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Changes of visceral properties and digestive enzymes in the herbivorous marine teleost Siganus canaliculatus fed on different diets

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Acta Oceanologica Sinica 2018年第2期37卷 85-93页

作者： XIE Dizhi XU Shude WU Qingyang CHEN Fang WANG Shuqi YOU Cuihong LI Yuanyou college of Marine Sciences South China Agricultural University guangdong Provincial Key Laboratory of Marine biotechnology Shantou University guangdong VTR Bio-tech co. Ltd

The rabbitfish Siganus canaliculatus is one of the few cultured herbivorous marine teleosts. To better understand the digestive physiology of this fish and provide data for designing formulated feed using macroalgae as an ingredient, the changes of visceral properties and digestive enzyme activities were investigated after the juveniles were fed on different types of food including raw fish（RF）, formulated diet（FD） or macroalgae Enteromorpha prolifra（EP） and Gracilaria lemaneiformis（GL） for eight weeks. The results showed that the hepatosomatic and viscerosomatic indices in the RF and FD groups, as well as the relative intestine length（RIL） in the EP and GL groups, were significantly higher than those in other groups. Additionally, differences in the histological structure of the liver and anterior intestine were also observed among different dietary groups. The hepatic nuclei were displaced to the periphery by lipid inclusions in fish fed RF. The highest levels of mucosal folds were found in the anterior intestines of fish fed macroalgae. Digestive enzyme activity profiles showed obvious fluctuations in the first three weeks, and then leveled off in the following weeks. The levels of protease, lipase and α-amylase in the alimentary tract showed changes related to the levels of dietary protein, lipid and carbohydrate, *** macroalgae significantly inhibited the activity of protease in the stomach, it increased RIL and the number of mucosal folds in the anterior intestine so as to compensate for the influences on protease activities in the stomach. This study suggests that the digestive tract of rabbitfish can well adapt to different diets, and needs about three weeks to physiologically acclimatize to the nutritional status, thus implying that rabbitfish are somewhat omnivorous.

关键词： digestive enzymes macroalgae Siganus canaliculatus visceral property

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Predictive value of T cell receptor repertoire profiling for immunosuppressive therapy in severe aplastic anemia

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Genes & Diseases 2024年第1期11卷 95-98页

作者： Cunte Chen Yuling Zhang Dongpei Lu Zelong Zhang Jun Yang Xiaowei Chen Ming Zhou Wenjian Mo Caixia Wang Qinghua Cai Yumiao Li Ruiqing Zhou Shilin Xu Wei Zhou Tingfen Deng Shiyi Pan Yanli Xu Shunqing Wang Yuping Zhang Department of Hematology Guangzhou First People's HospitalSouth China University of TechnologyGuangzhouGuangdong 510180China Guangzhou Junruikang biotechnology co. LtdGuangzhouGuangdong 510700China

Increasing evidence supports the hypothesis of autologous immune attack in severe aplastic anemia(SAA):the predominant role of activated cytotoxic T cells(CTL)expressing-interferon in inhibiting the growth of bone marrow(BM)cells,putative autoantigens,and oligoclonal expansion of CD8+T cells.1 For SAA patients,the definitive therapies are immunosuppressive therapy(IST)or hematopoietic stem transplantation(HSCT).

关键词： anemia aplastic interferon

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Effects of P-Glycoprotein Inhibitor and Elicitor on the Salt Tolerance of Rice Seedlings

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Journal of Integrative Plant Biology 2007年第5期49卷 588-597页

作者： Liang-Jun Fang Xiao-Qin Fu Qun-Shan Ye Tian Wu Zheng-Chao Wang Xiao Chen Zhi-Kai Zhu Xing-Fu Zhang Chui-Kang Fu Department of biotechnology Guangdong Ocean University Zhanjiang 524088 China

Hymexazol （3-Hydroxy-5-methylisoxazole） as the main ingredients of HI （elicitor） was used to screen salt-tolerant species from 122 salt-tolerant rice （Oryza sativa L.） cultivars under specific inducement. The results showed that the local species R6 is highly induce-sensitive. R6 showed salt tolerance during the whole growth period by using 1.0% NaCI solution after HI treatment. Cyclosporin A （CsA） and verapamil （VP） as P-glycoprotein （PGP） inhibitors and rifampin （RFP） as a PGP elicitor were used to treat R6. The morphological traits, structure of the root, physiological characteristics of leaf and root systems, the content of endog- enous hormones indole-3-acetic acid （IAA） and abscisic acid （ABA） etc. show that CsA, VP and RFP had remarkable effects on the rice＇s salt tolerance. Hymexazol inducement （HI） can improve the rice＇s salt tolerance greatly and make it more salt-resistant.

关键词： P-glycoprotein elicitor P-glycoprotein inhibitor rice salt tolerance.

