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Hyaluronidase-triggered anticancer drug and siRNA delivery from cascaded targeting nanoparticles for drug- resistant breast cancer therapy

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Nano Research 2017年第2期10卷 690-703页

作者： Jie Ding Tingxizi Liang Ying Zhou Zhiwei He Qianhao Min Liping Jiang Junjie Zhu State key laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China guangdong provincial key laboratory of Medical Molecular Diagnostics China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China

Drug resistance renders standard chemotherapy ineffective in the treatment of connective tissue growth factor （CTGF）-overexpressing breast cancer. By co-embedding the breast tumor cell-penetrating peptide （PEGA-pVEC） and hyaluronic acid （HA） as a targeting media, novel cascaded targeting nanoparficles （HACT NPs） were created on a rattle mesoporous silica （rmSiO2） scaffold for the pinpoint delivery of siRNAs along with an anticancer drug, aiming at overcoming the drug resistance of CTGF-overexpressing breast cancer in vivo. The targeting nanoparticles selectively accumulated in the vasculature under the guidance of the PEGA-pVEC peptide, cascaded by receptor-mediated endocytosis with the aid of another targeting agent, HA, presenting a greater in vivo tumor targeting ability than single targeting ligand vectors. In addition, an HA shell prevented the leakage of therapeutic drugs during the cargo transport process, until the hyaluronidase （HAase）-triggered degradation upon lysosomes entering, guaranteeing a controllable drug release inside the target cells. When the protective shell disintegrates, the released siRNA took charge to silence the gene associated with drug resistance, CTGF, thus facilitating doxorubicin-induced apoptosis. The cascaded targeting media （PEGA-pVEC and HA） advances precision-guided therapy in vivo, while the encapsulation of siRNAs into a chemotherapy drug delivery system provides an efficient strategy for the treatment of drug resistance cancers.

关键词： drug-resistant breast cancer siRNA breast tumor cell-penetrating peptide hyaluronic acid rattle mesoporous silica

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Improvement on hydrogen generation properties of Zr（BH4）4·8NH3

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Progress in Natural Science:Materials International 2021年第1期31卷 41-46页

作者： D.F.Wu L.Z.Ouyang J.M.Huang J.W.Liu H.Wang X.S.Yang H.Shao M.Zhu School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials South China University of Technology guangdong Research Institute of Rare Metals Guangdong Key Laboratory of Rare Earth Development and Application China-Australia Joint laboratory for Energy & Environmental Materials Key Laboratory of Fuel Cell Technology of Guangdong Province Advanced Manufacturing Technology Research Centre Department of Industrial and Systems Engineering The Hong Kong Polytechnic University Joint key laboratory of the Ministry of Education Institute of Applied Physics and Materials Engineering (IAPME) University of Macau

Hydrolysis of Zr（BH4）4·8NH3in deionized water can generate high purity hydrogen at room ***, the sluggish hydrolysis kinetics of Zr（BH4）4·8NH3hinders its practical use. To improve its hydrogen generation properties, the effects of magnetic stirring, changing hydrolysis solution and tuning the ammonia coordination number on the hydrolysis properties of Zr（BH4）4·8NH3were investigated. Results show that both changing hydrolysis solution and tuning the ammonia coordination number can enhance the hydrolysis *** hydrolysis kinetics properties of Zr（BH4）4·8NH3were significantly improved in MgCl2and *** Zr（BH4）4·8NH3（x ≤ 8） samples were synthesized by a ball-milling method with different ammonization time（10, 60 and 180 min）. Both the hydrolysis kinetics and hydrogen yield of Zr（BH4）4·8NH3（x ≤ 8） were enhanced as the ammonia coordination number（x） decreased. Thus, tuning ammonia coordination number is an effective way to control the hydrolysis properties of Zr（BH4）4·8NH3（x ≤ 8）.

