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Tiny 2D silicon quantum sheets:a brain photonic nanoagent for orthotopic glioma theranostics

Science Bulletin 2021年第2期66卷 147-157,M0004页

作者： Zhaohua Miao Dehong Hu Duyang Gao Linxin Fan Yan Ma Teng Ma Xin Liu Hairong Zheng Zhengbao Zha Zonghai Sheng Cheng-Yan Xu School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China Paul C.Lauterbur Research Center for biomedical imaging Shenzhen Key Laboratory of Ultrasound Imaging and TherapyInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Shenzhen Bay laboratory Shenzhen 518107China School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

We report that atomically thin two-dimensional silicon quantum sheets(2D Si QSs),prepared by a scalable approach coupling chemical delithiation and cryo-assisted exfoliation,can serve as a highperformance brain photonic nanoagent for orthotopic glioma *** the lateral size of approximately 14.0 nm and thickness of about 1.6 nm,tiny Si QSs possess high mass extinction coefficient of 27.5 Lg^(-1)cm^(-1)and photothermal conversion efficiency of 47.2%at 808 nm,respectively,concurrently contributing to the best photothermal performance among the reported 2 D mono-elemental materials(Xenes).More importantly,Si QSs with low toxicity maintain the trade-off between stability and degradability,paving the way for practical clinical translation in consideration of both storage and action of *** vitro Transwell filter experiment reveals that Si QSs could effectively go across the b End.3 cells *** the intravenous injection of Si QSs,orthotopic brain tumors are effectively inhibited under the precise guidance of photoacoustic imaging,and the survival lifetime of brain tumor-bearing mice is increased by two *** thin Si QSs with strong light-harvesting capability are expected to provide an effective and robust 2D photonic nanoplatform for the management of brain diseases.

关键词： Two-dimensional(2D)silicon Photothermal therapy Photoacoustic imaging Theranostic agents Orthotopic glioma

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Immune microenvironment-reshaping Au@Bi_(2)Te_(3) nanoparticles for spectral computed tomography/photoacoustic imaging-guided synergetic photo/radio/immunotherapy

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Nano Research 2023年第1期16卷 771-781页

作者： Kai Zhu Zede Wu Qiuyu Li Meirong Hou Honglei Hu Shuting Zheng Li Qi Yikai Xu Chenggong Yan Bingxia Zhao Department of Medical imaging Center Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangzhou key laboratory of Tumor Immunology Research Cancer Research InstituteSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China guangdong Provincial key laboratory of Medical Image Processing Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic TechnologySchool of Biomedical EngineeringSouthern Medical UniversityGuangzhou 510515China guangdong Provincial key laboratory of Shock and Microcirculation Guangzhou 510515China Experimental Education/Administration Center School of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510515China

Radiotherapy(RT)mediated tumor immunogenicity offers an opportunity for simultaneous RT and immunotherapy via immunogenic cell death(ICD),which releases damaged-associated molecular patterns and generates“eat me”signals for the innate immune system to modulate the ***,tumor hypoxia significantly reduces the therapeutic efficacy of RT and hampers its mediation of ICD ***,Au@Bi_(2)Te_(3)-polyethylene glycol(PEG)was rationally constructed as theranostic nanozymes for mild photothermal therapy,tumor hypoxia modulation,and RT adjuvant cancer *** tumor-specific production of oxygen could not only augment the effects of RT by enhanced reactive oxygen species(ROS)generation,but also reduce hypoxia-related cytokines and downregulate programmed cell death-ligand 1(PD-L1)to unleash immune-enhancing T ***,Au@Bi_(2)Te_(3)-PEG could act as an immune-blocking inhibitor by efficient ICD induction with the combination of mild-photothermal therapy+RT to inhibit the tumor immune escape and improve antitumor immune *** amounts of CD^(4+) and CD^(8+) Tcells and elevated levels of cytokines could be observed that eventually led to effective post-medication inhibition of primary and abscopal *** computed tomography/photoacoustic imaging allowed noninvasive and real-time tracking of nanoparticle(NP)accumulation and oxygenation status at tumor ***,Au@Bi_(2)Te_(3)-PEG NPs could serve as effective theranostic nanoregulators with remarkable synergistic mildphotothermal/RT/immunotherapy effects that helped reshape the immune microenvironment and had remarkable molecular imaging properties.

