检索结果-南通市图书馆

Ultra-conservative noncoding RNA uc.243 confers chemo-resistance by facilitating the efflux of the chemotherapeutic drug in ovarian cancer

引用

BIOCELL 2024年第8期48卷 1265-1273页

作者： sHAN JIANG XIUFENG LIN YANFEI CHEN XINNING LI JIALI KANG Department of Gynecology and Obstetrics The First Affiliated Hospital of Jinan UniversityGuangzhou510180China Reproductive Medical Center Boai Hospital of Zhongshan Affiliated to Southern Medical UniversityZhongshan528400China Department of Gynecology and Obstetrics Boai Hospital of Zhongshan Affiliated to Southern Medical UniversityZhongshan528400China Department of Gynecology and Obstetrics Guangzhou First People’s HospitalGuangzhou Medical UniversityGuangzhou510180China

Background:Despite improvements in objective response rates to cisplatin-based combination chemotherapy,the majority of advanced ovarian cancer remains suboptimal,resulting in poor *** has been found that non-coding RNAs(ncRNAs)not only participate in the transmission of signals between various cells but also participate in tumor immunity and anti-tumor immune responses,thereby regulating tumor occurrence and ***,the function and detailed mechanism of ultraconserved RNA(ucRNA)in ovarian cancer chemoresistance is still ***:Western blotting assay,Quantitative real-time PCR analysis(qPCR),and Kaplan-Meier Plotter analysis were performed to analyze the expression and prognosis of uc.243 in ovarian *** assay and Annexin V assay were performed to analyze the function of uc.243 in cisplatin resistance in ovarian cancer *** pull-down and qPCR experiments were performed to explore the molecular mechanism of uc.243 enhancing cisplatin resistance in ovarian cancer ***:Herein,we found that uc.243 was remarkably upregulated and correlated with patient survival in chemoresistance ovarian cancer patients compared with chemo-sensitive ovarian *** experiment displayed that uc.243 induced cisplatin resistance on ovarian cancer cells by facilitating the efflux of cisplatin(CDDP);but inhibiting the expression of uc.243 significantly reverses this ***,uc.243 can inhibit the binding of RNA binding protein DGCR8 microprocessor complex subunit to pri-miR-155,thereby inhibiting the cleavage of pri-miR-155 and decrease in mature miR-155,subsequently upregulates the expression of ATP binding cassette subfamily B member(ABCB1,ABCC2).Conclusion:Our research findings indicate that uc.243 can induce chemotherapy resistance in ovarian cancer,suggesting that it may become a new prognostic biomarker for malignant ovarian cancer.

关键词： Ultra-conserved non-coding RNA uc.243 Drug efflux Drug transporters Chemoresistance Ovarian cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine?Autophagy regulation also works

引用

Chinese Chemical Letters 2024年第6期35卷 474-479页

作者： Yuanyi Zhou Ke Ma Jinfeng Liu Zirun Zheng Bo Hu Yu Meng Zhizhong Li Mingshan Zhu Postdoctoral Innovation Practice Base The First and Fifth Affiliated Hospital of Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of spine and spinal Cord Reconstruction The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People’s Hospital)Heyuan 517465China school of Environment Jinan UniversityGuangzhou 511443China Department of Nephrology The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China

Exploring the therapeutic effect of single atom catalysts beyond reactive oxygen species(ROs)modulation would boost the prosperity of nanomedicine in cancer *** as a vital therapy target offers new options for the control of renal cell carcinoma(RCC)***,Fe single atom-decorated graphene oxide(Fe_(1)-GO)nanosheet is developed to be a feasible autophagy inducer in RCC *** the well-dispersed O-Fe_(1)-O active sites,Fe_(1)-GO kills ACHN cells effectively but maintains acceptable cytotoxicity to the normal podocyte and HK2 ***-depth analyses ascribe the inhibition of ACHN cells to the upregulated autophagy instead of the commonly known catalytic ROs *** in vivo therapeutic effect of Fe_(1)-GO nanomedicine is also validated by the RCC-bearing BALB/c mice model,realizing an 89% reduction of tumor weight and good *** work provides new insights into the design of autophagy regulators as well as potential therapeutic strategies for RCC treatment.