关键词： Hydrogen production Zr(BH 4 ) 4 ·8NH 3 Hydrolysis properties Ammonia coordination number

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Protecting-Group-Free Total Synthesis and Biological Investigation of Cabucine Oxindole A

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Chinese Journal of Chemistry 2021年第1期39卷 137-142页

作者： Shengling Xie Chengqing Ning Qingzhen Yu Jieping Hou Jing Xu Department of Chemistry and Shenzhen Grubbs Institute and guangdong provincial key Laborotory of Catalysis and Shenzhen key laboratory of Small Molecule Drug Discovery and Synthesis Southern University of Science and TechnologyShenzhenGuangdong 518055China

Owing to their challenging structures and promising biological profiles,spirooxindole alkaloids have long attracted much attention from the synthetic ***,we wish to describe a concise,protecting-group-free total synthesis of cabucine oxindole A,a putative natural spirooxindole alkaloid and a possible biosynthetic congener of cabucine and *** transformations of our approach include a one-step,organocatalytic and enantioselective construction of the spiro[pyrrolidine-3,3'-oxindole]moiety and a Korte rearrangement to furnish the final dihydropyran *** investigation of 1 and its synthetic intermediates revealed lactone 2 as a mild MOLT-4 and MCF7 cell line inhibitor.

关键词： Protecting-group-free Total synthesis Spirooxindole Alkaloid Asymmetric synthesis

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Lithocarpins E-G, Potent Anti-Tumor Tenellone-Macrolides from the Deep-Sea Fungus Phomopsis lithocarpus FS508

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Chinese Journal of Chemistry 2021年第5期39卷 1104-1112页

作者： Jianlin Xu Yuchan Chen Zhaoming Liu Saini Li Yong Wang Yuhong Ren Hongxin Liu Weimin Zhang State key laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbiol Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyGuangdong Institute of MicrobiologyGuangdong Academy of SciencesGuangzhouGuangdong 510070China State key laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China key laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

Lithocarpins E-G,featuring a rare naturally-occurring highly oxygenated tenellone-macrolide skeleton,were isolated from the culture extract of a marine-derived fungus Phomopsis lithocarpus *** structures were fully elucidated by NMR and MS spectroscopic analyses and electronic circular dichroism *** 1-3 were evaluated for their in vitro cytotoxicities against HepG2,MCF-7,SF-268,as well as A549 cell lines,among which,compound 1 exhibited inhibitory activity against HepG2 cells with an IC_(50) value of 6.3 μmol/*** further mechanistic investigation demonstrated that lithocarpin E could cause the apoptosis of HepG2 cells through activation of p-ERK,Bax,and caspase-3 gene expressions.

关键词： Phomopsis lithocarpus FS508 Polyketides Structure elucidation Antitumor agents Apoptosis

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Natural variations in grain length 10(GL10)regulate rice grain size

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Journal of Genetics and Genomics 2022年第5期49卷 405-413页

作者： Penglin Zhan Shuaipeng Ma Zhili Xiao Fangping Li Xin Wei Shaojun Lin Xiaoling Wang Zhe Ji Yu Fu Jiahao Pan Mi Zhou Yue Liu Zengyuan Chang Lu Li Suhong Bu Zupei Liu Haitao Zhu Guifu Liu Guiquan Zhang Shaokui Wang guangdong laboratory for Lingnan Modern Agriculture GuangzhouGuangdong 510642China State key laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Provincial Key Laboratory of Plant Molecular BreedingSouth China Agricultural UniversityGuangzhouGuangdong 510642China Department of Plant Sciences University of OxfordOxford OX13RBUK

Grain size is an important determinant of grain weight and yield in *** several genes related to grain size have been identified,natural variations in these genes that affect grain size are poorly ***,we describe the grain length QTL GL10,encoding MADS56,which positively regulates grain length and grain weight.A natural allelic variation of NIL-gl10,containing an~1.0-kb deletion in the first exon that abolishes its transcription,results in shorter grain length,lower grain weight and delayed flowering in gl10 *** knockout of GL10 in the HJX74 background leads to grain phenotypes similar to that of NIL-gl10,while overexpression of GL10 results in increased grain length and weight and earlier heading ***10 regulates grain length by promoting greater longitudinal cell growth in the grain ***,GL10 participates in the regulation of gibberellic acid(GA)signaling pathway genes in young panicle *** of GL10 haplotypes shows obvious divergence between the japonica and indica *** findings reveal an allelic variation of GL10 that may explain differences in grain length among modern cultivars and could be used to breed rice varieties with optimized grain shape.

