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Horticultural Plant Journal 2025年第1期11卷 189-198页

作者： Pinggen Xi Tianfang Guan Xiyuan Liu Xiaofeng Li Ziyuan Dou Liyun Shi Jiamin Huang Liqun Jiang Junjian Situ Minhui Li Guanghui Kong Zide Jiang guangdong province key laboratory of Microbial Signals and disease control/Department of Plant Pathology South China Agricultural UniversityGuangzhouGuangdong 510642China Rice Research Institute Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of New Technology in Rice BreedingGuangzhouGuangdong 510640China

Major facilitator superfamily(MFS)transporters are secondary active membrane transporters that play an important role in solute interchange and energy *** litchii causes the most destructive disease on lichi,litchi downy ***90 was reported as a key oosporogenesis ***,we identified an MFS transporter gene PlMFS1,which is up-regulated during oospore formation at the late infection stage,while down-regulated in the PlM90 *** investigate PlMFS1 function,we generated PlMFS1knockout mutants using CRISPR/Cas9-mediated genome editing *** with the wild-type strain SHS3,PlMFS1 deletion impaired mycelium growth,zoospore release,oospore production and ***,PlMFS1 deletion significantly affected *** utilization of fructose,lactose and maltose,and may be the PlMFS1 mechanism involved in mycelial ***1 gene deletion also led to deceased laccase activity,laccase-encoding gene downregulation and impaired *** *** our knowledge,this is the first report of an MFS transporter involved in sugar utilization,sexual reproduction,asexual reproduction and pathogenesis in oomycetes.

关键词： Peronophythora litchii Major facilitator superfamily Oospore Pathogenicity

Impact of coking plant to heavy metal characteristics in groundwater of surrounding areas:Spatial distribution,source apportionment and risk assessments

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Journal of Environmental Sciences 2025年第3期149卷 688-698页

作者： Congqing Wang Wanjun Wang ChaoWang Shixing Ren Yingjun Wu Meicheng Wen Guiying Li Taicheng An guangdong key laboratory of Environmental Catalysis and Health Risk control Guangdong Hong Kong-Macao Joint Laboratory for Contaminants Exposure and HealthInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Guangzhou key laboratory Environmental Catalysis and Pollution control Key Laboratory of City Cluster Environmental Safety and Green developmentSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China

Coking industry is a potential source of heavy metals(HMs)***,its impacts to the groundwater of surrounding residential areas have not been well *** study investigated the pollution characteristics and health risks of HMs in groundwater nearby a typical coking *** HMs including Fe,Zn,Mo,As,Cu,Ni,Cr,Pb and Cd were *** average concentration of total HMswas higher in the nearby area(244.27μg/L)than that of remote area away the coking plant(89.15μg/L).The spatial distribution of pollution indices including heavy metal pollution index(HPI),Nemerow index(NI)and contamination degree(CD),all demonstrated higher values at the nearby residential areas,suggesting coking activity could significantly impact the HMs distribution *** sources of HMs were identified by Positive Matrix Factorization(PMF)model,which indicated coal washing and coking emission were the dominant sources,accounted for 40.4%,and 31.0%,*** ingestionwas found to be the dominant exposure pathway with higher exposure dose to children than *** quotient(HQ)values were below 1.0,suggesting negligible non-carcinogenic health risks,while potential carcinogenic risks were from Pb and Ni with cancer risk(CR)values>10−*** Carlo simulation matched well with the calculated results with HMs concentrations to be the most sensitive *** study provides insights into understanding how the industrial coking activities can impact the HMs pollution characteristics in groundwater,thus facilitating the implement of HMs regulation in coking industries.

