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Chemistry　and　Pharmacological　Activity　of　Peptidoglycan　from　Lycium　Barbaruml

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chinese Chemical Letters 1996年第11期7卷 1009-1010页

作者： Zhao, CJ He, YQ Li, RZ Cui, GH BEIJING med univ DEPT TRADIT CHINESE MEDBEIJING 100083PEOPLES R CHINA

Two homogeneous new peptidoglycans were obtained from Lycium barbarum L. Theywere found to be effective ingredients capable of resining lipid peroxidation. The componentsand linkages of the two homogeneous polysaccharides were studied by means of complete acidhydrolysis, periodate oxidation. Smith degradation enzyme hydrolysis, IR, GC and aminoacid analysis. Homogeneous polysaccharide LBPC2 was found to be a β(1→4)(1→6) peptidoglycanwith MW of 1.2×104, composed of Xyl, Rha. Man in a molar ratio of8.8:2.3;1, LBPC4 was foundto be a a(1→4)(1→6) peptidoglycan with MW of 1.0×104, composed of glucans.

关键词： Activity Pharmacological Peptidoglycan Lycium Barbaruml

Clinical effects of acupuncture therapy for vascular dementia

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Neural Regeneration Research 2011年第3期6卷 193-199页

作者： Zhao, Lei Guo, Yi Xiong, Jun Wang, Wei Du, Yuanhao Yan, Lijuan Tianjin univ tradit chinese med Acupuncture & Moxibust Coll Tianjin 300193 Peoples R China Tianjin univ tradit chinese med Dept Acupuncture & Moxibust Affiliated Hosp 1 Tianjin 300193 Peoples R China

OBJECTIVE： To evaluate clinical acupuncture treatment studies for vascular dementia, as well as to collect high-quality evidence related to clinical acupuncture treatment for clinical diagnosis. DATA SOURCES： Pubmed database （1966-2010）, Embase database （1986-2010）, Cochrane Library （Issue 1,2010）, chinese Biomedical Literature Database （1979-2010）, China HowNet database （1979-2010）, VlP Journals Database （1989-2010）, and Wanfang database （1998-2010） were analyzed by computer.

关键词： acupuncture vascular dementia clinical evidence traditional chinese medicine

Effects of electroacupuncture on microcirculatory blood flow and glucose transporter function in the hippocampus

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Neural Regeneration Research 2011年第3期6卷 200-205页

作者： Lu, Yan Han, Bingbing Wang, Shijun Shandong univ tradit chinese med Dept Expt Acupuncturol Acupuncture & Moxibust Coll Jinan 250355 Shandong Peoples R China Shandong univ tradit chinese med Microcirculat Lab Basic Med Coll Jinan 250355 Shandong Peoples R China

Nerve cell metabolism in post brain ischemia depends on increased microcirculation perfusion and transport function of microvascular endothelial cells. In the present study, a rat model of middle cerebral artery occlusion was established to investigate the influence of electroacupuncture （EA） on hippocampal CA1 cerebral blood flow and glucose transporter 1 （GLUT1） expression in the microvascular endothelial cells. Following EA at Neiguan （PC 6）, the cerebral blood flow in the ischemic hippocampal CA1 region was significantly elevated, the number and microvascular integrated absorbance of the GLUTl-positive cells were significantly increased, nerve cell damage was ameliorated, and GLUT1 protein expression in the ischemic hippocampus was significantly increased. Results demonstrate that EA increased the cerebral blood flow of the hippocampal CA1 region and improved the glucose transport function, thereby attenuating neuronal injuries.

关键词： Electroacupuncture Neiguan (PC 6) focal cerebral ischemia microvascularendothelial cells glucose transporter 1 cerebral blood flow CA1 region neural regeneration

Sishengtang decoction in alleviation of toxic and side effects of transarterial embolization

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World Journal of Gastroenterology 1998年第2期4卷 79-81页

作者： Chen, Z Ling, CQ Huang, XQ Zhang, HW Second Mil med univ Changhai Hosp Dept Tradit Chinese Med Shanghai 200433 Peoples R China

AIM To observe the therapeutic effects of Sishengtang decoction in alleviating the toxic and side effects of transarterial embolization (TAE). METHODS Fifty four patients with liver cancer were divided randomly into Sishengtang decoction group (34 cases) and control group (20 cases). The changes of clinical symptoms and peripheral hemogram and some cellular immune functions were observed before and two weeks after TAE. RESULTS Sishengtang decoction was superior to the control group in improving the digestive tract reaction. The leucocytes of peripheral blood and cellular immune functions (activities of NK cells and LAK cells) of control group decreased obviously after TAE, while that of Sishengtang decoction group decreased slightly, without obvious difference as compared with that of preoperation. CONCLUSIONS Sishengtang decoction might improve the clinical symptoms and increase the leucocytes of peripheral blood and the cellular immune functions of TAE patients.