关键词： radioresistance immunotherapy immunogenic cell death hypoxia programmed cell death-ligand 1(PD-L1) spectral computed tomography(CT)

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电强化使得针灸针功能更强大

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Science Bulletin 2023年第24期68卷 3114-3116页

作者：乔若晨孔彬赵远锦 Department of Rheumatology and Immunology Nanjing Drum Tower HospitalClinical College of Nanjing University of Chinese MedicineNanjing 210023China guangdong key laboratory of biomedical measurements and ultrasound imaging School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China

Acupuncture,one of the major therapeutic methods of traditional Chinese medicine,is a treasure of traditional Chinese culture[1].Based on the theory of acupuncture points in meridians and channels,the therapeutic effect of acupuncture can be achieved by inserting the needles into the corresponding points,while“Ch’i”and“meridian”are the core of the acupuncture puzzle[2,3].

关键词： acupuncture 针灸针 Acupuncture

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Complex Frequency Features for TCD Signal Analysis

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Chinese Journal of biomedical Engineering(English Edition) 2017年第1期26卷 17-23页

作者： LIU Wei-xiang WANG Tian-fu CHEN Si-ping LUO Laurence WANG Xiao-yi guangdong Provincial key laboratory of biomedical Information Detection and ultrasound imaging Shenzhen Delicate Electronics Co. Ltd.

In this paper, we report on using pattern recognition techniques for embolic signal(ES) detection based on transcranial doppler ultrasound(TCD) audio data collected via machine EMS-9(from Shenzhen Delicate Electronics, Co. Ltd).Firstly, we adopted complex discrete fourier transform to get spectra of audio recordings; secondly, we used principal component analysis(PCA) for the visualization of selected signals, which makes it easy and intuitive to verify whether a signal contains an embolic component; finally we designed the classifier with support vector machines(SVM) for detection. With contrast to traditional methods of ES detection systems, the proposed approach considers two channel signals from the audio data collected by single transducer, and there is no predefined features for classification. The primary experimental results on real data are promising.

关键词： embolic signal transcranial doppler ultrasound(TCD) complex discrete fourier transform principal component analysis support vector machine

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Effect of Pulsed Electric Fields on Interface Properties of Phospholipids Dispersion

Effect of Pulsed Electric Fields on Interface Properties of ...

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2012 International Conference on Nano Materials and Electric Devices(ICNMED 2012)

作者： Dan Guo Jia Xiao Chen Jing Zeng Xin-An Han Zhong National-Reginoal key Technology Engineering laboratory for Medical ultrasound Guangdong Key Laboratory for Biomedical Measurements and Ultrasound ImagingDepartment of Biomedical Engineering School of Medicine Shenzhen University College of Light Industry and Food Sciences South China University of Technology

Effects of pulsed electric fields(PEF) treatment on interface properties of phospholipids dispersion were studied. Results showed that the conductivity of solutions with different concentration after PEF treatment increased while surface tension value decreased with increasing electric field strength. The absolute value of zeta potential firstly increased when the field intensity was within 00 k V/cm, and then decreased if the field intensity increased further. It can be inferred that the torque of phospholipids molecule may have changed and phospholipids molecule have rearranged after PEF treatment. Moreover, as a resemblance to biological membrane structure, the phospholipid molecules of cell membrane may generate micropores after rearrangement, which result in the cell electroporation.

关键词： Pulsed electric fields Phospholipids dispersion Interface properties Conductivity Zeta potential value

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Highly Sensitive MoS_2–Indocyanine Green Hybrid for Photoacoustic imaging of Orthotopic Brain Glioma at Deep Site

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Nano-Micro Letters 2018年第3期10卷 115-126页

作者： Chengbo Liu Jingqin Chen Ying Zhu Xiaojing Gong Rongqin Zheng Ningbo Chen Dong Chen Huixiang Yan Peng Zhang Hairong Zheng Zonghai Sheng Liang Song Research laboratory for biomedical Optics and Molecular imaging Shenzhen Key Laboratory for Molecular ImagingInstitute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen College of Advanced Technology University of Chinese Academy of Sciences Department of Medical ultrasound The Third Affiliated Hospital of Sun Yat-Sen University Translational Medicine R&D Center Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Paul C.Lauterbur Research Center for biomedical imaging Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences

Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS_2–ICG hybrid with indocyanine green(ICG) conjugated to the surface of MoS_2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS_2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS_2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS_2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS_2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine.

