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The expression of oxidative stress genes related to myocardial ischemia reperfusion injury in patients with ST-elevation myocardial infarction

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World Journal of Emergency Medicine 2022年第2期13卷 106-113页

作者： Qian-lin Gu Peng Jiang Hui-fen Ruan Hao Tang Yang-bing Liang Zhong-fu Ma Hong Zhan Emergency Department the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510000China Huangpu district Emergency Department the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510000China

BACKGROUND:We aimed to investigate the gene expression of myocardial ischemia/reperfusion injury(MIRI)in patients with acute ST-elevation myocardial infarction(STEMI)using stress and toxicity pathway gene chip technology and try to determine the underlying ***:The mononuclear cells were separated by ficoll centrifugation,and plasma total antioxidant capacity(T-AOC)was determined by the ferric reducing ability of plasma(FRAP)*** expression of toxic oxidative stress genes was determined and verified by oligo gene chip and quantitative real-time polymerase chain reaction(qRT-PCR).Additionally,gene ontology(GO)enrichment analysis was performed on DAVID website to analyze the potential mechanism ***:The total numbers of white blood cells(WBC)and neutrophils(N)in the peripheral blood of STEMI patients(the AMI group)were significantly higher than those in the control group(WBC:11.67±4.85×10^(9)/L vs.6.41±0.72×10^(9)/L,P<0.05;N:9.27±4.75×10^(9)/L vs.3.89±0.81×10^(9)/L,P<0.05),and WBCs were significantly associated with creatine kinase-myocardial band(CK-MB)on the first day(Y=8.945+0.018X,P<0.05).In addition,the T-AOC was significantly lower in the AMI group comparing to the control group(12.80±1.79 U/mL vs.20.48±2.55 U/mL,P<0.05).According to the gene analysis,eight up-regulated differentially expressed genes(DEGs)included GADD45A,PRDX2,HSPD1,DNAJB1,DNAJB2,RAD50,TNFSF6,and *** down-regulated DEGs contained CCNG1,CAT,CYP1A1,and ***6 and CYP1A1 were detected by polymerase chain reaction(PCR)to verify the expression at different time points,and the results showed that TNFSF6 was up-regulated and CYP1A1 was down-regulated as the total *** and kyoto encyclopedia of genes and genomes(KEGG)enrichment analysis suggested that the oxidative stress genes mediate MIRI via various ways such as unfolded protein response(UPR)and ***:WBCs,especially neutrophils,were the critical cells that mediating reperfusion injury

关键词： Acute myocardial infarction Myocardial ischemia/reperfusion injury Oxidative stress TNFSF6 CYP1A1 Unfolded protein response

Direct Re–Os dating of pyrite from the Jianchaling Au deposit,West Qinling,China

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Acta Geochimica 2022年第2期41卷 275-287页

作者： Suwei Yue Xiaohua Deng Zhenwen Lin guangzhou City University of Technology No.1 Xuefu RoadHuadu districtGuangzhou 510800China Beijing Institute of Geology for Mineral Resources Co.Ltd Beijing 100012China Guangdong Institute of Marine Geological Survey GuangdongGuangzhou 510080China

The West Qingling Orogen is endowed with more than 1100 t gold resources and with 50 gold deposits,ranking it the third-largest gold province in *** Jianchaling giant gold deposit with 52 t gold reserve is a typical orogenic gold deposit in West Qinling *** deposit lacks accurate and direct metallogenic *** pyrite samples collected from the quartz-polymetallic veins yielded Re–Os isochron age of 206.3±2.7 Ma and an initial187 Os/188 Os ratio of 0.1154±0.0016(MSWD=0.54).The pyrites were analyzed by the electron microprobe(EMPA),and the results show that the iron content ranges from 45.1 to 47.8 wt.%,the sulfur content ranges from 52.0 to 53.5 wt.%,and the gold content varies from0.022 to 0.035%.The higher gold content means that gold is closely related to pyrite,which is a gold-bearing ***,the age is very close to the previous fuchsite40 Ar/39 Ar isotopic ages of 199–194 Ma,which indicates that the gold mineralization at Jianchaling has begun in the Late Triassic(206 Ma),and continued into the Early *** summary and comparison,it is found that the gold metallogenic age of the southern ore belt of the Mian-Lue Suture belt in the West Qinling is younger than that of the northern ore belt,suggesting that the gold deposits in the southern ore belt such as Jianchaling were formed in the transitional period from oceanic subduction to continental collision.

