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Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

Science China(Life Sciences) 2025年第1期68卷 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing Chen Jiafu Ji Xiaofang Xing Key Laboratory of Carcinogenesis and Translational research(Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital&InstituteBeijing 100142China Department of Gastrointestinal cancer Center Peking University Cancer Hospital&InstituteBeijing 100142China Department of Liver Surgery&Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityKey Laboratory of Carcinogenesis and Cancer InvasionMinistry of EducationShanghai200032China State Key Laboratory of Holistic Integrative Management of Gastrointestinal cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital&InstituteBeijing 100142China

Extrachromosomal DNA(ecDNA)is a form of circular DNA mostly found in tumor *** the typical chromosomal DNA,ecDNA is circular,self-replicating,and carries complete or partial gene *** ecDNA occurrence remains a rare event in cancer,recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer,implying that ecDNA plays a central role in accelerating tumor *** has also been associated with increased tumor mutation burden,chromosomal instability,and even tumor microenvironment *** may be crucial in influencing tumor heterogeneity,drug sensitivity,oncogenic senescence,and tumor immunogenicity,leading to a worsening prognosis for tumor *** this way,several clinical trials have been conducted to investigate the importance of ecDNA in clinical *** this review,we summarize the biogenesis,characteristics,and current research methods of ecDNA,discuss the vital role of ecDNA-caused tumor heterogeneity in cancers,and highlight the potential role of ecDNA in cancer therapy.

关键词： extrachromosomal DNA cancer therapy tumor heterogeneity drug resistance tumor evolution

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NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS

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Chinese Chemical Letters 2025年第2期36卷 337-343页

作者： Xiaoshuai Wu Bailei Wang Yichen Li Xiaoxuan Guan Mingjing Yin Wenquan Lv Yin Chen Fei Lu Tao Qin Huyang Gao Weiqian Jin Yifu Huang Cuiping Li Ming Gao Junyu Lu Intensive Care Unit The Second Affiliated Hospital of Guangxi Medical University Department of Critical Care Medicine The Ninth Affiliated Hospital of Guangxi Medical University Life Sciences institute Guangxi Medical University Department of Emergency The First Affiliated Hospital of Guangxi Medical University College & Hospital of Stomatology Guangxi Medical University guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical University

Acute lung injury(ALI) was characterized by excessive reactive oxygen species(ROS) levels and inflammatory response in the lung. Scavenging ROS could inhibit the excessive inflammatory response, further treating ALI. Herein, we designed a novel nanozyme(P@Co) comprised of polydopamine(PDA) nanoparticles(NPs) loading with ultra-small Co, combining with near infrared(NIR) irradiation, which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI. For lipopolysaccharide(LPS) induced macrophages, P@Co + NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels, decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α) as well as inducing macrophage M2 directional polarization. Significantly, it displayed the outstanding activities of lowering acute lung inflammation, relieving diffuse alveolar damage, and up-regulating heat shock protein 70(HSP70) expression, resulting in synergistic enhanced ALI therapy effect. It offers a novel strategy for the clinical treatment of ROS related diseases.

关键词： Acute lung injury M2 directional polarization Nanozyme NIR driven ROS scavenging

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New poly-types of LPSO structures in a non-equilibrium Mg_(97)Zn_(1)Y_(1.6)Ca_(0.4)alloy

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China Foundry 2025年第1期22卷 83-89页

作者： Qian-qian Jin Zi-hui Tang Wen-long Xiao Xiu-yu Qu Xu-hao Han Lin Mei Xiao-hong Shao Xiu-liang Ma School of Biological and Chemical Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina Center for the Structure of Advanced Matter School of Electronic EngineeringGuangxi University of Science and TechnologyLiuzhou 545006GuangxiChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Bay Area Center for Electron Microscopy Songshan Lake Materials LaboratoryDongguan 523808GuangdongChina

In this study,a comprehensive analysis of microstructural features,morphology,crystal structures,and interface structures of long-period stacking ordered(LPSO)structures in a non-equilibrium Mg_(97)Zn_(1)Y_(16)Ca_(0.4)alloy cast in a steel mold was carried *** addition of Ca element plays an important role in the refinement of LPSO *** result reveals new poly-types including 20H F2F2F4,60R(F2F3F3)_(3),and 66H F2F3F3F2(F6)_(4)featuring a 6-Mg structure,alongside the prevalent 18R and 14H LPSO *** incoherent interface between 20H and the Mg matrix is split into two dislocation arrays,leading to the formation of a segment of 60R_(1).Moreover,the superstructure 116L,designated as(F2)_(18)F4,is formed through the ordered distribution of F4 stacking faults in 18R.