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Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5023-5035页

作者： Zhuchi Tu Sen Yan Bofeng Han Cajuan Li Weien Liang Yingqi Lin Yongyan Ding Huiyi Wei Lu Wang Hao Xu Jianmeng Ye Bang Li Shihua Li Xiao-Jiang Li guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhou 510632China Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine and PET/CT-MRI Centerthe First Affliated Hospital of Jinan UniversityGuangzhou 510630China guangdong landau biotechnology co.ltd Guangzhou 510555China

Tauopathy,characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau,and the accumulation of Aβ oligomers,constitute the major pathological hallmarks of Alzheimer's ***,the relationship and causal roles of these two pathological changes in neurodegeneration remain to be defined,even though they occur together or independently in several neurodegenerative diseases associated with cognitive and movement impairment.

关键词： pathological constitute marks

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Gut health:The results of microbial and mucosal immune interactions in pigs

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Animal Nutrition 2021年第2期7卷 282-294页

作者： Jie Peng Yimei Tang Yanhua Huang Innovative Institute of Animal Healthy Breeding Zhongkai University of Agriculture and EngineeringGuangzhouGuangdong510225China college of Animal Science and Technology Zhongkai University of Agriculture and EngineeringGuangzhouGuangdong510225China Guangzhou Fishtech biotechnology co. Ltd.Guangdong510640China

There are a large number of microorganisms in the porcine intestinal *** microorganisms and their metabolites contribute to intestinal mucosal immunity,which is of great importance to the health of the *** host immune system can regulate the distribution and composition of intestinal mi-croorganisms and regulate the homeostasis of intestinal flora by secreting a variety of immune effector factors,such as mucin,secretory immunoglobulin A(sIgA),regenerating islet-derivedⅢ(RegⅢ)γ,and ***,intestinal microorganisms can also promote the differentiation of immune cells including regulatory T cells(Treg)and Th17 cells through their specific components or *** have shown that imbalances in the intestinal flora can lead to bacterial translocation and compromised intestinal barrier function,affecting the health of the *** review focuses on the composition of the pig intestinal flora and the characteristics of intestinal mucosal immunity,discusses the interaction mechanism between the flora and intestinal mucosal immunity,as well as the regulation through fecal microbiota transplantation(FMT),dietary nutritional composition,probiotics and pre-biotics of pig intestinal ***,this review provides insights into the relationship between intestinal microorganisms and the mucosal immune system.

关键词： Gut microbe Pig Intestine Mucosal immunity

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ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury

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Neural Regeneration Research 2021年第8期16卷 1598-1605页

作者： Shi-Qin Lv Wutian Wu guangdong-Hong Kong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Re-Stem biotechnology co. Ltd.SuzhouJiangsu ProvinceChina

Both intracellular sigma peptide(ISP) and phosphatase and tensin homolog agonist protein(PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat model of brachial plexus injury was established by crush of the C6 ventral root. The rats were then treated with subcutaneous injection of PAP4(497 μg/d, twice per day) or ISP(11 μg/d, once per day) near the injury site for 21 successive days. After ISP and PAP treatment, the survival of motoneurons was increased, the number of regenerated axons and neuromuscular junctions was increased, muscle atrophy was reduced, the electrical response of the motor units was enhanced and the motor function of the injured upper limbs was greatly improved in rats with brachial plexus injury. These findings suggest that ISP and PAP4 promote the recovery of motor function after peripheral nerve injury in rats. The animal care and experimental procedures were approved by the Laboratory Animal Ethics committee of Jinan University of China(approval No. 20111008001) in 2011.

关键词： axon brachial plexus injury crush injury intracellular sigma peptide motor function PAP4 peripheral nerve protection regeneration repair

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Deep eutectic solvents and alkaline extraction of protein from seabuckthorn seed meal: a comparison study

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Food Science and Human Wellness 2022年第4期11卷 1028-1035页

作者： Junjie Lin Huan Xiang Dongxiao Sun-Waterhouse Chun Cui Wei Wang college of Food Science and Technology South China University of TechnologyGuangzhou 510640China guangdong Wei-Wei biotechnology co. LtdGuangzhou 510640China

Seabuckthorn seed meal(SSM) is a waste of oil extraction industry that rich in protein. In order to seek suitable protein extraction method, three different deep eutectic solvents(DESs)(including choline chlorideglycerol, choline chloride-oxalic acid and choline chloride-urea) were developed for extracting protein from SSM and compared with alkaline. Result indicated that alkaline could effectively extract 56.9% protein from SSM and its protein content was 73.1%, higher than DES at 31.0%-41.4% and 64.3%-67.5%, respectively. However, compared to alkali, DES led to a product with less β-sheet, more β-turn, more essential amino acids, higher total amino acid content, especially choline chloride-urea which extracted protein showing an integrated and similar protein weight distribution compared to SSM. Also, this protein extracted chloride-urea showed a highest digestibility in vitro(by pepsin)(54.2%). These results indicated that choline chloride-urea extraction is better than alkaline extraction for SSM.

