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Shenlian Extract Protects against Ultrafine Particulate Matter-Aggravated Myocardial Ischemic Injury by Inhibiting Inflammation and Cell Apoptosis

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Biomedical and Environmental Sciences 2025年第2期38卷 206-218页

作者： Shuiqing Qu Yan Liang Shuoqiu Deng Yu Li Yue Dai Chengcheng Liu Tuo Liu Luqi Wang Lina Chen Yujie Li Institute of Chinese materia medica China Academy of Chinese Medical SciencesBeijing 100700China Artemisinin research center China Academy of Chinese Medical SciencesBeijing 100700China

Objective Emerging evidence suggests that exposure to ultrafine particulate matter(UPM,aerodynamic diameter<0.1μm)is associated with adverse cardiovascular *** studies have found that Shenlian(SL)extract possesses anti-inflammatory and antiapoptotic properties and has a promising protective effect at all stages of the atherosclerotic disease *** this study,we aimed to investigated whether SL improves UPM-aggravated myocardial ischemic injury by inhibiting inflammation and cell *** We established a mouse model of MI+*** measurement,measurement of myocardialinfarct size,biochemical analysis,enzyme-linked immunosorbent assay(ELISA),histopathological analysis,Transferase dUTP Nick End Labeling(TUNEL),Western blotting(WB),Polymerase Chain Reaction(PCR)and so on were used to explore the anti-inflammatory and antiapoptotic effects of SL in vivo and in *** SL treatment can attenuate UPM-induced cardiac dysfunction by improving left ventricular ejection fraction,fractional shortening,and decreasing cardiac infarction *** significantly reduced the levels of myocardial enzymes and attenuated UPM-induced morphological ***,SL significantly reduced expression levels of the inflammatory cytokines IL-6,TNF-α,and *** further increased the infiltration of macrophages in myocardial tissue,whereas SL intervention reversed this *** also triggered myocardial apoptosis,which was markedly attenuated by SL *** results of in vitro experiments revealed that SL prevented cell damage caused by exposure to UPM combined with hypoxia by reducing the expression of the inflammatory factor NF-κB and inhibiting apoptosis in H9c2 *** Overall,both in vivo and in vitro experiments demonstrated that SL attenuated UPMaggravated myocardial ischemic injury by inhibiting inflammation and cell *** mechanisms were related to the downregulation of macrophages infiltrating heart tiss

关键词： Ultrafine particulate matter Shenlian extract Inflammation Apoptosis Macrophage

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TPMGD:A genomic database for the traditional medicines in Pakistan

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Chinese Herbal Medicines 2025年第1期17卷 87-93页

作者： Rushuang Xiang Huihua Wan Wei Sun Baozhong Duan Weiqian Chen Xue Cao Sifan Wang Chi Song Shilin Chen Yan Wang Atia-tul Wahab M.Iqbal Choudhary Xiangxiao Meng State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences College of Pharmaceutical Science Dali University H.E.J.research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi Dr.Panjwani center for Molecular Medicine and Drug research International Center for Chemical and Biological Sciences University of Karachi

Objective:In Pakistan,traditional medicines are an important component of the medical system,with numerous varieties and great ***,due to the scattered resources and the lack of systematic collection and collation,adulteration of traditional Pakistani medicine(TPM) is common,which severely affects the safety of their medicinal use and the import and export ***,it is urgent to systematically organize and unify the management of TPM and establish a set of standards and operable methods for the identification of ***:We collected and organized the information on 128 TPMs with regard to their medicinal parts,efficacy,usage,and genetic material,based on Pakistan Hamdard Pharmacopoeia of Eastern Medicine:Pharmaceutical *** genetic information of TPM is summarized from national center for biotechnology information(NCBI) and global pharmacopoeia genome database(GPGD).Furthermore,we utilized bioinformatics technology to supplement the chloroplast genome(cp-genome) data of 12 *** build the web server,we used the Linux+Apache+MySQL+PHP(LAMP) system and constructed the webpage on a PHP:Hypertext Preprocessor(PHP) model view controller(MVC) ***:We constructed a new genomic database,the traditional Pakistani medicine genomic database(TPMGD).This database comprises five entries,namely homepage,medicinal species,species identification,basic local alignment search tool(BLAST),and ***,TPMGD contains basic profiles of 128 TPMs and genetic information of 102 TPMs,including 140 cytochrome c oxidase subunit I(COI)sequences and 119 mitochondrial genome sequences from Bombyx mori,1 396 internal transcribed spacer 2(ITS2) sequences and 1 074 intergenic region(psbA-trnH) sequences specific to 92 and 83 plant species,***,TPMGD includes 199 cp-genome sequences of 82 ***:TPMGD is a multifunctional database that integrates species description,functional information inquiry,genetic information