关键词： Jianchaling Pyrite Re-Os West Qinling Orogenic gold deposit

Role of different types of water in bentonite clay on hydrate formation and decomposition

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Chinese Journal of Chemical Engineering 2022年第10期50卷 310-316页

作者： Yu Zhang Lei Zhang Chang Chen Hao-Peng Zeng Xiao-Sen Li Bo Yang Key Laboratory of Gas Hydrate Guangzhou Institute of Energy ConversionChinese Academy of SciencesGuangzhouGuangdong 510640China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and development GuangzhouGuangdong 510640China University of Chinese Academy of Sciences Beijing 10083China guangzhou Special Pressure Equipment Inspection and Research Institute Guangzhou 510663China

The equilibrium and kinetic of hydrate in sediments can be affected by the presence of external components like bentonite with a relatively large surface *** investigate the hydrate formation and decomposition behaviors in bentonite clay,the experiments of methane hydrate formation and decomposition using the multi-step decomposition method in bentonite with different water contents of 20%,40%and 60%(mass)were carried *** contents of bound,capillary and gravity water in bentonite clay and their roles during hydrate formation and decomposition were *** bentonite with water content of 20%(mass),the hydrate formation rate keeps fast during the whole formation process,and the final gas consumption under different initial formation pressures is *** bentonite with the water contents of 40%and 60%(mass),the hydrate formation rate declines significantly at the later stage of the hydrate *** final gas consumption of bentonite with the water contents of 40%and 60%(mass)is significantly higher than that with the water content of 20%(mass).During the decomposition process,the stable pressure increases with the decrease of the water *** mainly forms in free water in bentonite *** bentonite clay with the water contents of 20%and 40%(mass),the hydrate forms in capillary *** bentonite clay with the water content of 60%(mass),the hydrate forms both in capillary water and gravity *** bound water of dry bentonite clay is about 3.93%(mass)and the content of capillary water ranges from 42.37%to 48.21%(mass)of the dry bentonite clay.

关键词： Methane hydrate Bentonite Formation anddecomposition Bound water Capillary water

Control on the Morphology of ABA Amphiphilic Triblock Copolymer Micelles in Dioxane/Water Mixture Solvent

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Chinese Journal of Polymer Science 2018年第6期36卷 728-735页

作者： Yuan Gan Zhi-Da Wang Zhuo-Xin Lu Yan Shi Hong-Yi Tan Chang-Feng Yan Key Laboratory of Renewable Energy Guangzhou Institute of Energy ConversionChinese Academy of SciencesGuangzhou 510640China Guangdong Key Laboratory of New and Renewable Energy Research and development Guangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China

This work offers a typical understanding of the factors that govern the nanostructures of poly（4-vinyl pyridine）-b-polystyrene-bpoly（4-vinyl pyridine）（P4 VP-b-PS-b-P4 VP） block copolymers（BCs） in dioxane/water, in which water is a selective solvent for the P4 VP block. It is achieved through an investigation of the amphiphilic triblock copolymer micelles by variation of three different factors, including water content（above CWC but under the immobile concentration）, temperature（ranging from 20 °C to 80 °C）, and copolymer composition（low and high PS block length）. Transition of bead-like micelles to vesicles is observed with the increase of water content due to the increase of interfacial energy between the copolymer and the solvent. Effect of temperature superposed on that of water content results in various morphologies, such as beads, fibers, rods, capsules, toroids, lamellae, and vesicles. The interfacial tension between the BC and the solvent increases with the increase of water content but decreases with the increase of temperature, indicating that the micellar morphologies are resulted from the competitive interplay between the temperature and the water content and always change in a direction that decreases the interfacial energy. Based on the micellar structures obtained in this work and the effects of temperature superposed on water concentration, a diagram of phase evolution of different micellar morphologies is illustrated here, covering the temperature range from 20 °C to 80 °C and the water content changing from 20 vol% to 35 vol%. For the investigation of BC composition, morphological transition of vesicle-to-fiber, for high PS length, is observed as compared with bead-to-capsule for low PS length, as the temperature changes from 20 °C to 80 °C. Our research complements the protocols to control over the morphologies and the phase diagram describing P4 VP-b-PS-b-P4 VP micellar nanostructures in aqueous solution.