关键词： LPSO structures crystal structure Mg alloys heterogeneous interface

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Impact of residual antibiotics on microbial decomposition of livestock manures in Eutric Regosol:Implications for sustainable nutrient recycling and soil carbon sequestration

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Journal of Environmental Sciences 2025年第1期147卷 498-511页

作者： Linfa Fang Prakash Lakshmanan Xiaoxuan Su Yujia Shi Zheng Chen Yu Zhang Wei Sun Junxi Wu Ran Xiao Xinping Chen Interdisciplinary research Center for Agriculture Green Development in Yangtze River Basin College of Resources and EnvironmentSouthwest UniversityChongqing 400715China Key Laboratory of Sugarcane Biotechnology and Genetic Improvement(guangxi) Ministry of Agriculture and Rural AffairsGuangxi Key Laboratory of Sugarcane Genetic ImprovementSugarcane Research InstituteGuangxi Academy of Agricultural SciencesNanning 530007China Queensland Alliance for Agriculture and Food Innovation University of QueenslandSt Lucia 4067QLDAustralia Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and National Resources ResearchChinese Academy of SciencesBeijing 100101China

The land application of livestock manure has been widely acknowledged as a beneficial approach for nutrient recycling and environmental ***,the impact of residual antibiotics,a common contaminant of manure,on the degradation of organic compounds and nutrient release in Eutric Regosol is not well ***,we studied,how oxytetracycline(OTC)and ciprofloxacin(CIP)affect the decomposition,microbial community structure,extracellular enzyme activities and nutrient release from cattle and pig manure using litterbag incubation *** showed that OTC and CIP greatly inhibited livestock manure decomposition,causing a decreased rate of carbon(28%-87%),nitrogen(15%-44%)and phosphorus(26%-43%)*** relative abundance of gramnegative(G-)bacteria was reduced by 4.0%-13%while fungi increased by 7.0%-71%during a 28-day incubation ***-occurrence network analysis showed that antibiotic exposure disrupted microbial interactions,particularly among G-bacteria,G+bacteria,and *** changes in microbial community structure and function resulted in decreased activity of urease,β-1,4-N-acetyl-glucosaminidase,alkaline protease,chitinase,and catalase,causing reduced decomposition and nutrient release in cattle and pig *** findings advance our understanding of decomposition and nutrient recycling from manure-contaminated antibiotics,which will help facilitate sustainable agricultural production and soil carbon sequestration.

关键词： Residual antibiotics Livestock manure decomposition Microbial community Co-occurrence network Enzyme activities

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Phase transition in modified thermodynamics of Kerr-AdS black holes

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Chinese Physics C 2025年第1期49卷 350-358页

作者： Qin Liu Xiaoning Wu Xiao Zhang School of Physical Science and Technology Guangxi UniversityNanning 530004China guangxi Center for Mathematical research Guangxi UniversityNanning 530004China institute of Mathematics Academy of Mathematics and Systems Science and Hua Loo-Keng LaboratoryChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

In this study,we investigate the critical phenomena of Kerr-AdS black holes under the modified first law of ***,we considered modified black hole thermodynamics that exhibit a van der Waalslike phase *** critical exponents were calculated,and then,a swallowtail diagram of free energy was *** with existing results,the main difference is the correspondence between the thermal quantities of Kerr-AdS black holes and the van der Waals *** a previous study[***,***,and ***,***.D 85044005(2012)],the correspondence was(Ω_(H),J)→(V,P),while in our study,the correspondence was(J,Ω_(H))→(V,P).This difference was owing to the rotating *** modified black hole thermodynamics were associated with rotating *** free energy in such a reference contains extra rotating energy,which induces a Legendre transformation in the(Ω_(H),J)cross-section,causing the difference in correspondence.