关键词： Coking industry Heavy metal Groundwater Spatial distribution Source apportionment Monte Carlo simulation

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)key laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina guangdong Provincial Center for Quality control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Bioaccessibility and health risk assessment of hydrophobic organic pollutants in soils from four typical industrial contaminated sites in China

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Journal of Environmental Sciences 2025年第1期147卷 282-293页

作者： Shi-Ping Ou Xiao-Liang Liao Zi-Tao Huang Yan-Cong Hu Zongwei Cai Zhi-Feng Chen guangdong key laboratory of Environmental Catalysis and Health Risk control Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and HealthSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China State key laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China

There have been reports of potential health risks for people from hydrophobic organic pollutants,such as polycyclic aromatic hydrocarbons(PAHs),polychlorinated hydrocarbons(PCHs),and organophosphate flame retardants(OPFRs).When a contaminated site is used for residential housing or public utility and recreation areas,the soil-bound organic pollutantsmight pose a threat to human *** this study,we investigated the contamination profiles and potential risks to human health of 15 PAHs,6 PCHs,and 12 OPFRs in soils from four contaminated sites in *** used an in vitro method to determine the oral bioaccessibility of soil *** PAHswere found at concentrations ranging from26.4 ng/g to 987 ng/***(0.27-14.3 ng/g)and OPFRs(6.30-310 ng/g)were detected,but at low levels compared to earlier *** levels of PAHs,PCHs,and OPFRs released from contaminated soils into simulated gastrointestinal fluids ranged from 1.74%to 91.0%,2.51%to 39.6%,and 1.37%to 96.9%,*** on both spiked and unspiked samples,we found that the oral bioaccessibility of pollutantswas correlated with their logKow andmolecularweight,and the total organic carbon content and pH of *** in 13 out of 38 contaminated soil samples posed potential high risks to *** considering oral bioaccessibility,nine soils still posed potential risks,while the risks in the remaining soils became *** contribution of this paper is that it corrects the health risk of soil-bound organic pollutants by detecting bioaccessibility in actual soils from different contaminated sites.

关键词： Contaminated soil Hydrophobic organic pollutant Polycyclic aromatic hydrocarbon Oral bioaccessibility Risk assessment

P450 gene CYP321A8 is responsible for cross-resistance of insecticides in field populations of Spodoptera frugiperda

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Insect Science 2025年第1期32卷 227-242页

作者： Yumei Chen Yongjie Cen Yu Liu Yanan Peng Yiguang Lin Qili Feng Yong Xiao Sichun Zheng guangdong Provincial key laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Institute of Plant Protection Guangdong Academy of Agricultural SciencesKey Laboratory of Green Prevention and Control on Fruits and Vegetables in South China Ministry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of High Technology for Plant ProtectionGuangzhouChina

Continuous and long-term use of traditional and new pesticides can result in cross-resistance among pest populations in different *** on the mechanism of cross-resistance and related genes will help resistance management and field pest *** this study,the pesticide-resistance mechanism in Spodoptera frugiperda(FAW)was studied with field populations in 3 locations of South *** FAW populations were highly resistant to traditional insecticides,chlorpyrifos(organophosphate)and deltamethrin(pyrethroid),and had higher levels of cytochrome P450 activity than a non-resistant laboratory *** of P450 activity by piperonyl butoxide significantly increased the sensitivity of resistant FAW in 3 locations to chlorpyrifos,deltamethrin and chlorantraniliprole(amide),a new type of insecticide,suggesting that P450 detoxification is a critical factor for insecticide resistance in field FAW *** analysis indicated that 18 P450 genes were upregulated in the field FAW populations collected in 3 regions and in 2 consecutive years,with CYP321A8,the most significantly upregulated *** of CYP321A8 messenger RNA by RNA interference resulted in an increased sensitivity to the 3 tested insecticides in the field *** activity and molecular docking analyses indicated that CYP321A8 enzyme was able to metabolize the 3 tested insecticides and interact with 8 other types of insecticides,confirming that CYP321A8 is a key cross-resistance gene with a wide range of substrates in the field FAW populations across the different regions and can be used as a biomarker and target for management of FAW insecticide resistance in fields.

关键词： cross-resistance cytochrome P450 field population insecticide resistance Spodopterafrugiperda

On using an aerosol thermodynamic model to calculate aerosol acidity of coarse particles

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Journal of Environmental Sciences 2025年第2期148卷 46-56页

