者： ZHAO Wenzhi WANG Zhaoyun ZHANG Shuichang WANG Hongjun WANG Yunpeng Research Institute of Petroleum Exploration & development Petro- China Beijing 100083 China guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640. China

The potentials of gas generation by kerogen in the late period and by crude oil cracking are closely related to the origin of natural gas in the high- to over mature ma- rine area and their exploration perspectives. The carbon structure of kerogens, with different types and at different evolution stages, have been experimentally studied using the high magnetic field solid 13C nuclear magnetic resonance technique in order to determine the oil and gas potential of kerogens. Results show that the contents of gas potential carbon(GPC) of types I, II, III kerogens at the high- to over mature stage are very low, indicating their weak gas-generating capacity and limited gas production; however, the content of oil potential carbon(OPC) of the low mature type I kerogen is much higher, implying that a large amount of crude oil generated during the oil-generating period will be the material for later gas generation by oil cracking. The kinetic experiment of gas generation by crude oil cracking shows that, when the temperature is about 160℃(Ro=1.6%), the crude oil will start to produce large amounts of gas; the temperature range for major gas generation of crude oil is higher than that of the kerogens, and the gas production is 2 to 4 times higher than that of kerogens. The natural gas de- rived from oil cracking (called oil-cracked gas) is much abundant in methyl hexamethylene, which is quite different from the natural gas produced by thermal degradation of kerogens (named kerogen degradation gas) at high- to over mature stage.

关键词：石油裂化反应油原退化磁场结构 GPC

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development features of volcanic rocks of the Yingcheng Formation and their relationship with fault structure in the Xujiaweizi Fault Depression,Songliao Basin,China

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Petroleum Science 2012年第4期9卷 436-443页

作者： Cai Zhourong Huang Qiangtai Xia Bin Lii Baofeng Liu Weiliang Wan Zhifeng School of Marine Sciences Sun Yat-sen UniversityGuangzhouGuangdong 510006China Guangdong University Key Laboratory of Offshore Oil Exploration and development GuangzhouGuangdong 510006China Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering GuangzhouGuangdong 510006China guangzhou Institute of Geochemistry CASGuangzhouGuangdong 510640China

The Xujiaweizi Fault Depression is located in the northern Songliao Basin,Northeast *** exploration results show that the most favorable natural gas reservoirs are in the volcanic rocks of the Yingcheng Formation（K 1 yc）.Based on seismic interpretation,drill cores and the results of previous research,we analyzed the distribution of faults and the thickness of volcanic rocks in different periods of K 1 yc,and studied the relationship of volcanic activities and main *** rocks were formed in the Yingcheng period when the magma erupted along pre-existing fault *** volcanic activities strongly eroded the faults during the eruption process,which resulted in the structural traces in the seismic section being diffuse and *** tectonic activities weakened in the study area in the depression *** analysis of seismic interpretation,thin section microscopy and drill cores revealed that a large number of fractures generated in the volcanic rocks were affected by later continued weak tectonic activities,which greatly improved the physical properties of volcanic reservoirs,and made the volcanic rocks of K 1 yc be favorable natural gas *** above conclusions provide the basis to better understand the relationship of the volcanic rock distribution and faults,the mechanism of volcanic eruption and the formation of natural gas reservoirs in volcanic rocks.

关键词： Volcanic rock development features Yingcheng Formation Xujiaweizi Fault Depression Songliao Basin

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Association of hypoxia-inducible factor-1α (HIF1α) 1772C/T genepolymorphism with susceptibility to renal cell carcinoma/prostatecancer

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BIOCELL 2020年第2期44卷 257-262页

作者： HONGYAN LI CHUNLING LIAO WENJUAN WENG HONGZHEN ZHONG TIANBIAO ZHOU Department of Nephrology Huadu District People’s Hospital of GuangzhouSouthern Medical UniversityGuangzhouChina Department of Nephrology The Second Affiliated Hospital of Shantou University Medical CollegeShantou515041China

In this study,we used a meta-analysis method to evaluate the relationship between hypoxia-inducible factor-1α(HIF1α)1772C/T gene polymorphism(rs 11549465)and renal cell carcinoma(RCC)/prostate cancer *** searched for relevant studies(before March 1,2019)on Cochrane Library,Embase,and *** meeting the inclusion criteria were recruited into this *** outcome of dichotomous data was showed in the way of odds ratios(OR),and 95%confidence intervals(CI)were also *** this investigation,there was no association between HIF1α1772C/T gene polymorphism and susceptibility to RCC in Caucasians,Asians as well as overall *** addition,HIF1α1772C/T gene polymorphism was not found to be relevant to the survival in ***,the T allele was relevant to prostate cancer risk in all populations,but not in Caucasians and ***,the TT genotype and the CC genotype were not related to prostate cancer susceptibility in Asian,Caucasian,and all *** conclusion,the T allele of the HIF1α1772C/T gene polymorphism was related to prostate cancer risk in the overall populations.

关键词： Renal cell carcinoma (RCC) Prostate cancer Hypoxia-inducible factor-1α (HIF1α) 1772C/T gene polymorphism Meta-analysis

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