关键词： Rice GL10 OsMADS56 Grain length SSSL GA

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Synergistic cytotoxicity of binary combinations of inorganic and organic disinfection byproducts assessed by real-time cell analysis

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Journal of Environmental Sciences 2022年第7期34卷 222-231页

作者： Mengge Fan Longfei Shu Xinran Zhang Miao Yu Yongting Du Junlang Qiu Xin Yang guangdong provincial key laboratory of Environmental Pollution Control and Remediation Technology School of Environmental Science and EngineeringSun Yat-sen UniversityGuangzhou 510006China

Chlorine, chlorine dioxide, and ozone are widely used as disinfectants in drinking water treatments. However, the combined use of different disinfectants can result in the formation of various organic and inorganic disinfection byproducts(DBPs). The toxic interactions, including synergism, addition, and antagonism, among the complex DBPs are still unclear. In this study, we established and verified a real-time cell analysis(RTCA) method for cytotoxicity measurement on Chinese hamster ovary(CHO) cell. Using this convenient and accurate method, we assessed the cytotoxicity of a series of binary combinations consisting of one of the 3 inorganic DBPs(chlorite, chlorate, and bromate) and one of the 32 regulated and emerging organic DBPs. The combination index(CI) of each combination was calculated and evaluated by isobolographic analysis to reflect the toxic interactions. The results confirmed the synergistic effect on cytotoxicity in the binary combinations consisting of chlorite and one of the 5 organic DBPs(2 iodinated DBPs(I-DBPs) and 3 brominated DBPs(Br-DBPs)), chlorate and one of the 4 organic DBPs(3 aromatic DBPs and dibromoacetonitrile), and bromate and one of the 3 organic DBPs(2 I-DBPs and dibromoacetic acid). The possible synergism mechanism of organic DBPs on the inorganic ones may be attributed to the influence of organic DBPs on cell membrane and cell antioxidant system. This study revealed the toxic interactions among organic and inorganic DBPs, and emphasized the latent adverse outcomes in the combined use of different disinfectants.

关键词： Disinfection byproducts(DBPs) Real-time cell analysis(RTCA) Synergistic cytotoxicity

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Pesticide wastewater treatment using the combination of the microbial electrolysis desalination and chemical-production cell and Fenton process

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Frontiers of Environmental Science & Engineering 2020年第1期14卷 137-151页

作者： Songwei Lin Yaobin Lu Bo Ye Cuiping Zeng Guangli Liu Jieling Li Haiping Luo Renduo Zhang guangdong provincial key laboratory of Environmental Pollution Control and Remediation Technology School of Environmental Science and EngineeringSun Yat-sen UniversityGuangzhou 510006China

The combination of the microbial electrolysis desalination and chemical-production cell(MEDCC)and Fenton process for the pesticide wastewater treatment was investigate in this *** wastewater with several toxic pesticides,1633 mg/L COD,and 200 in chromaticity was used for the *** showed that desalination in the desalination chamber of MEDCC reached 78%.Organics with low molecular weights in the desalination chamber could be removed from the desalination chamber,resulting in 28%and 23%of the total COD in the acid-production and cathode chambers,*** desalination in the desalination chamber and organic transfer contributed to removal of pesticides(e.g.,triadimefon),which could not be removed with other methods,and of the organics with low molecular *** COD in the effluent of the MEDCC combined the Fenton process was much lower than that in the perixo-coagulaiton process(<150 vs.555 mg/L).The combined method consumed much less energy and acid for the pH adjustment than that the Fenton.

关键词： Pesticide wastewater COD removal Microbial electrolysis desalination and chemical-production cell Energy consumption Fenton oxidation

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Novel rhino-like SHJH^(hr) mice with thyroid dysfunction

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Zoological Research 2021年第6期42卷 734-738页

作者： Yong-Chao Li Jin-Feng Gao Ya-Lun Guan Xiao-Yue Wei Xue-Jiao Li Yun-Feng Li Zhong-Qiang Huang Shu-Hua Liu Ge Li Ping Xu Guang-Jin Pan Yu Zhang guangdong provincial key laboratory of laboratory Animals Guangdong Laboratory Animals Monitoring InstituteGuangzhouGuangdong 510663China key laboratory of Regenerative Biology South China Institute for Stem Cell Biology and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouGuangdong 510530China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510006China Shanghai Jihui laboratory Animal Care Co. Ltd.Shanghai 201611China

A new Hairless(Hr)gene mutant mouse line(SHJH^(hr))was identified,which showed hairless skin in adult individuals as reported in rhino *** Hr gene mutant identification with polymerase chain reaction(PCR)amplification and sequencing,seven mutants were identified,including nonsense mutant site 2134C→T(R467X),which produced a truncated Hr *** activity and heart rate were measured using a metabolic cage and blood pressure instrument,*** SHJH^(hr) mice showed a strong metabolic rate,high heart rate,and low blood *** analysis of the thyroid gland of SHJH^(hr) mice showed abnormal follicular structure and hypertrophic *** to ICR mice,thyroid function in 4-month-old SHJH^(hr) mice showed lower thyroid stimulating hormone(TSH)levels,and in 9-month-old SHJH^(hr) mice showed significantly higher TSH and thyroid hormone *** data indicate that SHJH^(hr) mice may be in a hyperthyroid state with increasing ***,based on the above results,we successfully established a novel mouse model with thyroid dysfunction.

