检索结果-南通市图书馆

Aluminum exposure impairs oocyte quality via subcellular structure disruption and DNA damage-related apoptosis in mice

引用

Journal of Environmental Sciences 2024年第5期139卷 308-319页

作者： Hongge Li Jingcai Liu Weihua Nong Mengying Shen Sheng Dou Shaochen Sun Junli Wang The Affiliated Hospital of Youjiang medical University for Nationalities Guangxi 533000China college of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China School of medical Laboratory Youjiang Medical University for NationalitiesGuangxi 533000China Industrial college of Biomedicine and Health Industry Youjiang Medical University for NationalitiesGuangxi 533000China Reproductive Medicine Guangxi Medical and Health Key Discipline Construction ProjectThe Affiliated Hospital of Youjiang Medical University for NationalitiesGuangxi 533000China

Aluminum(Al)can lead to an exposure of creature in varieties ways for its universality,and it could disturb normal physiological metabolism,with the damage to multisystem including *** the oocyte quality is critical for female reproduction,we inspected the toxicity of Al on mouse oocyte *** constructed in vitro exposure mouse model,and we found that 5 mmol/L Al had adverse effects on oocyte maturation by impairing organelle and *** spindle and misaligned chromosomes which might be considered to be caused by elevated levels of acetylation,as well as abnormal distribution of actin dynamics could hinder normal meiosis of *** dysfunction indicated that Al affected proteins synthesis,transport and digestion,which would further damage oocyte *** order to explore the mechanism of Al toxicity,our further investigation demonstrated that Al caused mitochondrial dysfunction and imbalance calcium homeostasis,resulting in limited energy ***,high level of reactive oxygen species,DNA damage and apoptosis caused by oxidative stress were also the manifestation of Al toxicity on *** conclusion,our study provided the evidence that Al exposure affected oocyte quality through its effects on spindle organization,actin dynamics,organelle function and the induction of DNA damage-related apoptosis with mouse model.

关键词： Aluminum Oocyte Cytoskeleton Organelle DNA damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Saponin Ⅰ from Shuitianqi(Rhizoma Schizocapasae Plantagineae) inhibits metastasis by negatively regulating the transforming growth factor-β1/Smad7 network and epithelial-mesenchymal transition in the intrahepatic metastasis Bagg's Albino/c mouse model

引用

Journal of Traditional Chinese Medicine 2024年第4期44卷 642-651页

作者： LYU Meixian ZHOU Huan ZHI Limin ZHOU Jinling GAN Rizhi QIN Yanping HE Nengting ZUO Qiqi LI Hao DONG Min LIANG Gang Pharmaceutical college Guangxi Medical University Department of Pharmacy Affiliated Tumor Hospital of Guangxi Medical University Drug clinical trial Facility office the People's Hospital of Guangxi Zhuang Autonomous Region college of Pharmacy Guangxi University of Chinese Medicine Department of Pharmacy the Second Affiliated Hospital of Guangxi Medical University Department of Pharmacy People's Hospital of Guangxi Hezhou Department of Pharmacy Guangzhou Women and Children's Medical Center Liuzhou Hospital Department of Pharmacy First Affiliated Hospital of Gannan Medical University

OBJECTIVE: To examine the influence of Saponin Ⅰ from Shuitianqi(Rhizoma Schizocapasae Plantagineae)(SSPH Ⅰ) on hepatocellular carcinoma(HCC) metastasis,and to elucidate the underlying ***: The intrahepatic metastasis Bagg's Albino/c(BALB/c) mouse model was established with human hepatocellular carcinomas(HepG2) cells, then treated with normal saline(once per day), cisplatin(2 mg/kg, once every 2 d), and SSPH Ⅰ(25, 50, and 75 mg/kg, once per day). Then, we assessed alterations in the hepatic pathology and target protein expressions in the intrahepatic metastasis BALB/c mouse model using a series of molecular biology ***: Based on our analysis, SSPH Ⅰ significantly alleviated hepatocyte necrosis and tumor cells ***, SSPH Ⅰ suppressed extracellular matrix(ECM) degradation and angiogenesis via a decrease in matrix etalloproteinase-2(MMP-2), MMP-9, CD31, CD34,and vascular endothelial growth factor(VEGF) ***, SSPH Ⅰ repressed invasion and metastasis by suppressing the transforming growth factor-β1(TGF-β 1)/Smad7 axis and epithelial-mesenchymal transition(EMT), as evidenced by the scarce TGF-β1, Ncadherin, and Vimentin expressions, and elevated Smad7 and E-cadherin ***: The SSPH Ⅰ-mediated negative regulation of the TGF-β 1/Smad7 axis and EMT are critical for the inhibition of HCC invasion and metastasis.