作者： Zhengyang Fang Shuwei Dong Chengpeng Huang Shiguo Jia Fu Wang Haoming Liu He Meng Lan Luo Yizhu Chen Huanhuan Zhang Rui Li Yujiao Zhu Mingjin Tang State key laboratory of Organic Geochemistry Guangdong Key Laboratory of Environmental Protection and Resources UtilizationGuangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 101408China Longhua Center for disease control and Prevention of Shenzhen Shenzhen 518109China School of Atmospheric Sciences and Southern Marine Science and Engineering guangdong laboratory(Zhuhai) Sun Yat-sen UniversityZhuhai 519082China Institute for Environmental and Climate Research Jinan UniversityGuangzhou 510632China Qingdao Eco-environment Monitoring Center of Shandong province Qingdao 266003China Environment Research Institute Shandong UniversityQingdao 266237China

Thermodynamic modeling is still themostwidely usedmethod to characterize aerosol acidity,a critical physicochemical property of atmospheric ***,it remains unclear whether gas-aerosol partitioning should be incorporated when thermodynamicmodels are employed to estimate the acidity of coarse *** this work,field measurements were conducted at a coastal city in northern China across three seasons,and covered wide ranges of temperature,relative humidity and NH_(3) *** examined the performance of different modes of ISORROPIA-II(a widely used aerosol thermodynamic model)in estimating aerosol acidity of coarse and fine *** M0 mode,which incorporates gas-phase data and runs the model in the forward mode,provided reasonable estimation of aerosol acidity for coarse and fine *** to M0,the M1 mode,which runs the model in the forward mode but does not include gas-phase data,may capture the general trend of aerosol acidity but underestimates pH for both coarse and fine particles;M2,which runs the model in the reverse mode,results in large errors in estimated aerosol pH for both coarse and fine particles and should not be used for aerosol acidity ***,M1 significantly underestimates liquid water contents for both fine and coarse particles,while M2 provides reliable estimation of liquid water *** summary,our work highlights the importance of incorporating gas-aerosol partitioning when estimating coarse particle acidity,and thus may help improve our understanding of acidity of coarse particles.

关键词： Aerosol acidity Coarse particles Thermodynamic model Aerosol liquid water ISORROPIA-II Gas-aerosol partitioning

Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming Li Jianfeng Li Guoliang Chen Tao Lin Penghui Zhang Kuileung Tong Ningning Chen Shaoyu Liu Shenzhen key laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2

Making stereopsis related to the ability of ocular deviation:a new paradigm for assessment of intermittent exotropia

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 308-314页

作者： Jian-Bing Li Wan-Ting Kong Tao Shen Yong-Guang Yuan Chong-Lin Chen Dan-Min Peng Min-Tong Liang Xuan He Dan Luo Jia-Yi Su Wei Wang Rui-Xin Wang Xin-Ping Yu State key laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510623Guangdong ProvinceChina Department of Ophthalmology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Guangzhou Xinhua University Guangzhou 510520Guangdong ProvinceChina

AIM:To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing ***:This was a prospective observational *** evaluated the control ability of intermittent exotropia(IXT)patients in three conditions:natural 2D optotype viewing,2D optotype viewing with polarized glasses,and 3D optotype viewing with polarized *** with a smartphone,we captured videos to analyze the accurate time of spontaneous exodeviation and subsequent realignment before and after breaking ***,the correlation of stereopsis were also ***:A total of 48 patients(age range:4-33y;54.17%male)participated in the *** viewing 3D optotypes with polarized glasses,their median control scores were 1(interquartile range,0-4)at distance and 0(0-1)at *** scores were significantly better than those observed under natural viewing conditions,which were 2.5(1-5)at a distance and 1(0-3)at near(Friedman test,P=0.049).Furthermore,those subjects who exhibited exophoria(realignment within 2 seconds)while viewing 3D optotypes with polarized glasses were more likely to have measurable stereo vision(Kendall’sτb=-0.344,P=0.018).CONCLUSION:IXT patients exhibit enhanced control ability when using polarized glasses to view 3D optotypes,notably improving realignment *** expands our understanding of current tests and offers a potentially sensitive method for assessing IXT severity.