关键词： chloroplast genome database DNA barcodes Pakistan traditional medicine

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Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway

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Chinese Journal of natural Medicines 2025年第1期23卷 43-53页

作者： Hui Wu Chenyang Ni Yu Zhang Yingying Song Longchan Liu Fei Huang Hailian Shi Zhengtao Wang Xiaojun Wu Shanghai Key Laboratory of Compound Chinese Medicines The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines Institute of Chinese Materia Medica The MOE Innovation Centre for Basic Medicine Research on Qi-Blood TCM Theories Shanghai University of Traditional Chinese Medicine

Stem-leaf saponins from Panax notoginseng(SLSP) comprise numerous PPD-type saponins with diverse pharmacological properties; however, their role in Parkinson's disease(PD),characterized by microglia-mediated neuroinflammation, remains unclear. This study evaluated the effects of SLSP on suppressing microglia-driven neuroinflammation in experimental PD models, including the 1-methyl-4-phenylpyridinium(MPTP)-induced mouse model and lipopolysaccharide(LPS)-stimulated BV-2 microglia. Our findings revealed that SLSP mitigated behavioral impairments and excessive microglial activation in models of PD, including MPTP-treated mice. Additionally, SLSP inhibited the upregulation of inducible nitric oxide synthase(i NOS) and cyclooxygenase-2(COX2) and attenuated the phosphorylation of PI3K,protein kinase B(AKT), nuclear factor-κB(NFκB), and inhibitor of NFκB protein α(IκBα) both in vivo and in vitro. Moreover, SLSP suppressed the production of inflammatory markers such as interleukin(IL)-1β, IL-6, and tumor necrosis factor alpha(TNF-α) in LPS-stimulated BV-2cells. Notably, the P2Y2R agonist partially reversed the inhibitory effects of SLSP in LPStreated BV-2 cells. These results suggest that SLSP inhibit microglia-mediated neuroinflammation in experimental PD models, likely through the P2Y2R/PI3K/AKT/NFκB signaling pathway. These novel findings indicate that SLSP may offer therapeutic potential for PD by attenuating microglia-mediated neuroinflammation.

关键词： Microglia NFκB Neuroinflammation P2Y2 receptor Stem-leaf saponins of Panax Notoginseng

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China(Life Sciences) 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Innovation research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Experiment center for Science and Technology Shanghai University of Traditional Chinese MedicineShanghai 201203China

Dear Editor,Phenotypic drug discovery,which observes compound effects on physiology,has given way to targeting specific molecules,but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al.,2022).Osteoarthritis(OA)is a prevalent chronic joint disorder,primarily affecting knee joints,with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).This imbalance and the discharge of inflammatory mediators perpetuate the cycle of inflammation and tissue ***,controlling inflammation and modulating osteoclastogenesis are critical therapeutic targets for managing OA.

关键词： inflammation drugs

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End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle

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Fundamental research 2025年第1期5卷 407-418页

作者： Xiaoyan Hu Jingqi Zeng Lijuan M Xiaomeng Wang Jing Du Lu Yao Zhisheng Wu Fujian University of Traditional Chinese Medicine Fuzhou 350122China Engineering research center for Pharmaceutics of Chinese materia medica and New Drug Development Ministry of EducationBeijing 100102China Beijing University of Chinese Medicine Beijing 100102China China Beijing Tongrentang Group Co. Ltd.Beijing 100062China

This study reported an original end-to-end dataflow engineering framework for the quality transfer principle to overcome the quality challenges in real-world honey ***,650 pivotal data points of physical and chemical quality attributes from 65 batches of honey intermediates were characterized through multiple sensors,which included rheological properties,acidity,moisture,and ***,a hypersensitized TAS1R2@AuNPs/SPCE biosensor was developed to identify biological quality attributes of honey,the powerful affinities between honey intermediates and the TAS1R2 receptor were discovered(KD<1×10^(−8)M),and the abnormal batches of B2,B23 and C23 were diagnosed by TAS1R2@AuNPs/SPCE biosensor and multivariable ***,the end-to-end dataflow containing physical,chemical and biological critical quality attributes was successfully established to interpret the quality transfer principle of honey manufacturing,which revealed that the front-end refining process was relatively unstable and the back-end refining process was a negligible influence on the quality of honey *** framework embraces quality management,quality transfer,and biosensor information,which will contribute to discovering the quality transfer principle in industrial innovation for intelligent manufacturing.