关键词： instrument dysfunction stimulating

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Protective effect of ginsenoside Rg1 on 661W cells exposed to oxygen-glucose deprivation/reperfusion via keap1/nrf2 pathway

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1026-1033页

作者： Ming Zhou Xin-Qi Ma Yi-Yu Xie Jia-Bei Zhou Xie-Lan Kuang Huang-Xuan Shen Chong-De Long State key laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060China

AIM:To construct an in vitro model of oxygen-glucose deprivation/reperfusion(OGD/R)induced injury to the optic nerve and to study the oxidative damage mechanism of ischemia-reperfusion(I/R)injury in 661W cells and the protective effect of ginsenoside ***:The 661W cells were treated with different concentrations of Na2S2O4 to establish OGD/R model in ***,intracellular reactive oxygen species(ROS)levels and superoxide dismutase(SOD)levels were measured at different time points during the reperfusion injury *** injury model was pretreated with graded concentrations of ginsenoside ***-time polymerase chain reaction(PCR)was used to measure the expression levels of cytochrome C(cyt C)/B-cell lymphoma-2(Bcl2)/Bcl2 associated protein X(Bax),heme oxygenase-1(HO-1),caspase9,nuclear factor erythroid 2-related factor 2(nrf2),kelch-like ECH-associated protein 1(keap1)and other *** blot was used to detect the expression of nrf2,phosphorylated nrf2(pnrf2)and keap1 protein ***:Compared to the untreated group,the cell activity of 661W cells treated with Na2S2O4 for 6 and 8h decreased(Pcell viability and SOD levels in comparison to the Na_(2)S_(2)O_(4)treated group(Pcells using Na_(2)S_(2)O_(4).Rg1 inhibits OGD/R-induced oxidative damage and alleviates the extent of apoptosis in 661W cells through the keap1/nrf2 pathway

关键词： oxygen-glucose deprivation/reoxygenation ginsenoside Rg1 oxidative stress phosphorylated nrf2

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Isolated diatomic Zn-Co metal–nitrogen/oxygen sites with synergistic effect on fast catalytic kinetics of sulfur species in Li-S battery

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Journal of Energy Chemistry 2023年第4期79卷 505-514页

作者： Chun-Lei Song Qiao-Tong He Zhongyi Zeng Jing-Yan Chen Tian Wen Yu-Xiao Huang Liu-Chun Zhuang Wei Yi Yue-Peng Cai Xu-Jia Hong School of Chemistry South China Normal UniversityGuangzhou 510006GuangdongChina Guangzhou Municipal and guangdong provincial key laboratory of Molecular Target&Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences&the Fifth Affiliated Hospital Guangzhou Medical UniversityGuangzhou 511436GuangdongChina

Lithium-sulfur batteries are severely restricted by low electronic conductivity of sulfur and Li_(2)S,shuttle effect,and slow conversion reaction of lithium polysulfides(LiPSs).Herein,we report a facile and highyield strategy for synthesizing dual-core single-atom catalyst(ZnCoN_(4)O_(2)/CN)with atomically dispersed nitrogen/oxygen-coordinated Zn-Co sites on carbon *** on density functional theory(DFT)calculations and LiPSs conversion catalytic ability,ZnCoN_(4)O_(2)/CN provides dual-atom sites of Zn and Co,which could facilitate Li^(+)transport and Li_(2)S diffusion,and catalyze LiPSs conversion more effectively than homonuclear bimetallic single-atom catalysts or their simple mixture and previously reported singleatom ***-S cell with ZnCoN_(4)O_(2)/CN modified separator showed excellent rate performance(789.4 mA h g^(-1)at 5 C)and stable long cycle performance(0.05%capacity decay rate at 6C with 1000cycles,outperforming currently reported single atomic catalysts for LiPSs *** work highlights the important role of metal active centers and provides a strategy for producing multifunctional dual-core single atom catalysts for high-performance Li-S cells.

关键词： Dual-core single-atom catalysts Lithium polysulfides Fast catalytic kinetics Li_(2)S diffusion Li-S battery

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