关键词： Kerr-AdS black hole black hole thermodynamics phase transition of black hole

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Transcriptome Analysis of Derris fordii and Derris elliptica to Identify Potential Genes Involved in Rotenoid Biosynthesis

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Phyton-International Journal of Experimental Botany 2025年第1期94卷 123-136页

作者： Yanlin Pan Yibin Zhang Xingui Wang Hongbo Qin Lunfa Guo guangxi institute of Botany Guangxi Zhuangzu Autonomous Region and the Chinese Academy of SciencesGuilin541006China guangxi Key Laboratory of Plant Conservation and Restoration Ecology in Karst Terrain Guangxi Institute of BotanyGuangxi Zhuangzu Autonomous Region and the Chinese Academy of SciencesGuilin541006China

Derris fordii and Derris elliptica belong to the Derris genus of the Fabaceae family, distinguished by their high isoflavonoid content, particularly rotenoids, which hold significance in pharmaceuticals and agriculture. Rotenone, as a prominent rotenoid, has a longstanding history of use in pesticides, veterinary applications, medicine, and medical research. The accumulation of rotenoids within Derris plants adheres to species-specific and tissue-specific patterns and is also influenced by environmental factors. Current research predominantly addresses extraction techniques, pharmacological applications, and pesticide formulations, whereas investigations into the biosynthesis pathway and regulatory mechanism of rotenoids remain relatively scarce. In this study, we observed notable differences in rotenone content across the roots, stems, and leaves of D. fordii, as well as within the roots of D. elliptica. Utilizing RNA sequencing (RNA-seq), we analyzed the transcriptomes and expression profiles of unigenes from these four tissues, identifying a total of 121,576 unigenes. Differentially expressed genes (DEGs) across four comparison groups demonstrated significant enrichment in the phenylpropanoid and flavonoid biosynthesis pathways. Key unigenes implicated in the rotenoid biosynthesis pathway were identified, with PAL, C4H, CHS, CHI, IFS, and HI4OMT playing critical roles in D. fordii, while IFS and HI4OMT were determined to be essential for rotenoid biosynthesis in D. elliptica. These findings enhance our understanding of the biosynthesis mechanism of rotenoids in Derris species. The unigenes identified in this study represent promising candidates for future investigations aimed at validating their roles in rotenoid biosynthesis.

关键词： Derris fordii Derris elliptica RNA-seq rotenoid comparative transcriptomic analysis

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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China(Life Sciences) 2025年第1期68卷 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gastroenterology Gansu Wuwei Tumor HospitalWuwei 730000China Cixian cancer institute Handan 056500China Linzhou cancer Hospital Linzhou 456550China Center for Disease Control and Prevention of Sheyang County Yancheng 224499China Department of cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410029China Luoshan Center for Disease Control and Prevention Xinyang 464299China Office for cancer Control and research Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150081China

Surveillance recommendations for gastric cancer(GC)in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline *** aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool,and assessed whether mild-precursor-lesion patients can be safely exempt from *** the multicenter communitybased cohort,75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until *** incidence rates(CIRs)of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank *** Cox regression models were used to detect potential factors for progression towards GC.A risk score was calculated as counts of selected *** independent cohort,including 26,586 participants was used for external *** a median follow-up of 6.25 years,CIRs of GC were 0.302%,0.436%,and 4.756%for normal group,non-neoplastic(atrophic gastritis/intestinal metaplasia)and neoplastic lesions(low-grade/high-grade dysplasia),respectively(Ptrend<0.001).Four predictors,including male,≥60 years,smoking,and limited vegetable consumption,were selected for ***-risk patients(≥3 risk factors)with non-neoplastic lesions showed higher GC risks(adjusted HR=7.73,95%CI:4.29–13.92),and their four-year CIR reached the one-year CIR of neoplastic *** categorizing non-neoplastic lesions by histological grade,both patients with moderate-to-severe lesions(aHR=3.07,95%CI:1.67–5.64)and high-risk patients with mild lesions(aHR=7.29,95%CI:3.58–14.86)showed higher *** trends were observed in validation ***-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline *** study provides evidence on supplementing current guideline recommendations.

关键词： stomach neoplasms precancerous conditions cancer screening cumulative incidence risk stratification

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Advances in neoadjuvant therapy for resectable intrahepatic cholangiocarcinoma: An invited commentary

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Oncology and Translational Medicine 2025年第1期11卷 1-4页

作者： Ruyu Han Peipei Song Wei Tang Tianqiang Song Lu Chen Tianjin Medical University cancer institute and Hospital National Clinical Research Center for CancerNational Key Laboratory of Druggability Evaluation and Systematic Translational MedicineTianjin Key Laboratory of Digestive CancerTianjin’s Clinical Research Center for CancerTianjinChina Department of Hepatobiliary cancer Liver Cancer Research CenterTianjin Medical University Cancer Institute and HospitalTianjinChina National Center for Global Health and Medicine TokyoJapan