关键词： Saponin I from Shuitianqi (Rhizoma Schizocapasae Plantagineae) Smad7 protein carcinoma, hepatocellular epithelial-mesenchymal transition transforming growth factor beta1

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Binary Hybrid Artificial Hummingbird with Flower Pollination Algorithm for Feature Selection in Parkinson’s Disease Diagnosis

引用

Journal of Bionic Engineering 2024年第2期21卷 1003-1021页

作者： Liuyan Feng Yongquan Zhou Qifang Luo college of Artificial Intelligence Guangxi University for NationalitiesNanning530006China Xiangsihu college of guangxi University for Nationalities Nanning532100GuangxiChina guangxi Key Laboratories of Hybrid Computation and IC Design Analysis Nanning530006China

Parkinson’s disease is a neurodegenerative disorder that inflicts irreversible damage on *** experimental data regarding Parkinson’s patients are redundant and irrelevant,posing significant challenges for disease ***,there is a need to devise an effective method for the selective extraction of disease-specific information,ensuring both accuracy and the utilization of fewer *** this paper,a Binary Hybrid Artificial Hummingbird and Flower Pollination Algorithm(FPA),called BFAHA,is proposed to solve the problem of Parkinson’s disease diagnosis based on speech ***,combining FPA with Artificial Hummingbird Algorithm(AHA)can take advantage of the strong global exploration ability possessed by FPA to improve the disadvantages of AHA,such as premature convergence and easy falling into local ***,the Hemming distance is used to determine the difference between the other individuals in the population and the optimal individual after each iteration,if the difference is too significant,the cross-mutation strategy in the genetic algorithm(GA)is used to induce the population individuals to keep approaching the optimal individual in the random search process to speed up finding the optimal ***,an S-shaped function converts the improved algorithm into a binary version to suit the characteristics of the feature selection(FS)*** this paper,10 high-dimensional datasets from UCI and the ASU are used to test the performance of BFAHA and apply it to Parkinson’s disease *** with other state-of-the-art algorithms,BFAHA shows excellent competitiveness in both the test datasets and the classification problem,indicating that the algorithm proposed in this study has apparent advantages in the field of feature selection.

关键词： Artificial Hummingbird Algorithm Flower pollination algorithm Feature selection Parkinson’s disease Meta-heuristic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sclerotherapy in a case of multiple glomuvenous malformation

引用

Chinese Journal of Plastic and Reconstructive Surgery 2024年第2期6卷 79-82页

作者： Shufen Wang Sijian Wen Jiarong Liang Hui Lui Xinyu Zhang Dermatology and Venereology First Clinical Medical College Guangxi Medical University Department of Dermatology and Venereology First Affiliated Hospital of Guangxi Medical University

In this study, we present a representative case of multiple glomuvenous malformation in a 12-year-old female patient. Approximately five years ago, the patient developed multiple blue-purple papules and plaques on her hypogastrium and right thigh, which progressively enlarged and presented tenderness. Histopathological examination confirmed the diagnosis of glomuvenous malformation. Following two injections of lauromacrogol, a significant improvement was observed in the lesions, including a resolution of tenderness. These findings suggest that sclerotherapy not only exhibits evident therapeutic efficacy but also effectively alleviates pain while addressing both aesthetic and therapeutic concerns.

关键词： Glomuvenous malformation Sclerotherapy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Physiological,transcriptome and gene functional analysis provide novel sights into cadmium accumulation and tolerance mechanisms in kenaf

引用

Journal of Environmental Sciences 2024年第3期137卷 500-514页

作者： Shan Cao Meng Wang Jiao Pan Dengjie Luo Samavia Mubeen Caijin Wang Jiao Yue Xia Wu Qijing Wu Hui Zhang Canni Chen Muzammal Rehman Sichen Xie Ru Li Peng Chen guangxi Key Laboratory of Agro-environment and Agric-products safety Key Laboratory of Plant Genetics and BreedingCollege of AgricultureGuangxi UniversityNanning 530004China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China