关键词： Fe single atom Autophagy Renal cell carcinoma Graphene oxide Cancer therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1361-1373页

作者： Wen-Feng Luo Yu-Ting Jiao Xiao-Ling Lin Ying Zhao sheng-Bo Wang Jian shen Jie Deng Yu-Feng Ye Ze-Ping Han Fang-Mei Xie Jin-Hua He Yu Wan Central Laboratory of Panyu Central hospital Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina south China Normal University-Panyu Central hospital Joint Laboratory of Translational Medical Research Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Digestive Disease Center Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina shunde Vocational and Technical College Foshan 528300Guangdong ProvinceChina Medical Imaging Institute of Panyu Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies ***-2 methylation(msDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum ***(CRC)is among the most prevalent and life-threatening malignancies ***2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum *** To validate the effectiveness of fecal DNA msDC2 testing in the detection of CRC among a high-risk Chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in *** A high-risk Chinese cohort consisting of 1130 individuals aged 40-79 years was selected for evaluation via fecal msDC2 *** and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were ***-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the *** A total of 1035 high-risk individuals were included in this study according to established *** them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological *** of the msDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other *** predictive values of the msDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,msDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(PsION Our findings confirmed that offering fecal msDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high

关键词： Colorectal cancer syndecan-2 DNA methylation Chinese population

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

引用

signal Transduction and Targeted Therapy 2024年第8期9卷 3176-3241页

作者： Pelin Lu Dongxue Ruan Meiqi Huang Mi Tian Kangshun Zhu Ziqi Gan Zecong Xiao Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630PR China Department of Minimally Invasive Interventional Radiology and Laboratory of Interventional RadiologyThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260PR China state Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120PR China Department of stomatology Chengdu Second People's HospitalChengdu 610021PR China hospital of stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510055PR China

The applications of hydrogels have expanded significantly due to their versatile,highly tunable properties and breakthroughs in biomaterial *** this review,we cover the major achievements and the potential of hydrogels in therapeutic applications,focusing primarily on two areas:emerging cell-based therapies and promising non-cell therapeutic *** the context of cell therapy,we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms,provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy,as well as list specific examples of their applications in different disease *** then explore the potential of hydrogels in drug delivery,physical intervention therapies,and other non-cell therapeutic areas(e.g.,bioadhesives,artificial tissues,and biosensors),emphasizing their utility beyond mere delivery ***,we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions,particularly in terms of integration with advanced biomanufacturing *** review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and noncell therapies,tailored to meet the therapeutic requirements of diverse diseases and situations.

关键词： directions overcome breakthrough

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma

引用

Frontiers of Medicine 2024年第4期18卷 708-720页

作者： Fan Zou Jialiang Wei Jialang Zhuang Yafang Liu Jizhou Tan Xianzhang Huang Ting Liu Guangdong Cardiovsacular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical ScienceGuangzhou510080China The second Clinical Medical College Guangzhou University of Chinese MedicineDepartment of Laboratory Medicine/State Key Laboratory of Traditional Chinese Medicine SyndromeGuangdong Provincial Hospital of Chinese MedicineGuangzhou510120China Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning530021China Department of stomatology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Science)Southern Medical UniversityGuangzhou510080China school of Food and Drug Shenzhen Polytechnic UniversityShenzhen518055China shenzhen second People’s hospital First Affiliated Hospital of Shenzhen UniversityShenzhen518055China

CD39 serves as a crucial biomarker for neoantigen-specific CD8^(+)T cells and is associated with antitumor activity and ***,the relationship between CD39 expression levels and the function of chimeric antigen receptor T(CAR-T)cells remains *** study aimed to investigate the role of CD39 in the functional performance of CAR-T cells against hepatocellular carcinoma(HCC)and explore the therapeutic potential of CD39 modulators,such as mitochondrial division inhibitor-1(mdivi-1),or knockdown CD39 through short hairpin *** findings demonstrated that glypican-3-CAR-T cells with moderate CD39 expression exhibited a strong antitumor activity,while high and low levels of CD39 led to an impaired cellular *** modulating the proportion of CD39 intermediate(CD39^(int))-phenotype CAR-T cells such as mdivi-1 and CD39 knockdown enhanced and impaired T cell function,*** combination of mdivi-1 and CD39 knockdown in CAR-T cells yielded the highest proportion of infiltrated CD39^(int)CAR-T cells and demonstrated a robust antitumor activity in *** conclusion,this study revealed the crucial role of CD39 in CAR-T cell function,demonstrated the potential therapeutic efficacy of combining mdivi-1 with CD39 knockdown in HCC,and provided a novel treatment strategy for HCC patients in the field of cellular immunotherapy.