关键词： End-to-end dataflow Quality transfer principle Critical quality attributes Biosensor Honey manufacturing

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Curvularin derivatives from hydrothermal vent sediment fungus Penicillium ***-50 guided by molecular networking and their antiinflammatory activity

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Chinese Journal of natural Medicines 2025年第1期23卷 119-128页

作者： Chunxue Yu Zixuan Xia Zhipeng Xu Xiyang Tang Wenjuan Ding Jihua Wei Danmei Tian Bin Wu Jinshan Tang Institute of Traditional Chinese Medicine and natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drug Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China Jinan University School of Traditional Chinese materia medica Shenyang Pharmaceutical University Ocean College Zhejiang UniversityZhoushan Campus

Guided by molecular networking, nine novel curvularin derivatives（1-9） and 16 known analogs（10-25） were isolated from the hydrothermal vent sediment fungus Penicillium sp. HL-50. Notably, compounds 5-7 represented a hybrid of curvularin and purine. The structures and absolute configurations of compounds 1-9 were elucidated via nuclear magnetic resonance（NMR） spectroscopy, X-ray diffraction, electronic circular dichroism（ECD） calculations,13C NMR calculation, modified Mosher's method, and chemical derivatization. Investigation of anti-inflammatory activities revealed that compounds 7-9, 11, 12, 14, 15, and 18 exhibited significant suppressive effects against lipopolysaccharide（LPS）-induced nitric oxide（NO）production in murine macrophage RAW264.7 cells, with IC50values ranging from 0.44 to 4.40μmol·L-1. Furthermore, these bioactive compounds were found to suppress the expression of inflammation-related proteins, including inducible NO synthase（i NOS）, cyclooxygenase-2（COX-2）, NLR family pyrin domain-containing protein 3（NLRP3）, and nuclear factor kappa-B（NF-κB）. Additional studies demonstrated that the novel compound 7 possessed potent antiinflammatory activity by inhibiting the transcription of inflammation-related genes, downregulating the expression of inflammation-related proteins, and inhibiting the release of inflammatory cytokines, indicating its potential application in the treatment of inflammatory diseases.

关键词： Anti-inflammatory activity Curvularin derivatives Molecular networking Penicillium sp. HL-50

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China(Life Sciences) 2025年第1期68卷 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care HospitalDongguan 523000China Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People’s HospitalSouthern University of Science and TechnologyShenzhen 518020China State Key Laboratory for Quality Ensurance andSustainable Use of Dao-di Herbs Artemisinin Research CenterandInstitute of Chinese Materia MedicaChina Academyof Chinese Medical SciencesBeijing 100700China State Key Laboratory of Antiviral Drugs School of PharmacyHenan UniversityKaifeng 475004China Reproductive Medicine center Foshan Women and Children HospitalFoshan 528000China

Ovarian endometrioma(OE),also known as“chocolate cysts,”is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus,leading to symptoms such as dysmenorrhea,pelvic pain,and ***,the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown,posing challenges for diagnosis and ***,we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell *** identified notable alterations in cell type-specific proportions and molecular signatures associated with ***,the activation of IGFBP5^(+) macrophages with pro-inflammatory properties,NK cell exhaustion,and aberrant proliferation of IQCG^(+) and KLF2^(+) epithelium are key features and may be the potential mechanisms underlying the pathogenesis of ***,our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Highly anticipated natural diterpenoids as an important source of new drugs in 2013-2023

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Chinese Chemical Letters 2025年第1期36卷 119-136页

作者： Yingjie Wang Peng Tang Wenchao Tu Qi Gao Cuizhu Wang Luying Tan Lixin Zhao Hongye Han Liefeng Ma Kouharu Otsuki Weilie Xiao Wenli Wang Jinping Liu Yong Li Zhajun Zhan Wei Li Xianli Zhou Ning Li School of Traditional Chinese materia medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning provinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of Medicinal Chemistry for natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Key Laboratory of Research and Development for Natural ProductsSchool of Pharmacy and School of Chemical Science and TechnologyState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanYunnan UniversityKunming 650091China School of Pharmacy Nantong UniversityNantong 226001China School of Pharmaceutical Sciences Jilin UniversityChangchun 130021China State Key Laboratory of Bioactive Substance and Function of natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China College of Pharmaceutical Sciences Zhejiang University of TechnologyHangzhou 310014China Faculty of Pharmaceutical Sciences Toho UniversityFunabashiChiba 274-8510Japan School of Life Science and Engineering Southwest Jiaotong UniversityChengdu 610031China

This review covers the structures of diterpenoids,including chain(72),monocyclic(9),labdane-type(67),clerodane-type(127)abietane-type(716),ent-kaurane-type(89),grayanane-type(331),ingenanetype(55),tigliane-type(154),daphnane-type(237),and aconitine-type diterpene alkaloids(265)with rich biological activities reported in *** the drugs in clinical use or under clinical investigation of diterpenoids and leading compounds were summarized.