关键词： Micelles Morphological control Self-assembly Block copolymer

Single and competitive adsorption affinity of heavy metals toward peanut shell-derived biochar and its mechanisms in aqueous systems

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Chinese Journal of Chemical Engineering 2020年第5期28卷 1375-1383页

作者： Rui Shan Yueyue Shi Jing Gu YazhuoWang Haoran Yuan guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640China Southern Marine Science and Engineering Guangdong Laboratory(guangzhou) Guangzhou 511458China CAS Key Laboratory of Renewable Energy Guangzhou 510640China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and development Guangzhou 510640China Nano Science and Technology Institute University of Science and Technology of ChinaSuzhou 215123China

Converting peanut shells into biochar by pyrolysis was considered an environmentally friendly and efficient method for agricultural solid waste *** properties of peanut shell-derived biochar(PBC)under different temperature and its adsorption capacity of heavy metals were *** was found that PBC400 exhibited the highest cumulative capability for heavy metals elimination in single solute because of its high specific surface area and rich functional ***,the competitive adsorption revealed that PBC had a substantial difference in adsorption affinity from diverse heavy metal ions,sorption capacity decreased as Pb2+>Cu2+>Cd2+>Ni2+>Zn2+,which was lower than in a single *** adsorption process using selected biochar was optimized with respect to p H,reaction time,adsorbent dose,and initial concentration of heavy *** kinetic data was well fitted with PSO model,and the Langmuir model was adopted for adsorption equilibrium data in both cases of single solutes and mixed solutes for all heavy metals,which indicated that the removal course was primarily explained by monolayer adsorption,and chemical adsorption occupied an important ***,peanut shells derived biochar could be a potential and green adsorbent for wastewater treatment.

关键词： Pyrolysis Biochar Heavy metal removal Competitive adsorption

Antimicrobial Resistance Analysis and Whole-Genome Sequencing of Salmonella Isolates from Environmental Sewage — guangzhou City, Guangdong Province, China, 2022–2023

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China CDC weekly 2024年第13期6卷 254-260页

作者： Bihui Su Guanghong Du Shuiping Hou Zongqiu Chen Xiaoying Wu Gang He Jun Yuan Chaojun Xie Tuberculosis Management and Treatment Department Guangzhou Chest HospitalGuangzhou CityGuangdong ProvinceChina School of Public Health Guangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina guangzhou Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Office of the Director Huadu District Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina

What is already known about this topic?S.1,4,[5],12:i:-and *** are emerging serotypes of Salmonella that require close monitoring for antimicrobial resistance and containment of their *** is added by this report?The study aimed to identify antimicrobial resistance genes(ARGs)in S.1,4,[5],12:i:-and *** strains isolated from environmental sewage in guangzhou City,Guangdong Province,China.A phylogenetic tree was constructed using single nucleotide polymorphism data to assess genetic relatedness among strains,offering insights for Salmonella infection outbreak investigations in the *** are the implications for public health practice?It is crucial to implement strategies,such as integrating different networks,to control the spread of drugresistant *** technologies must be utilized to disinfect sewage and eliminate *** food safety and proper sewage disinfection are essential to curb the dissemination of Salmonella.

关键词： Whole offering integrating

Experimental Study on Conversion Efficiency of A Floating OWC Pentagonal Backward Bent Duct Buoy Wave Energy Converter

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China Ocean Engineering 2019年第3期33卷 297-308页

作者： LI Meng WU Ru-kang WU Bi-jun ZHANG Yun-qiu guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510640 China Key Laboratory of Renewable Energy Chinese Academy of Sciences Guangzhou 510640 China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and development Guangzhou 510640 China University of Chinese Academy of Sciences Beijing 100049 China

Wave tank tests were carried out to evaluate the total efficiency of a floating OWC Pentagonal Backward Bent Duct Buoy (PBBDB). Two kinds of turbine generators were used in tests. The incident wave power, pneumatic power and electricity were measured. The test results show that the primary efficiency can reach up to 185.98% in regular waves and 85.86% in irregular waves. The total efficiency from wave to wire with Wells turbine-generator set is 33.43% in regular waves and 15.82% in irregular waves. The peak total efficiency of the PBBDB with check valves equipped with the impulse turbine-generator set is 41.68% in regular waves and 27.10% in irregular waves. The efficiency of the turbine-generator set is about 30% in the tests. Obviously, the total efficiency can be further improved with the increasing of turbine efficiency.