关键词： intermittent exotropia stereopsis control ability

Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer‑like social memory loss

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Military Medical Research 2025年第1期12卷 48-71页

作者： Hui-Yang Lei Gui-Lin Pi Ting He Rui Xiong Jing-Ru Lv Jia-Le Liu Dong-Qin Wu Meng-Zhu Li Kun Shi Shi-Hong Li Na-Na Yu Yang Gao Hui-Ling Yu Lin-Yu Wei Xin Wang Qiu-Zhi Zhou Pei-Lin Zou Jia-Yang Zhou Ying-Zhou Liu Nai-Ting Shen Jie Yang Dan Ke Qun Wang Gong-Ping Liu Xi-Fei Yang Jian-Zhi Wang Ying Yang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Traditional Chinese Medicine the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China key laboratory of Modern Toxicology of Shenzhen Shenzhen Center for Disease Control and PreventionShenzhen 518055GuangdongChina Co‑Innovation Center of Neuroregeneration Nantong UniversityNantong 226000JiangsuChina

Background:Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease(AD),which is closely related to tau pathology and hippocampal *** to the heterogeneity of brain neurons,the specific roles of different brain neurons in terms of their sensitivity to tau accumulation and their contribution to AD-like social memory loss remain ***,further investigation is ***:We investigated the effects of AD-like tau pathology by Tandem mass tag proteomic and phosphoproteomic analysis,social behavioural tests,hippocampal electrophysiology,immunofluorescence staining and in vivo optical fibre recording of GCaMP6f and ***,we utilized optogenetics and administered ursolic acid(UA)via oral gavage to examine the effects of these agents on social memory in ***:The results of proteomic and phosphoproteomic analyses revealed the characteristics of ventral hippocampal CA1(vCA1)under both physiological conditions and AD-like tau *** tau progressively accumulated,vCA1,especially its excitatory and parvalbumin(PV)neurons,were fully filled with mislocated and phosphorylated tau(p-Tau).This finding was not observed for dorsal hippocampal CA1(dCA1).The overexpression of human tau(hTau)in excitatory and PV neurons mimicked AD-like tau accumulation,significantly inhibited neuronal excitability and suppressed distinct discrimination-associated firings of these neurons within *** excitatory and PV neurons in vCA1 at specific rhythms and time windows efficiently ameliorated tau-impaired social ***,1 month of UA administration efficiently decreased tau accumulation via autophagy in a transcription factor EB(TFEB)-dependent manner and restored the vCA1 microcircuit to ameliorate tau-impaired social ***:This study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau

关键词： Alzheimer’s disease Tau protein Ventral hippocampus Social memory Ursolic acid Transcription factor EB(TFEB)

Prevalence,risk factors and clinical features of sensory A-V pattern exotropia

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 323-329页

作者： Bin-Bin Zhu Shi-Yu Tang Xiang-Jun Wang Li-Cheng Fu Jian-Hua Yan State key laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-Sen UniversityGuangzhou 510060Guangdong ProvinceChina Ophthalmology Department of Surgerythe Second People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina

AIM:To investigate the potential mechanisms of A-V pattern and evaluate the surgical outcomes used in the treatment of sensory ***:The medical records of patients with sensory A-V pattern exotropia who underwent strabismus surgery between May 2014 to June 2019 was retrospectively *** control group included sensory exotropia patients without A-V pattern and concomitant A-V pattern exotropia patients with normal vision who undergone strabismus surgery over this same time *** alignment,best corrected visual acuity,oblique muscle function,and stereopsis records were ***:Among the 843 eligible patients,91(10.79%;39 males and 52 females)had A-pattern(54,6.4%)or V-pattern(37,4.4%).Age at onset of vision impairment was 4±5y and at the time of surgery was 25±*** significant negative correlations were present between impaired visual acuity and the pre-operative exodeviation(r=-0.198,P=0.016)and patterns(r=-0.207,P=0.015).Age at surgery and exodeviation in patients with concomitant A-V pattern exotropia was significantly earlier as compared with that of sensory A-V pattern exotropia and sensory exotropia(both P<0.0001).There were no significant differences in these clinical variables between sensory exotropia with or without A-V *** and pattern were significantly reduced in patients receiving horizontal rectus surgery with or without oblique muscle surgery(both P<0.0001).CONCLUSION:The prevalence of sensory A-V pattern exotropia in our study is 10.79%.Visual acuity represents an important factor contributing to the occurrence and development of A-V *** horizontal rectus surgery can provide a good option for the correction of sensory A-V pattern exotropia.

关键词： sensory exotropia A-V pattern oblique muscle dysfunction horizontal rectus surgery