Kenaf is considered to have great potential for remediation of heavy metals in ***,studies on molecular mechanisms of root Cd accumulation and tolerance are still *** this study,two differently tolerant kenaf cultivars were selected as materials and the physiological and transcriptomic effects were evaluated under Cd *** study showed that 200μmol/L CdCl_(2) treatment triggered the reactive oxygen species(ROS)explosion and membrane lipid *** with the Cd-sensitive cultivar‘Z',the Cd-tolerant cultivar‘F'was able to resist oxidative stress in cells by producing higher antioxidant enzyme activities and increasing the contents of ascorbic acid(AsA)and glutathione(GSH).The root cell wall of‘F'exhibited higher polysaccharide contents under Cd treatment,providing more Cd-binding *** were 3,439 differentially expressed genes(DEGs)that were co-regulated by Cd treatment in two *** biosynthesis and plant hormone signal transduction pathways were significantly enriched by functional annotation *** associated with pectin,cellulose,and hemi-cellulose metabolism were involved in Cd chelation of root cell wall;V-ATPases,ABCC3 and Narmp3 could participated in vacuolar compartmentalization of Cd;PDR1 was responsible for Cd effux;the organic acid transporters contributed to the absorption of Cd in *** genes might have played key roles in kenaf Cd tolerance and Cd ***,HcZIP2 was identified to be involved in Cd uptake and transport in *** findings provide a deeper understanding of the molecular pathways underlying Cd accumulation and detoxification mechanisms in kenaf.

关键词： Kenaf Cd stress Physiological Transcriptome HcZIP2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spatially Coupled Codes via Bidirectional Block Markov Superposition Transmission

引用

Tsinghua Science and Technology 2024年第3期29卷 656-670页

作者： Gaoyan Li Shancheng Zhao Haiqiang Chen Jinming Wen college of Information Science and Technology Jinan UniversityGuangzhou 510632China guangxi Key Laboratory of Multimedia Communications and Network Technology Guangxi UniversityNanning 530004China

In this paper,we present a new class of spatially coupled codes obtained by using both non-recursive and recursive block-oriented *** resulting codes are termed as bidirectional block Markov superposition transmission(BiBMST)***,we perform an iterative decoding threshold analysis according to protograph-based extrinsic information transfer(PEXIT)charts for the BiBMST codes over the binary erasure channels(BECs).Secondly,we derive the generator and parity-check matrices of the BiBMST ***,extensive numerical results are presented to show the advantages of the proposed BiBMST ***,our numerical results show that,under the constraint of an equal decoding latency,the BiBMST codes perform better than the recursive BMST(rBMST)***,the simulation results show that,in finite-length regime,negligible performance gain is obtained by increasing the encoding *** solve this limitation by introducing partial superposition,and the resulting codes are termed as partially-connected BiBMST(PC-BiBMST)*** results have confirmed the advantages of the PC-BiBMST codes over the original BiBMST *** also present extensive simulation results to show the performance advantages of the PC-BiBMST codes over the spatially coupled low-density parity-check(SC-LDPC)codes,spatially coupled generalized LDPC(SC-GLDPC)codes,and the original BiBMST codes in the finite-length regime.

关键词： block Markov superposition transmission(BMST) protograph-based extrinsic information transfer(PEXIT) capacity-approaching codes spatial coupling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Empirical likelihood for spatial cross-sectional data models with matrix exponential spatial specification

引用

Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 125-139页

作者： LIU Yan RONG Jian-rong QIN Yong-song Nanning University Nanning 530200China Center for Applied Mathematics of guangxi and college of Mathematics and Statistics Guangxi Normal UniversityGuilin 541004China

In this paper,we study spatial cross-sectional data models in the form of matrix exponential spatial specification(MESS),where MESS appears in both dependent and error *** empirical likelihood(EL)ratio statistics are established for the parameters of the MESS *** is shown that the limiting distributions of EL ratio statistics follow chi-square distributions,which are used to construct the confidence regions of model *** experiments are conducted to compare the performances of confidence regions based on EL method and normal approximation method.

关键词： MESS empirical likelihood con dence region

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A time-dependent luminescent phosphor of Na_(2)Ba_(2)Si_(2)O_(7):Eu for multi-level encryption and dynamic information display

引用

Journal of Advanced Ceramics 2024年第4期13卷 429-436页

作者： Jie Shao Xiyang Li Meng Liu Haiqin Sun Qiwei Zhang Dengfeng Peng Fuchi Liu college of Physics and Technology Guangxi Normal UniversityGuilin 541004China guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

Photo-stimuli responsive materials show great potential in the fields of information encryption and storage due to their distinctive spatial or temporal color ***,the conventional single or multi-color static outputs by light stimulus difficulty meet practical requirements for high-security optical storage ***,a novel dynamic irradiation-responsive phosphor of Na_(2)Ba_(2)Si_(2)O_(7):Eu is demonstrated,exhibiting high storage stability and convenient readout *** inherent Eu^(2+)luminescence can be dynamically tuned,instantly read out,and conveniently erased by controlling irradiation duration of a portable diode laser(365 nm).The modulation mechanism is unraveled by optically induced oxidation reactions of Eu^(2+)→Eu^(3+)and defects as killer *** excellent luminescence modulation degree(ΔR_(t)=89.5%)and the accompanying larger color contrast enable the creation of invisible optical codes with multi-level encryption in bright or dark *** results indicate potential applications of Na_(2)Ba_(2)Si_(2)O_(7):-based materials in information encryption and invisible optical storage,and are expected to expand more investigations on optically induced PL modulation behaviors based on mixed valences and defects.