关键词： wave energy Oscillating Water Column (OWC) PBBDB Capture Width Ratio (CWR) total efficiency

Combination of low-energy shock-wave therapy and bone marrow mesenchymal stem cell transplantation to improve the erectile function of diabetic rats

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Asian Journal of Andrology 2017年第1期19卷 26-33页

作者： Hai-Tao Shan Hai-Bo Zhang Wen-Tao Chen Feng-Zhi Chen Tao Wang Jin-Tai Luo Min Yue Ji-Hong Lin An-Yang Wei Department of Urology Medical Center for Overseas Patients Nanfang Hospital Southern Medical University Guangzhou China Department of Urology Shawan People's Hospital Panyu District Guangzhou China Shenzhen Hyde Medical Equipment Co. Ltd. Shenzhen China Department of Urology Longjiang HospitalShunde District Foshan China Laboratory Animals Center Southern Medical University Guangzhou China.

Stem cell transplantation and low-energy shock-wave therapy （LESWT） have emerged as potential and effective treatment protocols for diabetic erectile dysfunction. During the tracking of transplanted stem cells in diabetic erectile dysfunction models, the number of visible stem cells was rather low and decreased quickly. LESWT could recruit endogenous stem cells to the cavernous body and improve the microenvironment in diabetic cavernous tissue. Thus, we deduced that LESWT might benefit transplanted stem cell survival and improve the effects of stem cell transplantation. In this research, 42 streptozotocin-induced diabetic rats were randomized into four groups： the diabetic group （n = 6）, the LESWT group （n = 6）, the bone marrow-derived mesenchymal stem cell （BMSC） transplantation group （n = 15）, and the combination of LESWT and BMSC transplantation group （n = 15）. One and three days after BMSC transplantation, three rats were randomly chosen to observe the survival numbers of BMSCs in the cavernous body. Four weeks after BMSC transplantation, the following parameters were assessed： the surviving number of transplanted BMSCs in the cavernous tissue, erectile function, real-time polymerase chain reaction, and penile immunohistochemical assessment. Our research found that LESWT favored the survival of transplanted BMSCs in the cavernous body, which might be related to increased stromal cell-derived factor-1 expression and the enhancement of angiogenesis in the diabetic cavernous tissue. The combination of LESWT and BMSC transplantation could improve the erectile function of diabetic erectile function rats more effectively than LESWT or BMSC transplantation performed alone.

关键词： bone marrow mesenchymal stem cell diabetes mellitus erectile function low-energy shock-wave therapy

Jet Characteristics and Optimization of a Cavitation Nozzle for Hydraulic Fracturing Applications

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Fluid Dynamics & Materials Processing 2024年第1期20卷 179-192页

作者： Yu Gao Zhenqiang Xu Kaixiang Shen Shenzhen South China Sea Oil Economic development Co. Ltd.Shenzhen518000China guangzhou Marine Geological Survey China Geological SurveyGuangzhou511458China National Engineering Research Center of Gas Hydrate Exploration and development Guangzhou511458China

Hydraulic jetting is a form of fracturing that involves using a high-pressure jet of water to create fractures in the reservoir rock with a nozzle serving as the central component of the hydraulic sandblasting perforation *** this study,the flow behavior of the nozzle is simulated numerically in the framework of a SST k-ωturbulence *** results show that the nozzle structure can significantly influence the jet performance and related cavitation *** orthogonal experiments,the nozzle geometric parameters are optimized,and the following configuration is found accordingly:contraction angle 20°,contraction segment length 6 mm,cylindrical segment diameter 6 mm,cylindrical segment length 12 mm,spread segment length 10 mm,and spread angle 55°.

关键词： Cavitation jet angle nozzle hydraulic characteristics nozzle parameters