关键词： CD39 CAR-T cells mdivi-1 hepatocellular carcinoma antitumor activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of pediatric Tuina on children's recurrent acute respiratory tract infections: a retrospective cohort study in southern China

引用

Journal of Traditional Chinese Medicine 2024年第3期44卷 586-594页

作者： YIN Lingjia sTALsBY LUNDBORG Cecilia WU Darong YANG Jinghua ALVEssON Helle Molsted CAI Jianxiong LU Taoying XIE Qianwen MARRONE Gaetano Department of Global Public Health Karolinska InstitutetStockholm 17177Swede state Key Laboratory of Dampness syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Outcome Assessment Research Team in Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Health Construction Administration Centre Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine syndrome the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Department of Pediatrics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

OBJECTIVE: To determine the effectiveness of pediatric Tuina(PT) in preventing recurrent acute respiratory tract infections(ARTIs) in children. METHODs: This is a retrospective cohort study based on the electronic medical records of children with recurrent ARTIs in 2016. children were divided into a PT group or a non-PT group, according to whether they had received PT or not in 2016. The primary outcome was the number of ARTI episodes in 2017 and 2018. The secondary outcomes were the number of ARTIs leading to outpatient department visits and outpatient antibiotic prescriptions due to ARTIs in the same time period. Negative binomial regressions were used to detect the association between PT and the outcomes. REsULTs: A total of 2303 children were included in the analysis, including 94 in the PT group and 2209 in the non-PT group. children who received PT six or more times in 2016 had fewer episodes of ARTIs in 2017 [incidence rate ratio(IRR): 0.59, 95% confidence interval(CI)(0.42-0.84)] and 2018 [IRR: 0.58, 95% CI(0.36-0.94)] and fewer outpatient department visits due to ARTIs in 2017 [IRR: 0.56, 95% CI(0.38-0.83)] than children who had not received PT in 2016. There was no significant difference in the number of outpatient antibiotic prescriptions between the two groups. CONCLUsIONs: Receiving PT six or more times within one year is associated with a decrease in recurrent ARTIs in children in the following two years. Randomized controlled trials are needed for effect evaluation prior to establishing PT as a method for preventing recurrent ARTIs among children.

关键词： child massage pediatric Tuina respiratory tract infections

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Increased retinal venule diameter as a prognostic indicator for recurrent cerebrovascular events:a prospective observational study

引用

Neural Regeneration Research 2024年第5期19卷 1156-1160页

作者： Ying Zhao Dawei Dong Ding Yan Bing Yang Weirong Gui Man Ke Anding Xu Zefeng Tan Department of Neurology and stroke Center the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Clinical Neuroscience Institute the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Neurology the First People’s Hospital of FoshanFoshanGuangdong ProvinceChina

Microvasculature of the retina is considered an alternative marker of cerebral vascular risk in healthy ***,the ability of retinal vasculature changes,specifically focusing on retinal vessel diameter,to predict the recurrence of cerebrovascular events in patients with ischemic stroke has not been determined *** previous studies have shown a link between retinal vessel diameter and recurrent cerebrovascular events,they have not incorporated this information into a predictive ***,this study aimed to investigate the relationship between retinal vessel diameter and subsequent cerebrovascular events in patients with acute ischemic ***,we sought to establish a predictive model by combining retinal veessel diameter with traditional risk *** performed a prospective observational study of 141 patients with acute ischemic stroke who were admitted to the First Affiliated hospital of Jinan *** of these patients underwent digital retinal imaging within 72 hours of admission and were followed up for 3 *** found that,after adjusting for related risk factors,patients with acute ischemic stroke with mean arteriolar diameter within 0.5-1.0 disc diameters of the disc margin(MAD_(0.5-1.0DD))of≥74.14μm and mean venular diameter within 0.5-1.0 disc diameters of the disc margin(MVD_(0.5-1.0DD))of≥83.91μm tended to experience recurrent cerebrovascular *** established three multivariate Cox proportional hazard regression models:model 1 included traditional risk factors,model 2 added MAD_(0.5-1.0DD)to model 1,and model 3 added MVD0.5-1.0DD to model *** 3 had the greatest potential to predict subsequent cerebrovascular events,followed by model 2,and finally model *** findings indicate that combining retinal venular or arteriolar diameter with traditional risk factors could improve the prediction of recurrent cerebrovascular events in patients with acute ischemic stroke,and that retinal imaging c

关键词： acute ischemic stroke arteriolar cerebrovascular events diameter digital retinal imaging microvasculature prediction recurrent retina venular

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MAPK9 as a therapeutic target:unveiling ferroptosis in localized prostate cancer progression