Intrahepatic cholangiocarcinoma(ICC)poses a significant threat to human health owing to its high malignancy rate and poor ***-gery is the most effective treatment option for ***,the prognosis remains unfavorable even after surgical ***,neo-adjuvant therapy has emerged as a potential treatment option for patients with *** therapy can improve patient prognosis by reducing the tumor size and eliminating tiny lesions that are not visible to the naked ***,specific treatment options for neoad-juvant therapy are *** review summarizes the studies on neoadjuvant therapy for ICC in the last decade,including chemotherapy,radiotherapy,interventional therapy,targeted therapy,and immunotherapy,with the aim of providing suggestions for the selection of clinical treatment options for patients with *** reports suggest that chemotherapy is the most effective neoadjuvant treatment ***-ever,radiotherapy and interventional therapies require further investigation to obtain conclusive *** targeted thera-pies and immunotherapies have been studied less extensively,several ongoing clinical trials are investigating these promising approaches.

关键词： Intrahepatic cholangiocarcinoma Resectable Neoadjuvant therapy

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Fisetin micelles precisely exhibit a radiosensitization effect by inhibiting PDGFRβ/STAT1/STAT3/Bcl-2 signaling pathway in tumor

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Chinese Chemical Letters 2025年第02期36卷 262-269页

作者： Yuanyuan Zeng Fang Liu Jun Wang Bianfei Shao Tao He Zhongzheng Xiang Yan Wang Shunyao Zhu Tian Yang Siting Yu Changyang Gong Lei Liu Department of Radiation Oncology Cancer CenterState Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer Hospital Chongqing Key Laboratory of translational research for cancer Metastasis and individualized Treatment Chongqing University Cancer Hospital Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Pharmacy The First Affiliated Hospital of Wannan Medical CollegeYijishan Hospital of Wannan Medical College institute of Surgery research Daping HospitalThird Military Medical University

It is of great significance to find safe and effective radiosensitizers. A primary investigation has been made on fisetin's modification of radiation effect, but its radiosensitization and related mechanisms still need to be deeply clarified. Furthermore, fisetin with high hydrophobicity is difficult to dissolve in water,severely limiting its research and application. In this study, we fabricated a safe and soluble radiosensitizer fisetin micelle for precisely enhancing radiotherapy by inhibiting platelet-derived growth factor receptor-β(PDGFRβ)/signal transducer and activator of transcription 1(STAT1)/signal transducer and activator of transcription 3(STAT3)/B cell lymphoma 2(Bcl-2) signaling pathway in the tumor. Systematic and detailed studies were performed to verify its radiosensitization effect in vitro and in vivo. On the cellular level, fisetin micelles selectively increased the radiosensitivity of tumor cells(CT26 and 4T1 cells)and had little effect on the sensitivity of normal mouse cells(L929 cells) to radiation. In the mouse models of colon and breast cancers, fisetin micelles showed an efficient radiosensitization capacity without apparent toxicity. Additionally, we first found that fisetin micelles played a radiotherapy sensitization role by inhibiting the PDGFRβ/STAT1/STAT3/Bcl-2 pathway activity. In general, this work not only confirmed that fisetin micelles precisely exhibit a radiosensitization effect in vitro and in vivo, but also profoundly explored its mechanisms underlying, to provide a theoretical and experimental basis for the clinical application of fisetin micelles.

关键词： Fisetin Platelet-derived growth factor receptor-β Polymetric micelles Radiosensitizer Radiotherapy

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VP-VO core-shell heterostructure:Harmonizing adsorption and catalysis of polysulfdes for high-performance Li-S batteries

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Journal of Energy Chemistry 2025年第2期101卷 837-843页

作者： Tao Ren Xinji Dong Xiaolan Li Haojie Zhu Cheng Yang Jinliang Zhu School of Resources Environment and Materials State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi University institute of Materials research Tsinghua Shenzhen International Graduate School Tsinghua University

*** Lithium-sulfur(Li-S) batteries are broadly considered as an outstanding candidate for the future sustainable energy storage pathway due to their high theoretical capacity,high energy density,and low cost [1,2].However,their practical deployment has been hindered by the sluggish 16-electron conversion process and shuttle of lithium polysulfides(LiPSs),which result in the loss of active sulfu r species [3,4].

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