关键词： Sishengtang decoction liver neoplasms/therapy embolization, therapeutic immunity , cellular killer cell, natural killer cell , lymphokine activated leucocytes

Protective actions of salvianolic acid A on hepatocyte injured by peroxidation in vitro

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World Journal of Gastroenterology 2000年第3期6卷 402-404页

作者： Hu YY Liu CH Wang RP Liu C Liu P Zhu DY Shanghai univ tradit chinese med Inst Liver Dis Shanghai 200032 Peoples R China

INTRODUCTION Salvianolic radix,one of the most commonly usedtraditional chinese herbs,was widely studied aboutits actions against liver injury and fibrosis,and wasone of the focuses of recent *** acid-A(SA-A)was an aq... 详细信息

关键词： Salvianolic acid A hepatocyte carbon tetrachloride liver injury lipid peroxidation water soluble vitamin E ALT AST superoxide dismutase malondiadehyde catalase lactase dehydrogenase glutathione peroxidase glutathione

Effects of salvianolic acid-A on NIH/3T3 fibroblast proliferation,collagen synthesis and gene expression

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World Journal of Gastroenterology 2000年第3期6卷 361-364页

作者： Liu CH Hu YY Wang XL Liu P Xu LM Shanghai univ tradit chinese med Inst Liver Dis Shanghai 200032 Peoples R China

AIM To investigate the mechanisms ofsalvianolic acid A（SA-A）against liver fibrosisin *** NIH/3T3 fibroblasts were culturedroutinely,and incubated with 10-4mol/L-10-7mol/L SA-A for 22 *** cell viability wasassayed by[3H]proline incorporation,cellproliferation by[3H]TdR incorporation,cellcollagen synthetic rate was measured with[3H]proline impulse and collagenase *** total RNA was prepared from thecontrol cells and the drug treated cellsrespectively,and α（1）I pro-collagen mRNAexpression was semi-quantitatively analyzedwith *** 10-4mol/L SA-A decreased cellviability and exerted some cytotoxiciy,while10-5mol/L-10-7mol/L SA-A did not affect cellviability,but inhibited cell proliferationsignificantly,and 10-6mol/L SA-A had the besteffect on cell viability among theseconcentrations of drugs.10-5mol/L-10-6mol/LSA-A inhibited intracellular collagen syntheticrate,but no significant influence on extracellularcollagen *** 10-5mol/L and10-6mol/L SA-A could decrease α（1）I pro-collagen mRNA expression *** SA-A had potent action againstliver *** inhibited NIH/3T3 fibroblastproliferation,intracellular collagen syntheticrate and type I pro-collagen gene expression,which may be one of the main mechanisms of thedrug.

关键词： salvianolic acid-A NIH/3T3 fibroblast cell viability cell proliferation collagen gene expression

Structures of Isodoternifolin A and B

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chinese Chemical Letters 1996年第9期7卷 816-817页

作者： Wang, ZM Feng, H Liang, XT chinese ACAD tradit chinese med INST CHINESE MAT MEDBEIJING 100700PEOPLES R CHINA chinese ACAD med SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA

Two new diterpenoids, named isodoternifolins A(1) and B(2), together with seven known compounds were isolated from the ethanol extract of dried stems and leaves of Isodon ternifolius (D. Don) Kudo. The structures of 1 and 2 were determined as 7 beta-hydroxy-6 beta,11 alpha,15 beta-triacetoxy-7 alpha, 20-epoxy-entkaur-16-ene and 6 beta,7 beta,15 beta-trihydroxy-11 alpha-acetoxy-7 alpha,20-epoxy-entkaur-16-ene by chemical and spectral evidence respectively.

关键词： Structures of Isodoternifolin A and B

A NEW BICOUMARIN FROM PLEUROSPERMUM RIVULORUM (DIELS)

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chinese Chemical Letters 1995年第5期6卷 385-386页

作者： Xiao, YQ Liu, XH Baba, K Taniguchi, M chinese Acad tradit chinese med Inst Chinese Meteria Med Beijing 100700 Peoples R China Osaka univ Pharmaceut Sci Osaka 580 Japan

From the BtOAc extract of the underground parts of Pleurospermum rivulorum (Diels), a new bicoumarin, rivulobirin was isolated along with eight known furocoumarins.

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Dual innervation of spinal ganglion neurons on perineum and bladder

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chinese Science Bulletin 1998年第2期43卷 137-140页

作者： Guowei Lü Zhuo Meng Baohong Li Zhigao Jin Capital univ med Sci Dept Neurobiol Beijing 100054 Peoples R China chinese Acad tradit chinese med Inst Acupuncture Beijing 100700 Peoples R China

Experiments were performed on 13 Wister rats. Fastblus (FB) was injected into subcutaneous tissue in perineum area and nuclear yellow (NY) was injected into subserous lamina of the bladder wall, respectively. FB, NY and FB+NY were mostly found in the spinal ganglions of L6, S1 ans S2 segments. The numbers of FB,NY and FB+NY labeled cells were 146, 186 and 81, in a total of 463 labeled cells and their proportion was 40%, 51% and 9%, respectively. The result indicates that the spinal ganglion neurons dually innervate both the somatic and visceral tissues, and the convergence of somato_visceral sensory pathways might occur in the spinal ganglion cells.

关键词： spinal ganglion double fluorescent labeling somatovisceral interaction.