关键词： Seabuckthorn seed meal Protein extraction Deep eutectic solvent Alkaline extraction and acid precipitation Amino acids

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Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress,NF-κB signaling and proinflammatory cytokine production in streptozotocin-induced diabetic mice

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Food Science and Human Wellness 2021年第1期10卷 87-93页

作者： Huan Xiang Dongxiao Sun-Waterhouse Chun Cui School of Food Science and Engineering South China University of TechnologyGuangzhou510640GuangdongChina guangdong Weiwei biotechnology co. LTDGuangzhou510640GuangdongChina School of Chemical Sciences The University of AucklandPrivate Bag 92019AucklandNew Zealand

Auricularia auricula(AA)and Auricularia polytricha(AP)are popular edible *** study successfully produced hypoglycemic polysaccharides from un-smashed or smashing and sieving(through a 10-mesh sieve)AA and AP(termed as AAP/AAP-10 and APP/APP-10)via scalable processes(water extraction,ethanolic precipitation and deproteinization).This is the first report to compare the effectiveness of AAP and APP in combating streptozotocin-induced oxidative stress and diabetes-related changes in mice(body weight,fasting blood glucose,serum insulin,proinflammatory mediator and cytokines,oxidative stress-related products,antioxidant enzymes).APP and AAP with different molecular weights and monosaccharide molar ratios could be therapeutic options for diabetes with a low dose(100 mg/kg/day)likely working *** the same dose,APP generally performed more effective than AAP,and AAP-10/APP-10 seemed slightly more beneficial than AAP/*** mechanism underlying these antidiabetic functions might involve the NF-κB and associated signalling *** is cheaper than AA,thereby representing a favorable source of functional polysaccharides.

关键词： Polysaccharides Auricularia auricula Auricularia polytricha Hypoglycemic effect Oxidative stress

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Mechanism underlying Fanmugua(Fructus Caricae)leaf multicomponent synergistic therapy for anemia:data mining based on hematopoietic network

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Journal of Traditional Chinese Medicine 2023年第3期43卷 542-551页

作者： JIA Lihong TIE Defu FAN Zhaohui CHEN Dan CHEN Qizhu CHEN Jun BO Huaben School of Bioscience and Biopharmaceutics Guangdong Province Key Laboratory for Biotechnology Drug CandidatesGuangdong Pharmaceutical UniversityGuangdong 510006China Department of Pharmacy Zhanjiang Health School of GuangdongGuangdong 524037China college of Pharmacy Guangdong Pharmaceutical UniversityGuangdong 510006China

OBJECTIVE:To investigate the underlying mechanism of Fanmugua(Fructus Caricae) Leaf(CPL) multicomponent synergistic therapy for ***:The components were identified in the *** databases were searched for targets of *** analysis was used to determine the targets associated with anemia and in bone *** on the Kyoto Encyclopedia of Genes and Genomes database,pathways and targets related to hematopoiesis were *** key targets were obtained by protein-protein interaction *** docking was used to analyze the binding ability of key targets and active *** marrow cells were used as an experimental model to verify the drug ***:A total of 139 components and 1868 targets of CPL were retrieved from the *** disease enrichment analysis,543 targets for hemorrhagic anemia,223 targets for aplastic anemia,and 126 targets for sickle cell anemia were *** organ enrichment yielded 27,29,and 20 targets of bone *** on KEGG pathway enrichment,a total of 47 shared hematopoietic pathways and 42 related targets were *** key targets were vascular endothelial growth factor A(VEGFA),interleukin 10(IL-10),plateletendothelial cell adhesion molecule-1(PECAM1),C-C motif chemokine 2(CCL2),and vascular cell adhesion molecule 1(VCAM1).The CPL active components included ursolic acid,quercetin,and *** expression of VEGFA was significantly increased after CPL *** and ursolic acid acted on *** and Hesperidin acted on *** acted on IL-10,CCL2,VCAM1,and *** experiments revealed that CPL could promote the proliferation and migration of bone marrow ***:CPL has the synergistic efficacy of treating anemia through multiple components,targets,and pathways.

关键词： anemia data mining network pharmacology molecular docking simulation Carica papaya(Fructus Caricae)Leaf synergistic effect

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Effects of Surface Modifi cation on the Properties of Microcapsules for Self-healing

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Journal of Wuhan University of Technology(Materials Science) 2015年第6期30卷 1234-1239页

作者：蔡秀兰 FU Datian QU Ailan Pharmacy college Guangdong Pharmaceutical University School of Life Sciences and biotechnology Jinan University

Poly（urea-formaldehyde）（UF） microcapsules with epoxy resin E-51 as core material used as self-healing materials were prepared by interfacial polymerization method. The surface of UF microcapsules was modifi ed by γ-（2,3-epoxypropoxy） propytrimethoxysilane（KH-560）. The interfacial interactions between UF microcapsules and KH-560 were studied by Fourier transform infrared spectroscopy（FTIR） and X-ray photoelectron spectrometric analysis（XPS） of microcapsules. The surface topography of microcapsules was characterized by scanning electron microscopy（SEM）. The thermal stability and mechanical properties were evaluated. FTIR and XPS results showed that there were physical and chemical combinations between the silicon coupling agent and the microcapsules surface. The thermal stability and mechanical property analysis showed that the addition of KH-560 could greatly improve the thermal stability, tensile property and elastic property. SEM results indicated that the addition of KH-560 could improve the bonding between the surface of microcapsules and resin matrix and improve the ability of self-healing.

关键词： microcapsule KH-560 surface modifi cation interfacial polymerization method

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