关键词： MoS2–ICG hybrid Orthotopic brain glioma Photoacoustic imaging Molecular imaging

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The Forward and Inverse Problem Based on Magneto-Acoustic Tomography with Current Injection

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Journal of biomedical Science and Engineering 2017年第5期10卷 97-105页

作者： Hui Xia Guoqiang Liu Xin Huang Liang Guo Yanjiu Yang Minhua Lu Department of Engineering Electromagnetics Applications Institute of Electrical Engineering Chinese Academy of Sciences Beijing China University of Chinese Academy of Sciences Beijing China guangdong key laboratory for biomedical measurements and ultrasound imaging Shenzhen China

The Magneto-acoustic Tomography with Current Injection (MAT-CI) is a new biological electrical impedance imaging technique that combines Electrical Impedance Tomography (EIT) with Ultrasonic imaging (UI), which possesses the non-invasive and high-contrast of the EIT and the high-resolution of the UI. The MAT-CI is expected to acquire high quality image and embraces a wide application. Its principle is to put the conductive sample in the Static Magnetic Field(SMF) and inject a time-varying current, during which the SMF and the current interact and generate the Lorentz Force that inspire ultrasonic signal received by the ultrasonic transducers positioned around the sample. And then according to related reconstruction algorithm and ultrasonic signal, electrical conductivity image is obtained. In this paper, a forward problem mathematical model of the MAT-CI has been set up to deduce the theoretical equation of the electromagnetic field and solve the sound source distribution by Green’s function. Secondly, a sound field restoration by Wiener filtering and reconstruction of current density by time-rotating method have deduced the Laplace’s equation that caters to the current density to further acquire the electrical conductivity distribution image of the sample through iteration method. In the end, double-loop coils experiments have been conducted to verify its feasibility.

关键词： Magneto-Acoustic Tomography With Current Injection Axial Symmetry Model the Forward and Inverse Problem of Electromagnetic Field Reconstruction Image Reconstruction Electrical Conductivity Image

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Graphene-loaded metal wire grating for deep and broadband THz modulation in total internal reflection geometry

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Photonics Research 2018年第12期6卷 1151-1157页

作者： YIWEN SUN RICCARDO DEGLJINNOCENTI DAVID A.RITCHIE HARVEY E.BEERE LONG XIAO MICHAEL RUGGIERO J.AXEL ZEITLER RAYKO I.STANTCHEV DANNI CHEN ZHENGCHUN PENG EMMA MACPHERSON XUDONG LIU National-Regional key Technology Engineering laboratory for Medical ultrasound Guangdong Key Laboratory for Biomedical Measurements and Ultrasound ImagingDepartment of Biomedical EngineeringSchool of MedicineShenzhen UniversityShenzhen 518060China Cavendish laboratory University of CambridgeJ J Thomson AvenueCambridge CB30HEUK Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA Department of Chemistry University of Vermont82 University PlaceBurlingtonVermont 05405USA Department of Chemical Engineering and Biotechnology University of CambridgePembroke StreetCambridge CB2 3RAUK Department of Electronic Engineering The Chinese University of Hong KongHong KongChina key laboratory of Ministry of Education for Optoelectronic Devices and Systems College of Optoelectronic EngineeringShenzhen University Shenzhen 518060China Department of Physics University of WarwickGibbet Hill RoadCoventry CV4 7ALUK

We employed a metallic wire grating loaded with graphene and operating in total internal reflection (TIR) geometry to realize deep and broadband THz modulation. The non-resonant field enhancement effect of the evanescent wave in TIR geometry and in the subwavelength wire grating was combined to demonstrate a ～77% modulation depth (MD) in the frequency range of 0.2–1.4 THz. This MD, achieved electrically with a SiO_2∕Si gated graphene device, was 4.5 times higher than that of the device without a metal grating in transmission geometry. By optimizing the parameters of the metallic wire grating, the required sheet conductivity of graphene for deep modulation was lowered to 0.87 mS. This work has potential applications in THz communication and real-time THz imaging.