关键词： natural diterpenoids Structures Bioactivities Druggability Leading compounds New drugs

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Advancements in proteogenomics for preclinical targeted cancer therapy research

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Biophysics Reports 2025年第01期11卷 56-76页

作者： Yuying Suo Yuanli Song Yuqiu Wang Qian Liu Henry Rodriguez Hu Zhou Department of Analytical Chemistry State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Otolaryngology Eye & ENT Hospital Fudan University Office of Cancer Clinical Proteomics research National Cancer Institute National Institutes of Health

Advancements in molecular characterization technologies have accelerated targeted cancer therapy research at unprecedented resolution and dimensionality. Integrating comprehensive multi-omic molecular profiling of a tumor, proteogenomics, marks a transformative milestone for preclinical cancer research. In this paper, we initially provided an overview of proteogenomics in cancer research,spanning genomics, transcriptomics, and proteomics. Subsequently, the applications were introduced and examined from different perspectives, including but not limited to genetic alterations, molecular quantifications, single-cell patterns, different post-translational modification levels, subtype signatures,and immune landscape. We also paid attention to the combined multi-omics data analysis and pancancer analysis. This paper highlights the crucial role of proteogenomics in preclinical targeted cancer therapy research, including but not limited to elucidating the mechanisms of tumorigenesis, discovering effective therapeutic targets and promising biomarkers, and developing subtype-specific therapies.

关键词： Proteogenomics Targeted cancer therapy Integrated omics analysis

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Plasma metabolomics combined with mass spectrometry imaging reveals crosstalk between tumor and plasma in gastric cancer genesis and metastasis

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Chinese Chemical Letters 2025年第1期36卷 506-512页

作者： Yanhua Chen Xian Ding Jun Zhou Zhaoying Wang Yunhai Bo Ying Hu Qingce Zang Jing Xu Ruiping Zhang Jiuming He Fen Yang Zeper Abliz Key Laboratory of Mass Spectrometry Imaging and Metabolomics(State Ethnic Affairs Commission) Center for Imaging and Systems BiologyCollege of Life and Environmental SciencesMinzu University of ChinaBeijing 100081China State Key Laboratory of Bioactive Substance and Function of natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100050China Key Laboratory of Carcinogenesis and Translational research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational research(Ministry of Education) Center of Drug Clinical TrialPeking University Cancer Hospital and InstituteBeijing 100142China Beijing Engineering research center of Food Environment and Public Health Minzu University of ChinaBeijing 100081China Key laboratory of Ethnomedicine of Ministry of Education School of PharmacyMinzu University of ChinaBeijing 100081China Key Laboratory of Carcinogenesis and Translational research(Ministry of Education) Department of BioBankPeking University Cancer Hospital and InstituteBeijing 100142China Pharmacy Department of Beijing Chao–Yang Hospital Capital Medical UniversityBeijing 100020China

Gastric Carcinoma(GC)is a highly fatal malignant tumor with a poor *** elevated mortality rates are primarily due to its proclivity for late-stage *** the metabolic interactions between tumor microenvironment and the systemic bloodstream could help to clearly understand the mechanisms and identify precise biomarkers of tumor growth,proliferation,and *** this study,an integrative approach that combines plasma metabolomics with mass spectrometry imaging of tumor tissue was developed to investigate the global metabolic landscape of GC tumorigenesis and *** results showed that the oxidized glutathione to glutathione ratio(GSSH/GSH)became increased in non-distal metastatic GC(M0),which means an accumulation of oxidative stress in tumor ***,it was found that the peroxidation of polyunsaturated fatty acids,such as 9,10-EpOMe,9-HOTrE,etc.,were accelerated in both plasma and tumor tissues of distal metastatic GC(M1).These changes were further confirmed the potential effect of CYP2E1 and GGT1 in metastatic potential of GC by mass spectrometry imaging(MSI)and immunohistochemistry(IHC).Collectively,our findings reveal the integrated multidimensional metabolomics approach is a clinical useful method to unravel the bloodtumor metabolic crosstalk,illuminate reprogrammed metabolic networks,and provide reliable circulating biomarkers.

关键词： Metabolomics Spatial-resolved metabolomics Gastric cancer Blood-tumor metabolic crosstalk Lipid peroxidation

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