引用

BIOCELL 2024年第5期48卷 771-792页

作者： CHENG-GONG LUO JIAO ZHANG YUN-ZHAO AN XUAN LIU sHUAI-JIE LI WEI ZHANG KAI LI XU ZHAO DONG-BO YUAN LING-YUE AN WEI CHEN YE TIAN BIN XU Department of Urology Guizhou Provincial People’s HospitalGuiyangChina Department of Urology First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Background:Ferroptosis,a lipid peroxidation-mediated programmed cell death,is closely linked to tumor development,including prostate cancer(PCa).Despite established connections between ferroptosis and PCa,a comprehensive investigation is essential for understanding its impact on patient ***:A risk model incorporating four ferroptosis-related genes was developed and *** risk scores correlated with an increased likelihood of biochemical recurrence(BCR),diminished immune infiltration,and adverse clinicopathological *** corroborate these results,we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort(TCGA)and the Gene Expression synthesis Cohort(GEO).Moreover,we conducted further investigations into the pivotal gene identified in our model to explore its impact on tumor characteristics through cell proliferation and invasion assays,as well as animal studies conducted in ***,we conducted further experiments involving ferroptosis-related analysis to validate its association with ***:The risk model demonstrated exceptional predictive capabilities for prognosis and therapeutic outcomes in PCa ***-activated protein kinase 9(MAPK9)emerged as a crucial gene within the *** vivo and in vitro experiments explored MAPK9’s role in ferroptosis and its influence on tumor migration and ***:The findings provide a novel perspective for advancing ferroptosis exploration in PCa,bridging basic research and clinical applications.

关键词： Ferroptosis Biochemical recurrence Prostate cancer TCGA GEO MAPK9

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Galvanostatic method assembled ZIFs nanostructure as novel nanozyme for the glucose oxidation and biosensing

引用

Chinese Chemical Letters 2024年第9期35卷 279-283页

作者： Erzhuo Cheng Yunyi Li Wei Yuan Wei Gong Yanjun Cai Yuan Gu Yong Jiang Yu Chen Jingxi Zhang Guangquan Mo Bin Yang The Fourth Affiliated hospital of guangzhou Medical University School of Biomedical EngineeringGuangzhou Medical UniversityGuangzhou 511436China Department of Nephrology First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Oncology Xiangyang Central Hospital of Hubei University of Arts and ScienceXiangyang 441000China

Recently,the composite of soft conductive substrates,such as carbon fiber(CF),with metal-organic frameworks(MOFs)has been employed in a myriad of *** composite material has demonstrated exceptional potential in the realm of electrochemical sensing ***,the rapid growth of MOFs on the surface of CF remains a ***,we propose a simple galvanostatic method as an effective strategy for rapidly growing zeolitic imidazolate frameworks(ZIFs)on CF,and obtain nanocaltrop-like ZIFs modified CF(NC-ZIFs/CF)glucose(Glu)sensor platform with distinctive *** prepared NC-ZIFs/CF demonstrated significant electrocatalytic activity towards the oxidation of Glu in alkaline media,characterized by a pronounced augmentation in oxidation current *** an applied potential of 0.4 V,NC-ZIFs/CF exhibited a remarkably broad detection range(3–30,000μmol/L)and demonstrated outstanding selectivity,repeatability and ***,the NC-ZIFs/CF was efficaciously employed for the detection of blood Glu levels in the serum of both normoglycemic and hyperglycemic patients,obtaining highly reliable *** work demonstrates the feasibility of using galvanostatic method assembly to induce the growth of MOFs on conductive substrates,providing new ideas for electrocatalysis sensors and other electrochemical applications.

关键词： sensor MOFs Electrocatalytic oxidation Electrochemical assembly Glucose

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current status of cognition and skin care behavior in adolescent patients with acne:A survey in China

引用

Chinese Medical Journal 2024年第4期137卷 476-477页

作者： Jing Tian Hong shu Qiufang Qian Zhong shen Chunyu Zhao Li song Ping Li Xiuping Han Hua Qian Jinping Chen Hua Wang Lin Ma Yuan Liang Department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Dermatology Kunming Children’s HospitalKunmingYunnan 650034China Department of Dermatology Children’s Hospital of ShanghaiChildren’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Loreal China Co. LtdShanghai 200040China Department of Dermatology Henan Children’s HospitalChildren’s Hospital Affiliated to Zhengzhou UniversityZhengzhou Hospital Beijing Children’s HospitalZhengzhou Children’s HospitalZhengzhouHenan 450052China Department of Dermatology Shenzhen Children’s HospitalShenzhenGuangdong 518026China Department of Dermatology Shengjing Hospital of China Medical UniversityShenyangLiaoning 110004China Department of Dermatology Children’s Hospital of Soochow UniversitySuzhouJiangsu 215025China Department of Dermatology Guangzhou Women and Children's Medical CenterGuangzhouGuangdong 510623China Department of Dermatology Children’s Hospital of Chongqing Medical UniversityChongqing 400014China

To the Editor:Acne vulgaris(AV)is a common inflammatory skin ***-based epidemiological studies have reported associations between dietary habits,lifestyle factors,family history,and the occurrence and development of acne.^([1–4])This study investigated the skincare behavior and cognition of patients with AV regarding predisposing factors using a designed electronic questionnaire.

关键词： patients dietary behavior

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：