关键词： modulation depth (MD) graphene Wire grating

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Axial gradient excitation accelerates volumetric imaging of two-photon microscopy

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Photonics Research 2022年第3期10卷 687-696页

作者： Yufeng Gao Xianyuan Xia Lina Liu Ting Wu Tingai Chen Jia Yu Zhili Xu Liang Wang Fei Yan Zhuo Du Jun Chu Yang Zhan Bo Peng Hui Li Wei Zheng Research Center for biomedical Optics and Molecular imaging Shenzhen Key Laboratory for Molecular ImagingGuangdong Provincial Key Laboratory of Biomedical Optical Imaging TechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China CAS key laboratory of Health Informatics Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Paul C.Lauterbur Research Center for biomedical imaging Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State key laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China key laboratory of Genetic Network Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Centre for Micro Nano Systems and Bionic Medicine Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Two-photon excitation fluorescence microscopy(TPM),owing to its capacity for subcellular resolution,intrinsic optical sectioning,and superior penetration depth in turbid samples,has revolutionized biomedical ***,its layer-by-layer scanning to form a three-dimensional image inherently limits the volumetric imaging speed and increases phototoxicity *** this study,we develop a gradient excitation technique to accelerate TPM volumetric *** axial positions of the fluorophores can be decoded from the intensity ratio of the paired images obtained by sequentially exciting the specimen with two axially elongated two-photon beams of complementary gradient *** achieved a 0.63μm axial localization precision and demonstrate the flexibility of the gradient TPM on various sparsely labeled samples,including bead phantoms,mouse brain tissues,and live *** with traditional TPM,our technique improves volumetric imaging speed(by at least sixfold),decreases photobleaching(i.e.,less than 2.07±2.89%in 25 min),and minimizes photodamages.

关键词： excitation gradient photon

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Analysis of the Expression of Angioarchitecture-related Factors in Patients with Cerebral Arteriovenous Malformation

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Chinese Medical Journal 2017年第20期130卷 2465-2472页

作者： Guang-Zhong Chen Yu Ke Kun Qin Meng-Qi Dong Shao-Jian Zeng Xiao-Feng Lin Sheng-Quan Zhan Kai Tang Chao Peng Xiao-Wen Ding Dong Zhou Department of Neurosurgery Guangdong General Hospital Institute of Neuroscience Guangdong Academy of Medical Sciences Guangzhou Guangdong 510080 China Department of biomedical Engineering Key Laboratory of Biomaterials of Guangdong Higher Education Institutes College of Life Science and Technology Jinan University Guangzhou Guangdong 510632 China

Background： Cerebral arteriovenous malformation （cAVM） is a type of vascular malformation associated with vascular remodeling, hemodynamic imbalance, and inflammation. We detected four angioarchitecture-related cytokines to make a better understanding of the potential aberrant signaling in the pathogenesis of cAVM and found useful proteins in predicting the risk of cerebral hemorrhage. Methods： lmmunohistochemical analysis was conducted on specimens from twenty patients with cAVM diagnosed via magnetic resonance imaging and digital subtraction angiography and twenty primary epilepsy controls using antibodies against vascular endothelial growth factor receptor-2 （VEGFR-2）, matrix metalloproteinase-9 （MMP-9）, vascular cell adhesion molecule （VCAM- 1 ）, and endothelial nitric oxide synthase （eNOS）. Western blotting and real-time fluorescent quantitative polymerase chain reaction （PCR） were performed to determine protein and mRNA expression levels. Student＇s t-test was used for statistical analysis. Results： VEGFR-2, MMP-9, VCAM-1, and eNOS expression levels increased in patients with cAVM compared with those in normal cerebral vascular tissue, as determined by immunohistochemical analysis. In addition, Western blotting and real-time PCR showed that the protein and mRNA expression levels ofVEGFR-2, MMP-9, VCAM-1, and eNOS were higher in the cAVM group than in the control group, all the differences mentioned were statistically significant （P 〈 0,05）. Conclusions： VEGFR-2, MMP-9, VCAM-1, and eNOS are upregulated in patients with cAVM and might play important roles in angiogenesis, vascular remodeling, and migration in patients with cAVM. MMP-9, VEGFR-2, VCAM-1, and eNOS might be potential excellent group proteins in predicting the risk of cerebral hemorrhage at arteriovenous malformation.

关键词： Angioarchitecture-related Factors Cerebral Arteriovenous Malformation Endothelial Nitric Oxide Synthase Matrix Metalloproteinase-9: Vascular Cell Adhesion Molecule-1 Vascular Endothelial Growth Factor Receptor-2

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