关键词： light irradiation luminescent modulation invisible optical storage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis, Molecular Dynamics Simulation and Experimental Validation

引用

Chinese Journal of Integrative Medicine 2024年第5期30卷 408-420页

作者： FENG Min-chao LUO Fang HUANG Liang-jiang LI Kai CHEN Zu-min LI Hui YAO Chun QIN Bai-jun CHEN Guo-zhong The First Clinical medical college Guangxi University of Traditional Chinese MedicineNanning 530000China guangxi Key Laboratory of Molecular Biology of Traditional Chinese Medicine and Preventive Medicine Nanning 530000China Graduate School Guangxi University of Traditional Chinese MedicineNanning 530000China Department of Gastroenterology the First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530023China

Objective: To identify the core targets of Rheum palmatum L. and Salvia miltiorrhiza Bge.,(Dahuang-Danshen, DH-DS) and the mechanism underlying its therapeutic efficacy in acute pancreatitis(AP)using a network pharmacology approach and validate the findings in animal experiments. Methods: Network pharmacology analysis was used to elucidate the mechanisms underlying the therapeutic effects of DH-DS in AP. The reliability of the results was verified by molecular docking simulation and molecular dynamics ***, the results of network pharmacology enrichment analysis were verified by immunohistochemistry,Western blot analysis and real-time quantitative PCR, respectively. Results: Sixty-seven common targets of DH-DS in AP were identified and mitogen-activated protein kinase 3(MAPK3), Janus kinase 2(JAK2), signal transducer and activator of transcription 3(STAT3), protein c-Fos(FOS) were identified as core targets in the protein interaction(PPI) network analysis. Gene ontology analysis showed that cellular response to organic substance was the main functions of DH-DS in AP, and Kyoto Encyclopedia of Genes and Genomes analysis showed that the main pathway included Th17 cell differentiation. Molecular docking simulation confirmed that DH-DS binds with strong affinity to MAPK3, STAT3 and FOS. Molecular dynamics simulation revealed that FOS-isotanshinone Ⅱ and STAT3-dan-shexinkum d had good binding capacity. Animal experiments indicated that compared with the AP model group, DH-DS treatment effectively alleviated AP by inhibiting the expression of interleukin-1β, interleukin-6 and tumor necrosis factor-α, and blocking the activation of Th17 cell differentiation(P<0.01). Conclusion: DH-DS could inhibit the expression of inflammatory factors and protect pancreatic tissues,which would be functioned by regulating Th17 cell differentiation-related m RNA and protein expressions.

关键词： Rheum palmatum L. Salvia miltiorrhiza Bge. molecular docking simulation network pharmacology acute pancreatitis Th17 cell differentiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ganoderma lucidum:a comprehensive review of phytochemistry,efficacy,safety and clinical study

引用

Food Science and Human Wellness 2024年第2期13卷 568-596页

作者： Sijia Wu Siyuan Zhang Bo Peng Dechao Tan Mingyue Wu Jinchao Wei Yitao Wang Hua Luo Macao Centre for Research and Development in Chinese Medicine State Key Laboratory of Quality Research in Chinese MedicineInstitute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China college of Pharmacy Guangxi Medical UniversityNanning 530021China guangxi University of Chinese Medicine Nanning 530001China

Ganoderma lucidum,one of the most well-known edible fungi,is believed to be very beneficial for longevity and vitality.A long usage history suggests that *** has various clinical therapeutic *** experimental studies have confirmed that *** has multiple pharmacological effects,including antitumor,anti-microbial,anti-HIV protease,and antidiabetic activity and so *** the deepening of research,more than 300 compounds have been isolated from *** is an increasing population of ***-based products,and its international development is ***,*** has drawn much attention to its chemical composition,therapeutic effect,clinical value,and *** paper provides a comprehensive review of these aspects to enhance the global promotion of ***.

关键词： Ganoderma lucidum Phytochemistry Efficacy Safety Clinical study

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：